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Article: Comment on Wijnia, J.W. A Clinician's View of Wernicke-Korsakoff Syndrome.

Manigrasso, Michele / Velotti, Nunzio / De Palma, Giovanni Domenico / Musella, Mario

2023 Volume 12, Issue 19

Abstract: We have read with great interest the article by Wijnia [ ... ]. ...

Abstract	We have read with great interest the article by Wijnia [...].
Language	English
Publishing date	2023-10-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12196393
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Article: Abdominal Wall Hernias-State of the Art of Laparoscopic versus Robotic Surgery.

Anoldo, Pietro / Manigrasso, Michele / D'Amore, Anna / Musella, Mario / De Palma, Giovanni Domenico / Milone, Marco

Journal of personalized medicine

2024 Volume 14, Issue 1

Abstract: Abdominal wall hernia repair, a common surgical procedure, includes various techniques to minimize postoperative complications and enhance outcomes. This review focuses on the comparison between laparoscopic and robotic approaches in treating inguinal ... ...

Abstract	Abdominal wall hernia repair, a common surgical procedure, includes various techniques to minimize postoperative complications and enhance outcomes. This review focuses on the comparison between laparoscopic and robotic approaches in treating inguinal and ventral hernias, presenting the ongoing situation of this topic. A systematic search identified relevant studies comparing laparoscopic and robotic approaches for inguinal and ventral hernias. Randomized control trials, retrospective, and prospective studies published after 1 January 2000, were included. Search terms such as hernia, inguinal, ventral, laparoscopy, robotic, and surgery were used. A total of 23 articles were included for analysis. Results indicated similar short-term outcomes for robotic and laparoscopic techniques in inguinal hernia repair, with robotic groups experiencing less postoperative pain. However, longer operative times and higher costs were associated with robotic repair. Robotic ventral hernia repair demonstrated potential benefits, including shorter hospital stay, lower recurrence and lower reoperation rates. While robotic surgery offers advantages such as shorter hospital stays, faster recovery, and less postoperative pain, challenges including costs and training requirements need consideration. The choice between laparoscopic and robotic approaches for abdominal wall hernias should be tailored based on individual surgeon expertise and resource availability, emphasizing a balanced evaluation of benefits and challenges.
Language	English
Publishing date	2024-01-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm14010100
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Article ; Online: Is proctoscopy sufficient for the evaluation of colorectal anastomosis prior to ileostomy reversal? A nationwide retrospective analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative group (SICO-CCN).

Manigrasso, Michele / Degiuli, Maurizio / Maione, Francesco / Venetucci, Pietro / Roviello, Franco / De Palma, Giovanni Domenico / Milone, Marco

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

2024 Volume 26, Issue 3, Page(s) 439–448

Abstract: Aim: Several methods for assessing anastomotic integrity have been proposed, but the best is yet to be defined. The aim of this study was to compare the different methods to assess the integrity of colorectal anastomosis prior to ileostomy reversal.: ... ...

Abstract	Aim: Several methods for assessing anastomotic integrity have been proposed, but the best is yet to be defined. The aim of this study was to compare the different methods to assess the integrity of colorectal anastomosis prior to ileostomy reversal. Method: A retrospective cohort analysis on patients between 1 January 2010 and 31 December 2020 with a defunctioning stoma for middle and low rectal anterior resection was performed. A propensity score matching comparison between patients who underwent proctoscopy alone and patients who underwent proctoscopy plus any other preoperative method to assess the integrity of colorectal anastomosis prior to ileostomy reversal (transanal water-soluble contrast enema via conventional radiology, transanal water-soluble contrast enema via CT, and magnetic resonance) was performed. Results: The analysis involved 1045 patients from 26 Italian referral colorectal centres. The comparison between proctoscopy alone versus proctoscopy plus any other preoperative tool showed no significant differences in terms of stenoses (p = 0.217) or leakages (p = 0.103) prior to ileostomy reversal, as well as no differences in terms of misdiagnosed stenoses (p = 0.302) or leakages (p = 0.509). Interestingly, in the group that underwent proctoscopy and transanal water-soluble contrast enema the comparison between the two procedures demonstrated no significant differences in detecting stenoses (2 vs. 0, p = 0.98), while there was a significant difference in detecting leakages in favour of transanal water-soluble contrast enema via CT (3 vs. 12, p = 0.03). Conclusions: We can confirm that proctoscopy alone should be considered sufficient prior to ileostomy reversal. However, in cases in which the results of proctoscopy are not completely clear or the surgeon remains suspicious of an anastomotic leakage, transanal water-soluble contrast enema via CT could guarantee its detection.
MeSH term(s)	Humans ; Proctoscopy ; Ileostomy/methods ; Retrospective Studies ; Constriction, Pathologic/surgery ; Surgical Oncology ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/surgery ; Enema/methods ; Contrast Media ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Anastomotic Leak/diagnostic imaging ; Anastomotic Leak/etiology ; Anastomotic Leak/surgery ; Water ; Italy
Chemical Substances	Contrast Media ; Water (059QF0KO0R)
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1440017-0
ISSN	1463-1318 ; 1462-8910
ISSN (online)	1463-1318
ISSN	1462-8910
DOI	10.1111/codi.16864
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Zs.A 5799: Show issues

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Article: Cyanoacrylate in Colorectal Surgery: Is It Safe?

D'Amore, Anna / Anoldo, Pietro / Manigrasso, Michele / Aprea, Giovanni / De Palma, Giovanni Domenico / Milone, Marco

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: Anastomotic leakage (AL) of a gastrointestinal (GI) anastomosis continues to be an important complication in GI surgery. Since its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide "prophylaxis" ...

Abstract	Anastomotic leakage (AL) of a gastrointestinal (GI) anastomosis continues to be an important complication in GI surgery. Since its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide "prophylaxis" against AL. However, although in surgical practice it is increasingly used, evidence on humans is still lacking. The aim of this study is to analyze in humans the safety of CA to seal colorectal anastomosis. All consecutive patients from Jannuary 2022 through December 2022 who underwent minimally invasive colorectal surgery were retrospectively analyzed from a prospectively maintained database. Inclusion criteria were a histological diagnosis of cancer, a totally minimally invasive procedure, and the absence of intraoperative complications. 103 patients were included in the study; N-butyl cyanoacrylate with metacryloxisulfolane (Glubran 2
Language	English
Publishing date	2023-08-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12155152
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Article: Re-thoracoscopy for the management of gastric conduit dehiscence after minimally invasive McKeown esophagectomy.

Anoldo, Pietro / Vertaldi, Sara / Manigrasso, Michele / D'Amore, Anna / De Palma, Giovanni Domenico / Milone, Marco

International journal of surgery case reports

2023 Volume 103, Page(s) 107876

Abstract: Introduction and importance: Gastric conduit dehiscence after esophagectomy represents a severe complication associated with high mortality. Surgical management is achieved through thoracotomy, but often ends up in conduit sacrifice and diversion.: ... ...

Abstract	Introduction and importance: Gastric conduit dehiscence after esophagectomy represents a severe complication associated with high mortality. Surgical management is achieved through thoracotomy, but often ends up in conduit sacrifice and diversion. Case presentation: A 59-years-old man underwent minimally invasive McKeown esophagectomy for esophageal adenocarcinoma. After a worsening of the postoperative course and evidence at the CT scan and endoscopy of highly suspect gastric conduit failure, the patient underwent an exploratory thoracoscopy, which revealed a partial dehiscence of the gastric conduit treated with resection of the dehiscent gastric wall by a linear stapler on the guide of a 36-french orogastric tube. Patient had a regular postoperative course without any complications and was discharged on the 6th postoperative day. Clinical discussion: The management of conduit necrosis is extremely challenging. There are several interventional options and it is difficult to decide the most appropriate treatment for each individual patient. In our case we decided to perform a reintervention with a thoracoscopic approach, resecting the dehiscent area of the gastric conduit. Conclusions: Minimally invasive surgery is a valid option for the management of post-operative complications, including those in emergency setting. Re-suturing a partial dehiscence of gastric conduit may be feasible if tissue conditions allow.
Language	English
Publishing date	2023-01-10
Publishing country	Netherlands
Document type	Case Reports
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2023.107876
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Article ; Online: Could atmospheric temperature impact on adequate colon cleansing for colonoscopy? An observational, single-institution study.

Maione, Francesco / Manigrasso, Michele / Milone, Marco / Gennarelli, Nicola / Maione, Rosa / Cantore, Grazia / Chini, Alessia / De Palma, Giovanni Domenico

International journal of colorectal disease

2023 Volume 38, Issue 1, Page(s) 96

Abstract: Purpose: Several risk factors affecting the adequacy of colon cleansing have been proposed during the last decades. However, less is known about the impact that atmospheric aspects could have on adequacy of the bowel cleansing. The study aimed to ... ...

Abstract	Purpose: Several risk factors affecting the adequacy of colon cleansing have been proposed during the last decades. However, less is known about the impact that atmospheric aspects could have on adequacy of the bowel cleansing. The study aimed to investigate if the atmospheric temperature could impact on the bowel cleansing during colonoscopy. Methods: A prospective maintained database of the colonoscopies performed since 1 Results: One thousand two hundred twenty patients were enrolled. High atmospheric temperature (> 25 °C) significantly influenced the colon cleansing (p < 0.0001). Adequate colon cleansing was negatively influenced by gender (female patients were associated with higher colon cleansing rate, p = 0.013), diabetes (p < 0.0001), previous pelvic surgery (p = 0.001), use of Beta-Blocker (p = 0.001), anti-platelet (p = 0.017), angiotensin converting enzyme inhibitors (p = 0.001), the adoption of 4 L Poly Ethylene Glycol solution (p = 0.009), single-dose regimen (p < 0.0001) low patients' compliance (p < 0.0001), higher age and body mass index (p < 0.0001 and p = 0.025), lower education levels (p < 0.0001). On the contrary, admission to the ward to perform bowel preparation positively impacted on colon cleansing (p = 0.002). Conclusion: Atmospheric temperature could play an important role in the colon cleansing during colonoscopy, being high temperature (> 25 °C) associated with lower rate of adequate bowel cleansing. However, being this relationship never studied before, these results must be confirmed by other studies.
MeSH term(s)	Female ; Humans ; Cathartics/adverse effects ; Colon ; Colonoscopy/methods ; Polyethylene Glycols/adverse effects ; Prospective Studies ; Retrospective Studies ; Temperature
Chemical Substances	Cathartics ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2023-04-13
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-023-04393-x
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Zs.A 2121: Show issues

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Article ; Online: Dual docking technique for robotic repair of simultaneous inguinal and umbilical hernia: A preliminary single center experience.

Anoldo, Pietro / Manigrasso, Michele / D'Amore, Anna / Musella, Mario / De Palma, Giovanni Domenico / Milone, Marco

The international journal of medical robotics + computer assisted surgery : MRCAS

2023 , Page(s) e2586

Abstract: Background: This study aimed to assess clinical results in terms of intraoperative outcomes, recovery and recurrence of our robotic technique for the treatment of patients affected by simultaneous inguinal and umbilical hernia, providing technical ... ...

Abstract	Background: This study aimed to assess clinical results in terms of intraoperative outcomes, recovery and recurrence of our robotic technique for the treatment of patients affected by simultaneous inguinal and umbilical hernia, providing technical details to facilitate multiquadrant surgery in robotic hernia repair. Methods: Data from patients affected by simultaneous primary inguinal and umbilical hernia who underwent robotic repair with our dual docking technique was retrospectively analysed. Results: Fifteen patients were included. No intraoperative complications occurred. All patients achieved complete mobilisation within 7 h. The mean length of hospital stay was 21.6 h, with five patients discharged on the same day of surgery. There was no major complication and no recurrence within the median follow-up period of 673 days. Conclusions: This surgical technique shows optimal postoperative outcomes, such as early mobilisation and short length of stay. Our study provides an aid to surgeons performing multiquadrant robotic surgery for the treatment of abdominal hernias.
Language	English
Publishing date	2023-10-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2586
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Article ; Online: Robotic 8-mm trocar fascial wounds: To close or not to close?

Milone, Marco / Anoldo, Pietro / Manigrasso, Michele / Cantore, Grazia / Campanile, Silvia / Rompianesi, Gianluca / Troisi, Roberto Ivan / D'Amore, Anna / De Palma, Giovanni Domenico

The international journal of medical robotics + computer assisted surgery : MRCAS

2024 Volume 20, Issue 2, Page(s) e2624

Abstract: Background: The aim of this study was to investigate 8-mm robotic trocar site hernia (TSH) rate over the short and long term, providing aids to manage the related fascial wounds.: Methods: A retrospective analysis of 320 patients undergoing robotic ... ...

Abstract	Background: The aim of this study was to investigate 8-mm robotic trocar site hernia (TSH) rate over the short and long term, providing aids to manage the related fascial wounds. Methods: A retrospective analysis of 320 patients undergoing robotic surgery was conducted. The primary outcome was 8-mm TSH rate with a minimum follow-up of 12 months. The secondary outcome was the rate of haematomas and infections related to 8-mm wounds and their association with patient comorbidities and trocar position. Results: One case of TSH was observed (0.31%). There were 15 cases of wound infection (4.68%) and 22 cases of wound haematoma (6.87%). Trocar related complications were significantly associated with patient comorbidities, not with trocar position. Conclusions: Our results do not justify the 8-mm fascial wound closure. Data concerning the association between trocar-related complications and patient comorbidities strengthen the need to implement the control of metabolic state and correct administration of perioperative therapy in high-risk patients.
MeSH term(s)	Humans ; Robotic Surgical Procedures/adverse effects ; Retrospective Studies ; Laparoscopy/adverse effects ; Laparoscopy/methods ; Surgical Instruments/adverse effects ; Thyrotropin
Chemical Substances	Thyrotropin (9002-71-5)
Language	English
Publishing date	2024-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2151860-9
ISSN	1478-596X ; 1478-5951
ISSN (online)	1478-596X
ISSN	1478-5951
DOI	10.1002/rcs.2624
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Article: Can Computed Tomography Colonography Replace Optical Colonoscopy in Detecting Colorectal Lesions?: State of the Art.

Chini, Alessia / Manigrasso, Michele / Cantore, Grazia / Maione, Rosa / Milone, Marco / Maione, Francesco / De Palma, Giovanni Domenico

Clinical endoscopy

2022 Volume 55, Issue 2, Page(s) 183–190

Abstract: Colorectal cancer is an important cause of morbidity and mortality worldwide. Optical colonoscopy (OC) is widely accepted as the reference standard for the screening of colorectal polyps and cancers, and computed tomography colonography (CTC) is a valid ... ...

Abstract	Colorectal cancer is an important cause of morbidity and mortality worldwide. Optical colonoscopy (OC) is widely accepted as the reference standard for the screening of colorectal polyps and cancers, and computed tomography colonography (CTC) is a valid alternative to OC. The purpose of this review was to assess the diagnostic accuracy of OC and CTC for colorectal lesions. A literature search was performed in PubMed, Embase, and Cochrane Library, and 18 articles were included. CTC has emerged in recent years as a potential screening examination with high accuracy for the detection of colorectal lesions. However, the clinical application of CTC as a screening technique is limited because it is highly dependent on the size of the lesions and has poor performance in detecting individual lesions <5 mm or flat lesions, which, although rarely, can have a malignant potential.
Language	English
Publishing date	2022-02-24
Publishing country	Korea (South)
Document type	Journal Article ; Review
ZDB-ID	2643507-X
ISSN	2234-2443 ; 2234-2400
ISSN (online)	2234-2443
ISSN	2234-2400
DOI	10.5946/ce.2021.254
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Article: Endoscopic Diagnosis and Management of Barrett's Esophagus with Low-Grade Dysplasia.

Maione, Francesco / Chini, Alessia / Maione, Rosa / Manigrasso, Michele / Marello, Alessandra / Cassese, Gianluca / Gennarelli, Nicola / Milone, Marco / De Palma, Giovanni Domenico

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 5

Abstract: Barrett's Esophagus is a common condition associated with chronic gastroesophageal reflux disease. It is well known that it has an association with a higher incidence of esophageal adenocarcinoma, but this neoplastic transformation is first preceded by ... ...

Abstract	Barrett's Esophagus is a common condition associated with chronic gastroesophageal reflux disease. It is well known that it has an association with a higher incidence of esophageal adenocarcinoma, but this neoplastic transformation is first preceded by the onset of low and high-grade dysplasia. The evaluation of low grade dysplastic esophageal mucosa is still controversial; although endoscopic surveillance is preferred, several minimally invasive endoscopic therapeutic approaches are available. Endoscopic mucosal resection and radiofrequency ablation are the most used endoscopic treatments for the eradication of low-grade dysplasia, respectively, for nodular and flat dysplasia. Novel endoscopic treatments are cryotherapy ablation and argon plasma coagulation, that have good rates of eradication with less complications and post-procedural pain.
Language	English
Publishing date	2022-05-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12051295
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