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  1. Article ; Online: Effectiveness of Benralizumab in severe eosinophilic asthma: Distinct sub-phenotypes of response identified by cluster analysis by Di Bona et al.

    Maniscalco, Mauro

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

    2021  Volume 52, Issue 2, Page(s) 359–360

    MeSH term(s) Antibodies, Monoclonal, Humanized ; Asthma/diagnosis ; Asthma/drug therapy ; Cluster Analysis ; Humans ; Phenotype ; Pulmonary Eosinophilia/diagnosis ; Pulmonary Eosinophilia/drug therapy
    Chemical Substances Antibodies, Monoclonal, Humanized ; benralizumab (71492GE1FX)
    Language English
    Publishing date 2021-11-23
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 645204-8
    ISSN 1365-2222 ; 0954-7894 ; 0960-2178
    ISSN (online) 1365-2222
    ISSN 0954-7894 ; 0960-2178
    DOI 10.1111/cea.14059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Are biologics effective on lung hyperinflation in patients with resistant asthma? A reply.

    Cazzola, Mario / Maniscalco, Mauro

    Respiratory medicine

    2024  , Page(s) 107653

    Language English
    Publishing date 2024-04-26
    Publishing country England
    Document type Letter
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2024.107653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Nitric Oxide View: Perspectives and Applications.

    Maniscalco, Mauro

    Current medicinal chemistry

    2020  Volume 27, Issue 42, Page(s) 7134–7135

    MeSH term(s) Humans ; Nitric Oxide
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2020-12-17
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/092986732742201105102021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exploring the Role of Nitric Oxide in Lower Airway Diseases: Insights and Real-world Application.

    Ambrosino, Pasquale / Maniscalco, Mauro / Marcuccio, Giuseppina

    Current medicinal chemistry

    2024  

    Language English
    Publishing date 2024-01-10
    Publishing country United Arab Emirates
    Document type Editorial
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0109298673289734231228105444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Deconditioning in COVID-19 survivors with reduced exercise performance: A role for endothelial dysfunction?

    Ambrosino, Pasquale / Maniscalco, Mauro

    Medical hypotheses

    2022  Volume 163, Page(s) 110847

    Abstract: Recent studies have reported an impaired exercise response at cardiopulmonary exercise testing (CPET) during convalescence from coronavirus disease 2019 (COVID-19). In detail, these previous reports suggest the presence of functional limitations in a ... ...

    Abstract Recent studies have reported an impaired exercise response at cardiopulmonary exercise testing (CPET) during convalescence from coronavirus disease 2019 (COVID-19). In detail, these previous reports suggest the presence of functional limitations in a consistent proportion of COVID-19 survivors, in the absence of relevant alterations of ventilatory and gas exchange parameters at CPET. Therefore, deconditioning has been proposed as the main mechanism of the reduced peak oxygen uptake in this clinical setting. This interpretation of the results is supported by the evidence that deconditioning is a recognized aspect of the post-intensive care syndrome, with acute sarcopenia being frequently observed among COVID-19 survivors. Here, we hypothesized the role of endothelial dysfunction as a key pathogenic mechanism of the functional limitations of COVID-19, including multisystem deconditioning and subsequent exercise intolerance.
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2022.110847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nasal nitric oxide and chronic rhinosinusitis with nasal polyps: Is it a matter of inflammation or mechanical obstruction?

    Ambrosino, Pasquale / Motta, Andrea / Maniscalco, Mauro

    International forum of allergy & rhinology

    2023  Volume 13, Issue 12, Page(s) 2266–2267

    MeSH term(s) Humans ; Nasal Polyps ; Nitric Oxide ; Inflammation ; Sinusitis ; Nose ; Chronic Disease ; Rhinitis
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Letter
    ZDB-ID 2625826-2
    ISSN 2042-6984 ; 2042-6976
    ISSN (online) 2042-6984
    ISSN 2042-6976
    DOI 10.1002/alr.23291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Nasal nitric oxide as biomarker in the evaluation and management of chronic rhino-sinusitis with nasal polyposis.

    Maniscalco, Mauro

    European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

    2017  Volume 274, Issue 10, Page(s) 3817–3818

    Language English
    Publishing date 2017
    Publishing country Germany
    Document type Letter
    ZDB-ID 1017359-6
    ISSN 1434-4726 ; 0937-4477
    ISSN (online) 1434-4726
    ISSN 0937-4477
    DOI 10.1007/s00405-017-4591-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Quality of life and work functionality in severe asthma patients: the impact of biological therapies.

    Leso, Veruscka / Candia, Claudio / Pacella, Daniela / Molino, Antonio / Nocera, Caterina / Maniscalco, Mauro / Iavicoli, Ivo

    Journal of occupational medicine and toxicology (London, England)

    2024  Volume 19, Issue 1, Page(s) 8

    Abstract: Background: Severe asthma can cause poor health status, poor health-related quality of life (HRQoL) and an impaired functioning at work. However, to date, limited data are available on the impact of the biological therapies on such outcomes. Therefore, ... ...

    Abstract Background: Severe asthma can cause poor health status, poor health-related quality of life (HRQoL) and an impaired functioning at work. However, to date, limited data are available on the impact of the biological therapies on such outcomes. Therefore, aim of the present study was to prospectively assess the clinical, quality of life and work functionality issues in severe asthma patients both at baseline and after 6 months of biological therapies and determine which individual, pathological and occupational factors can influence such parameters.
    Methods: Fifty-two patients were enrolled between December 2022 and June 2023. Patients' personal, clinical, functional and occupational features were assessed. The Short Form Health Survey (SF-12), the Work Productivity and Activity Impairment (WPAI) questionnaire and the Work Ability Index (WAI) were employed to assess HRQoL, the employee's productivity and perception of work ability, respectively.
    Results: Among the enrolled patients, 30 (57.70%) were employed. Biological therapy induced a significant improvement in clinical and functional parameters, e.g., FEV1% (72 ± 12 vs.87 ± 13%; 72 ± 14 vs. 86 ± 14%), FVC% (92 ± 11 vs. 101 ± 11%; 90 ± 13 vs. 98 ± 14%) and FEV
    Conclusions: Our study pointed out that biological therapies improved clinical, general life and occupational outcomes in patients with severe asthma. The correlation between clinical aspects and psychological and occupational issues suggest the relevance for a multidisciplinary management of the disease for an effective participation of patients in the world of work.
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2223190-0
    ISSN 1745-6673
    ISSN 1745-6673
    DOI 10.1186/s12995-024-00406-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Exploring novel perspectives on eosinophilic inflammation in severe asthma.

    Candia, Claudio / Ambrosino, Pasquale / D'Anna, Silvestro E / Motta, Andrea / Maniscalco, Mauro

    Biomarkers in medicine

    2024  

    Abstract: Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely ... ...

    Abstract Two recent articles by the same research group documented that patients with severe eosinophilic asthma exhibit an increased proportion of a subtype of eosinophils, namely CD62L
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2023-0801
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Implementing Translational Research to Understand the Future of COVID-19 and Its Long-Term Consequences: A Degrowth Perspective or the Transformation of a Global Emergency?

    Ambrosino, Pasquale / Moretta, Pasquale / Lanzillo, Anna / Formisano, Roberto / Maniscalco, Mauro

    Biomedicines

    2023  Volume 11, Issue 1

    Abstract: It has now been three years since the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first gave rise to a global health crisis [ ... ]. ...

    Abstract It has now been three years since the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first gave rise to a global health crisis [...].
    Language English
    Publishing date 2023-01-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11010117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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