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  1. Book ; Online: Application of Data Collected by Endpoint Detection and Response Systems for Implementation of a Network Security System based on Zero Trust Principles and the EigenTrust Algorithm

    Kumar, Nitesh / Kasbekar, Gaurav S. / Manjunath, D.

    2022  

    Abstract: Traditionally, security systems for enterprises have implicit access based on strong cryptography, authentication and key sharing, wherein access control is based on Role Based Access Control (RBAC), in which roles such as manager, accountant and so on ... ...

    Abstract Traditionally, security systems for enterprises have implicit access based on strong cryptography, authentication and key sharing, wherein access control is based on Role Based Access Control (RBAC), in which roles such as manager, accountant and so on provide a way of deciding a subject's authority. However, years of post-attack analysis on enterprise networks has shown that a majority of times, security breaches occur intentionally or accidently due to implicitly trusted people of an enterprise itself. Zero Trust Architecture works on the principle of never granting trust implicitly, but rather continuously evaluating the trust parameters for each resource access request and has a strict, but not rigid, set of protocols for access control of a subject to resources. Endpoint Detection and Response (EDR) systems are tools that collect a large number of attributes in and around machines within an enterprise network to have close visibility into sophisticated intrusion. In our work, we seek to deploy EDR systems and build trust algorithms using tactical provenance analysis, threshold cryptography and reputation management to continuously record data, evaluate trust of a subject, and simultaneously analyze them against a database of known threat vectors to provide conditional access control. However, EDR tools generate a high volume of data that leads to false alarms, misdetections and correspondingly a high backlog of tasks that makes it infeasible, which is addressed using tactical provenance analysis and information theory.

    Comment: 3 pages
    Keywords Computer Science - Cryptography and Security ; Computer Science - Networking and Internet Architecture
    Subject code 005
    Publishing date 2022-03-17
    Publishing country us
    Document type Book ; Online
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  2. Article ; Online: An unusual case of ear mould impression material as a foreign body in the middle ear: case report.

    Manjunath, D / Vadlamani, S / Gaur, S K / Dutt, S N

    The Journal of laryngology and otology

    2021  Volume 135, Issue 3, Page(s) 276–279

    Abstract: Background: The occurrence of retained ear mould impression material is rare and can lead to complications. The current case report describes one such complication, where the silicone impression material used to take the impression of the ear canal ... ...

    Abstract Background: The occurrence of retained ear mould impression material is rare and can lead to complications. The current case report describes one such complication, where the silicone impression material used to take the impression of the ear canal flowed into the middle ear through the pre-existing tympanic membrane perforation. Five days later, the patient presented with worsened hearing and blood-tinged discharge from the ear. Ear microscopy revealed a greenish foreign body in the middle ear.
    Case report: The foreign body was removed by tympanotomy and the perforation repaired using a temporalis fascia graft. A hearing aid was prescribed after ensuring that the perforation had healed.
    Conclusion: It is essential that the audiologist perform a basic otological examination before prescribing a hearing aid and preparing an ear mould. A clinical approach algorithm for audiologists, for prior to taking an impression, is suggested.
    MeSH term(s) Aged, 80 and over ; Ear, Middle/injuries ; Female ; Foreign Bodies/etiology ; Hearing Aids/adverse effects ; Humans ; Silicones ; Tympanic Membrane Perforation/complications
    Chemical Substances Silicones
    Language English
    Publishing date 2021-02-26
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 218299-3
    ISSN 1748-5460 ; 0022-2151
    ISSN (online) 1748-5460
    ISSN 0022-2151
    DOI 10.1017/S0022215121000517
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  3. Article: Revisiting SIR in the age of COVID-19: Explicit Solutions and Control Problems

    Borkar, Vivek S. / Manjunath, D.

    Abstract: The non-population conserving SIR (SIR-NC) model to describe the spread of infections in a community is proposed and studied. Unlike the standard SIR model, SIR-NC does not assume population conservation. Although similar in form to the standard SIR, SIR- ...

    Abstract The non-population conserving SIR (SIR-NC) model to describe the spread of infections in a community is proposed and studied. Unlike the standard SIR model, SIR-NC does not assume population conservation. Although similar in form to the standard SIR, SIR-NC admits a closed form solution while allowing us to model mortality, and also provides different, and arguably a more realistic, interpretation of the model parameters. Numerical comparisons of this SIR-NC model with the standard, population conserving, SIR model are provided. Extensions to include imported infections, interacting communities, and models that include births and deaths are presented and analyzed. Several numerical examples are also presented to illustrate these models. Two control problems for the SIR-NC epidemic model are presented. First we consider the continuous time model predictive control in which the cost function variables correspond to the levels of lockdown, the level of testing and quarantine, and the number of infections. We also include a switching cost for moving between lockdown levels. A discrete time version that is more amenable to computation is then presented along with numerical illustrations. We then consider a multi-objective and multi-community control where we can define multiple cost functions on the different communities and obtain the minimum cost control to keep the value function corresponding to these control objectives below a prescribed threshold.
    Keywords covid19
    Publisher ArXiv
    Document type Article
    Database COVID19

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  4. Book ; Online: Revisiting SIR in the age of COVID-19

    Borkar, Vivek S. / Manjunath, D.

    Explicit Solutions and Control Problems

    2020  

    Abstract: The non-population conserving SIR (SIR-NC) model to describe the spread of infections in a community is proposed and studied. Unlike the standard SIR model, SIR-NC does not assume population conservation. Although similar in form to the standard SIR, SIR- ...

    Abstract The non-population conserving SIR (SIR-NC) model to describe the spread of infections in a community is proposed and studied. Unlike the standard SIR model, SIR-NC does not assume population conservation. Although similar in form to the standard SIR, SIR-NC admits a closed form solution while allowing us to model mortality, and also provides different, and arguably a more realistic, interpretation of the model parameters. Numerical comparisons of this SIR-NC model with the standard, population conserving, SIR model are provided. Extensions to include imported infections, interacting communities, and models that include births and deaths are presented and analyzed. Several numerical examples are also presented to illustrate these models. Two control problems for the SIR-NC epidemic model are presented. First we consider the continuous time model predictive control in which the cost function variables correspond to the levels of lockdown, the level of testing and quarantine, and the number of infections. We also include a switching cost for moving between lockdown levels. A discrete time version that is more amenable to computation is then presented along with numerical illustrations. We then consider a multi-objective and multi-community control where we can define multiple cost functions on the different communities and obtain the minimum cost control to keep the value function corresponding to these control objectives below a prescribed threshold.

    Comment: SIAM Journal of Control and Optimization 2020
    Keywords Mathematics - Optimization and Control ; Electrical Engineering and Systems Science - Systems and Control ; Physics - Physics and Society ; covid19
    Publishing date 2020-10-13
    Publishing country us
    Document type Book ; Online
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  5. Article ; Online: Ionic Pairing and Selective Solvation of Butylmethylimidazolium Chloride Ion Pairs in DMSO-Water Mixtures: A Comprehensive Examination via Molecular Dynamics Simulations and Potentials of Mean Force Analysis.

    Dixit, Mayank / Hajari, Timir / Meti, Manjunath D / Srivastava, Srishti / Srivastava, Amar / Daniel, Joseph

    The journal of physical chemistry. B

    2024  Volume 128, Issue 9, Page(s) 2168–2180

    Abstract: Ionic liquids (ILs) with dimethyl sulfoxide (DMSO) and water act as a promising solvent medium for the dissolution of cellulose in an efficient manner. To develop a proper solvent system, it is really important to understand the thermodynamics of the ... ...

    Abstract Ionic liquids (ILs) with dimethyl sulfoxide (DMSO) and water act as a promising solvent medium for the dissolution of cellulose in an efficient manner. To develop a proper solvent system, it is really important to understand the thermodynamics of the molecular solutions consisting of ILs, DMSO, and water. The ion-pairing propensity of the ILs in the presence of DMSO and water plays a crucial role in governing the property of the solvent mixtures. Employing all-atom molecular dynamics simulations, we estimate the potentials of mean force between BMIM
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c06876
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  6. Article: Perioperative anaesthesia management of renal transplant recipients - A national cross-sectional survey.

    Deo, Alka S / Manjunath, Deepti / Prasad, Ambika / Deepa, D

    Indian journal of anaesthesia

    2023  Volume 67, Issue Suppl 4, Page(s) S288–S291

    Language English
    Publishing date 2023-11-21
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.ija_492_23
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    Zs.B 1841: Show issues Location:
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  7. Article ; Online: Therapeutic potential of 4-substituted coumarins

    Manmohan Sharma / Vivek K. Vyas / Shaival Bhatt / Manjunath D. Ghate

    European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100086- (2022)

    A conspectus

    2022  

    Abstract: Substituted coumarins are a very large family of naturally occurring compounds, and substituted coumarins are versatile scaffolds for the development of medicinally active compounds. Coumarins are extensively found in higher plant families such as ... ...

    Abstract Substituted coumarins are a very large family of naturally occurring compounds, and substituted coumarins are versatile scaffolds for the development of medicinally active compounds. Coumarins are extensively found in higher plant families such as Rutaceae and Umbelliferae, and are ingredients in various essential oils such as cinnamon bark oil, cassia leaf oil, and lavender oil. Coumarin-based compounds are obtained from nature and substituted coumarins synthesized by chemists demonstrate antitumor, antibacterial, antifungal, anticancer, anticoagulant, antimalarial, antiviral, anti-HIV and anti-inflammatory activities. They are also used as fluorescent dyes and probes and possess a variety of other bioactive properties. Coumarin and its derivatives might have diverse mechanisms of action on different targets for different activities depending on the substitution pattern on the coumarin scaffold. The important progress of natural and synthetic 4-substituted coumarin derivatives that are biologically active against many diseases is the subject of this review study. The research for more potent molecules begins with the substitution of the coumarin scaffold on the C-4 position, which showed anticancer activity against A549, ACHN, H727, MCF-7, and HL60 cancer cell lines. Overall, the expansion of anticancer, antibacterial, and antimalarial agents is covered by substitution at the C-4 position of the coumarin scaffold. This comprehensive study could aid in the development of more strong drug candidates for numerous diseases in the future, with broad and fascinating therapeutic applications.
    Keywords 4-Substituted coumarins ; Anticancer ; Antibacterial ; Antiviral ; Antifungal ; Pharmacy and materia medica ; RS1-441 ; Other systems of medicine ; RZ201-999
    Subject code 540
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  8. Article ; Online: Medicinal chemistry strategies for the development of phosphodiesterase 10A (PDE10A) inhibitors - An update of recent progress.

    Amin, Harsh S / Parikh, Palak K / Ghate, Manjunath D

    European journal of medicinal chemistry

    2021  Volume 214, Page(s) 113155

    Abstract: Phosphodiesterase 10A is a member of Phosphodiesterase (PDE)-superfamily of the enzyme which is responsible for hydrolysis of cAMP and cGMP to their inactive forms 5'-AMP and 5'-GMP, respectively. PDE10A is highly expressed in the brain, particularly in ... ...

    Abstract Phosphodiesterase 10A is a member of Phosphodiesterase (PDE)-superfamily of the enzyme which is responsible for hydrolysis of cAMP and cGMP to their inactive forms 5'-AMP and 5'-GMP, respectively. PDE10A is highly expressed in the brain, particularly in the putamen and caudate nucleus. PDE10A plays an important role in the regulation of localization, duration, and amplitude of the cyclic nucleotide signalling within the subcellular domain of these regions, and thereby modulation of PDE10A enzyme can give rise to a new therapeutic approach in the treatment of schizophrenia and other neurodegenerative disorders. Limitation of the conventional therapy of schizophrenia forced the pharmaceutical industry to move their efforts to develop a novel treatment approach with reduced side effects. In the past decade, considerable developments have been made in pursuit of PDE10A centric antipsychotic agents by several pharmaceutical industries due to the distribution of PDE10A in the brain and the ability of PDE10A inhibitors to mimic the effect of D2 antagonists and D1 agonists. However, no selective PDE10A inhibitor is currently available in the market for the treatment of schizophrenia. The present compilation concisely describes the role of PDE10A inhibitors in the therapy of neurodegenerative disorders mainly in psychosis, the structure of PDE10A enzyme, key interaction of different PDE10A inhibitors with human PDE10A enzyme and recent medicinal chemistry developments in designing of safe and effective PDE10A inhibitors for the treatment of schizophrenia. The present compilation also provides useful information and future direction to bring further improvements in the discovery of PDE10A inhibitors.
    MeSH term(s) Chemistry, Pharmaceutical ; Drug Development ; Humans ; Molecular Structure ; Phosphodiesterase Inhibitors/chemical synthesis ; Phosphodiesterase Inhibitors/chemistry ; Phosphodiesterase Inhibitors/pharmacology ; Phosphoric Diester Hydrolases/metabolism
    Chemical Substances Phosphodiesterase Inhibitors ; PDE10A protein, human (EC 3.1.4.-) ; Phosphoric Diester Hydrolases (EC 3.1.4.-)
    Language English
    Publishing date 2021-01-09
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2021.113155
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    Zs.B 784: Show issues Location:
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  9. Article ; Online: In-silico identification and exploration of small molecule coumarin-1,2,3-triazole hybrids as potential EGFR inhibitors for targeting lung cancer.

    Kumar, Sunil / Ali, Iqra / Abbas, Faheem / Shafiq, Faiza / Yadav, Ashok Kumar / Ghate, Manjunath D / Kumar, Deepak

    Molecular diversity

    2024  

    Abstract: Globally, lung cancer is a significant public health concern due to its role as the leading cause of cancer-related mortalities. The promising target of EGFR for lung cancer treatment has been identified, providing a potential avenue for more effective ... ...

    Abstract Globally, lung cancer is a significant public health concern due to its role as the leading cause of cancer-related mortalities. The promising target of EGFR for lung cancer treatment has been identified, providing a potential avenue for more effective therapies. The purpose of the study was to design a library of 1843 coumarin-1,2,3-triazole hybrids and screen them based on a designed pharmacophore to identify potential inhibitors targeting EGFR in lung cancer with minimum or no side effects. Pharmacophore-based screening was carried out and 60 hits were obtained. To gain a better understanding of the binding interactions between the compounds and the targeted receptor, molecular docking was conducted on the 60 screened compounds. In-silico ADME and toxicity studies were also conducted to assess the drug-likeness and safety of the identified compounds. The results indicated that coumarin-1,2,3-triazole hybrids COUM-0849, COUM-0935, COUM-0414, COUM-1335, COUM-0276, and COUM-0484 exhibit dock score of - 10.2, - 10.2, - 10.1, - 10.1, - 10, - 10 while reference molecule - 7.9 kcal/mol for EGFR (PDB ID: 4HJO) respectively. The molecular docking and molecular dynamics simulations revealed that the identified compounds formed stable interactions with the active site of EGFR, indicating their potential as inhibitors. The in-silico ADME and toxicity studies showed that the compounds had favorable drug-likeness properties and low toxicity, further supporting their potential as therapeutic agents. Finally, we performed DFT studies on the best-selected ligands to gain further insights into their electronic properties. The findings of this study provide important insights into the potential of coumarin-1,2,3-triazole hybrids as promising EGFR inhibitors for the management of lung cancer.
    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-024-10817-9
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    Zs.A 4946: Show issues Location:
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  10. Book ; Online: Index Coding at the WiFi Edge

    Chhangte, Lalhruaizela / Viterbo, Emanuele / Manjunath, D / Karamchandani, Nikhil

    An Implementation Study for Video Delivery

    2020  

    Abstract: HTTP based video streaming has become the de facto standard for video content delivery across different video streaming services. However, video content delivery continues to be challenged at the wireless edge by inadequate and highly variable bandwidth. ...

    Abstract HTTP based video streaming has become the de facto standard for video content delivery across different video streaming services. However, video content delivery continues to be challenged at the wireless edge by inadequate and highly variable bandwidth. In this paper, we describe WiCode, a platform that improves HTTP based video content delivery at the WiFi edge. WiCode uses coded delivery at the WiFi AP to reduce data transmissions in order to improve the perceived performance of video streaming at the users. WiCode performs index coding on video segments to reduce the number of bits transmitted. Further, it also performs index coding on UDP packets that are retransmitted to reduce the number of bits transmitted. This paper describes the design and implementation of WiCode, and the practical gains achievable due to employing coded delivery in a real system taking into account the overheads introduced by WiCode. The WiCode module at the client side is a browser plugin that does not require any client side device configuration changes. We also show the effect of variable and fixed length segment size on the perceived performance of WiCode.

    Comment: International Conference on Signal Processing and Communications (SPCOM 2020)
    Keywords Computer Science - Networking and Internet Architecture
    Publishing date 2020-07-27
    Publishing country us
    Document type Book ; Online
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