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Article ; Online: Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model.

Saha, Moumita / Das, Sanjib / Manna, Krishnendu / Saha, Krishna Das

2023 Volume 43, Issue 10

Abstract: Ferroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an hallmark of non-alcoholic fatty liver disease (NAFLD). Melatonin (MLT) is ... ...

Abstract	Ferroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an hallmark of non-alcoholic fatty liver disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT's action to counteract ferroptosis in NAFLD. Hence, the present study investigated the role of MLT in improvement of NAFLD-induced ferroptosis. HepG2 cells were treated with free fatty acids (FFAs) to induce in vitro NAFLD state and C57BL/6 mice were fed with high-fat diet (HFD) followed by MLT administration. The results indicated that MLT administration caused the recovery from both FFA- and HFD-induced ferroptotic state via increasing GSH and SOD level, decreasing lipid reactive oxygen species (ROS) and malondialdehyde (MDA) level, increasing Nrf2 and HO-1 level to defend cells against an oxidative environment. MLT also altered the expression of two key proteins GPX4 and SLC7A11 back to their normal levels, which would otherwise cause ferroptosis. MLT also protected against histopathological damage of both liver tissue and HepG2 cells as depicted by Oil Red O, HE staining and immunofluorescence microscopy. MLT also had control over pAMPKα as well as PPARγ and PPARα responsible for lipid homeostasis and lipogenesis. In brief, MLT exerted its multifaceted effect in FFA- and HFD-induced NAFLD by retrieving cellular oxidative environment, reducing lipogenesis and lipid peroxidation and modulating Nrf2/HO-1 and GPX4/SLC7A11 axis to combat ferroptosis.
MeSH term(s)	Mice ; Animals ; Non-alcoholic Fatty Liver Disease/etiology ; Melatonin/pharmacology ; Ferroptosis ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Mice, Inbred C57BL ; Oxidation-Reduction ; Lipid Peroxides
Chemical Substances	Melatonin (JL5DK93RCL) ; NF-E2-Related Factor 2 ; Lipid Peroxides
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20230128
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Article: Melatonin Suppresses NLRP3 Inflammasome Activation via TLR4/NF-κB and P2X7R Signaling in High-Fat Diet-Induced Murine NASH Model.

Saha, Moumita / Manna, Krishnendu / Das Saha, Krishna

Journal of inflammation research

2022 Volume 15, Page(s) 3235–3258

Abstract: Background: NLRP3 inflammasome activation plays a critical role in mediating inflammation and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and hepatocellular carcinoma. Melatonin (MLT) controls high-fat diet- ... ...

Abstract	Background: NLRP3 inflammasome activation plays a critical role in mediating inflammation and NASH (non-alcoholic steatohepatitis) progression that ultimately leads to cirrhosis and hepatocellular carcinoma. Melatonin (MLT) controls high-fat diet-induced NASH in the murine model by modulating NLRP3 mediated inflammation. P2X7R-mediated inflammasome activation is reported in several inflammatory models including NASH. Objective: The role of MLT in P2X7R-mediated inflammation in the NASH model has not yet been explored. The present study investigated the role of MLT in amending high-fat diet-induced nonalcoholic steatohepatitis in the murine liver. Methods: To evaluate the hepatological changes, mice were divided into four groups to investigate the improvement potential of this MLT (10 and 20 mg/kg) and to assess the experimental findings. Histology, biochemical assays, ELISA, FACS analysis, Western blotting, and IF were performed to assess the physical and molecular changes upon melatonin treatment. Results: The result demonstrated that MLT administration reduced HFD (high-fat diet)-induced non-alcoholic steatohepatitic indices, which successively restored the hepatic morphological architecture and other pathophysiological features too. Moreover, the application of MLT suppressed HFD-induced activation of the inflammasome and through TLR4/NF-κB signaling. Herein, we report that MLT significantly suppresses P2X7R expression and calcium influx along with inflammasome in both in vitro and in vivo. The docking study revealed a strong binding affinity of MLT with P2X7R. Moreover, the results also showed that the Nrf2 level was boosted which may normalize the expression of antioxidant proteins that safeguard against oxidative damage triggered by inflammation. Furthermore, some matrix metalloproteinases like MMP 2 and MMP 9 were repressed and TIMP-1 level was increased, which also signifies that MLT could improve liver fibrosis in this model. Conclusion: Based on our findings, this study may conclude that MLT could be used as a therapeutic agent in the high-fat diet-induced NASH model as it has persuasive anti-inflammatory potential.
Language	English
Publishing date	2022-05-31
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S343236
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Article: Assessment of arsenic sorption properties of lactic acid bacteria isolated from fecal samples for application as bioremediation tool

Bhakta, Jatindra N. / Ohnishi, Kouhei / Tsunemitsu, Yuta / Ueno, Daisei / Manna, Krishnendu

Applied water science. 2022 June, v. 12, no. 6

2022

Abstract: Arsenic intoxication through contaminated water and food is a challenging problem worldwide. The objective of the present study was to isolate the As-resistant lactic acid bacteria (LAB) and assess the As sorption stoichiometry of LAB to validate its ... ...

Abstract	Arsenic intoxication through contaminated water and food is a challenging problem worldwide. The objective of the present study was to isolate the As-resistant lactic acid bacteria (LAB) and assess the As sorption stoichiometry of LAB to validate its practical application as a bioremediation tool. The present study isolated 50 As-resistant LAB colonies from human (HS1-25) and albino mice (MM1-25) fecal samples. Out of 50 As-resistant LAB, the HS12 isolate exhibited the highest As removal efficiency (0.021 mg/h/g). The As bioremediation kinetic study determined the contact time 10 min and the pH between 5 and 7 for optimum As biosorption from the water. The Langmuir isotherm model (R² = 0.993) was well fitted with the data than the Freundlich isotherm model (R² = 0.876). The As bioaccumulation and scanning electron microscopy studies proved that binding of As onto cell membrane (0.000037 mg/g) and within the cell (0.000036 mg/g) are the mechanism of As sequestration of LAB HS12. The biosorption of As (2.28–20.37%) from fruit juice, soft drink and coffee as well as multimetals (0.025–0.179 mg/l; 16.22–98.69%) along with As (0.00024 mg/l) from water validated the practical application potential of HS12. The phylogenetic analysis of 16S rDNA amplicon (500 bp) of isolated potential HS12 LAB strains showed 97% similarity to Lactobacillus reuteri. Due to having As biosorption efficiency from water and liquid foods, it can be concluded that the human origin identified L. reuteri HS12 strain could be employed as a novel candidate of As bioremediation to safe environmental and human health.
Keywords	Lactobacillus reuteri ; albino ; arsenic ; bioaccumulation ; bioremediation ; biosorption ; cell membranes ; fruit juices ; human health ; humans ; lactic acid ; models ; pH ; phylogeny ; poisoning ; soft drinks ; sorption isotherms ; stoichiometry ; water ; water pollution
Language	English
Dates of publication	2022-06
Size	p. 116.
Publishing place	Springer International Publishing
Document type	Article
ZDB-ID	2594789-8
ISSN	2190-5495 ; 2190-5487
ISSN (online)	2190-5495
ISSN	2190-5487
DOI	10.1007/s13201-022-01634-2
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Article: Manjari Medika Grape Seed Extract Protects Methotrexate-Induced Hepatic Inflammation: Involvement of NF-κB/NLRP3 and Nrf2/HO-1 Signaling System.

Manna, Krishnendu / Khan, Zareen S / Saha, Moumita / Mishra, Snehasis / Gaikwad, Nilesh / Bhakta, Jatindra Nath / Banerjee, Kaushik / Das Saha, Krishna

Journal of inflammation research

2023 Volume 16, Page(s) 467–492

Abstract: Objective: Grape Seed Extract is a natural source of various polyphenols, which have been shown to possess potent antioxidant and free radical-scavenging activities. The earlier studies have reported that grape seed extract exhibits broad-spectrum ... ...

Abstract	Objective: Grape Seed Extract is a natural source of various polyphenols, which have been shown to possess potent antioxidant and free radical-scavenging activities. The earlier studies have reported that grape seed extract exhibits broad-spectrum pharmacological activities. Therefore, studying the hepatoprotective effects and elucidation of mechanisms of action of the Indian Variety, Manjari Medika grape seed extract (GSE), may give an insight into therapeutic benefits. Methotrexate (MTX) is the first-line pharmacological therapy for different rheumatic diseases. The major adverse events such as hepatotoxicity are evident even in the low doses used for the treatment. The present study investigated the role of MTX on hepatic damage in murine liver and the plausible protective effects of the Indian grape variety, Manjari Medika grape seed extract, in ameliorating it. Methods and results: To assess the hepatological modulation, mice were divided into eight groups to investigate the ameliorative potential of this GSE (75 and 125 mg/kg) and correlate the experimental findings. The active components of the extract were assessed through UPLC-(ESI)-QToF-MS analysis. On the other hand, various biochemical and immunological indices were carried out to correlate the experimental data. The result demonstrated that the prophylactic administration of GSE reduced MTX-induced hepatic toxicity indices, which subsequently restored the hepatic morphological architecture. Moreover, the application of GSE in a dual dosage (75 and 125 mg/kg) suppressed MTX-induced reactive oxygen species generation, followed by lipid peroxidation and cellular nitrite formation. MTX-induced inflammasome activation through the redox-assisted cascade of TLR4/NF-κB signaling was further reduced by applying the GSE. The results showed that the activation of cytoprotective transcription factor Nrf2 enhanced the level of endogenous antioxidants. Furthermore, through the regulation of TLR4/NF-κB and Nrf2/HO-1 axis, this extract could reduce the MTX-mediated hepatic damage. Conclusion: Our findings suggest that Manjari Medika seed extract could be used as a therapeutic agent to relieve the side effects of MTX and other hepatic disorders.
Language	English
Publishing date	2023-02-07
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494878-0
ISSN	1178-7031
ISSN	1178-7031
DOI	10.2147/JIR.S338888
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Article ; Online: Quercetin counteracts monosodium glutamate to mitigate immunosuppression in the thymus and spleen via redox-guided cellular signaling.

Das, Debasmita / Banerjee, Arnab / Manna, Krishnendu / Sarkar, Deotima / Shil, Aparna / Sikdar Ne E Bhakta, Mausumi / Mukherjee, Sandip / Maji, Bithin Kumar

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 126, Page(s) 155226

Abstract: Background: Chronic inflammation brought on by oxidative stress can result in several immunopathologies. Natural compounds with antioxidant characteristics, like quercetin, have shown effectiveness in reducing oxidative damage and regulating the immune ... ...

Abstract	Background: Chronic inflammation brought on by oxidative stress can result in several immunopathologies. Natural compounds with antioxidant characteristics, like quercetin, have shown effectiveness in reducing oxidative damage and regulating the immune response. Purpose: The commonly used food additive monosodium glutamate (M) causes immunosuppression by disrupting redox equilibrium and inducing oxidative stress. The goal of this work is to examine the therapeutic potential of quercetin against immunotoxicity brought on by M, revealing the molecular route implicated in such immunopathology by targeting the thymus and spleen, to support the development of future anti-inflammatory and antioxidant therapies. Study design and methods: M-fed rats were employed as an immunotoxicity model and were supplemented with quercetin for four weeks. Hematological and biochemical parameters were measured; H&E staining, immunohistochemistry, flow cytometry, real-time quantitative PCR, and western blotting were performed. Results: Based on the findings, TLR4 was activated by M to cause oxidative stress-mediated inflammation, which was alleviated by the supplementation of quercetin by modulating redox homeostasis to neutralize free radicals and suppress the inflammatory response. To prevent M-induced inflammation, quercetin demonstrated anti-inflammatory functions by blocking NF-kB activation, lowering the production of pro-inflammatory cytokines, and increasing the release of anti-inflammatory cytokines. By normalizing lipid profiles and lowering the potential risk of immunological deficiency caused by M, quercetin also improves lipid metabolism. Additionally, it has shown potential for modifying insulin levels, suggesting a possible function in controlling M-induced alteration in glucose metabolism. The addition of quercetin to M enhanced the immune response by improving immunoglobulin levels and CD4/CD8 expression in the thymus and spleen. Additionally, quercetin inhibited apoptosis by controlling mitochondrial caspase-mediated cellular signaling, suggesting that it may be able to halt cell death in M-fed rats. Conclusion: The results of this study first indicate that quercetin, via modulating redox-guided cellular signaling, has a promising role in reducing immune disturbances. This study illuminates the potential of quercetin as a safe, natural remedy for immunopathology caused by M, including thymic hypoplasia and/or splenomegaly, and paves the way for future anti-inflammatory and antioxidant supplements.
MeSH term(s)	Rats ; Animals ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Antioxidants/metabolism ; Sodium Glutamate/metabolism ; Sodium Glutamate/pharmacology ; Sodium Glutamate/therapeutic use ; Spleen ; Oxidation-Reduction ; Oxidative Stress ; Inflammation/metabolism ; Immunosuppression Therapy ; Anti-Inflammatory Agents/pharmacology ; Cytokines/metabolism
Chemical Substances	Quercetin (9IKM0I5T1E) ; Antioxidants ; Sodium Glutamate (W81N5U6R6U) ; Anti-Inflammatory Agents ; Cytokines
Language	English
Publishing date	2023-11-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.155226
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Article ; Online: Tannic acid-stabilized gold nano-particles are superior to native tannic acid in inducing ROS-dependent mitochondrial apoptosis in colorectal carcinoma cells

Nag, Sayoni / Manna, Krishnendu / Saha, Krishna Das

RSC advances

2019 Volume 9, Issue 14, Page(s) 8025–8038

Abstract: Gold nanoparticle formulated tannic acid (AuNP-TA) was synthesized, and its anticancer activity was compared to that of free tannic acid (TA). The half maximal inhibitory concentration ( ... ...

Abstract	Gold nanoparticle formulated tannic acid (AuNP-TA) was synthesized, and its anticancer activity was compared to that of free tannic acid (TA). The half maximal inhibitory concentration (IC
Language	English
Publishing date	2019-03-11
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra00808j
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Article ; Online: Chrysin-loaded PLGA attenuates OVA-induced allergic asthma by modulating TLR/NF-κB/NLRP3 axis.

Roy, Saheli / Manna, Krishnendu / Jha, Tarun / Saha, Krishna Das

Nanomedicine : nanotechnology, biology, and medicine

2020 Volume 30, Page(s) 102292

Abstract: Asthma, one of the significant public health problems, is triggered by certain inflammatory processes in the airways that are not addressed propitiously by current therapies. Though pieces of evidence on allergic asthma mitigation by the anti- ... ...

Abstract	Asthma, one of the significant public health problems, is triggered by certain inflammatory processes in the airways that are not addressed propitiously by current therapies. Though pieces of evidence on allergic asthma mitigation by the anti-inflammatory bioflavonoid chrysin (CHR) are accumulating, poor bioavailability, and low solubility curtail drug development. To overcome these shortcomings, CHR loaded nanoparticle (CHR-NP) was formulated, and its salutary effect in preclinical murine allergic asthma model via the peroral route was evaluated. The spherical nanosized particles showed slow, sustained release in vitro. Moreover, CHR-NP dramatically reduced the serum IgE, ovalbumin (OVA)-induced lung histological alteration, as well as Th2 (T-helper 2) cytokines in the bronchoalveolar lavage fluid (BALF). It also suppressed the elevated serum pro-inflammatory cytokines and their upstream TLR/NF-κB/NLRP3 pathway activation in lung superior to CHR and almost identical to dexamethasone (DEX). Thus this study suggests the potentiality of CHR-NP in ameliorating allergic asthma progression.
MeSH term(s)	A549 Cells ; Animals ; Asthma/chemically induced ; Bronchoalveolar Lavage Fluid ; Cytokines/metabolism ; Flavonoids/administration & dosage ; Humans ; Hypersensitivity/etiology ; Immunoglobulin E/blood ; Inflammation Mediators/metabolism ; Lung/immunology ; Lung/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Microscopy, Atomic Force ; Microscopy, Electron, Transmission ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Ovalbumin/administration & dosage ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage ; Toll-Like Receptors/metabolism
Chemical Substances	Cytokines ; Flavonoids ; Inflammation Mediators ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Toll-Like Receptors ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Immunoglobulin E (37341-29-0) ; chrysin (3CN01F5ZJ5) ; Ovalbumin (9006-59-1)
Language	English
Publishing date	2020-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2183417-9
ISSN	1549-9642 ; 1549-9634
ISSN (online)	1549-9642
ISSN	1549-9634
DOI	10.1016/j.nano.2020.102292
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Article ; Online: Tender coconut water attenuates heat stress-induced testicular damage through modulation of the NF-κB and Nrf2 pathways.

Kumar, Soumya Sundar / Manna, Krishnendu / Das, Asima

Food & function

2018 Volume 9, Issue 10, Page(s) 5463–5479

Abstract: Tender coconut water (TCW), a well-known plant beverage, has been used as a stress-relieving traditional medicine since ancient times. It is also used to treat various ailments of disease, including hepatic disorders, renal disorders, gastric disorders ... ...

Abstract	Tender coconut water (TCW), a well-known plant beverage, has been used as a stress-relieving traditional medicine since ancient times. It is also used to treat various ailments of disease, including hepatic disorders, renal disorders, gastric disorders and reproductive disorders. However, the reasons for its effectiveness as a natural antioxidant as well as its testicular protective effects against whole body heat stress (HS)-induced oxidative imbalance remain to be revealed. The present study aimed to elucidate the protective efficacy of TCW on HS-induced testicular damage in a murine system and to explore the possible mechanism of action. Standardized liquid chromatography-mass spectrometry (LC-MS) was used to detect the presence of active components in TCW. Male Wistar rats were exposed to acute HS with or without TCW treatment to evaluate the degree of testicular damage, which was monitored through histological as well as biochemical analysis. Assessment of endogenous antioxidant response and the modulation of signaling pathways associated with inflammation were also subjected to immunofluorescence and flow cytometric evaluation. Acute hyperthermia caused an elevation of excess generation of oxygen radicals following the suppression of antioxidant capacity and augmentation of lipid peroxidation in murine testicles, which was restored by treatment with TCW. The results also demonstrated marked phosphorylation of IKKα/β and IκBα following the activation of NF-κB-guided pro-inflammation upon HS. TCW treatment reversed the HS-induced proinflammatory state through activation of the Nrf2-assisted antioxidant response, which restored the testicular damage. TCW provided competent scientific evidence to substantiate the claims for its use in the treatment of HS-induced inflammation and inflammation-mediated testicular damage.
MeSH term(s)	Animals ; Cocos/chemistry ; Cocos/metabolism ; Heat-Shock Response ; Lipid Peroxidation ; Male ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/genetics ; NF-kappa B/metabolism ; Oxidative Stress ; Plant Preparations/metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Testis/metabolism
Chemical Substances	NF-E2-Related Factor 2 ; NF-kappa B ; Plant Preparations ; Reactive Oxygen Species
Language	English
Publishing date	2018-08-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c8fo01207e
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Article ; Online: Tender coconut water attenuates heat stress-induced testicular damage through modulation of the NF-κB and Nrf2 pathways

Kumar, Soumya Sundar / Manna, Krishnendu / Das, Asima

Food & function. 2018 Oct. 17, v. 9, no. 10 p.5463-5479

2018

Abstract	Tender coconut water (TCW), a well-known plant beverage, has been used as a stress-relieving traditional medicine since ancient times. It is also used to treat various ailments of disease, including hepatic disorders, renal disorders, gastric disorders and reproductive disorders. However, the reasons for its effectiveness as a natural antioxidant as well as its testicular protective effects against whole body heat stress (HS)-induced oxidative imbalance remain to be revealed. The present study aimed to elucidate the protective efficacy of TCW on HS-induced testicular damage in a murine system and to explore the possible mechanism of action. Standardized liquid chromatography-mass spectrometry (LC-MS) was used to detect the presence of active components in TCW. Male Wistar rats were exposed to acute HS with or without TCW treatment to evaluate the degree of testicular damage, which was monitored through histological as well as biochemical analysis. Assessment of endogenous antioxidant response and the modulation of signaling pathways associated with inflammation were also subjected to immunofluorescence and flow cytometric evaluation. Acute hyperthermia caused an elevation of excess generation of oxygen radicals following the suppression of antioxidant capacity and augmentation of lipid peroxidation in murine testicles, which was restored by treatment with TCW. The results also demonstrated marked phosphorylation of IKKα/β and IκBα following the activation of NF-κB-guided pro-inflammation upon HS. TCW treatment reversed the HS-induced proinflammatory state through activation of the Nrf2-assisted antioxidant response, which restored the testicular damage. TCW provided competent scientific evidence to substantiate the claims for its use in the treatment of HS-induced inflammation and inflammation-mediated testicular damage.
Keywords	IKappaB kinase ; animal models ; antioxidant activity ; beverages ; coconut water ; digestive system diseases ; fever ; flow cytometry ; fluorescent antibody technique ; heat ; heat stress ; histology ; inflammation ; laboratory animals ; lipid peroxidation ; liquid chromatography ; males ; mass spectrometry ; mechanism of action ; mice ; phosphorylation ; protective effect ; rats ; reactive oxygen species ; reproductive disorders ; signal transduction ; testes ; traditional medicine ; transcription factor NF-kappa B
Language	English
Dates of publication	2018-1017
Size	p. 5463-5479.
Publishing place	The Royal Society of Chemistry
Document type	Article ; Online
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/c8fo01207e
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Article ; Online: Tannic acid and vitamin E loaded PLGA nanoparticles ameliorate hepatic injury in a chronic alcoholic liver damage model via EGFR-AKT-STAT3 pathway.

Nag, Sayoni / Manna, Krishnendu / Saha, Moumita / Das Saha, Krishna

Nanomedicine (London, England)

2019 Volume 15, Issue 3, Page(s) 235–257

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Animals ; Apoptosis/drug effects ; Disease Models, Animal ; Drug Delivery Systems ; Drug Liberation/drug effects ; ErbB Receptors/genetics ; Gene Expression Regulation/drug effects ; Humans ; Liver/drug effects ; Liver/pathology ; Liver Diseases, Alcoholic/drug therapy ; Liver Diseases, Alcoholic/pathology ; Mice ; Nanoparticles/chemistry ; Oncogene Protein v-akt/genetics ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/pharmacology ; STAT3 Transcription Factor/genetics ; Tannins/chemistry ; Tannins/pharmacology ; Vitamin E/chemistry ; Vitamin E/pharmacology
Chemical Substances	STAT3 Transcription Factor ; STAT3 protein, human ; Tannins ; Vitamin E (1406-18-4) ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Oncogene Protein v-akt (EC 2.7.11.1)
Language	English
Publishing date	2019-12-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2277839-1
ISSN	1748-6963 ; 1743-5889
ISSN (online)	1748-6963
ISSN	1743-5889
DOI	10.2217/nnm-2019-0340
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