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  1. Article ; Online: Robotic left ventral segmentectomy.

    Mangiameli, Giuseppe / Durand, Marion

    JTCVS techniques

    2021  Volume 8, Page(s) 205–207

    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2021.04.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Vats lobectomy for lung cancer. What has been the evolution over the time?

    Re Cecconi, Emanuela / Mangiameli, Giuseppe / De Simone, Matilde / Cioffi, Ugo / Marulli, Giuseppe / Testori, Alberto

    Frontiers in oncology

    2024  Volume 13, Page(s) 1268362

    Abstract: Video assisted thoracic surgery (VATS) lobectomy is the treatment of choice for early-stage lung cancer. It is safe and effective compared to open surgery, as demonstrated by a large body of scientific evidence over the last few decades. VATS lobectomy's ...

    Abstract Video assisted thoracic surgery (VATS) lobectomy is the treatment of choice for early-stage lung cancer. It is safe and effective compared to open surgery, as demonstrated by a large body of scientific evidence over the last few decades. VATS lobectomy's evolution was driven by the need to decrease post-operative pain by reducing the extent of surgical accesses, maintaining the same oncological efficacy of open lobectomy with less invasiveness. VATS lobectomy just turned 30 years old, evolving and changing significantly from its origins. The aim of this mini review is to retrace the history, starting from a multiport approach to a single port approach. At the end of this mini review, we will discuss the advanced and the future challenges of the technique that has revolutionized thoracic surgery.
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1268362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Lung Cancer Treatment: From Tradition to Innovation.

    Mangiameli, Giuseppe / Cioffi, Ugo / Testori, Alberto

    Frontiers in oncology

    2022  Volume 12, Page(s) 858242

    Abstract: Lung cancer (LC) is the second most commonly diagnosed cancer and the primary cause of cancer death worldwide in 2020. LC treatment is associated with huge costs for patients and society; consequently, there is an increasing interest in the prevention, ... ...

    Abstract Lung cancer (LC) is the second most commonly diagnosed cancer and the primary cause of cancer death worldwide in 2020. LC treatment is associated with huge costs for patients and society; consequently, there is an increasing interest in the prevention, early detection with screening, and development of new treatments. Its surgical management accounts for at least 90% of the activity of thoracic surgery departments. Surgery is the treatment of choice for early-stage non-small cell LC. In this article, we discuss the state of the art of thoracic surgery for surgical management of LC. We start by describing the milestones of LC treatment, which are lobectomy and an adequate lymphadenectomy, and then we focus on the traditional and innovative minimally invasive surgical approaches available: video-assisted thoracoscopic surgery (VATS) and robotic-assisted thoracoscopic surgery (RATS). A brief overview of the innovation and future perspective in thoracic surgery will close this mini-review.
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.858242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Lung Metastases: Current Surgical Indications and New Perspectives.

    Mangiameli, Giuseppe / Cioffi, Ugo / Alloisio, Marco / Testori, Alberto

    Frontiers in surgery

    2022  Volume 9, Page(s) 884915

    Abstract: Pulmonary metastasectomy is an established treatment that can provide improved long- term survival for patients with metastatic tumor(s) in the lung. In this mini-review, we discuss the state of the art of thoracic surgery in surgical management of lung ... ...

    Abstract Pulmonary metastasectomy is an established treatment that can provide improved long- term survival for patients with metastatic tumor(s) in the lung. In this mini-review, we discuss the state of the art of thoracic surgery in surgical management of lung metastases which actually occurs for a large part of surgical activity in thoracic surgery department. We describe the principles of surgical therapy that have been defined across the time, and that should remain the milestones of lung metastases treatment: a radical surgery and an adequate lymphadenectomy. We then focus on current surgical indications and report the oncological results according to the surgical approach (open vs. mini-invasive), the histological type and number of lung metastases, and in case of re-metastasectomy. Finally, we conclude with a brief overview about the future perspectives in thoracic surgery in treatment of lung metastases.
    Language English
    Publishing date 2022-04-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.884915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Extracorporeal membrane oxygenation support in oncological thoracic surgery.

    Mangiameli, Giuseppe / Testori, Alberto / Cioffi, Ugo / Alloisio, Marco / Cariboni, Umberto

    Frontiers in oncology

    2022  Volume 12, Page(s) 1005929

    Abstract: The use of extracorporeal lung support (ECLS) during thoracic surgery is a recent concept that has been gaining increasing approval. Firstly introduced for lung transplantation, this technique is now increasingly adopted also in oncological thoracic ... ...

    Abstract The use of extracorporeal lung support (ECLS) during thoracic surgery is a recent concept that has been gaining increasing approval. Firstly introduced for lung transplantation, this technique is now increasingly adopted also in oncological thoracic surgical procedures. In this review, we focus on the cutting-edge application of extracorporeal membrane oxygenation (ECMO) during oncological thoracic surgery. Therefore, we report the most common surgical procedures in oncological thoracic surgery that can benefit from the use of ECMO. They will be classified and discussed according to the aim of ECMO application. In particular, the use of ECMO is usually limited to certain lung surgery procedures that can be resumed such as in procedures in which an adequate ventilation is not possible such as in single lung patients, procedures where conventional ventilation can cause conflict with the surgical field such as tracheal or carinal surgery, and conventional procedures requiring both ventilators and hemodynamic support. So far, all available evidence comes from centers with large experience in ECMO and major thoracic surgery procedures.
    Language English
    Publishing date 2022-11-25
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2022.1005929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Giant presternal subcutaneous bronchogenic cyst: a rare but possible occurrence.

    Mangiameli, Giuseppe / Arame, Alex / Le Pimpec-Barthes, Françoise

    Asian cardiovascular & thoracic annals

    2020  Volume 28, Issue 8, Page(s) 507–509

    Abstract: Bronchogenic cysts are generally detected in the mediastinum, along the tracheobronchial tree, or in the lung parenchyma. Subcutaneous presternal bronchogenic cysts have been rarely described, and they are usually of small size (<3 cm) and reported in ... ...

    Abstract Bronchogenic cysts are generally detected in the mediastinum, along the tracheobronchial tree, or in the lung parenchyma. Subcutaneous presternal bronchogenic cysts have been rarely described, and they are usually of small size (<3 cm) and reported in children. We report a case of giant presternal subcutaneous bronchogenic cyst in a 20-year-old man. Presternal subcutaneous bronchogenic cysts, despite their rarity, should be considered in the differential diagnosis of all subcutaneous cystic masses, independent of their size and the patient's age.
    MeSH term(s) Biopsy ; Bronchogenic Cyst/diagnostic imaging ; Bronchogenic Cyst/pathology ; Bronchogenic Cyst/surgery ; Diagnosis, Differential ; Humans ; Male ; Predictive Value of Tests ; Subcutaneous Tissue/diagnostic imaging ; Subcutaneous Tissue/pathology ; Subcutaneous Tissue/surgery ; Tomography, X-Ray Computed ; Young Adult
    Language English
    Publishing date 2020-07-12
    Publishing country England
    Document type Case Reports
    ZDB-ID 1400468-9
    ISSN 1816-5370 ; 0218-4923
    ISSN (online) 1816-5370
    ISSN 0218-4923
    DOI 10.1177/0218492320943338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Preoperative CT-Guided Near-Infrared Dye Marking for Thoracoscopic Resection of Pulmonary Nodules: A Case Report.

    Voulaz, Emanuele / Testori, Alberto / D'Antuono, Felice / Cariboni, Umberto / Alloisio, Marco / Mangiameli, Giuseppe

    Frontiers in surgery

    2022  Volume 9, Page(s) 919227

    Abstract: Localization of small-sized pulmonary nodules is challenging during video-assisted thoracoscopic surgery. Several preoperative strategies have been developed to mark these targets. We describe our localization strategy using a preoperative computed ... ...

    Abstract Localization of small-sized pulmonary nodules is challenging during video-assisted thoracoscopic surgery. Several preoperative strategies have been developed to mark these targets. We describe our localization strategy using a preoperative computed tomography-guided near-infrared dye marking.
    Language English
    Publishing date 2022-06-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.919227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Thymomectomy versus complete thymectomy in early-stage non-myasthenic thymomas: a multicentric propensity score-matched study.

    Voulaz, Emanuele / Perroni, Gianluca / Russo, Anna / Patirelis, Alexandro / Mangiameli, Giuseppe / Alloisio, Marco / Ambrogi, Vincenzo

    Interactive cardiovascular and thoracic surgery

    2022  Volume 35, Issue 1

    Abstract: Objectives: Thymomectomy is gaining consensus over complete thymectomy in early-stage thymoma without myasthenia gravis. This is due both to the difficulty of establishing prospective and randomized controlled studies and to the lack of well-defined ... ...

    Abstract Objectives: Thymomectomy is gaining consensus over complete thymectomy in early-stage thymoma without myasthenia gravis. This is due both to the difficulty of establishing prospective and randomized controlled studies and to the lack of well-defined selection criteria. This bicentric, retrospective propensity score-matched study aims at comparing oncological outcomes, measured in terms of overall survival and thymoma-related survival, in patients undergoing either thymomectomy or complete thymectomy.
    Methods: We retrospectively analysed medical records of patients with clinical early-stage (I and II) thymoma undergoing thymomectomy or complete thymectomy. Exclusion criteria were the presence of myasthenia gravis, clinical advanced tumours and thymic carcinoma. A propensity score-matching analysis was applied to reduce potential preoperative selection biases such as comorbidity (Charlson score), tumour maximal diameter and surgical approach (open versus minimal). All variables were dichotomized.
    Results: A total of 255 patients were enrolled from 2 different Hospitals, 126 underwent complete thymectomy and 129 a thymomectomy. Disease-free and thymoma-related survivals showed a 5-year rate of 87.7% and 96.0% and a 10-year rate of 82.2% and 91.9%, respectively. Propensity score-matching analysis selected a total of 176 patients equally divided between the 2 groups. No difference was found for both disease-free (P = 0.11) and thymoma-related (P = 0.37) survival in the 2 groups of resection. Multivariable Cox regression analysis showed that histology (P < 0.001), residual disease (P < 0.001) and adjuvant chemotherapy (P < 0.001) were the only predictors of shorter disease-free survival. Whereas there was no evidence to confirm that disease-free and thymoma-related survivals were influenced by resection extent.
    Conclusions: Thymomectomy is an adequate surgical resection for non-myasthenic thymoma, achieving disease-free and thymoma-related survivals comparable to those after complete thymectomy.
    MeSH term(s) Humans ; Myasthenia Gravis/surgery ; Neoplasm Staging ; Propensity Score ; Prospective Studies ; Retrospective Studies ; Thymectomy/adverse effects ; Thymoma/pathology ; Thymus Neoplasms/pathology
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2095298-3
    ISSN 1569-9285 ; 1569-9293
    ISSN (online) 1569-9285
    ISSN 1569-9293
    DOI 10.1093/icvts/ivac167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Right tracheal sleeve pneumonectomy with VV-ECMO assistance for non-small cell lung cancer through anterior thoracotomy: a single centre experience.

    Marziali, Valentina / Mangiameli, Giuseppe / Crepaldi, Alessandro / Piccioni, Federico / Costantini, Elena / Citterio, Enrico / Borbone, Alessandro / Cariboni, Umberto

    Frontiers in surgery

    2023  Volume 10, Page(s) 1238462

    Abstract: For a long time, non-small cell lung cancer (NSCLC) arising less than 2 cm distal to the carina has been usually considered unresectable and incurable with a radical or extended resection because of surgical technical difficulty and airway management. ... ...

    Abstract For a long time, non-small cell lung cancer (NSCLC) arising less than 2 cm distal to the carina has been usually considered unresectable and incurable with a radical or extended resection because of surgical technical difficulty and airway management. Recently, the introduction of more advanced surgical techniques, often including the use of extracorporeal life support (ECLS), has allowed us to extend the limits of conventional surgery, increasing the rate of complete surgical resection. ECLS also overcomes the limitation of conventional ventilation during complex tracheo-bronchial reconstruction, avoiding the presence of disturbing lines or tubes that obstruct the operative field during a challenging surgery. In this article, we share our experience in performing right tracheal sleeve pneumonectomy with veno-venous extracorporeal membrane oxygenation (VV-ECMO) in three cases by anterior right thoracotomy, reporting our tips and tricks.
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2023.1238462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Blood-Derived Systemic Inflammation Markers and Risk of Nodal Failure in Stage Ia Non-Small Cell Lung Cancer: A Multicentric Study.

    Tacconi, Federico / Mangiameli, Giuseppe / Voulaz, Emanuele / Patirelis, Alexandro / Carlea, Federica / Rocca, Eleonora La / Tamburrini, Alessandro / Vanni, Gianluca / Ambrogi, Vincenzo

    Journal of clinical medicine

    2023  Volume 12, Issue 15

    Abstract: Background: Unexpected spread to regional lymph nodes can be found in up to 10% of patients with early stage non-small cell lung cancer (NSCLC), thereby affecting both prognosis and treatment. Given the known relation between systemic inflammation and ... ...

    Abstract Background: Unexpected spread to regional lymph nodes can be found in up to 10% of patients with early stage non-small cell lung cancer (NSCLC), thereby affecting both prognosis and treatment. Given the known relation between systemic inflammation and tumor progression, we sought to evaluate whether blood-derived systemic inflammation markers might help to the predict nodal outcome in patients with stage Ia NSCLC.
    Methods: Preoperative levels of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation score (SII, platelets × NLR) were collected from 368 patients who underwent curative lung resection for NSCLC. After categorization, inflammatory markers were subjected to logistic regression and time-event analysis in order to find associations with occult nodal spread and postoperative nodal recurrence.
    Results: No inflammation marker was associated with the risk of occult nodal spread. SII showed a marginal effect on early nodal recurrence at a quasi-significant level (
    Conclusions: blood-derived inflammation markers had no value in the preoperative prediction of nodal status. Nevertheless, our results might suggest a modulating effect of platelet-derived inflammation markers on nodal progression after the resection of tumors larger than 2 cm.
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12154912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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