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Article ; Online: The molecular characteristics of recurrent/metastatic HPV-positive head and neck squamous cell carcinoma: A systematic review of the literature.

Flach, Susanne / Maniam, Pavithran / Hey, Shi Ying / Manickavasagam, Jaiganesh

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2024

Abstract: Objectives: About 17% of patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC), which is mainly comprised of oropharyngeal SCC (OPSCC), will experience disease recurrence, which is often considered incurable ... ...

Abstract	Objectives: About 17% of patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC), which is mainly comprised of oropharyngeal SCC (OPSCC), will experience disease recurrence, which is often considered incurable when manifested at a metastatic and/or recurrent stage. We conducted a critical qualitative systematic review. Our objectives were to provide an overview of the molecular landscape of recurrent/metastatic HPV-positive HNSCC as well as novel molecular biomarkers. Design: A literature review was conducted to identify studies reporting on the molecular characteristics of recurrent/metastatic HPV-positive HNSCC, novel molecular biomarkers and treatment options. The reviews of abstracts, full articles, and revision of the included studies, followed by data extraction and quality assessment were performed by three independent assessors. All primary literature, such as retrospective, prospective, and clinical trials as well as basic research studies were considered, and the final search was conducted at the end of February 2023. The level of evidence was rated using the guidelines published by the Oxford Centre for Evidence-based Medicine and quality was assessed using the Newcastle-Ottawa Scale criteria. Results and conclusions: The literature search resulted in the identification of 1991 articles. A total of 181 full articles were screened, and 66 articles were included in this analysis. Several studies reported that recurrent/metastatic HPV-positive HNSCC had higher rates of TP53 mutation and were genomically similar to HPV-negative HNSCC. The detection of circulating tumour tissue-modified HPV DNA (ctHPVDNA) as a specific biomarker has shown promising results for monitoring treatment response and recurrence in the subset of HPV-positive HNSCC. In addition, evidence for targeted therapy in recurrent/metastatic HPV-positive HNSCC has emerged, including agents that inhibit overexpressed EGFR. Studies of combination immunotherapy are also underway. Our review outlines the latest evidence on the distinct molecular profiles of recurrent/metastatic HPV-positive HNSCC as well as the clinical potential of ctHPVDNA testing in routine practice. More controlled and longitudinal studies are needed to identify additional molecular targets and to assess the performance and benefits of novel molecular biomarkers in clinical practice.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.14161
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Article ; Online: A systematic review: impact of in-office biopsy on safety and waiting times in head and neck cancer.

Lim, A E / Rogers, A D G / Owusu-Ayim, M / Ranjan, S / Manickavasagam, J / Montgomery, J

The Journal of laryngology and otology

2022 Volume 136, Issue 10, Page(s) 909–916

Abstract: Objective: This study aimed to assess the current literature on the safety and impact of in-office biopsy on cancer waiting times as well as review evidence regarding cost-efficacy and patient satisfaction.: Method: A search of Cinahl, Cochrane ... ...

Abstract	Objective: This study aimed to assess the current literature on the safety and impact of in-office biopsy on cancer waiting times as well as review evidence regarding cost-efficacy and patient satisfaction. Method: A search of Cinahl, Cochrane Library, Embase, Medline, Prospero, PubMed and Web of Science was conducted for papers relevant to this study. Included articles were quality assessed and critically appraised. Results: Of 19 741 identified studies, 22 articles were included. Lower costs were consistently reported for in-office biopsy compared with operating room biopsy. Four complications requiring intervention were documented. In-office biopsy is highly tolerated, with a procedure abandonment rate of less than 1 per cent. When compared with operating room biopsy, it is associated with significantly reduced time-to-diagnosis and time-to-treatment initiation. It is linked to improved overall three-year survival. Conclusion: In-office biopsy is a safe procedure that may help certain patients avoid general anaesthetic. It was shown to significantly reduce time-to-diagnosis and time-to-treatment initiation when compared with operating room biopsy. This may have important implications for oncological outcomes. In-office biopsy requires fewer resources and is likely to be cost-saving five-years following introduction. With high rates of sensitivity and specificity, in-office biopsy should be considered as the first-line procedure to achieve tissue diagnosis.
MeSH term(s)	Anesthetics, General ; Biopsy/adverse effects ; Cost-Benefit Analysis ; Head and Neck Neoplasms/diagnosis ; Humans ; Waiting Lists
Chemical Substances	Anesthetics, General
Language	English
Publishing date	2022-01-10
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S002221512100428X
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Article ; Online: Laparoscopic instrument use in laryngeal surgery: transoral resection of a supraglottic haemangioma.

Bannon, R / Gohil, R / Manickavasagam, J

The Journal of laryngology and otology

2017 Volume 131, Issue 9, Page(s) 823–826

Abstract: Background: Adult laryngeal haemangiomas are rare vascular tumours that have been managed by a variety of surgical techniques.: Methods: This paper describes a case of near-fatal acute airway obstruction secondary to such a lesion, followed by our ... ...

Abstract	Background: Adult laryngeal haemangiomas are rare vascular tumours that have been managed by a variety of surgical techniques. Methods: This paper describes a case of near-fatal acute airway obstruction secondary to such a lesion, followed by our approach to surgical resection using a laparoscopic bipolar tissue-sealing device. Results: This technique resulted in successful excision of the lesion, with no evidence of recurrence at one year of follow up. Conclusion: Laparoscopic bipolar instruments can be used for the resection of moderate to large laryngeal haemangiomas as an alternative to laser excision.
MeSH term(s)	Adult ; Glottis/pathology ; Glottis/surgery ; Hemangioma/surgery ; Humans ; Laryngeal Neoplasms/surgery ; Laryngectomy/instrumentation ; Male ; Treatment Outcome
Language	English
Publishing date	2017-09
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215117001438
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Article: A novel hybrid approach to forecast crude oil futures using intraday data.

Manickavasagam, Jeevananthan / Visalakshmi, S / Apergis, Nicholas

Technological forecasting and social change

2020 Volume 158, Page(s) 120126

Abstract: Prediction of oil prices is an implausible task due to the multifaceted nature of oil markets. This study presents two novel hybrid models to forecast WTI and Brent crude oil prices using combinations of machine learning and nature inspired algorithms. ... ...

Abstract	Prediction of oil prices is an implausible task due to the multifaceted nature of oil markets. This study presents two novel hybrid models to forecast WTI and Brent crude oil prices using combinations of machine learning and nature inspired algorithms. The first approach, MARSplines-IPSO-BPNN, Multivariate Adaptive Regression Splines (MARSPlines) find the important variables that affect crude oil prices. Then, the selected variables are fed into an Improved Particle Swarm Optimization (IPSO) method to obtain the best estimates of the parameters of the Backpropagation Neural Network (BPNN). Once these parameters are obtained, the variables are fed into the BPNN model to generate the required forecasts. The second approach, MARSplines-FPA-BPNN, generates the parameters of BPNN through the Flower Pollination Algorithm (FPA). The forecasting ability of these new models is compared to certain benchmark models. The findings document that the MARSplines-FPA-BPNN model performs better than the other competitive models.
Keywords	covid19
Language	English
Publishing date	2020-06-04
Publishing country	United States
Document type	Journal Article
ISSN	0040-1625
ISSN	0040-1625
DOI	10.1016/j.techfore.2020.120126
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Article ; Online: Sheffield suction holder clips for endolaryngeal laser surgery.

Manickavasagam, J / Jebreel, A

The Journal of laryngology and otology

2013 Volume 127, Issue 9, Page(s) 927–929

Abstract: Background: There has been a major evolution in laryngeal surgery, largely due to an improved understanding of disease pathogenesis and advances in technology, especially the introduction of lasers.: Method and results: Continuous laser plume ... ...

Abstract	Background: There has been a major evolution in laryngeal surgery, largely due to an improved understanding of disease pathogenesis and advances in technology, especially the introduction of lasers. Method and results: Continuous laser plume evacuation during endolaryngeal surgery improves visualisation of the surgical field. Hence, microlaryngoscopes are fitted with smoke evacuation channels on their sides. We have devised a new, simple and efficient suction holder clip for endolaryngeal surgery that has distinct advantages over other suction holders.
MeSH term(s)	Equipment Design ; Humans ; Laryngeal Neoplasms/surgery ; Laryngoscopes/standards ; Laryngoscopes/utilization ; Laser Therapy/instrumentation ; Microsurgery ; Suction/instrumentation ; Suction/standards ; Surgical Instruments/utilization
Language	English
Publishing date	2013-09
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215113001734
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Article ; Online: Large retropharyngeal abscess: a case of mistaken identity.

Makaram, N / Gohil, R / Gardiner, Q / Manickavasagam, J

BMJ case reports

2016 Volume 2016

Abstract: We report an unusual case of nasopharyngeal carcinoma (NPC), presenting initially as a retropharyngeal collection. We discuss the investigation, diagnosis and management of NPC and furthermore review the literature of NPC, emphasising the varied ... ...

Abstract	We report an unusual case of nasopharyngeal carcinoma (NPC), presenting initially as a retropharyngeal collection. We discuss the investigation, diagnosis and management of NPC and furthermore review the literature of NPC, emphasising the varied presentation. A 44-year-old Caucasian male ex-smoker presented with a 10-day history of a painless left-sided neck lump; progressive dysphagia and unintentional weight loss. Examination demonstrated a large left posterior pharyngeal swelling with soft palatal effacement, confirmed on nasoendoscopy. A CT scan revealed a fluid collection in the retropharyngeal space, which partially occluded the nasopharynx, and numerous satellite lesions were identified along with cervical lymphadenopathy. The suspected abscess was drained in theatre and nasopharyngeal biopsies were taken. These revealed Epstein-Barr virus-positive NPC. Staging investigations revealed a T4N2M0l carcinoma. Treatment consisted of radical chemoradiation therapy with curative intent. NPC is known for its varied and late presentation, and is an important condition to be aware of when considering a differential diagnosis of pharyngeal masses.
MeSH term(s)	Adult ; Carcinoma ; Chemoradiotherapy/methods ; Deglutition Disorders/etiology ; Diagnosis, Differential ; Drainage/methods ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/pathology ; Epstein-Barr Virus Infections/therapy ; Herpesvirus 4, Human/isolation & purification ; Humans ; Male ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/complications ; Nasopharyngeal Neoplasms/diagnosis ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/therapy ; Neck/pathology ; Retropharyngeal Abscess/complications ; Retropharyngeal Abscess/diagnosis ; Retropharyngeal Abscess/pathology ; Retropharyngeal Abscess/therapy ; Tomography, X-Ray Computed ; Treatment Outcome ; Weight Loss
Language	English
Publishing date	2016-09-16
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1757-790X
ISSN (online)	1757-790X
DOI	10.1136/bcr-2016-216718
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Article ; Online: Transoral robotic resection of a large schwannoma in the retropharyngeal space.

Gungadeen, A / Lisseter, R / Manickavasagam, J / Paleri, V

The Journal of laryngology and otology

2016 Volume 130, Issue 4, Page(s) 401–403

Abstract: Background: External approaches have been traditionally used for the complete excision of large retropharyngeal space lesions.: Case report: This paper describes a case of a large schwannoma of the retropharyngeal space excised transorally with the ... ...

Abstract	Background: External approaches have been traditionally used for the complete excision of large retropharyngeal space lesions. Case report: This paper describes a case of a large schwannoma of the retropharyngeal space excised transorally with the use of a robotic system. This lesion measured 2.7 × 1.2 cm in axial dimensions and over 5.8 cm in craniocaudal length. The lesion was delivered en bloc with an intact capsule. No peri- or post-operative complications were encountered. The procedure allowed quick resumption of an oral diet and a return to normal activity for the patient. Conclusion: This is, to our knowledge, the first report of this technique used in the excision of a large retropharyngeal space mass.
MeSH term(s)	Humans ; Male ; Middle Aged ; Mouth ; Natural Orifice Endoscopic Surgery/methods ; Neurilemmoma/surgery ; Pharyngeal Neoplasms/surgery ; Robotic Surgical Procedures/methods
Language	English
Publishing date	2016-04
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215116000190
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Article ; Conference proceedings: Outpatient (Same-day Discharge) versus Inpatient Parotidectomy: A Systematic Review and Meta-analysis

Flach, S / Hey, S / Lim, A / Maniam, P / Li, Z / Donnan, P / Manickavasagam, J

Laryngo-Rhino-Otologie

2021 Volume 100, Issue S 02

Event/congress	100 JAHRE DGHNO-KHC: WO KOMMEN WIR HER? WO STEHEN WIR? WO GEHEN WIR HIN?, HNO-Online-Kongress, 2021-05-12
Language	English
Publishing date	2021-05-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	96005-6
ISSN	1438-8685 ; 0935-8943 ; 0340-1588
ISSN (online)	1438-8685
ISSN	0935-8943 ; 0340-1588
DOI	10.1055/s-0041-1728910
Database	Thieme publisher's database

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Article ; Online: Aggressive cutaneous squamous cell carcinoma arising from a human papillomavirus-infected epidermoid cyst of the conchal bowl.

McAllister, P / Affleck, A / Manickavasagam, J / Evans, A

Clinical and experimental dermatology

2017 Volume 43, Issue 2, Page(s) 201–203

MeSH term(s)	Aged ; Biopsy ; Carcinoma, Squamous Cell/etiology ; Cell Transformation, Neoplastic ; Ear Auricle/pathology ; Ear Neoplasms/etiology ; Epidermal Cyst/complications ; Epidermal Cyst/pathology ; Epidermal Cyst/virology ; Humans ; Male ; Papillomaviridae ; Papillomavirus Infections/complications ; Skin Neoplasms/etiology
Language	English
Publishing date	2017-12-11
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.13305
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Zs.A 1278: Show issues

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Article ; Online: E-cigarettes and head and neck cancers: A systematic review of the current literature.

Flach, Susanne / Maniam, Pavithran / Manickavasagam, Jaiganesh

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

2019 Volume 44, Issue 5, Page(s) 749–756

Abstract: Background: Cigarette smoking is a well-established risk factor for head and neck (HN) cancers. Use of electronic cigarettes (e-cigarettes) is gaining popularity, being advertised as benign alternatives to tobacco. A wide variety of potentially harmful ... ...

Abstract	Background: Cigarette smoking is a well-established risk factor for head and neck (HN) cancers. Use of electronic cigarettes (e-cigarettes) is gaining popularity, being advertised as benign alternatives to tobacco. A wide variety of potentially harmful chemical components with variable quantity have been identified in e-liquids and aerosols of e-cigarettes. However, use of e-cigarettes remains controversial due to conflicting evidence. Objectives: We aimed to assess the association between e-cigarettes and HN cancers. We conducted a systematic review to evaluate the literature for evidence on carcinogenic effects of e-cigarettes in the pathogenesis of HN cancers. Type of review: Qualitative systematic review. Search strategy: A PubMed/MEDLINE, Cochrane, CINAHL Plus, Trip Medical Database and Web of Science search was done for studies on e-cigarettes and HN cancer. Evaluation method: Abstract review of all articles, full article revision of included studies, data extraction and quality assessment were performed by two independent assessors. Results: The literature search resulted in the identification of 359 articles. Eighteen articles were selected for inclusion into the systematic review. The majority were laboratory-based studies, followed by several cohort and case studies, representing low-level evidence. A few reports suggested DNA damage following exposure to e-cigarettes potentially due to increased oxidative stress. Flavoured e-liquids appear to be more harmful. There is variable evidence from clinical studies. Conclusions: Our review outlines potential dangers associated with the use of e-cigarettes and their role in HN cancers. More longitudinal and controlled studies are needed to assess the possible link between e-cigarettes and HN cancers.
MeSH term(s)	Electronic Nicotine Delivery Systems ; Global Health ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/etiology ; Humans ; Incidence ; Risk Assessment/methods ; Risk Factors
Language	English
Publishing date	2019-07-23
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	2205891-6
ISSN	1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
ISSN (online)	1749-4486
ISSN	1749-4478 ; 0307-7772 ; 1365-2273
DOI	10.1111/coa.13384
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