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  1. AU="Manhard, John"
  2. AU="C Gräf"
  3. AU="Fisher, Aron B."

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  1. Article: A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters.

    Fagre, Anna C / Manhard, John / Adams, Rachel / Eckley, Miles / Zhan, Shijun / Lewis, Juliette / Rocha, Savannah M / Woods, Catherine / Kuo, Karina / Liao, Wuxiang / Li, Lin / Corper, Adam / Challa, Dilip / Mount, Emily / Tumanut, Christine / Tjalkens, Ronald B / Aboelleil, Tawfik / Fan, Xiaomin / Schountz, Tony

    bioRxiv : the preprint server for biology

    2020  

    Abstract: The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir and dexamethasone have demonstrated limited efficacy, only slightly reducing ... ...

    Abstract The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir and dexamethasone have demonstrated limited efficacy, only slightly reducing disease burden, thus novel approaches for clinical management of COVID-19 are needed. We identified a panel of human monoclonal antibody clones from a yeast display library with specificity to the SARS-CoV-2 spike protein receptor binding domain that neutralized the virus
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.09.25.313601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Potent SARS-CoV-2 Neutralizing Human Monoclonal Antibody That Reduces Viral Burden and Disease Severity in Syrian Hamsters.

    Fagre, Anna C / Manhard, John / Adams, Rachel / Eckley, Miles / Zhan, Shijun / Lewis, Juliette / Rocha, Savannah M / Woods, Catherine / Kuo, Karina / Liao, Wuxiang / Li, Lin / Corper, Adam / Challa, Dilip / Mount, Emily / Tumanut, Christine / Tjalkens, Ronald B / Aboellail, Tawfik / Fan, Xiaomin / Schountz, Tony

    Frontiers in immunology

    2020  Volume 11, Page(s) 614256

    Abstract: The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir and dexamethasone have demonstrated limited efficacy, only slightly reducing ... ...

    Abstract The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir and dexamethasone have demonstrated limited efficacy, only slightly reducing disease burden, thus novel approaches for clinical management of COVID-19 are needed. We identified a panel of human monoclonal antibody clones from a yeast display library with specificity to the SARS-CoV-2 spike protein receptor binding domain that neutralized the virus
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/pharmacology ; Antibodies, Neutralizing/immunology ; Antibodies, Neutralizing/pharmacology ; Antibodies, Viral/immunology ; Antibodies, Viral/pharmacology ; COVID-19/blood ; COVID-19/immunology ; Chlorocebus aethiops ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin G/pharmacology ; Male ; Mesocricetus ; SARS-CoV-2/immunology ; Severity of Illness Index ; Vero Cells ; Viral Load/drug effects ; Viral Load/immunology ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2020-12-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.614256
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A potent SARS-CoV-2 neutralizing human monoclonal antibody that reduces viral burden and disease severity in Syrian hamsters

    Fagre, Anna C. / Manhard, John / Adams, Rachel / Eckley, Miles / Zhan, Shijun / Lewis, Juliette / Rocha, Savanna M. / Woods, Catherine / Kuo, Karina / Liao, Wuxiang / Li, Lin / Corper, Adam / Challa, Dilip / Mount, Emily / Tumanut, Christine / Tjalkens, Ronald B. / Aboelleil, Tawfik / Fan, Xiaomin / Schountz, Tony

    bioRxiv

    Abstract: The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir and dexamethasone have demonstrated limited efficacy, only slightly reducing ... ...

    Abstract The emergence of COVID-19 has led to a pandemic that has caused millions of cases of disease, variable morbidity and hundreds of thousands of deaths. Currently, only remdesivir and dexamethasone have demonstrated limited efficacy, only slightly reducing disease burden, thus novel approaches for clinical management of COVID-19 are needed. We identified a panel of human monoclonal antibody clones from a yeast display library with specificity to the SARS-CoV- 2 spike protein receptor binding domain that neutralized the virus in vitro. Administration of the lead antibody clone to Syrian hamsters challenged with SARS-CoV-2 significantly reduced viral load and histopathology score in the lungs. Moreover, the antibody interrupted monocyte infiltration into the lungs, which may have contributed to the reduction of disease severity by limiting immunopathological exacerbation. The use of this antibody could provide an important therapy for treatment of COVID-19 patients.
    Keywords covid19
    Language English
    Publishing date 2020-09-25
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2020.09.25.313601
    Database COVID19

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    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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