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  1. Article ; Online: Editorial.

    Mann, Colin

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2016  Volume 51, Issue 3, Page(s) 124

    Language English
    Publishing date 2016
    Publishing country England
    Document type Editorial
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2016.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Congratulations!

    Mann, Colin

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2016  Volume 51, Issue 3, Page(s) 123

    MeSH term(s) Anniversaries and Special Events ; Bibliometrics ; Canada ; Computer-Assisted Instruction ; Education, Medical, Continuing/standards ; Humans ; Ophthalmology/education ; Ophthalmology/organization & administration ; Patient Care ; Periodicals as Topic/standards ; Societies, Medical/organization & administration
    Language English
    Publishing date 2016-06
    Publishing country England
    Document type Editorial
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2016.04.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: National Ophthalmologist Wellness Survey (NOWS) 2019.

    Gould, Lisa F / Hayda, Ihor / Mann, Colin

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2020  Volume 55, Issue 3 Suppl 1, Page(s) 29–32

    MeSH term(s) Attitude of Health Personnel ; Burnout, Professional/epidemiology ; Canada ; Health Promotion/statistics & numerical data ; Health Surveys/statistics & numerical data ; Humans ; Mental Disorders/epidemiology ; Occupational Stress/epidemiology ; Ophthalmologists/statistics & numerical data ; Societies, Medical/organization & administration ; Societies, Medical/statistics & numerical data ; Surveys and Questionnaires
    Language English
    Publishing date 2020-05-06
    Publishing country England
    Document type Letter
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2020.02.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Wellness during the pandemic.

    Gould, Lisa / Mann, Colin / Gupta, R Rishi / Bellan, Lorne

    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

    2020  Volume 55, Issue 3 Suppl 1, Page(s) 1

    MeSH term(s) Attitude to Health ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Family Health ; Health Promotion ; Humans ; Mental Health ; Pandemics ; Physicians/psychology ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-25
    Publishing country England
    Document type Editorial
    ZDB-ID 80091-0
    ISSN 1715-3360 ; 0008-4182
    ISSN (online) 1715-3360
    ISSN 0008-4182
    DOI 10.1016/j.jcjo.2020.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 588: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: The Canadian Ophthalmology Society's adaptation of the Medically Necessary Time-sensitive Surgical Procedures triage and prioritization tool.

    Teja, Salina / Mann, Colin / Hooper, Phil / Buys, Yvonne / Yin, Vivian T

    Canadian journal of surgery. Journal canadien de chirurgie

    2021  Volume 64, Issue 1, Page(s) E48–E50

    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/transmission ; Canada ; Health Priorities ; Humans ; Infection Control ; Ophthalmologic Surgical Procedures ; Patient Selection ; Societies, Medical ; Triage/organization & administration
    Language English
    Publishing date 2021-02-03
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 410651-9
    ISSN 1488-2310 ; 0008-428X
    ISSN (online) 1488-2310
    ISSN 0008-428X
    DOI 10.1503/cjs.012120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 221: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Structural basis for VLDLR recognition by eastern equine encephalitis virus.

    Yang, Pan / Li, Wanyu / Fan, Xiaoyi / Pan, Junhua / Mann, Colin J / Varnum, Haley / Clark, Lars E / Clark, Sarah A / Coscia, Adrian / Smith, Katherine Nabel / Brusic, Vesna / Abraham, Jonathan

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Alphaviruses are arthropod-borne enveloped RNA viruses that include several important human pathogens with outbreak potential. Among them, eastern equine encephalitis virus (EEEV) is the most virulent, and many survivors develop neurological sequelae, ... ...

    Abstract Alphaviruses are arthropod-borne enveloped RNA viruses that include several important human pathogens with outbreak potential. Among them, eastern equine encephalitis virus (EEEV) is the most virulent, and many survivors develop neurological sequelae, including paralysis and intellectual disability. The spike proteins of alphaviruses comprise trimers of heterodimers of their envelope glycoproteins E2 and E1 that mediate binding to cellular receptors and fusion of virus and host cell membranes during entry. We recently identified very-low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2), two closely related proteins that are expressed in the brain, as cellular receptors for EEEV and a distantly related alphavirus, Semliki forest virus (SFV)
    Language English
    Publishing date 2023-11-14
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.14.567065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The evolution and determinants of neutralization of potent head-binding antibodies against Ebola virus.

    Yu, Xiaoying / Hastie, Kathryn M / Davis, Carl W / Avalos, Ruben Diaz / Williams, Dewight / Parekh, Diptiben / Hui, Sean / Mann, Colin / Hariharan, Chitra / Takada, Ayato / Ahmed, Rafi / Saphire, Erica Ollmann

    Cell reports

    2023  Volume 42, Issue 11, Page(s) 113366

    Abstract: Monoclonal antibodies against the Ebola virus (EBOV) surface glycoprotein are effective treatments for EBOV disease. Antibodies targeting the EBOV glycoprotein (GP) head epitope have potent neutralization and Fc effector function activity and thus are of ...

    Abstract Monoclonal antibodies against the Ebola virus (EBOV) surface glycoprotein are effective treatments for EBOV disease. Antibodies targeting the EBOV glycoprotein (GP) head epitope have potent neutralization and Fc effector function activity and thus are of high interest as therapeutics and for vaccine design. Here we focus on the head-binding antibodies 1A2 and 1D5, which have been identified previously in a longitudinal study of survivors of EBOV infection. 1A2 and 1D5 have the same heavy- and light-chain germlines despite being isolated from different individuals and at different time points after recovery from infection. Cryoelectron microscopy analysis of each antibody in complex with the EBOV surface GP reveals key amino acid substitutions in 1A2 that contribute to greater affinity, improved neutralization potency, and enhanced breadth as well as two strategies for antibody evolution from a common site.
    MeSH term(s) Humans ; Ebolavirus ; Hemorrhagic Fever, Ebola ; Antibodies, Neutralizing ; Antibodies, Viral ; Cryoelectron Microscopy ; Longitudinal Studies
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.113366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases.

    Herman, Jonathan D / Atyeo, Caroline / Zur, Yonatan / Cook, Claire E / Patel, Naomi J / Vanni, Kathleen M / Kowalski, Emily N / Qian, Grace / Srivatsan, Shruthi / Shadick, Nancy A / Rao, Deepak A / Kellman, Benjamin / Mann, Colin J / Lauffenburger, Douglas / Wallace, Zachary S / Sparks, Jeffrey A / Alter, Galit

    Science translational medicine

    2023  Volume 15, Issue 712, Page(s) eadf6598

    Abstract: Beyond the acute illness caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, about one-fifth of infections result in long-term persistence of symptoms despite the apparent clearance of infection. Insights into the mechanisms that ... ...

    Abstract Beyond the acute illness caused by severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, about one-fifth of infections result in long-term persistence of symptoms despite the apparent clearance of infection. Insights into the mechanisms that underlie postacute sequelae of COVID-19 (PASC) will be critical for the prevention and clinical management of long-term complications of COVID-19. Several hypotheses have been proposed that may account for the development of PASC, including persistence of virus and dysregulation of immune responses. Among the immunological changes noted in PASC, alterations in humoral immunity have been observed in some patient subsets. To begin to determine whether SARS-CoV-2- or other pathogen-specific humoral immune responses evolve uniquely in PASC, we performed comprehensive antibody profiling against SARS-CoV-2, a panel of endemic pathogens, and a panel of routine vaccine antigens using systems serology in two cohorts of patients with preexisting systemic autoimmune rheumatic disease (SARD) who either developed or did not develop PASC. A distinct qualitative shift observed in Fcγ receptor (FcγR) binding was observed in individuals with PASC. Specifically, individuals with PASC harbored weaker FcγR-binding anti-SARS-CoV-2 antibodies and stronger FcγR-binding antibody responses against the endemic coronavirus OC43. Individuals with PASC developed an OC43 S2-specific antibody response with stronger FcγR binding, linked to cross-reactivity across SARS-CoV-2 and common coronaviruses. These findings identify previous coronavirus imprinting as a potential marker for the development of PASC in individuals with SARDs.
    MeSH term(s) Immunity, Humoral ; Rheumatic Diseases/complications ; Rheumatic Diseases/immunology ; SARS-CoV-2/immunology ; Humans ; Male ; Female ; Middle Aged ; Aged ; Post-Acute COVID-19 Syndrome/complications ; Post-Acute COVID-19 Syndrome/immunology ; Endemic Diseases ; Receptors, Fc/metabolism ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Spike Glycoprotein, Coronavirus/immunology
    Chemical Substances Receptors, Fc ; Antibodies, Viral ; spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2023-09-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.adf6598
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6941: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Hybrid Immunity Shifts the Fc-Effector Quality of SARS-CoV-2 mRNA Vaccine-Induced Immunity.

    Bowman, Kathryn A / Stein, Daniel / Shin, Sally / Ferbas, Kathie G / Tobin, Nicole H / Mann, Colin / Fischinger, Stephanie / Ollmann Saphire, Erica / Lauffenburger, Douglas / Rimoin, Anne W / Aldrovandi, Grace / Alter, Galit

    mBio

    2022  Volume 13, Issue 5, Page(s) e0164722

    Abstract: Despite the robust immunogenicity of SARS-CoV-2 mRNA vaccines, emerging data have revealed enhanced neutralizing antibody and T cell cross-reactivity among individuals that previously experienced COVID-19, pointing to a hybrid immune advantage with ... ...

    Abstract Despite the robust immunogenicity of SARS-CoV-2 mRNA vaccines, emerging data have revealed enhanced neutralizing antibody and T cell cross-reactivity among individuals that previously experienced COVID-19, pointing to a hybrid immune advantage with infection-associated immune priming. Beyond neutralizing antibodies and T cell immunity, mounting data point to a potential role for additional antibody effector functions, including opsinophagocytic activity, in the resolution of symptomatic COVID-19. Whether hybrid immunity modifies the Fc-effector profile of the mRNA vaccine-induced immune response remains incompletely understood. Thus, here we profiled the SARS-CoV-2 specific humoral immune response in a group of individuals with and without prior COVID-19. As expected, hybrid Spike-specific antibody titers were enhanced following the primary dose of the mRNA vaccine but were similar to those achieved by naive vaccinees after the second mRNA vaccine dose. Conversely, Spike-specific vaccine-induced Fc-receptor binding antibody levels were higher after the primary immunization in individuals with prior COVID-19 and remained higher following the second dose compared to those in naive individuals, suggestive of a selective improvement in the quality, rather than the quantity, of the hybrid humoral immune response. Thus, while the magnitude of antibody titers alone may suggest that any two antigen exposures-either hybrid immunity or two doses of vaccine alone-represent a comparable prime/boost immunologic education, we find that hybrid immunity offers a qualitatively improved antibody response able to better leverage Fc-effector functions against conserved regions of the virus.
    MeSH term(s) Humans ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; Viral Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing ; Vaccination ; RNA, Messenger ; Spike Glycoprotein, Coronavirus/genetics ; Immunity, Humoral ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Viral Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing ; RNA, Messenger ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2022-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.01647-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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