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  1. Article ; Online: The Genus Cryptocarya: A Review on Phytochemistry and Pharmacological Activities.

    Manh Ha, Nguyen / The Son, Ninh

    Chemistry & biodiversity

    2023  Volume 20, Issue 3, Page(s) e202201102

    Abstract: Cryptocarya (the laurel family) is a large genus of great economic plants found in tropics and subtropics. Plants of this genus are a rich resource of essential oils, and pharmacological compounds. An overview of phytochemistry and pharmacological aspect ...

    Abstract Cryptocarya (the laurel family) is a large genus of great economic plants found in tropics and subtropics. Plants of this genus are a rich resource of essential oils, and pharmacological compounds. An overview of phytochemistry and pharmacological aspect is not yet available. This review aims to establish insightful information on phytochemistry, and pharmacological values. The literature collection is based on keywords 'Cryptocarya', 'phytochemistry', and 'pharmacology' using a broad panel of scientific sources, such as Google Scholar, Sciencedirect, and Wiley. Since the 1950s, Cryptocarya plants have been the main object in various phytochemical studies, by which about 390 metabolite compounds were isolated. Alkaloids, α-pyrones, and flavonoids could be seen as the main classes of Cryptocarya isolates. Cryptocarya constituents displayed potential pharmacological values such as anti-inflammatory, antimicrobial, antioxidative, antiviral, vasorelaxant activities, especially cytotoxicity.
    MeSH term(s) Ethnopharmacology ; Cryptocarya ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/chemistry ; Oils, Volatile/pharmacology ; Phytotherapy/methods
    Chemical Substances Plant Extracts ; Phytochemicals ; Oils, Volatile
    Language English
    Publishing date 2023-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2139001-0
    ISSN 1612-1880 ; 1612-1872
    ISSN (online) 1612-1880
    ISSN 1612-1872
    DOI 10.1002/cbdv.202201102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics of oocytes that failed to fertilize after intracytoplasmic sperm injection.

    Thanh Hoa, N / Khanh Trang, H N / Minh Duc, N / Manh Ha, N

    La Clinica terapeutica

    2023  Volume 174, Issue 2, Page(s) 189–194

    Abstract: Background: We assessed the morphologies of meiotic spindles in oocytes that failed to fertilize following intracytoplasmic sperm injection (ICSI) and identified factors contributing to failed fertilization.: Methods: A total of 225 unfertilized ... ...

    Abstract Background: We assessed the morphologies of meiotic spindles in oocytes that failed to fertilize following intracytoplasmic sperm injection (ICSI) and identified factors contributing to failed fertilization.
    Methods: A total of 225 unfertilized oocytes were collected after ICSI. Oocytes were fixed and stained for tubulin and chromosomes. Meiotic spindle morphologies, chromosome alignment, and sperm nuclear decondensation were assessed to identify contributing factors to fertilization failure. We identified relationships between several factors and both abnormal spindle morphologies and sperm nuclear decondensation in oocytes that failed to fertilize.
    Results: Three causes for unfertilized oocytes after ICSI were identified: (I) the absence of a sperm nucleus in the ooplasm; (II) failed oocyte activation; and (III) defects in pronucleus formation or migration. The rate of disarranged polar spindles in oocytes collected from women older than 35 years (73.3%; 33/45 oocytes) was significantly higher than that of those collected from women 35 years and younger (50.4%; 68/135 oocytes; odds ratio [OR]: 2.71, 95% confidence interval [CI]: 1.29-5.69, p = 0.009). The proportion of unfertilized oocytes with abnormal spindles and chromosome misalignment was significantly higher in oocytes collected from women older than 35 years than those from women 35 years and younger (62.2% vs. 41.5%, p = 0.016). The proportion of partially decondensed chromatin in the abnormal sperm morphology group was significantly higher than in the normal sperm morphology group (66.7% versus 52.9%, OR: 1.78, 95% CI: 1.01-3.11, p = 0.044).
    Conclusions: The main contributor to the failure of oocytes to fertilize after ICSI is failed oocyte activation. The ICSI technique used, the maternal age, and sperm morphology are also contributing factors in fertilization failure after ICSI.
    MeSH term(s) Male ; Female ; Humans ; Sperm Injections, Intracytoplasmic ; Fertilization in Vitro/methods ; Semen ; Fertilization ; Spermatozoa/physiology ; Oocytes/physiology
    Language English
    Publishing date 2023-03-15
    Publishing country Italy
    Document type Observational Study
    ZDB-ID 123320-8
    ISSN 1972-6007 ; 0009-9074
    ISSN (online) 1972-6007
    ISSN 0009-9074
    DOI 10.7417/CT.2023.2518
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Wound healing capacity of using mesenchymal stem cell-derived exosomes originated from human adipose tissue and cold atmospheric plasma.

    Quynh, D T / Trang Uyen, T T / My Nhung, H T / Hoang Tung, D / Thu Huyen, N / Ngoc Thanh, L / Thom, V T / Bich Phuong, L T / Manh Ha, N

    La Clinica terapeutica

    2024  Volume 175, Issue 2, Page(s) 135–143

    Abstract: Background: Recently, cold atmospheric plasma (CAP), as well as adipose mesenchymal stem cells derived exosomes (ADMSCs-EX), have been applied separately to wound healing treatment. However, no study has investigated the additive effect on the healing ... ...

    Abstract Background: Recently, cold atmospheric plasma (CAP), as well as adipose mesenchymal stem cells derived exosomes (ADMSCs-EX), have been applied separately to wound healing treatment. However, no study has investigated the additive effect on the healing mechanism of these two methods in the same skin lesion treatment model.
    Aim: We conduct this study to describe the results of using CAP and human ADMSCs-EX on in vitro wound healing.
    Methods: Exosomes were isolated from donor adipose tissue samples by ultracentrifugation method, characterized by transmission electron microscopy (TEM) and Western blot. Assessment in vitro wound healing on proliferation and migration evaluation experiments on human fibroblasts with culture medium supplemented with 10µg total exosomal proteins/1 mL and irradiated with CAP with an intensity of 30 seconds/cm2.
    Results: Experimental results to evaluate the ability to stimulate fibroblast migration, showed that cell migration speed in the group supplemented with ADMSCs-EX was equivalent to the group with a combination of CAP and ADMSCs-EX and had the highest rate with 87.8 ± 4.2 % and 84.4 ± 5.3 % while in the control group it was the lowest with 61.9 ± 11.4% (p<0.05). The group supplemented with CAP gave fibroblast proliferation and migration results similar to the control group (p>0.05), showing the safety of CAP with the growth of the cells.
    Conclusions: Therefore, in animal models, we intend to use a combination of these two therapies by using ADMSCs-EX injection therapy into the dermis at the wound edge to avoid the impact of CAP affecting the cell proliferation.
    MeSH term(s) Animals ; Humans ; Exosomes ; Plasma Gases/pharmacology ; Adipose Tissue ; Wound Healing ; Mesenchymal Stem Cells
    Chemical Substances Plasma Gases
    Language English
    Publishing date 2024-04-05
    Publishing country Italy
    Document type Observational Study
    ZDB-ID 123320-8
    ISSN 1972-6007 ; 0009-9074
    ISSN (online) 1972-6007
    ISSN 0009-9074
    DOI 10.7417/CT.2024.5046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Obstetric and Perinatal Outcomes of Dichorionic-Diamniotic Twin Pregnancies Conceived by IVF/ICSI Compared with Those Conceived Spontaneously.

    Duy Anh, N / Thu Ha, N T / Khac Toan, N / Tuan Dat, D / Huyen Thuong, P T / Tra Giang, D T / Anh Duc, T / Xuan Anh, B / Manh Ha, N / Minh Duc, N

    La Clinica terapeutica

    2022  Volume 173, Issue 2, Page(s) 155–163

    Abstract: Introduction: This study aimed to investigate differences in mater-nal and perinatal outcomes between dichorionic-diamniotic (DCDA) twin pregnancies between those conceived spontaneously and those conceived through in vitro fertilization (IVF)/ ... ...

    Abstract Introduction: This study aimed to investigate differences in mater-nal and perinatal outcomes between dichorionic-diamniotic (DCDA) twin pregnancies between those conceived spontaneously and those conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).
    Methods: This study was a single-center, retrospective cohort study. All women with DCDA twin pregnancies were considered for inclusion. Monochorionic twins and higher-order multiple pre-gnancies were excluded. All data related to maternal and perinatal outcomes were extracted from the hospital database and compared between spontaneously conceived DCDA twin pregnancies and those conceived by IVF/ICSI. Multivariable logistic regression was used to adjust for confounders to determine factors associated with maternal and perinatal outcomes.
    Results: Of 739 identified DCDA twin pregnancies, 483 (65.4%) were conceived through IVF/ICSI treatment (IVF/ICSI group), and 256 (34.6%) were spontaneously conceived (SC group). Women in the IVF/ICSI group were older and had fewer previous live births than women in the SC group. The women in the IVF/ICSI group had significantly higher risks of preeclampsia (adjusted odds ratio [aOR]: 2.50; 95% confidence interval [CI]: 1.12-5.55), cesarean delivery (aOR: 2.0; 95% CI: 1.27-3.17), an postpartum hemorrhage following cesarean section (aOR: 3.15; 95% CI: 1.53-6.45). The DCDA twins in the IVF/ICSI group were delivered at an earlier gestational age (36.2 vs. 36.7 weeks, p < 0.001), had slightly lower mean birth weights (2298 vs. 2367 g, p = 0.005), and required more respiratory support (aOR: 0.69; 95% Cl: 0.48-0.98) than those in the SC group.
    Conclusions: Our study demonstrated that women with DCDA twin pregnancies conceived through IVF/ICSI experienced more complications than those with SC DCDA twin pregnancies. Newborns in the IVF/ICSI group had a slightly lower mean birth weight and required respiratory support more frequently, but no other significant differences in perinatal outcomes or perinatal mortality were observed between the two groups.
    MeSH term(s) Cesarean Section ; Female ; Fertilization in Vitro ; Humans ; Infant, Newborn ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy, Twin ; Retrospective Studies ; Sperm Injections, Intracytoplasmic
    Language English
    Publishing date 2022-04-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123320-8
    ISSN 1972-6007 ; 0009-9074
    ISSN (online) 1972-6007
    ISSN 0009-9074
    DOI 10.7417/CT.2022.2410
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  5. Article ; Online: The Efficacy of Fetoscopic Laser Surgery in Twin-Twin Transfusion Syndrome: A Preliminary Vietnamese Study.

    Duy Anh, N / Duy An, N / Huyen Thuong, P T / Thu Ha, N T / Sim, N T / Sy Hung, H / Manh Tri, N / Duc Lam, N / Tuan Dat, D / Ville, Y / Manh Ha, N / Minh Duc, N

    La Clinica terapeutica

    2022  Volume 173, Issue 3, Page(s) 265–273

    Abstract: Background: Twin-twin transfusion syndrome (TTTS) is a severe prenatal complication of monochorionic diamniotic twins (MCDA). If left untreated, TTTS is associated with a high risk of neonatal death and neurological complications. Various treatment ... ...

    Abstract Background: Twin-twin transfusion syndrome (TTTS) is a severe prenatal complication of monochorionic diamniotic twins (MCDA). If left untreated, TTTS is associated with a high risk of neonatal death and neurological complications. Various treatment methods for TTTS have been proposed, but fetoscopic laser surgery (FLS) is currently the primary treatment for TTTS in global fetal medicine centers. The objective of this study was to evaluate the outcome of TTTS following FLS treatment at Hanoi Obstetrics and Gynecology Hospital (HOGH), a new fetal medicine center in Vietnam.
    Methods: A prospective study of a series of 33 consecutive TTTS cases prior to 26 weeks of gestation subjected to FLS at HOGH in Vie-tnam between September 2019 to July 2021. Neonates were monitored for at least six months after birth.
    Results: The survival rate of at least one fetus reached 84.85%. No short-term neurological complications have been reported upon follow-up of the newborn up to six months after birth. There were three stillbirth cases (9.09%), one case of preterm ruptured membra-nes (PROM) (3.03%) after seven days of surgery and three cases of recurrent TTTS after surgery using the Solomon technique (25%). No maternal complications were observed. The mean gestational age at birth was 33.76 ± 4.52 weeks, with a mean interval of 12.24 ± 6.67 weeks between intervention and delivery. Nine cases (30%) were born prematurely before 32 weeks. Additionally, 60% of recipients and nearly 90% of donors weighed less than 2500 grams.
    Conclusions: FLS leads to high survival rates for fetuses with TTTS. FLS seems to be an effective therapeutic option for TTTS before 26 weeks of gestation.
    MeSH term(s) Asians ; Female ; Fetofetal Transfusion/complications ; Fetofetal Transfusion/surgery ; Humans ; Infant ; Infant, Newborn ; Laser Therapy ; Pregnancy ; Pregnancy Complications ; Prospective Studies ; Vietnam/epidemiology
    Language English
    Publishing date 2022-05-25
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123320-8
    ISSN 1972-6007 ; 0009-9074
    ISSN (online) 1972-6007
    ISSN 0009-9074
    DOI 10.7417/CT.2022.2430
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  6. Article ; Online: Multidimensional Analysis of the Mother-to-child Transmission Risk Factors in Chronic Hepatitis B Virus Infection in Pregnant Women in Vietnam.

    Ngoc Tram, H T / Thu Huong, B T / Duc Hinh, N / Thuy, P T / Lan Anh, L T / Kim Phuon, D T / Thu Lan, H / Cam Tu, H / Koerber, N / Bauer, T / Khanh Lam, H / Manh Ha, N / Minh Duc, N / Thanh Hiep, N / Protzer, U / Tien Dung, N

    La Clinica terapeutica

    2023  Volume 174, Issue 3, Page(s) 266–274

    Abstract: Background: Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We investigate of the ... ...

    Abstract Background: Hepatitis B virus (HBV) infection remains a major public health problem. The interaction between HBV and the host inflammatory response is an important factor contributing to liver damage and disease development. We investigate of the correlation between peripheral blood cell levels, HBV DNA, and the risk of transmission to the baby in pregnant women infected with hepatitis B.
    Methods: A multidimensional analysis was performed on data collected from 60 Vietnamese pregnant women and their babies (cord blood).
    Results: Taking the risk ratio test results of cord blood HBsAg as a positive probability, the boundary of maternal PBMC concentration is 8.03x106 cells/ml (with negative correlation) and for CBMCs is 6.64x106 cells/ml (with positive correlation). That means that HBsAg positivity in the blood may be related to the increasing of CBMCs and the diminution of maternal PBMCs. When the maternal viral load is higher than 5x107 copies/ml, the risk of being HBsAg-positive in cord blood is 123% (RR=2.23 [1.48,3.36]); when the viral load is lower than this baseline, the risk is decreased by 55% (RR=0.45 [0.30,0.67]) (p<0.001).
    Conclusions: With several steps of the analysis, this study found maternal peripheral blood cell levels and cord blood positively cor-related in pregnant women with a load lower than 5x107 copies of HBV DNA/ml. The study's results suggest that the role of PBMCs and HBV DNA in vertical infection is essential.
    MeSH term(s) Infant ; Female ; Pregnancy ; Humans ; Hepatitis B, Chronic/epidemiology ; Pregnant Women ; Hepatitis B Surface Antigens ; Infectious Disease Transmission, Vertical ; DNA, Viral/genetics ; Vietnam/epidemiology ; Leukocytes, Mononuclear ; Hepatitis B e Antigens ; Hepatitis B virus/genetics ; Hepatitis B ; Risk Factors ; Pregnancy Complications, Infectious/epidemiology
    Chemical Substances Hepatitis B Surface Antigens ; DNA, Viral ; Hepatitis B e Antigens
    Language English
    Publishing date 2023-05-18
    Publishing country Italy
    Document type Observational Study
    ZDB-ID 123320-8
    ISSN 1972-6007 ; 0009-9074
    ISSN (online) 1972-6007
    ISSN 0009-9074
    DOI 10.7417/CT.2023.2533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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