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  1. Article: Computational study to discover potent phytochemical inhibitors against drug target, squalene synthase from

    Wadanambi, Padmika Madushanka / Mannapperuma, Uthpali

    Heliyon

    2021  Volume 7, Issue 6, Page(s) e07178

    Abstract: Aims: The parasite, : Main methods: Multiple sequence alignment was carried to detect conserved regions across squalene synthases from different : Key findings: Seven phytochemicals displayed binding energies less than -9 kcal/mol hence ... ...

    Abstract Aims: The parasite,
    Main methods: Multiple sequence alignment was carried to detect conserved regions across squalene synthases from different
    Key findings: Seven phytochemicals displayed binding energies less than -9 kcal/mol hence demonstrating ability to be strongly bound to the active site of LdSQS to inhibit the enzymatic activity. Ancistrotanzanine B demonstrated the lowest binding affinity of -9.83 kcal/mol superior to reported inhibitors in literature. Conserved two aspartate rich regions and two signatory motifs were found in the
    Significance: Based on the current study, these hits can be further structurally optimized and validated under laboratory conditions to develop antileishmanial drugs.
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2021.e07178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Safety monitoring of treatment in bipolar disorder in a tertiary care setting in Sri Lanka and recommendations for improved monitoring in resource limited settings.

    Mannapperuma, Uthpali / Galappatthy, Priyadarshani / Jayakody, Raveendra Laal / Mendis, Jayan / de Silva, Varuni Asanka / Hanwella, Raveen

    BMC psychiatry

    2019  Volume 19, Issue 1, Page(s) 194

    Abstract: Background: Safety monitoring of medicines is essential during therapy for bipolar disorder (BD). We determined the extent of safety monitoring performed according to the International Society for Bipolar Disorders (ISBD) guidelines in patients with BD ... ...

    Abstract Background: Safety monitoring of medicines is essential during therapy for bipolar disorder (BD). We determined the extent of safety monitoring performed according to the International Society for Bipolar Disorders (ISBD) guidelines in patients with BD attending the main tertiary care psychiatry clinics in Sri Lanka to give realistic recommendations for safety monitoring in resource limited settings.
    Methods: Patients diagnosed with BD on mood stabilizer medications for more than 1 year were recruited. Data were collected retrospectively from clinic and patient held records and compared with the standards of care recommended by ISBD guidelines for safety monitoring of medicines.
    Results: Out of 256 patients diagnosed with BD, 164 (64.1%) were on lithium. Only 75 (45.7%) had serum lithium measurements done in the past 6 months and 96 (58.5%) had concentrations recorded at least once in the past year. Blood urea or creatinine was measured in the last 6 months only in 30 (18.3%). Serum electrolytes and thyroid-stimulating hormone (TSH) concentrations were measured in the last year only in 34 (20.7%) and 30 (18.3%) respectively. Calcium concentrations were not recorded in any patient. None of the patients on sodium valproate (n = 119) or carbamazepine (n = 6) had blood levels recorded to establish therapeutic concentrations. Atypical antipsychotics were prescribed for 151 (59%), but only 13 (8.6%) had lipid profiles and only 31 (20.5%) had blood glucose concentration measured annually. Comorbidities experienced by patients influenced monitoring more than the medicines used. Patients with diabetes, hypothyroidism and hypercholesterolemia were more likely to get monitored for fasting blood glucose and (p < 0.001), TSH (p < 0.001) and lipid profiles (p < 0.001). Lithium therapy was associated with TSH monitoring (p < 0.05). Therapy with atypical antipsychotics was not associated with fasting blood glucose or lipid profile monitoring (p > 0.05). A limitation of the study is that although some tests were performed, the results may not have been recorded.
    Conclusions: Safety monitoring in BD was suboptimal compared to the ISBD guidelines. ISBD standards are difficult to achieve in resource limited settings due to a multitude of reasons. Realistic monitoring benchmarks and recommendations are proposed for methods to improve monitoring in resource limited settings based on our experience.
    MeSH term(s) Adolescent ; Adult ; Aged ; Antipsychotic Agents/blood ; Antipsychotic Agents/economics ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/blood ; Bipolar Disorder/drug therapy ; Bipolar Disorder/economics ; Bipolar Disorder/epidemiology ; Drug Monitoring/economics ; Drug Monitoring/methods ; Female ; Follow-Up Studies ; Health Resources/economics ; Humans ; Lithium/blood ; Lithium/economics ; Lithium/therapeutic use ; Male ; Middle Aged ; Retrospective Studies ; Sri Lanka/epidemiology ; Tertiary Healthcare/economics ; Tertiary Healthcare/methods ; Treatment Outcome ; Young Adult
    Chemical Substances Antipsychotic Agents ; Lithium (9FN79X2M3F)
    Language English
    Publishing date 2019-06-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-244X
    ISSN (online) 1471-244X
    DOI 10.1186/s12888-019-2183-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Asian Pharmacometrics Network: The historical background, establishment, objectives and roles, and recent activities.

    Kaibara, Atsunori / Peng, Ao / Xie, Rujia / Ho, Yunn-Fang / Lin, Chun-Jung / Tham, Lai-San / Mallayasamy, Surulivelrajan / Sathirakul, Korbtham / Lo, Yoke-Lin / Tran, Manh Hung / Pham, Van Toi / Kharis Nugroho, Akhmad / Myo Oo, Khin / Kunwar, Bimal / Mannapperuma, Uthpali / Ya, Kimheang / Usman, Muhammad / Ming, Long Chiau / Park, Kyungsoo

    CPT: pharmacometrics & systems pharmacology

    2022  Volume 11, Issue 4, Page(s) 403–408

    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Medicine prices, availability and affordability in Sri Lanka.

    Senarathna, S M D K Ganga / Mannapperuma, Uthpali / Fernandopulle, B M Rohini

    Indian journal of pharmacology

    2011  Volume 43, Issue 1, Page(s) 60–63

    Abstract: Background: No pricing formula has been implemented from November 2002 to date in Sri Lanka. Therefore, we initiated a study in 2003 to determine the prices, availability and affordability of medicines in the private sector of Sri Lanka in the absence ... ...

    Abstract Background: No pricing formula has been implemented from November 2002 to date in Sri Lanka. Therefore, we initiated a study in 2003 to determine the prices, availability and affordability of medicines in the private sector of Sri Lanka in the absence of a price control.
    Materials and methods: The World Health Organization/Health Action International methodology was used. The study was conducted in retail pharmacies (Rajya Osu Sala) of State Pharmaceuticals Corporation (semigovernment) and privately owned retail pharmacies (n = 15) in 2003, 2006 and 2009 in a geographical area. Essential medicines (n = 28) were studied and, for each medicine, innovator, most sold generic and cheapest generic were monitored. The medicine's median price was compared with the international reference prices (IRP) to obtain the median price ratio. The daily wage of the lowest-paid government worker was used to calculate affordability.
    Results: Innovators were five to six-times the IRP at privately owned pharmacies and four to seven-times at the Rajya Osu Sala. The prices of generics were ≤1 the IRP during 6 years in privately owned and Rajya Osu Sala pharmacies. Cheapest generics were high in availability (>80%) throughout the study period. Innovators cost more than a day's wage of the lowest-paid government worker; in contrast, generics were always less than one day's wage. There seems to be no difference in affordability between privately owned or semigovernment pharmacies.
    Conclusion: In Sri Lanka, generic medicines have effective pricing and are available and affordable. No drastic changes in prices of medicine in the private sector were observed over the 6 years despite removal of price control.
    Language English
    Publishing date 2011-03-24
    Publishing country India
    Document type Journal Article
    ZDB-ID 605829-2
    ISSN 1998-3751 ; 0253-7613
    ISSN (online) 1998-3751
    ISSN 0253-7613
    DOI 10.4103/0253-7613.75672
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biowaiver Monograph for Immediate-Release Solid Oral Dosage Forms: Amoxicillin Trihydrate.

    Thambavita, Dhanusha / Galappatthy, Priyadarshani / Mannapperuma, Uthpali / Jayakody, Lal / Cristofoletti, Rodrigo / Abrahamsson, Bertil / Groot, Dirk W / Langguth, Peter / Mehta, Mehul / Parr, Alan / Polli, James E / Shah, Vinod P / Dressman, Jennifer

    Journal of pharmaceutical sciences

    2017  Volume 106, Issue 10, Page(s) 2930–2945

    Abstract: Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according ...

    Abstract Literature and experimental data relevant to waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release solid oral dosage forms containing amoxicillin trihydrate are reviewed. Solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), therapeutic uses, therapeutic index, excipient interactions, as well as dissolution and BE and bioavailability studies were taken into consideration. Solubility and permeability studies indicate that amoxicillin doses up to 875 mg belong to BCS class I, whereas 1000 mg belongs to BCS class II and doses of more than 1000 mg belong to BCS class IV. Considering all aspects, the biowaiver procedure can be recommended for solid oral products of amoxicillin trihydrate immediate-release preparations containing amoxicillin as the single active pharmaceutical ingredient at dose strengths of 875 mg or less, provided (a) only the excipients listed in this monograph are used, and only in their usual amounts, (b) the biowaiver study is performed according to the World Health Organization-, U.S. Food and Drug Administration-, or European Medicines Agency-recommended method using the innovator as the comparator, and (c) results comply with criteria for "very rapidly dissolving" or "similarly rapidly dissolving." Products containing other excipients and those containing more than 875 mg amoxicillin per unit should be subjected to an in vivo BE study.
    MeSH term(s) Administration, Oral ; Amoxicillin/chemistry ; Animals ; Biological Availability ; Biopharmaceutics/methods ; Dosage Forms ; Excipients/chemistry ; Humans ; Permeability ; Solubility ; Therapeutic Equivalency
    Chemical Substances Dosage Forms ; Excipients ; Amoxicillin (804826J2HU)
    Language English
    Publishing date 2017-05-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3151-3
    ISSN 1520-6017 ; 0022-3549
    ISSN (online) 1520-6017
    ISSN 0022-3549
    DOI 10.1016/j.xphs.2017.04.068
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