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Article ; Online: Use of a relative motion flexion orthosis with dorsal hood to protect a middle phalanx finger fracture and zone III extensor tendon repair, while correcting a secondary fixed flexion proximal interphalangeal joint flexion contracture: A case report.

Johnson, Clyde / Manolopoulos, Kate

Journal of hand therapy : official journal of the American Society of Hand Therapists

2023 Volume 36, Issue 2, Page(s) 448–455

Abstract: Background: Proximal interphalangeal joint (PIPJ) contractures, zone III extensor tendon injuries and phalanx fractures are challenging to treat in isolation. In this case the patient presented with all 3 of these issues in a single digit, presenting a ... ...

Abstract	Background: Proximal interphalangeal joint (PIPJ) contractures, zone III extensor tendon injuries and phalanx fractures are challenging to treat in isolation. In this case the patient presented with all 3 of these issues in a single digit, presenting a unique problem for the hand therapist. Purpose: A case report to examine the effectiveness of using single orthosis to treat an index finger following a combined zone III extension tendon repair, surgically stabilized second phalanx fracture and PIPJ flexion contracture. Methods: A patient presented to therapy with a 40° PIPJ flexion contracture and minus 70° of active PIPJ extension (ICD10 M25.64) after left index surgical fixation of a middle phalanx fracture (ICD10 S62.621B) and zone III extensor tendon repair (ICD10 S66.321A). To correct the contracture, a distal elastic strap was added to a relative motion flexion orthosis with dorsal hood. This applied a gentle extension force to the PIPJ. Once the contracture resolved a short arc motion program (SAM) was initiated using the same orthosis. Results: At 20 weeks post initial therapy evaluation, active range of motion (extension/flexion) of the PIPJ was 5°/100° and distal interphalangeal joint (DIPJ) 0°/60°. The Quick DASH score improved 50 points from an initial 59 points to 9 points. The patient reported good satisfaction and full function of the hand. Conclusion: Our case report demonstrated the effective use of a single relative motion flexion orthosis with a dorsal hood when treating a complex hand injury involving an open zone III injury, second phalanx fracture and 40-degree PIPJ contracture.
MeSH term(s)	Humans ; Fractures, Bone ; Finger Injuries/surgery ; Contracture/etiology ; Contracture/surgery ; Tendons ; Orthotic Devices ; Finger Joint/surgery ; Range of Motion, Articular
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	639284-2
ISSN	1545-004X ; 0894-1130
ISSN (online)	1545-004X
ISSN	0894-1130
DOI	10.1016/j.jht.2022.12.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Sklerosierende Cholangitis und Gallengangsstenosen in der ERCP nach Lebertransplantation

Manolopoulos, Konstantinos

Untersuchung zu möglichen Ursachen

1999

Author's details	vorgelegt von Konstantinos Manolopoulos
Language	German
Size	IV, 125 Bl., Ill., graph. Darst., 30 cm
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Hannover, Med. Hochsch., Diss., 2000
HBZ-ID	HT012971088
Database	Catalogue ZB MED Medicine, Health

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2001 E 1105	order for loan	Magazin

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Article ; Online: Treatment of a zone III extensor tendon injury using a single relative motion with dorsal hood orthosis and a modified short arc motion protocol-A case report.

Johnson, Clyde / Swanson, Megan / Manolopoulos, Kate

Journal of hand therapy : official journal of the American Society of Hand Therapists

2019 Volume 34, Issue 1, Page(s) 135–141

Abstract: Study design: Case report.: Introduction: Zone III extensor tendon injuries are typically treated with early mobilization or by a period of immobilization followed by gradual motion. In both scenarios, the use of multiple orthoses is required.: ... ...

Abstract	Study design: Case report. Introduction: Zone III extensor tendon injuries are typically treated with early mobilization or by a period of immobilization followed by gradual motion. In both scenarios, the use of multiple orthoses is required. Purpose of the study: This case report examines the effective use of a single, modified relative motion orthosis throughout the protected rehabilitation phase after a zone III extensor tendon repair. Methods: A patient with extensor tendon zone III laceration to his index finger (10th revision of the International Statistical Classification of Diseases and Related Health Problems s66.328) was treated using a single, relative motion with dorsal hood orthosis. The exercise protocol followed a modified immediate short arc motion program. Results: Following laceration and complete rupture of the central slip, the patient regained full range of motion, strength, and function. Discussion: It is becoming more common to use a relative motion flexion (RMF) orthosis to correct or improve extensor lag due to boutonniere deformity or stiffness after finger fractures. There is very little literature to support the use of the RMF orthosis after zone III extensor tendon repair. To produce a single orthosis that is useful through the entire protected phase of rehabilitation, the RMF orthosis is easily modified by addding a dorsal hood to create the relative motion dorsal hood orthosis (RMDH). Conclusion: Our case report shows the successful treatment of a zone III extensor tendon repair using a single relative motion with dorsal hood orthosis and early active motion throughout the entire protected phase of rehabilitation.
MeSH term(s)	Finger Injuries/therapy ; Humans ; Orthotic Devices ; Range of Motion, Articular ; Tendon Injuries/therapy ; Tendons
Language	English
Publishing date	2019-05-10
Publishing country	United States
Document type	Case Reports
ZDB-ID	639284-2
ISSN	1545-004X ; 0894-1130
ISSN (online)	1545-004X
ISSN	0894-1130
DOI	10.1016/j.jht.2019.03.014
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Book ; Thesis: La Grèce agricole et son intégration dans la C.E.E

Manolopoulos, Konstantinos

1980

Institution	Institut Catholique des Hautes Etudes Commerciales
Author's details	Konstantinos Manolopoulos
Language	French
Size	II, 140, III Seiten
Publisher	Institut Catholique des Hautes Etudes Commerciales
Publishing place	Bruxelles
Publishing country	Belgium
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Diplomarbeit, 1980
HBZ-ID	HT030699263
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

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Article ; Online: Muscular Adaptations to Concurrent Resistance Training and High-Intensity Interval Training in Adults with Type 2 Diabetes: A Pilot Study.

Orlando, Giorgio / Pugh, Jamie / Faulkner, Steve / Balducci, Stefano / Sacchetti, Massimo / Pugliese, Giuseppe / Bazzucchi, Ilenia / Haxhi, Jonida / Martinez-Valdes, Eduardo / Falla, Deborah / Manolopoulos, Konstantinos / Nimmo, Myra A

International journal of environmental research and public health

2023 Volume 20, Issue 18

Abstract: This pilot study aimed to compare the effects of eight weeks of concurrent resistance training (RT) and high-intensity interval training (HIIT) vs. RT alone on muscle performance, mass and quality in adults with type 2 diabetes (T2DM). Twelve T2DM adults ...

Abstract	This pilot study aimed to compare the effects of eight weeks of concurrent resistance training (RT) and high-intensity interval training (HIIT) vs. RT alone on muscle performance, mass and quality in adults with type 2 diabetes (T2DM). Twelve T2DM adults were randomly allocated to the RT + HIIT (n = 5) or RT (n = 7) group. Before and after training, maximal oxygen uptake (VO
Language	English
Publishing date	2023-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20186746
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Article ; Online: Adipose tissue function and insulin sensitivity in syndromic obesity of Bardet-Biedl syndrome.

Baig, Shanat / Wanninayake, Subadra / Foggensteiner, Lukas / Elhassan, Yasir S / Manolopoulos, Konstantinos / Ali, Sadaf / Lassen, Pierre Bel / Clément, Karine / Steeds, Richard P / Tomlinson, Jeremy W / Geberhiwot, Tarekegn

International journal of obesity (2005)

2023 Volume 47, Issue 5, Page(s) 382–390

Abstract: Background: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive syndromic obesity of childhood onset among many other features. To date, the excess risk of metabolic complications of severe early-onset obesity in BBS remains controversial. In- ... ...

Abstract	Background: Bardet-Biedl syndrome (BBS) is a rare autosomal recessive syndromic obesity of childhood onset among many other features. To date, the excess risk of metabolic complications of severe early-onset obesity in BBS remains controversial. In-depth investigation of adipose tissue structure and function with detailed metabolic phenotype has not been investigated yet. Objective: To investigate adipose tissue function in BBS. Design: A prospective cross-sectional study. Main outcome measure: To determine if there are differences in insulin resistance, metabolic profile, adipose tissue function and gene expression in patients with BBS compared to BMI-matched polygenic obese controls. Method: 9 adults with BBS and 10 controls were recruited from the national centre for BBS, Birmingham, UK. An in-depth study of adipose tissue structure and function along with insulin sensitivity was performed using hyperinsulinemic-euglycemic clamp studies, adipose tissue microdialysis, histology and RNA sequencing, and measurement of circulating adipokines and inflammatory biomarkers. Results: Adipose tissue structure, gene expression and in vivo functional analysis between BBS and polygenic obesity cohorts were similar. Using hyperinsulinemic-euglycemic clamp and surrogate markers of insulin resistance, we found no significant differences in insulin sensitivity between BBS and obese controls. Furthermore, no significant changes were noted in an array of adipokines, cytokines, pro-inflammatory markers and adipose tissue RNA transcriptomic. Conclusion: Although childhood-onset extreme obesity is a feature of BBS, detailed studies of insulin sensitivity and adipose tissue structure and function are similar to common polygenic obesity. This study adds to the literature by suggesting that it is the quality and quantity of adiposity not the duration that drives the metabolic phenotype.
MeSH term(s)	Humans ; Bardet-Biedl Syndrome/genetics ; Bardet-Biedl Syndrome/metabolism ; Insulin Resistance ; Cross-Sectional Studies ; Prospective Studies ; Pediatric Obesity/complications ; Pediatric Obesity/epidemiology ; Adipose Tissue/metabolism ; Adipokines
Chemical Substances	Adipokines
Language	English
Publishing date	2023-02-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-023-01280-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Arterio-venous differences in peripheral blood mononuclear cells across human adipose tissue and the effect of adrenaline infusion.

Thompson, D / Manolopoulos, K / Bouloumié, A

International journal of obesity (2005)

2012 Volume 36, Issue 9, Page(s) 1256–1258

Abstract: Recent evidence indicates that adipose tissue macrophages and lymphocytes have a major role in the pathophysiology of obesity. The arterio-venous (A-V) difference technique has been used very effectively to understand adipose tissue metabolism in humans ... ...

Abstract	Recent evidence indicates that adipose tissue macrophages and lymphocytes have a major role in the pathophysiology of obesity. The arterio-venous (A-V) difference technique has been used very effectively to understand adipose tissue metabolism in humans in vivo, and we set out to investigate whether it is possible to apply and use this technique to determine A-V differences for peripheral blood mononuclear cells (PBMCs) across human adipose tissue. We used flow-cytometric analysis of arterial blood and venous blood draining upper- (abdominal) and lower-body (femoral) adipose tissue depots in middle-aged volunteers (age 45±8 years, BMI 25.9±4.1 kg m(-2)). We determined A-V differences for various PBMCs. In basal conditions, there was evidence of modest retention of some PBMCs in adipose tissue, whereas the infusion of low-dose (physiological) adrenaline led to a marked release of many PBMCs (with little evidence of depot-specific differences). In addition to the demonstration that this approach is technically feasible, these results also indicate that physiological stimuli that change adrenaline concentrations and/or adipose tissue blood flow (such as physical activity) provoke the release of PBMCs from femoral and abdominal adipose depots.
MeSH term(s)	Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Adrenergic Agonists/administration & dosage ; Adrenergic Agonists/pharmacology ; Arteries/drug effects ; Arteries/metabolism ; Epinephrine/administration & dosage ; Epinephrine/pharmacology ; Female ; Flow Cytometry ; Humans ; Infusions, Intravenous ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/metabolism ; Male ; Middle Aged ; Obesity/drug therapy ; Obesity/metabolism ; Regional Blood Flow ; Veins/drug effects ; Veins/metabolism
Chemical Substances	Adrenergic Agonists ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2012-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/ijo.2011.219
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Article: Endometriose und Infertilität.

Manolopoulos, K / Tinneberg, H-R

Zentralblatt fur Gynakologie

2005 Volume 127, Issue 5, Page(s) 325–328

Abstract: Endometriosis seems to be a common fertility barrier which is affected by immunological and local mechanical factors. The established use of assisted reproductive technologies (ART) provides increasing knowledge about folliculogenesis, fertilization, ... ...

Title translation	Endometriosis and infertility.
Abstract	Endometriosis seems to be a common fertility barrier which is affected by immunological and local mechanical factors. The established use of assisted reproductive technologies (ART) provides increasing knowledge about folliculogenesis, fertilization, embryo development and pregnancy rates. Nevertheless, controversial discussion about the success of ART in endometriosis exists although the progress of reproductive technologies is improving constantly in many ways. Despite all discussions the question remains still to be unanswered, whether or not endometriosis is indeed limiting the success in reproductive medicine.
MeSH term(s)	Endometriosis/complications ; Female ; Fertilization ; Humans ; Infertility, Female/etiology ; Pregnancy ; Reproductive Techniques, Assisted
Language	German
Publishing date	2005-10
Publishing country	Germany
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	200948-1
ISSN	0044-4197
ISSN	0044-4197
DOI	10.1055/s-2005-836866
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Article ; Online: Gestational diabetes mellitus: why screen and how to diagnose.

Karagiannis, T / Bekiari, E / Manolopoulos, K / Paletas, K / Tsapas, A

Hippokratia

2011 Volume 15, Issue 2, Page(s) 187–188

Language	English
Publishing date	2011-10-24
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2491943-3
ISSN	1790-8019 ; 1108-4189
ISSN (online)	1790-8019
ISSN	1108-4189
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Article ; Online: Gestational diabetes mellitus: why screen and how to diagnose.

Karagiannis, T / Bekiari, E / Manolopoulos, K / Paletas, K / Tsapas, A

Hippokratia

2010 Volume 14, Issue 3, Page(s) 151–154

Abstract: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Women with GDM and their offspring have an increased risk of developing type 2 diabetes mellitus in the future. The ... ...

Abstract	Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Women with GDM and their offspring have an increased risk of developing type 2 diabetes mellitus in the future. The global incidence of GDM is difficult to estimate, due to lack of uniform diagnostic criteria. Various diagnostic criteria have been proposed. The benefit of treating GDM has also been controversial. The clinical significance of treating maternal hyperglycemia was made evident in the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study. The HAPO study demonstrated that there is a continuous association of maternal glucose levels with adverse pregnancy outcomes and served as the basis for a new set of diagnostic criteria, proposed in 2010 by the International Association of Diabetes and Pregnancy Groups (IADPSG). According to these criteria the diagnosis of GDM is made if there is at least one abnormal value (≥92, 180 and 153 mg/dl for fasting, one-hour and two-hour plasma glucose concentration respectively), after a 75 g oral glucose tolerance test (OGTT).
Language	English
Publishing date	2010-10-26
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2491943-3
ISSN	1790-8019 ; 1108-4189
ISSN (online)	1790-8019
ISSN	1108-4189
Database	MEDical Literature Analysis and Retrieval System OnLINE

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