Artikel ; Online: Effect of Porins and bla
Microbial drug resistance (Larchmont, N.Y.)
2018 Band 24, Heft 7, Seite(n) 877–881
Abstract: Imipenem with relebactam is a novel β-lactam-β-lactamase inhibitor that has activity against most KPC-producing Enterobacteriaceae. Using 10 isolates of KPC-possessing Klebsiella pneumoniae, we assessed the relationship between imipenem-relebactam ... ...
Abstract | Imipenem with relebactam is a novel β-lactam-β-lactamase inhibitor that has activity against most KPC-producing Enterobacteriaceae. Using 10 isolates of KPC-possessing Klebsiella pneumoniae, we assessed the relationship between imipenem-relebactam minimum inhibitory concentrations (MICs) and mechanisms known to contribute to antimicrobial resistance. The effect of adding a second agent was assessed by time-kill experiments. Mutations affecting the genes encoding porins ompK35 and ompK36 and identification of β-lactamases were assessed by PCR. Expression of bla |
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Mesh-Begriff(e) | Anti-Bacterial Agents/pharmacology ; Azabicyclo Compounds/pharmacology ; Bacterial Proteins/genetics ; Drug Combinations ; Drug Resistance, Bacterial/drug effects ; Drug Resistance, Bacterial/genetics ; Gene Expression Regulation, Bacterial/drug effects ; Gene Expression Regulation, Bacterial/genetics ; Humans ; Imipenem/pharmacology ; Klebsiella Infections/drug therapy ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests/methods ; Porins/genetics ; beta-Lactamases |
Chemische Substanzen | Anti-Bacterial Agents ; Azabicyclo Compounds ; Bacterial Proteins ; Drug Combinations ; Porins ; MK-7655 (1OQF7TT3PF) ; Imipenem (71OTZ9ZE0A) ; beta-Lactamases (EC 3.5.2.6) |
Sprache | Englisch |
Erscheinungsdatum | 2018-05-21 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 1290490-9 |
ISSN | 1931-8448 ; 1076-6294 |
ISSN (online) | 1931-8448 |
ISSN | 1076-6294 |
DOI | 10.1089/mdr.2018.0065 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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