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  1. Article ; Online: A comparison of app-defined fertile days from two fertility tracking apps using identical cycle data.

    Manhart, Michael D / Duane, Marguerite

    Contraception

    2022  Volume 115, Page(s) 12–16

    Abstract: Objective: The Natural Cycles app employs daily basal body temperature to define the fertile window via a proprietary algorithm and is clinically established effective in preventing pregnancy. We sought to (1) compare the app-defined fertile window of ... ...

    Abstract Objective: The Natural Cycles app employs daily basal body temperature to define the fertile window via a proprietary algorithm and is clinically established effective in preventing pregnancy. We sought to (1) compare the app-defined fertile window of Natural Cycles to that of CycleProGo, an app that uses BBT and cervical mucus to define the fertile window and (2) compare the app-defined fertile windows to the estimated physiologic fertile window.
    Study design: Daily BBT were entered into Natural Cycles from 20 randomly selected regularly cycling women with at least 12 complete cycles from the CycleProGo database. The proportion of cycles with equivalent (±1 cycle day) fertile-window starts and fertile-window ends was determined. The app-defined fertile windows were then compared to the estimated physiologic fertile window using Peak mucus to estimate ovulation.
    Results: Fifty seven percent of cycles (136/238) had equivalent fertile-window starts and 36% (72/181) had equivalent fertile-window end days. The mean overall fertile-window length from Natural Cycles was 12.8 days compared to 15.1 days for CycleProGo (p < 0.001). The Natural Cycles algorithm declared 12% to 30% of cycles with a fertile-window start and 13% to 38% of cycles with a fertile-window end within the estimated physiologic fertile window. The CycleProGo algorithm declared 4% to 14% of cycles with a fertile-window start and no cycles with a fertile-window end within the estimated physiologic fertile window.
    Conclusions: Natural Cycles designated a higher proportion of cycles days as infertile within the estimated physiologic fertile window than CycleProGo.
    Implications: Use of cervical mucus in addition to BBT may improve the accuracy of identifying the fertile window. Additional studies with other markers of ovulation and the fertile window would give additional insight into the clinical implications of app-defined fertile window differences.
    MeSH term(s) Cervix Mucus ; Female ; Fertility/physiology ; Humans ; Mobile Applications ; Natural Family Planning Methods ; Ovulation ; Ovulation Detection ; Pregnancy
    Language English
    Publishing date 2022-07-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80106-9
    ISSN 1879-0518 ; 0010-7824
    ISSN (online) 1879-0518
    ISSN 0010-7824
    DOI 10.1016/j.contraception.2022.07.007
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  2. Article: A Comparison of User Behaviors for a Fertility-Tracking App: Does Training in an NFP Method Improve Persistence and Use?

    Manhart, Michael D

    The Linacre quarterly

    2019  Volume 87, Issue 1, Page(s) 53–59

    Abstract: This study explores differences in the use of CyclePro: Summary: " ... ...

    Abstract This study explores differences in the use of CyclePro
    Summary: "CyclePro
    Language English
    Publishing date 2019-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604903-5
    ISSN 2050-8549 ; 0024-3639
    ISSN (online) 2050-8549
    ISSN 0024-3639
    DOI 10.1177/0024363919870435
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  3. Article ; Online: Microbial population dynamics decouple growth response from environmental nutrient concentration.

    Fink, Justus Wilhelm / Held, Noelle A / Manhart, Michael

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 2, Page(s) e2207295120

    Abstract: How the growth rate of a microbial population responds to the environmental availability of chemical nutrients and other resources is a fundamental question in microbiology. Models of this response, such as the widely used Monod model, are generally ... ...

    Abstract How the growth rate of a microbial population responds to the environmental availability of chemical nutrients and other resources is a fundamental question in microbiology. Models of this response, such as the widely used Monod model, are generally characterized by a maximum growth rate and a half-saturation concentration of the resource. What values should we expect for these half-saturation concentrations, and how should they depend on the environmental concentration of the resource? We survey growth response data across a wide range of organisms and resources. We find that the half-saturation concentrations vary across orders of magnitude, even for the same organism and resource. To explain this variation, we develop an evolutionary model to show that demographic fluctuations (genetic drift) can constrain the adaptation of half-saturation concentrations. We find that this effect fundamentally differs depending on the type of population dynamics: Populations undergoing periodic bottlenecks of fixed size will adapt their half-saturation concentrations in proportion to the environmental resource concentrations, but populations undergoing periodic dilutions of fixed size will evolve half-saturation concentrations that are largely decoupled from the environmental concentrations. Our model not only provides testable predictions for laboratory evolution experiments, but it also reveals how an evolved half-saturation concentration may not reflect the organism's environment. In particular, this explains how organisms in resource-rich environments can still evolve fast growth at low resource concentrations. Altogether, our results demonstrate the critical role of population dynamics in shaping fundamental ecological traits.
    MeSH term(s) Biological Evolution ; Population Dynamics ; Acclimatization ; Adaptation, Physiological ; Nutrients
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2207295120
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  4. Article ; Online: The search for universality in evolutionary landscapes: Comment on "From genotypes to organisms: State-of-the-art and perspectives of a cornerstone in evolutionary dynamics" by Susanna Manrubia, José A. Cuesta, et al.

    Manhart, Michael / Bonhoeffer, Sebastian

    Physics of life reviews

    2021  Volume 39, Page(s) 76–78

    MeSH term(s) Biological Evolution ; Genotype
    Language English
    Publishing date 2021-08-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2148883-6
    ISSN 1873-1457 ; 1571-0645
    ISSN (online) 1873-1457
    ISSN 1571-0645
    DOI 10.1016/j.plrev.2021.08.004
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  5. Article: Natural Family Planning and Marital Chastity: The Effects of Periodic Abstinence on Marital Relationships.

    Fehring, Richard J / Manhart, Michael D

    The Linacre quarterly

    2020  Volume 88, Issue 1, Page(s) 42–55

    Abstract: Marital chastity is the practice of periodic abstinence with use of natural family planning (NFP). The purpose of this study was to determine the influence of the most common methods of contraception (female sterilization, oral contraceptive pills, and ... ...

    Abstract Marital chastity is the practice of periodic abstinence with use of natural family planning (NFP). The purpose of this study was to determine the influence of the most common methods of contraception (female sterilization, oral contraceptive pills, and condoms) and NFP on divorce/separation and cohabitation rates among reproductive age women. The study involved an extensive review of the literature on the effects of practice of NFP on marital dynamics and a statistical analysis of 2,550 ever-married women in the (2015-2017) National Survey of Family Growth data set. Importance of religion and frequency of church attendance were included in the analysis. With ever-use of NFP, 14 percent were divorced or separated, and 27 percent to 39 percent were divorced or separated with ever-use of oral contraceptive pills. Stepwise logistic regression indicated that ever-use of contraception was associated with increased odds of divorce or separation (odds ratio [OR] = 2.05; confidence interval [CI]: 1.96-2.49) and cohabitation (2.95, CI: 2.20-3.95). Ever-use of NFP yielded 58 percent lower odds for divorce or separation. Frequent church attendance was associated with lower odds of divorce or separation and cohabitation. Although there are lower odds of divorce among NFP users, the reason might be due to their religiosity.
    Summary: This study showed that ever-use of natural family planning (NFP) among ever-married women was associated with 58 percent lower odds of divorce than among women who never-used NFP. Ever-use of contraceptive methods was associated with two times the odds of divorce and four times for cohabitation compared to those women who never-used those methods. Use of periodic abstinence with NFP is the practice of marital chastity and is thought to strengthen the marital relationship.
    Language English
    Publishing date 2020-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604903-5
    ISSN 2050-8549 ; 0024-3639
    ISSN (online) 2050-8549
    ISSN 0024-3639
    DOI 10.1177/0024363920930875
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  6. Article ; Online: Evaluation of a fertility awareness-based shared decision-making tool part 1: Study design and impact on clinician knowledge.

    Duane, Marguerite / Martinez, Virginia / Berry, Meghan / Manhart, Michael D

    PEC innovation

    2022  Volume 1, Page(s) 100061

    Abstract: Objective: To assess the impact of a Shared Decision-Making (SDM) tool for fertility awareness-based methods (FABMs) of family planning.: Methods: Clinicians familiar with at least one FABM were randomly invited to participate in a prospective cross- ... ...

    Abstract Objective: To assess the impact of a Shared Decision-Making (SDM) tool for fertility awareness-based methods (FABMs) of family planning.
    Methods: Clinicians familiar with at least one FABM were randomly invited to participate in a prospective cross-over study to compare usual practice to the use of the SDM tool when discussing FABMs with patients. Patients completed surveys pre- and post-office visit and six months later. The primary outcome explored the effect of online education on use of the SDM tool on clinicians' knowledge of FABMs.
    Results: Of 278 clinicians contacted, 54% could not be reached, and 15% did not provide women's health services. The 26 clinicians enrolled were experienced, with more than half recommending FABMs for ≥10 years, and 73% recommending more than one FABM to patients. Knowledge scores significantly improved after online training and use of the SDM tool (baseline mean score = 9.54 (scale of 0-12); post-training mean score = 10.73,
    Conclusions: Education about FABMs and training on use of the SDM tool improved knowledge scores even among an experienced cohort of clinicians.
    Innovation: The novel SDM tool can better equip clinicians to meet the rising patient interest in FABMs.
    Language English
    Publishing date 2022-06-28
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-6282
    ISSN (online) 2772-6282
    DOI 10.1016/j.pecinn.2022.100061
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  7. Article ; Online: Evaluation of a fertility awareness-based shared decision-making tool part 2: Patient experiences.

    Duane, Marguerite / Martinez, Virginia / Berry, Meghan / Gilpatrick, Sarah / Manhart, Michael D

    PEC innovation

    2023  Volume 2, Page(s) 100169

    Abstract: Objective: To assess patient experiences using a Shared Decision-Making (SDM) Tool for fertility awareness-based methods (FABMs) of family planning.: Methods: The study employed a prospective crossover design to evaluate impact of the SDM tool ... ...

    Abstract Objective: To assess patient experiences using a Shared Decision-Making (SDM) Tool for fertility awareness-based methods (FABMs) of family planning.
    Methods: The study employed a prospective crossover design to evaluate impact of the SDM tool compared to usual practice when discussing FABMs with patients. Patients completed pre- and post-office visit surveys and an online survey six months later. The primary outcomes evaluated the effect of the SDM tool on patient satisfaction and FABM continuity of use rates.
    Results: There was no significant difference in likelihood of changing family planning methods immediately after the office visit; however, by six months a significantly larger proportion of patients had started or changed FABMs in the experimental group (52%, 34/66) compared to the control group (36%, 24/66) (
    Conclusions: Use of the SDM tool increased persistent use of and satisfaction with chosen FABMs at six months.
    Innovations: The novel SDM tool can enhance patients' understanding and facilitate the selection of a more suitable method leading to increased satisfaction.
    Language English
    Publishing date 2023-05-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-6282
    ISSN (online) 2772-6282
    DOI 10.1016/j.pecinn.2023.100169
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  8. Article ; Online: Extended Multimodal Flat Detector CT Imaging in Acute Ischemic Stroke: A Pilot Study.

    Hoelter, Philip / Lang, Stefan / Beuscher, Vanessa / Kallmuenzer, Bernd / Manhart, Michael / Schwab, Stefan / Doerfler, Arnd

    Journal of digital imaging

    2023  Volume 36, Issue 3, Page(s) 1198–1207

    Abstract: By using Flat detector computed tomography (FD-CT), a one-stop-shop approach in the diagnostic workup of acute ischemic stroke (AIS) might be achieved. Although information on upstream vessels is warranted, dedicated FD-CT protocols which include the ... ...

    Abstract By using Flat detector computed tomography (FD-CT), a one-stop-shop approach in the diagnostic workup of acute ischemic stroke (AIS) might be achieved. Although information on upstream vessels is warranted, dedicated FD-CT protocols which include the imaging of the cervical vasculature are still lacking. We aimed to prospectively evaluate the implementation of a new multimodal FD-CT protocol including cervical vessel imaging in AIS patients. In total, 16 patients were included in this study. Eight patients with AIS due to large vessel occlusion (LVO) prospectively received a fully multimodal FD-CT imaging, including non-enhanced flat detector computed tomography (NE-FDCT), dynamic perfusion flat detector computed tomography (FD-CTP) and flat detector computed tomography angiography (FD-CTA) including cervical imaging. For comparison of time metrics and image quality, eight AIS patients, which received multimodal CT imaging, were included retrospectively. Although image quality of NE-FDCT and FD-CTA was rated slightly lower than NE-CT and CTA, all FD-CT datasets were of diagnostic quality. Intracerebral hemorrhage exclusion and LVO detection was reliably possible. Median door-to-image time was comparable for the FD-CT group and the control group (CT:30 min, IQR27-58; FD-CT:44.5 min, IQR31-55, p = 0.491). Door-to-groin-puncture time (CT:79.5 min, IQR65-90; FD-CT:59.5 min, IQR51-67; p = 0.016) and image-to-groin-puncture time (CT:44 min, IQR30-50; FD-CT:14 min, IQR12-18; p < 0.001) were significantly shorter, when patients were directly transferred to the angiosuite, where FD-CT took place. Our study indicates that using a new fully multimodal FD-CT approach including imaging of cervical vessels for first-line imaging in AIS patients is feasible and comparable to multimodal CT imaging with substantial potential to streamline the stroke workflow.
    MeSH term(s) Humans ; Ischemic Stroke ; Pilot Projects ; Retrospective Studies ; Stroke/diagnostic imaging ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033897-4
    ISSN 1618-727X ; 0897-1889
    ISSN (online) 1618-727X
    ISSN 0897-1889
    DOI 10.1007/s10278-022-00699-4
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    Zs.A 2941: Show issues Location:
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  9. Book ; Online ; Thesis: Numerical Investigation of Secondary Currents in Partially Filled Pipe Flow

    Brosda, Julian [Verfasser] / Manhart, Michael [Akademischer Betreuer] / Uhlmann, Markus Gutachter] / Nikora, Vladimir [Gutachter] / [Manhart, Michael [Gutachter]

    2022  

    Author's details Julian Frederic Brosda ; Gutachter: Markus Uhlmann, Vladimir Nikora, Michael Manhart ; Betreuer: Michael Manhart
    Keywords Geowissenschaften ; Earth Sciences
    Subject code sg550
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  10. Article ; Online: Growth tradeoffs produce complex microbial communities on a single limiting resource.

    Manhart, Michael / Shakhnovich, Eugene I

    Nature communications

    2018  Volume 9, Issue 1, Page(s) 3214

    Abstract: The relationship between the dynamics of a community and its constituent pairwise interactions is a fundamental problem in ecology. Higher-order ecological effects beyond pairwise interactions may be key to complex ecosystems, but mechanisms to produce ... ...

    Abstract The relationship between the dynamics of a community and its constituent pairwise interactions is a fundamental problem in ecology. Higher-order ecological effects beyond pairwise interactions may be key to complex ecosystems, but mechanisms to produce these effects remain poorly understood. Here we model microbial growth and competition to show that higher-order effects can arise from variation in multiple microbial growth traits, such as lag times and growth rates, on a single limiting resource with no other interactions. These effects produce a range of ecological phenomena: an unlimited number of strains can exhibit multistability and neutral coexistence, potentially with a single keystone strain; strains that coexist in pairs do not coexist all together; and a strain that wins all pairwise competitions can go extinct in a mixed competition. Since variation in multiple growth traits is ubiquitous in microbial populations, our results indicate these higher-order effects may also be widespread, especially in laboratory ecology and evolution experiments.
    MeSH term(s) Bacteria/growth & development ; Microbiota ; Models, Biological
    Language English
    Publishing date 2018-08-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-018-05703-6
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