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Article ; Online: Ocular Exercises as a Non Conventional Approach towards Tension-type Headache

Pranali Mahendra Pachkhede / Rajat Manoj Singh

Journal of Clinical and Diagnostic Research, Vol 17, Iss 7, Pp 06-

A Narrative Review

2023 Volume 10

Abstract: Tension-type Headaches (TTH) are the most prevalent type of headache, with upto 78% of people experiencing them at some point in their lives. In comparison to migraine, TTH is more incapacitating and results in more lost workdays. TTH’s multifactorial ... ...

Abstract	Tension-type Headaches (TTH) are the most prevalent type of headache, with upto 78% of people experiencing them at some point in their lives. In comparison to migraine, TTH is more incapacitating and results in more lost workdays. TTH’s multifactorial aetiology is thought to involve both, hereditary and environmental elements. There are three types of TTH-episodic, chronic, and frequent episodic. Patients describe their headache as tightness around the head, pressing, and dull. Studies on the impact of eye movement have been conducted. Only top-notch experimental trials were applied in the study. Physiotherapy is one of the most effective but at the same time, not much preferred by people due to lack of awareness. By the present review, it would be helpful, as people will start to use physiotherapy approaches. A moderate risk of bias was detected in the quality critical appraisal. With the information at hand, only a narrative description could be included. The present research only identified a few low quality studies, but its results imply that, ocular exercises can effectively alleviate primary headache and symptoms. More rigorous methodological standards and high quality Randomised Control Study (RCTs) are needed to validate and further understanding of the effects of organised workouts aiming to reduce pain intensity and frequency, symptoms, and medication use, among other things, in the treatment of primary headaches.
Keywords	eyeball movement ; outcome measure ; physiotherapy rehabilitation ; Medicine ; R
Subject code	150
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Design, Optimization and Performance Assessment of Single Port Film Bulk Acoustic Resonator through Finite Element Simulation.

Patel, Raju / Adhikari, Manoj Singh / Tripathi, Shailendra Kumar / Sahu, Sourabh

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 21

Abstract: In this paper, the study is supported by design, FEA simulation, and practical RF measurements on fabricated single-port-cavity-based acoustic resonator for gas sensing applications. In the FEA simulation, frequency domain analysis was performed to ... ...

Abstract	In this paper, the study is supported by design, FEA simulation, and practical RF measurements on fabricated single-port-cavity-based acoustic resonator for gas sensing applications. In the FEA simulation, frequency domain analysis was performed to enhance the performance of the acoustic resonator. The structural and surface morphologies of the deposited ZnO as a piezoelectric layer have been studied using XRD and AFM. The XRD pattern of deposited bulk ZnO film indicates the perfect single crystalline nature of the film with dominant phase (002) at 2θ = 34.58°. The AFM micrograph indicates that deposited piezoelectric film has a very smooth surface and small grain size. In the fabrication process, use of bulk micro machined oxide (SiO
Language	English
Publishing date	2023-11-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23218920
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Integrated proteomics, genomics, metabolomics approaches reveal oxalic acid as pathogenicity factor in Tilletia indica inciting Karnal bunt disease of wheat

Vishakha Pandey / Manoj Singh / Dinesh Pandey / Anil Kumar

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 14

Abstract: Abstract Tilletia indica incites Karnal bunt (KB) disease in wheat. To date, no KB resistant wheat cultivar could be developed due to non-availability of potential biomarkers related to pathogenicity/virulence for screening of resistant wheat genotypes. ... ...

Abstract	Abstract Tilletia indica incites Karnal bunt (KB) disease in wheat. To date, no KB resistant wheat cultivar could be developed due to non-availability of potential biomarkers related to pathogenicity/virulence for screening of resistant wheat genotypes. The present study was carried out to compare the proteomes of T. indica highly (TiK) and low (TiP) virulent isolates. Twenty one protein spots consistently observed as up-regulated/differential in the TiK proteome were selected for identification by MALDI-TOF/TOF. Identified sequences showed homology with fungal proteins playing essential role in plant infection and pathogen survival, including stress response, adhesion, fungal penetration, invasion, colonization, degradation of host cell wall, signal transduction pathway. These results were integrated with T. indica genome sequence for identification of homologs of candidate pathogenicity/virulence related proteins. Protein identified in TiK isolate as malate dehydrogenase that converts malate to oxaloacetate which is precursor of oxalic acid. Oxalic acid is key pathogenicity factor in phytopathogenic fungi. These results were validated by GC-MS based metabolic profiling of T. indica isolates indicating that oxalic acid was exclusively identified in TiK isolate. Thus, integrated omics approaches leads to identification of pathogenicity/virulence factor(s) that would provide insights into pathogenic mechanisms of fungi and aid in devising effective disease management strategies.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: SAP

Jain, Vineeta / Wetzker, Ulf / Laxmi, Vijay / Gaur, Manoj Singh / Mosbah, Mohamed / Mery, Dominique

A Secure Low-Latency Protocol for Mitigating High Computation Overhead in WI-FI Networks

2023

Abstract: 84620 ... 84635 ... The increase in popularity of wireless networks in industrial, embedded, medical and public sectors has made them an appealing attack surface for attackers who exploit the vulnerabilities in network protocols to launch attacks such as ... ...

Abstract	84620 84635 The increase in popularity of wireless networks in industrial, embedded, medical and public sectors has made them an appealing attack surface for attackers who exploit the vulnerabilities in network protocols to launch attacks such as Evil Twin, Man-in-the-middle, sniffing, etc., which may result in economic and non-economic losses. To protect wireless networks against such attacks, IEEE 802.11 keep updating the protocol standards with new and more secure versions. There has always been a direct correlation between attacks and the improvement of protocol standards. As the sophistication of attacks increases, protocol standards tend to move towards higher security, resulting in a significant rise in both latency and computational overhead, and severe degradation in the performance of low-latency applications such as Industrial Internet of Things (IIoT), automotive, robotics, etc. In this paper, we make an attempt to highlight the importance of both latency and security in wireless networks from implementation and performance perspective. We make a review of existing IEEE 802.11 protocols in terms of security offered and overhead incurred to substantiate the fact that there is a need of a protocol which in addition to providing optimum security against attacks also maintains the latency and overhead. We also propose a secure and low-latency protocol known as Secure Authentication Protocol (SAP) which operates in two phases - registration and authentication, where the first phase is a one time process implemented using asymmetric cryptography and the second phase is implemented using symmetric cryptography. The protocol is structured in a way that it maintains the original structure of IEEE 802.11 protocols and performs both phases using fewer messages than existing protocols. By simulating the protocol using well-established OMNeT++ simulator, we proved that the proposed protocol incurs a low computation overhead, making it ideal for low-latency applications. We extensively verified the security ...
Keywords	Wireless network ; security ; low-latency ; omputation overhead ; authentication ; reauthentication ; DDC::000 Informatik ; Informationswissenschaft ; allgemeine Werke
Subject code	303
Language	English
Publishing date	2023-08-15
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Complementary Proteomics, Genomics approaches identifies potential pathogenicity/virulence factors in Tilletia indica induced under the influence of host factor

Vishakha Pandey / Atul Kumar Gupta / Manoj Singh / Dinesh Pandey / Anil Kumar

Scientific Reports, Vol 9, Iss 1, Pp 1-

2019 Volume 15

Abstract: Abstract Karnal bunt disease of wheat is incited by quarantine fungal pathogen T. indica. Till date, there is little information on the pathogenic mechanisms involved in Karnal bunt. In order to understand the molecular mechanisms of disease pathogenesis, ...

Abstract	Abstract Karnal bunt disease of wheat is incited by quarantine fungal pathogen T. indica. Till date, there is little information on the pathogenic mechanisms involved in Karnal bunt. In order to understand the molecular mechanisms of disease pathogenesis, highly aggressive T. indica TiK isolate was cultured in the presence of host factor extracted from developing spikes of wheat variety WH-542. Modulation in protein profile of mycelial proteins and secretome from TiK cultured in the absence and presence of host factor was analyzed by 2-DE. Fifteen and twenty nine protein spots were up-regulated/differentially regulated in the proteome of mycelial and secreted proteins, respectively and identified using MALDI-TOF/TOF. Identified proteins are involved in suppression of host defense responses, lignin degradation of plant cell wall, penetration, adhesion of pathogen to host tissues, pathogen mediated reactive oxygen species generation, hydrolytic enzymes, detoxification of host generated reactive oxygen species. Further, integration of proteomic and genomic analysis has led to candidate pathogenicity/virulence factors identification. They were functionally annotated by sequence as well as structure based analysis. In this study, complementation of proteomics and genomics approaches resulted in novel pathogenicity/virulence factor(s) identification in T. indica.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Silver Nanoparticles and Its Mechanistic Insight for Chronic Wound Healing

Manoj Singh / Vanita Thakur / Vikas Kumar / Mayank Raj / Shivani Gupta / Nisha Devi / Sushil Kumar Upadhyay / Markéta Macho / Avik Banerjee / Daniela Ewe / Kumar Saurav

Molecules, Vol 27, Iss 5587, p

Review on Recent Progress

2022 Volume 5587

Abstract: Wounds are structural and functional disruptions of skin that occur because of trauma, surgery, acute illness, or chronic disease conditions. Chronic wounds are caused by a breakdown in the finely coordinated cascade of events that occurs during healing. ...

Abstract	Wounds are structural and functional disruptions of skin that occur because of trauma, surgery, acute illness, or chronic disease conditions. Chronic wounds are caused by a breakdown in the finely coordinated cascade of events that occurs during healing. Wound healing is a long process that split into at least three continuous and overlapping processes: an inflammatory response, a proliferative phase, and finally the tissue remodeling. Therefore, these processes are extensively studied to develop novel therapeutics in order to achieve maximum recovery with minimum scarring. Several growth hormones and cytokines secreted at the site of lesions tightly regulates the healing processes. The traditional approach for wound management has been represented by topical treatments. Metal nanoparticles (e.g., silver, gold and zinc) are increasingly being employed in dermatology due to their favorable effects on healing, as well as in treating and preventing secondary bacterial infections. In the current review, a brief introduction on traditional would healing approach is provided, followed by focus on the potential of wound dressing therapeutic techniques functionalized with Ag-NPs.
Keywords	wound ; wound healing ; silver nanoparticles ; dermatology ; inflammatory response ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multivariate verification for sybil attack detection in VANET

Grover Jyoti / Gaur Manoj Singh / Laxmi Vijay

Open Computer Science, Vol 5, Iss 1, Pp 60-

2015 Volume 78

Abstract: Wireless vehicular communication is used to enhance traffic safety and to minimize congestion, thereby leading to increased driving efficiency. A malicious node can transmit an inaccurate message to trigger inevitable situations by pretending to be ... ...

Abstract	Wireless vehicular communication is used to enhance traffic safety and to minimize congestion, thereby leading to increased driving efficiency. A malicious node can transmit an inaccurate message to trigger inevitable situations by pretending to be multiple (other) vehicles. Therefore, it is critical to identify malicious nodes as well as fake messages generated by such nodes, and discard such messages quickly. In a Sybil attack, an attacker participates in the network with multiple forged identities in order to disrupt the fundamental operations of VANET. Sybil attacks are particularly easy to launch in VANETs due to the open and broadcast nature of communication medium. In this paper, we present the implementation of simulated Sybil attack scenario in VANET and its consequences on the performance of the network. We also propose a lightweight, scalable and distributed detection approach based on the difference in movement patterns of Sybil nodes and legitimate nodes. In our approach, each Road Side Unit (RSU) computes, stores and verifies various parameter values including RSS, distance, angle of passing-by vehicles through passive overhearing process to detect Sybil attackers. The combination of different parameters makes our detection approach highly accurate. We validate our results on realistic traces obtained from a multi-agent microscopic traffic simulator (MMTS). Simulation results show the effectiveness of the proposed approach to locate Sybil nodes with a different number of network parameters.
Keywords	vanet ; security ; sybil attack ; identity forging ; simulation ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	000
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	De Gruyter
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of granulocyte transfusions in combating life-threatening infections in patients with severe neutropenia

Akanksha Garg / Anshul Gupta / Ashish Mishra / Manoj Singh / Sanjeev Yadav / Soniya Nityanand

PLoS ONE, Vol 13, Iss 12, p e

Experience from a tertiary care centre in North India.

2018 Volume 0209832

Abstract: Bacterial and fungal infections still remain an important cause of mortality in patients with hematological malignancies and in recipients of hematopoietic stem cell transplants (HSCT) especially in developing countries like India. Granulocyte ... ...

Abstract	Bacterial and fungal infections still remain an important cause of mortality in patients with hematological malignancies and in recipients of hematopoietic stem cell transplants (HSCT) especially in developing countries like India. Granulocyte transfusions (GTX) from healthy donors may lead to early clearance of index infection and thus prevent mortality. The aim of the present study was to evaluate the efficacy of GTX in combating life-threatening infections and preventing mortality in patients of hematological disorders/recipients of HSCT with severe neutropenia. This study was a prospective, observational analysis of patients with different hematological disorders/recipients of HSCT, who received GTX from January 2014 to December 2017. All patients had an Absolute neutrophil Count (ANC) < 0.5 x 109/L and a life threatening sepsis defined by presence of hemodynamic instability/ impending septic shock/ continuous high fever despite the use of the highest line of antimicrobials. A total of 143 granulocyte collections were done for 66 infectious episodes (IEs) in 60 patients. Multidrug resistant organisms (MDROs) were observed in 47/66 IEs (71.2%) and fungal infections were seen in 9/66 IEs (13.6%). Resolution of index infection after GTX was seen in 45/66 IEs (68.2%), and the 30 day overall survival (OS) was 67.7%. OS was significantly higher in patients who received GTX within 7 days of neutropenic sepsis (p = 0.01). Patients with MDROs who received early GTX therapy had a better OS as compared to those who received late GTX (p = 0.02). GTX were well tolerated and only 6 patients' developed mild features of transfusion related acute lung injury (TRALI) which was managed conservatively, and 1 patient demonstrated hypocalcemic tetany. GTX may be of particular relevance in countries like India, where the incidence of infections is very high in neutropenic patients and there is an increasing emergence of MDROs.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Proposed Optimization Method in Network Based DAC Software - a Literature Review

Ramesh Joshi / Manoj Singh / Kiran Trivedi

International Journal of Computer Science and Network Solutions, Vol 2, Iss

2014 Volume 2

Keywords	Electronic computers. Computer science ; QA75.5-76.95 ; Instruments and machines ; QA71-90 ; Mathematics ; QA1-939 ; Science ; Q
Language	English
Publishing date	2014-02-01T00:00:00Z
Publisher	International Journal of Computer Science and Network Solutions
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Follicular Dowling Degos disease

Saurabh Singh / Sujay Khandpur / Parul Verma / Manoj Singh

Indian Journal of Dermatology, Venereology and Leprology, Vol 79, Iss 6, Pp 802-

A rare variant of an evolving dermatosis

2013 Volume 804

Abstract: Dowling Degos disease is a rare, reticulate pigmentary disorder with variable phenotypic expression that manifests as hyperpigmented macules and reticulate pigmentary anomaly of the flexures. Many variants of this condition and its overlap with other ... ...

Abstract	Dowling Degos disease is a rare, reticulate pigmentary disorder with variable phenotypic expression that manifests as hyperpigmented macules and reticulate pigmentary anomaly of the flexures. Many variants of this condition and its overlap with other reticulate pigmentary disorders have been reported in the literature. We present here two cases of DDD with follicular localization, both clinically and histologically. It was associated with ichthyosis vulgaris in one case. Follicular DDD is an uncommon variant of this evolving dermatosis. Our report supports the possible role for disordered follicular keratinisation in its pathogenesis.
Keywords	Dowling Degos disease ; follicular Dowling Degos disease ; reticulate pigmentary disorders ; Dowling Degos disease and ichthyosis ; Dermatology ; RL1-803 ; Medicine ; R
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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