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  1. Book ; Online: Synthesis, Application and Biological Evaluation of Chemical Organic Compounds

    Ivanov, Iliyan / Manolov, Stanimir

    2023  

    Keywords Research & information: general ; Chemistry ; Organic chemistry ; 1H-indole ; VEGFR-2 inhibitors ; molecular docking ; MD simulations ; MM-GBSA ; PLIP ; DFT ; ADMET ; in vitro antiproliferative ; N-acyl-L-valine ; 4H-1,3-oxazol-5-one ; 2-acylamino ketone ; 1,3-oxazole ; diphenyl sulfone scaffold ; drug design ; in silico studies ; antimicrobial and antibiofilm actions ; antioxidant effect ; alternative toxicity testing ; nanocomposites ; antibacterial ; electrical conductivity ; BaSO4 ; polymerization ; furan ; 1,2,3,4-tetrahidroquinoline ; 1,2,3,4-tetrahidroisoquinoline ; piperidine ; pyrrolidine ; in silico ; in vitro biological activity ; antiaging ; sheep placenta ; antioxidant ; SAMP8 ; histology ; procainamide ; chloranilic acid ; DDQ ; charge transfer complex ; chitosan ; iron(III) ; deferoxamine ; nanoparticles ; antibacterial activity ; toxicity ; Glehnia littoralis ; osteoblast differentiation ; collagen synthesis ; alkaline phosphatase activity ; osteoblast ; osterix expression ; RUNX2 expression ; ketoprofen ; 1,2,3,4-tetrahydroquinoline ; 1,2,3,4-tetrahydroisoquinoline ; hybrid molecules ; molecular dynamics ; ambrox ; deuteration ; perfumes ; n/a
    Language English
    Size 1 electronic resource (180 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030645271
    ISBN 9783036590660 ; 3036590668
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Characterization of Polyphenols from

    Bojilov, Dimitar / Manolov, Stanimir / Nacheva, Angelika / Dagnon, Soleya / Ivanov, Iliyan

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 12

    Abstract: In the present work, we have investigated the polyphenolic composition ... ...

    Abstract In the present work, we have investigated the polyphenolic composition of
    MeSH term(s) Polyphenols/pharmacology ; Solvents ; Antioxidants/pharmacology ; Quercetin ; Kaempferols/pharmacology ; Chloroform ; Plant Extracts/pharmacology ; Flavonoids/pharmacology ; Glycosides/pharmacology ; Nitric Oxide ; Chenopodium ; Butanols
    Chemical Substances Polyphenols ; ethyl acetate (76845O8NMZ) ; Solvents ; Antioxidants ; Quercetin (9IKM0I5T1E) ; Kaempferols ; Chloroform (7V31YC746X) ; Plant Extracts ; Flavonoids ; Glycosides ; Nitric Oxide (31C4KY9ESH) ; Butanols
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28124816
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microwave-assisted synthesis of 1,2,3,4-tetrahydroisoquinoline sulfonamide derivatives and their biological evaluation

    Manolov Stanimir P. / Ivanov Iliyan I. / Bojilov Dimitar G.

    Journal of the Serbian Chemical Society, Vol 86, Iss 2, Pp 139-

    2021  Volume 151

    Abstract: Herein we report an alternative eco-friendly method for the synthesis of 1,2,3,4-tetrahydroisoquinoline sulfonamide derivatives. All obtained compounds were screened for their in vitro inhibition of albumin denaturation, antioxidant, antitryptic and ... ...

    Abstract Herein we report an alternative eco-friendly method for the synthesis of 1,2,3,4-tetrahydroisoquinoline sulfonamide derivatives. All obtained compounds were screened for their in vitro inhibition of albumin denaturation, antioxidant, antitryptic and antibacterial activity, and have shown significant results. The lipophilicity was established using both reversed-phase thin layer chromatography and in silico calculations.
    Keywords sio2/ppa ; microwave synthesis ; inhibition of albumin denaturation ; h2o2 scavenging activity ; antitryptic activity ; antibacterial activity ; Chemistry ; QD1-999
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Serbian Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Novel Flurbiprofen Derivatives as Antioxidant and Anti-Inflammatory Agents: Synthesis, In Silico, and In Vitro Biological Evaluation.

    Ivanov, Iliyan / Manolov, Stanimir / Bojilov, Dimitar / Marc, Gabriel / Dimitrova, Diyana / Oniga, Smaranda / Oniga, Ovidiu / Nedialkov, Paraskev / Stoyanova, Maria

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 2

    Abstract: In this study, we present the synthesis of five novel compounds by combining flurbiprofen with various substituted 2-phenethylamines. The synthesized derivatives underwent comprehensive characterization using techniques such ... ...

    Abstract In this study, we present the synthesis of five novel compounds by combining flurbiprofen with various substituted 2-phenethylamines. The synthesized derivatives underwent comprehensive characterization using techniques such as
    MeSH term(s) Humans ; Flurbiprofen/pharmacology ; Antioxidants/pharmacology ; Molecular Docking Simulation ; Anti-Inflammatory Agents/pharmacology ; Radiopharmaceuticals
    Chemical Substances Flurbiprofen (5GRO578KLP) ; Antioxidants ; Anti-Inflammatory Agents ; Radiopharmaceuticals
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29020385
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: HPLC Analysis and In Vitro and In Silico Evaluation of the Biological Activity of Polyphenolic Components Separated with Solvents of Various Polarities from

    Bojilov, Dimitar / Manolov, Stanimir / Ahmed, Sezan / Dagnon, Soleya / Ivanov, Iliyan / Marc, Gabriel / Oniga, Smaranda / Oniga, Ovidiu / Nedialkov, Paraskev / Mollova, Silviya

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 17

    Abstract: Helichrysum ... ...

    Abstract Helichrysum italicum
    MeSH term(s) Solvents ; Chloroform ; Helichrysum ; Chromatography, High Pressure Liquid ; Hexanes ; Quercetin ; Tandem Mass Spectrometry ; Glycosides ; Hydroxyl Radical
    Chemical Substances Solvents ; Chloroform (7V31YC746X) ; n-hexane (2DDG612ED8) ; Hexanes ; Quercetin (9IKM0I5T1E) ; Glycosides ; Hydroxyl Radical (3352-57-6)
    Language English
    Publishing date 2023-08-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28176198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Chemical Composition of Essential Oils from

    Mollova, Silviya / Dzhurmanski, Anatoli / Fidan, Hafize / Bojilov, Dimitar / Manolov, Stanimir / Dincheva, Ivayla / Stankov, Stanko / Stoyanova, Albena / Ercisli, Sezai / Assouguem, Amine / Marc, Romina Alina / Ullah, Riaz / Bari, Ahmed

    ACS omega

    2023  Volume 8, Issue 17, Page(s) 15441–15449

    Abstract: ... The ... ...

    Abstract The genus
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Silica-supported polyphosphoric acid in the synthesis of 4-substituted tetrahydroisoquinoline derivatives.

    Manolov, Stanimir / Nikolova, Stoyanka / Ivanov, Iliyan

    Molecules (Basel, Switzerland)

    2013  Volume 18, Issue 2, Page(s) 1869–1880

    Abstract: We report herein an application of an α-amidoalkylation reaction, as an alternative efficient synthesis of 4-aryl- and 4-methyl-1,2,3,4-tetrahydroisoquinoline derivatives. The amides required for this purpose would result from reaction of ... ...

    Abstract We report herein an application of an α-amidoalkylation reaction, as an alternative efficient synthesis of 4-aryl- and 4-methyl-1,2,3,4-tetrahydroisoquinoline derivatives. The amides required for this purpose would result from reaction of aminoacetaldehyde dimethylacetal with different substituted benzenes in polyphosphoric acid, followed by acylation of the obtained amines with different acid chlorides or sulfochlorides. We compared the cyclisation step using conventional (milieu of acetic-trifluoracetic acid = 4:1) and solid supported reagents (SiO₂/PPA), as recovered, regenerated and reused without loss of its activity catalyst. We found that in comparison to conventional methods, the yields of the reaction are greater and the reaction time is shorter.
    MeSH term(s) Amides/chemical synthesis ; Amides/chemistry ; Amines/chemical synthesis ; Amines/chemistry ; Phosphoric Acids/chemistry ; Polymers/chemistry ; Silicon Dioxide/chemistry ; Tetrahydroisoquinolines/chemical synthesis ; Tetrahydroisoquinolines/chemistry
    Chemical Substances Amides ; Amines ; Phosphoric Acids ; Polymers ; Tetrahydroisoquinolines ; Silicon Dioxide (7631-86-9) ; polyphosphoric acid (8017-16-1)
    Language English
    Publishing date 2013-02-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules18021869
    Database MEDical Literature Analysis and Retrieval System OnLINE

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