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  1. Article: Impaired Self-Awareness in Parkinson's and Huntington's Diseases: A Literature Review of Neuroimaging Correlates.

    Tondelli, Manuela / Manigrasso, Miriana / Zamboni, Giovanna

    Brain sciences

    2024  Volume 14, Issue 3

    Abstract: Little is known about the brain correlates of anosognosia or unawareness of disease in Parkinson's Disease (PD) and Huntington's Disease (HD). The presence of unawareness or impaired self-awareness (ISA) of illness has profound implications for patients ... ...

    Abstract Little is known about the brain correlates of anosognosia or unawareness of disease in Parkinson's Disease (PD) and Huntington's Disease (HD). The presence of unawareness or impaired self-awareness (ISA) of illness has profound implications for patients and their caregivers; therefore, studying awareness and its brain correlates should be considered a key step towards developing effective recognition and management of this symptom as it offers a window into the mechanism of self-awareness and consciousness as critical components of the human cognition. We reviewed research studies adopting MRI or other in vivo neuroimaging technique to assess brain structural and/or functional correlates of unawareness in PD and HD across different cognitive and motor domains. Studies adopting task or resting-state functional magnetic resonance imaging, and/or 18-F fluorodeoxyglucose positron emission tomography brain imaging and/or magnetic resonance imaging structural measures were considered. Only six studies investigating neuroimaging features of unawareness in PD and two in HD were identified; there was great heterogeneity in the clinical characteristics of the study participants, domain of unawareness investigated, method of unawareness assessment, and neuroimaging technique used. Nevertheless, some data converge in identifying regions of the salience and frontoparietal networks to be associated with unawareness in PD patients. In HD, the few data are affected by the variability in the severity of motor symptoms. Further studies are needed to better understand the mechanisms and brain correlates of unawareness in PD and HD; in addition, the use of dopaminergic medications should be carefully considered.
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci14030204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comment on Wijnia, J.W. A Clinician's View of Wernicke-Korsakoff Syndrome.

    Manigrasso, Michele / Velotti, Nunzio / De Palma, Giovanni Domenico / Musella, Mario

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: We have read with great interest the article by Wijnia [ ... ]. ...

    Abstract We have read with great interest the article by Wijnia [...].
    Language English
    Publishing date 2023-10-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Passive Vaping from Sub-Ohm Electronic Cigarette Devices.

    Manigrasso, Maurizio / Protano, Carmela / Vitali, Matteo / Avino, Pasquale

    International journal of environmental research and public health

    2021  Volume 18, Issue 21

    Abstract: To investigate passive vaping due to sub-ohm electronic cigarettes (e-cigs), aerosol number size distribution measurements (6 nm-10 µm) were performed during volunteer-vaping sessions. E-liquids, with vegetable glycerin (VG) and propylene glycol (PG), ... ...

    Abstract To investigate passive vaping due to sub-ohm electronic cigarettes (e-cigs), aerosol number size distribution measurements (6 nm-10 µm) were performed during volunteer-vaping sessions. E-liquids, with vegetable glycerin (VG) and propylene glycol (PG), with a VG/PG ratio of 50/50 (with nicotine) and 80/20 (without nicotine), were vaped with a double-coil, single aerosol exit hole at 25-80 W electric power, corresponding to 130-365 kW m
    MeSH term(s) Aerosols ; Electronic Nicotine Delivery Systems ; Humans ; Nicotine ; Propylene Glycol ; Vaping
    Chemical Substances Aerosols ; Propylene Glycol (6DC9Q167V3) ; Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2021-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph182111606
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  4. Article: Abdominal Wall Hernias-State of the Art of Laparoscopic versus Robotic Surgery.

    Anoldo, Pietro / Manigrasso, Michele / D'Amore, Anna / Musella, Mario / De Palma, Giovanni Domenico / Milone, Marco

    Journal of personalized medicine

    2024  Volume 14, Issue 1

    Abstract: Abdominal wall hernia repair, a common surgical procedure, includes various techniques to minimize postoperative complications and enhance outcomes. This review focuses on the comparison between laparoscopic and robotic approaches in treating inguinal ... ...

    Abstract Abdominal wall hernia repair, a common surgical procedure, includes various techniques to minimize postoperative complications and enhance outcomes. This review focuses on the comparison between laparoscopic and robotic approaches in treating inguinal and ventral hernias, presenting the ongoing situation of this topic. A systematic search identified relevant studies comparing laparoscopic and robotic approaches for inguinal and ventral hernias. Randomized control trials, retrospective, and prospective studies published after 1 January 2000, were included. Search terms such as hernia, inguinal, ventral, laparoscopy, robotic, and surgery were used. A total of 23 articles were included for analysis. Results indicated similar short-term outcomes for robotic and laparoscopic techniques in inguinal hernia repair, with robotic groups experiencing less postoperative pain. However, longer operative times and higher costs were associated with robotic repair. Robotic ventral hernia repair demonstrated potential benefits, including shorter hospital stay, lower recurrence and lower reoperation rates. While robotic surgery offers advantages such as shorter hospital stays, faster recovery, and less postoperative pain, challenges including costs and training requirements need consideration. The choice between laparoscopic and robotic approaches for abdominal wall hernias should be tailored based on individual surgeon expertise and resource availability, emphasizing a balanced evaluation of benefits and challenges.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14010100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Is proctoscopy sufficient for the evaluation of colorectal anastomosis prior to ileostomy reversal? A nationwide retrospective analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative group (SICO-CCN).

    Manigrasso, Michele / Degiuli, Maurizio / Maione, Francesco / Venetucci, Pietro / Roviello, Franco / De Palma, Giovanni Domenico / Milone, Marco

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2024  Volume 26, Issue 3, Page(s) 439–448

    Abstract: Aim: Several methods for assessing anastomotic integrity have been proposed, but the best is yet to be defined. The aim of this study was to compare the different methods to assess the integrity of colorectal anastomosis prior to ileostomy reversal.: ... ...

    Abstract Aim: Several methods for assessing anastomotic integrity have been proposed, but the best is yet to be defined. The aim of this study was to compare the different methods to assess the integrity of colorectal anastomosis prior to ileostomy reversal.
    Method: A retrospective cohort analysis on patients between 1 January 2010 and 31 December 2020 with a defunctioning stoma for middle and low rectal anterior resection was performed. A propensity score matching comparison between patients who underwent proctoscopy alone and patients who underwent proctoscopy plus any other preoperative method to assess the integrity of colorectal anastomosis prior to ileostomy reversal (transanal water-soluble contrast enema via conventional radiology, transanal water-soluble contrast enema via CT, and magnetic resonance) was performed.
    Results: The analysis involved 1045 patients from 26 Italian referral colorectal centres. The comparison between proctoscopy alone versus proctoscopy plus any other preoperative tool showed no significant differences in terms of stenoses (p = 0.217) or leakages (p = 0.103) prior to ileostomy reversal, as well as no differences in terms of misdiagnosed stenoses (p = 0.302) or leakages (p = 0.509). Interestingly, in the group that underwent proctoscopy and transanal water-soluble contrast enema the comparison between the two procedures demonstrated no significant differences in detecting stenoses (2 vs. 0, p = 0.98), while there was a significant difference in detecting leakages in favour of transanal water-soluble contrast enema via CT (3 vs. 12, p = 0.03).
    Conclusions: We can confirm that proctoscopy alone should be considered sufficient prior to ileostomy reversal. However, in cases in which the results of proctoscopy are not completely clear or the surgeon remains suspicious of an anastomotic leakage, transanal water-soluble contrast enema via CT could guarantee its detection.
    MeSH term(s) Humans ; Proctoscopy ; Ileostomy/methods ; Retrospective Studies ; Constriction, Pathologic/surgery ; Surgical Oncology ; Rectal Neoplasms/diagnostic imaging ; Rectal Neoplasms/surgery ; Enema/methods ; Contrast Media ; Anastomosis, Surgical/adverse effects ; Anastomosis, Surgical/methods ; Anastomotic Leak/diagnostic imaging ; Anastomotic Leak/etiology ; Anastomotic Leak/surgery ; Water ; Italy
    Chemical Substances Contrast Media ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.16864
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5799: Show issues Location:
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  6. Article ; Online: Response to: What is the role of submucosal tattoos in device assisted enteroscopy?

    Manigrasso, M / Elmore, U / Vignali, A / De Palma, G D / Milone, M

    Techniques in coloproctology

    2020  Volume 24, Issue 5, Page(s) 497–498

    MeSH term(s) Carbon ; Endoscopy, Gastrointestinal ; Tattooing
    Chemical Substances chinese ink ; Carbon (7440-44-0)
    Language English
    Publishing date 2020-03-17
    Publishing country Italy
    Document type Letter ; Comment
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-020-02192-y
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    Zs.A 5842: Show issues Location:
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  7. Article ; Online: May SARS-CoV-2 diffusion be favored by alkaline aerosols and ammonia emissions?

    Manigrasso, M. / Protano, C. / Guerriero, E. / Vitali, M. / Avino, P.

    2020  

    Abstract: Ammonia is a common factor linking air in bat caves and air pollution in the proximity of agricultural fields treated with livestock farming sewage and slaughterhouses, where important clusters of COVID-19 have recently been reported all over the world. ... ...

    Abstract Ammonia is a common factor linking air in bat caves and air pollution in the proximity of agricultural fields treated with livestock farming sewage and slaughterhouses, where important clusters of COVID-19 have recently been reported all over the world. Such a commonality has a further connection with the known behavior of some viruses of the coronavirus family, such as the murine hepatitis virus, whose spike glycoprotein (S) can be triggered to a membrane-binding conformation at pH 8.0. Within the airborne route of virus transmission, with particular relevance for crowded and enclosed environments, these observations have prompted a hypothesis that may represent a contributing cause to interpret the geographical variability of the virus diffusion and the surging rise of COVID-19 cases in slaughterhouses all over the world. The hypothesis is that, in these environments, the SARS-CoV-2 S protein may find on a fraction of the airborne particles an alkaline pH, favorable to trigger the conformational changes, needed to induce the fusion of the viral envelope with the plasma membrane of the target cells.
    Keywords aerosol ; ammonia ; livestock farming sewage ; ph ; sars-cov-2 ; slaughterhouses ; covid19
    Language English
    Publisher MDPI AG
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Robotic rectal resection preserving the inferior mesenteric artery - a video vignette.

    Milone, M / Manigrasso, M / Gandini, M / Aprea, S / Vertaldi, S / De Palma, G D

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2019  Volume 22, Issue 1, Page(s) 113–114

    MeSH term(s) Adenocarcinoma/surgery ; Aged, 80 and over ; Female ; Humans ; Ligation/methods ; Mesenteric Artery, Inferior/surgery ; Mesenteric Veins/surgery ; Proctectomy/methods ; Rectal Neoplasms/surgery ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2019-08-27
    Publishing country England
    Document type Case Reports ; Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14834
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  9. Article ; Online: Totally robotic splenic flexure resection with intracorporeal anastomosis - a video vignette.

    Milone, M / Manigrasso, M / D'Ambra, M / De Palma, G D

    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

    2019  Volume 21, Issue 8, Page(s) 975

    MeSH term(s) Adenocarcinoma/surgery ; Aged ; Anastomosis, Surgical ; Colon, Transverse/surgery ; Colonic Neoplasms/surgery ; Humans ; Male ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2019-05-31
    Publishing country England
    Document type Case Reports ; Letter ; Video-Audio Media
    ZDB-ID 1440017-0
    ISSN 1463-1318 ; 1462-8910
    ISSN (online) 1463-1318
    ISSN 1462-8910
    DOI 10.1111/codi.14680
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    In stock of ZB MED Cologne/Königswinter

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  10. Article ; Online: The third arm: the surgeon's friend in the management of intraoperative complications in robotic-assisted rectal surgery.

    Milone, M / Manigrasso, M / Gandini, M / Aprea, S / De Palma, G D

    Techniques in coloproctology

    2019  Volume 23, Issue 10, Page(s) 1015

    MeSH term(s) Blood Loss, Surgical ; Hemostasis, Surgical/methods ; Humans ; Proctectomy/adverse effects ; Proctectomy/methods ; Rectal Neoplasms/surgery ; Robotic Surgical Procedures/adverse effects ; Robotic Surgical Procedures/methods
    Language English
    Publishing date 2019-08-27
    Publishing country Italy
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2083309-X
    ISSN 1128-045X ; 1123-6337
    ISSN (online) 1128-045X
    ISSN 1123-6337
    DOI 10.1007/s10151-019-02067-x
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