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  1. AU="Mansfield, Joshua"
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  3. AU="Concetta Aprea"
  4. AU="Cushing, D J"
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  6. AU="Martinez Rolón, Juliana"
  7. AU="Roeder, Elizabeth R"
  8. AU="van der Kevie-Kersemaekers, Anne-Marie M F"
  9. AU="Ghuman, Samarjit Singh"
  10. AU="Ahu Cerit Çakır"
  11. AU="Sun, Yin-Qiang"
  12. AU=Brown M.W.
  13. AU="Andrés Izaguirre"
  14. AU="Mahdieh Eftekhari"
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  17. AU="Fusco, Augusto"
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  20. AU="Seuthe, Leni Katharina"
  21. AU="Schuetz, Thomas J"
  22. AU="Thielen, Peter"
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  24. AU="Joseph O. Fadare"
  25. AU="Koech, O K"
  26. AU="Kapp, William"
  27. AU="Argañaraz, Gustavo A."
  28. AU="Winters, Adrienna"
  29. AU="Iman Mamdouh Talaat"
  30. AU="Benjamin Kingsley Harley"
  31. AU="Cirio, Maria Cecilia"
  32. AU="Rodriguez-Rodriguez, Alvaro Manuel"
  33. AU="Anna Maria Aloisi"
  34. AU="Na, Li"
  35. AU="Beatriz Aguiar Jordão Paranhos"
  36. AU="johnson, Michael"
  37. AU=Hunt S A
  38. AU="Gniazdowski, Victoria"
  39. AU="Griffin, Matthew E"
  40. AU="Bean, Paris"
  41. AU="Elomaa, Paula"
  42. AU="Robert Fowler"
  43. AU="Nielsen, Stine"
  44. AU="Chabartier, Cyrille"

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  1. Artikel ; Online: Elevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli Heat-Stable Toxin Induces Epithelial IL-33 Release and Alters Intestinal Immunity.

    Motyka, Natalya I / Stewart, Sydney R / Hollifield, Ian E / Kyllo, Thomas R / Mansfield, Joshua A / Norton, Elizabeth B / Clements, John D / Bitoun, Jacob P

    Infection and immunity

    2021  Band 89, Heft 4

    Abstract: ... ...

    Abstract Enterotoxigenic
    Mesh-Begriff(e) Animals ; Cell Line ; Cyclic GMP/biosynthesis ; Cytokines/metabolism ; Disease Models, Animal ; Enterotoxigenic Escherichia coli/physiology ; Enterotoxins/immunology ; Escherichia coli Infections/etiology ; Escherichia coli Infections/metabolism ; Female ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Mucosal ; Immunization ; Inflammation Mediators/metabolism ; Interleukin-33/biosynthesis ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Mice
    Chemische Substanzen Cytokines ; Enterotoxins ; Inflammation Mediators ; Interleukin-33 ; Cyclic GMP (H2D2X058MU)
    Sprache Englisch
    Erscheinungsdatum 2021-03-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/IAI.00707-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPARγ and Occludin Expression in Chronic Simian Immunodeficiency Virus-Infected Rhesus Macaques.

    Kumar, Vinay / Mansfield, Joshua / Fan, Rong / MacLean, Andrew / Li, Jian / Mohan, Mahesh

    Journal of immunology (Baltimore, Md. : 1950)

    2018  Band 200, Heft 8, Seite(n) 2677–2689

    Abstract: Intestinal epithelial barrier dysfunction is a well-known sequela of HIV/SIV infection that persists despite antiretroviral therapy. Although inflammation is a triggering factor, the underlying molecular mechanisms remain unknown. Emerging evidence ... ...

    Abstract Intestinal epithelial barrier dysfunction is a well-known sequela of HIV/SIV infection that persists despite antiretroviral therapy. Although inflammation is a triggering factor, the underlying molecular mechanisms remain unknown. Emerging evidence suggests that epithelial barrier function is epigenetically regulated by inflammation-induced microRNAs (miRNAs). Accordingly, we profiled and characterized miRNA/mRNA expression exclusively in colonic epithelium and identified 46 differentially expressed miRNAs (20 upregulated and 26 downregulated) in chronically SIV-infected rhesus macaques (
    Mesh-Begriff(e) Animals ; Down-Regulation/genetics ; Inflammation/metabolism ; Inflammation/virology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/virology ; Intestines/virology ; Macaca mulatta ; MicroRNAs/metabolism ; Occludin/genetics ; PPAR gamma/genetics ; Simian Acquired Immunodeficiency Syndrome/genetics ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/pathogenicity ; Up-Regulation/genetics
    Chemische Substanzen MicroRNAs ; Occludin ; PPAR gamma
    Sprache Englisch
    Erscheinungsdatum 2018-03-07
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1701148
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Hefte anzeigen Standort:
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  3. Artikel ; Online: Cannabinoid Attenuation of Intestinal Inflammation in Chronic SIV-Infected Rhesus Macaques Involves T Cell Modulation and Differential Expression of Micro-RNAs and Pro-inflammatory Genes.

    Kumar, Vinay / Torben, Workineh / Mansfield, Joshua / Alvarez, Xavier / Vande Stouwe, Curtis / Li, Jian / Byrareddy, Siddappa N / Didier, Peter J / Pahar, Bapi / Molina, Patricia E / Mohan, Mahesh

    Frontiers in immunology

    2019  Band 10, Seite(n) 914

    Abstract: Cannabis use is frequent in HIV-infected individuals for its appetite stimulation and anti-inflammatory effects. To identify the underlying molecular mechanisms associated with these effects, we simultaneously profiled micro-RNA (miRNA) and mRNA ... ...

    Abstract Cannabis use is frequent in HIV-infected individuals for its appetite stimulation and anti-inflammatory effects. To identify the underlying molecular mechanisms associated with these effects, we simultaneously profiled micro-RNA (miRNA) and mRNA expression in the colon of chronically simian immunodeficiency virus (SIV)-infected rhesus macaques administered either vehicle (VEH/SIV;
    Mesh-Begriff(e) Animals ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/pathology ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/pathology ; Dronabinol/pharmacology ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/immunology ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/pathology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Macaca mulatta ; Male ; MicroRNAs/immunology ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/pathology ; Simian Immunodeficiency Virus/immunology
    Chemische Substanzen MicroRNAs ; Dronabinol (7J8897W37S)
    Sprache Englisch
    Erscheinungsdatum 2019-04-30
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2019.00914
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Notes from the Field: Comparison of COVID-19 Mortality Rates Among Adults Aged ≥65 Years Who Were Unvaccinated and Those Who Received a Bivalent Booster Dose Within the Preceding 6 Months - 20 U.S. Jurisdictions, September 18, 2022-April 1, 2023.

    Johnson, Amelia G / Linde, Lauren / Payne, Amanda B / Ali, Akilah R / Aden, Vanessa / Armstrong, Brandy / Armstrong, Brett / Auche, Steven / Bayoumi, Nagla S / Bennett, Sarah / Boulton, Rachelle / Chang, Carolyn / Collingwood, Abigail / Cueto, Kevin / Davidson, Sherri L / Du, Yi / Fleischauer, Aaron / Force, Victoria / Frank, Darren /
    Hamilton, Ross / Harame, Kaitlin / Harrington, Pauline / Hicks, Liam / Hodis, Jeffrey D / Hoskins, Mikhail / Jones, Amanda / Kanishka, Fnu / Kaur, Ramandeep / Kirkendall, Samantha / Khan, Saadiah I / Klioueva, Anna / Link-Gelles, Ruth / Lyons, Shelby / Mansfield, Joshua / Markelz, Amanda / Masarik, John / Mendoza, Erica / Morris, Keeley / Omoike, Enaholo / Paritala, Sai / Patel, Komal / Pike, Melissa / Pompa, Xandy Peterson / Praetorius, Kevin / Rammouni, Nadine / Razzaghi, Hilda / Riggs, Alexa / Shi, Minchan / Sigalo, Nekabari / Stanislawski, Emma / Tilakaratne, Buddhi P / Turner, Kathryn A / Wiedeman, Caleb / Silk, Benjamin J / Scobie, Heather M

    MMWR. Morbidity and mortality weekly report

    2023  Band 72, Heft 24, Seite(n) 667–669

    Mesh-Begriff(e) Aged ; Humans ; COVID-19/mortality ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Vaccines, Combined
    Chemische Substanzen COVID-19 Vaccines ; Vaccines, Combined
    Sprache Englisch
    Erscheinungsdatum 2023-06-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7224a6
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Trends in Laboratory-Confirmed SARS-CoV-2 Reinfections and Associated Hospitalizations and Deaths Among Adults Aged ≥18 Years - 18 U.S. Jurisdictions, September 2021-December 2022.

    Ma, Kevin C / Dorabawila, Vajeera / León, Tomás M / Henry, Hannah / Johnson, Amelia G / Rosenberg, Eli / Mansfield, Joshua A / Midgley, Claire M / Plumb, Ian D / Aiken, Julia / Khanani, Quratul Ain / Auche, Steven / Bayoumi, Nagla S / Bennett, Sarah A / Bernu, Carmen / Chang, Carolyn / Como-Sabetti, Kathryn J / Cueto, Kevin / Cunningham, Spencer /
    Eddy, Meredith / Falender, Rebecca A / Fleischauer, Aaron / Frank, Darren M / Harrington, Pauline / Hoskins, Mikhail / Howsare, Adam / Ingaiza, Lucy M / Islam, Aras S / Jensen, Shelli A / Jones, Jefferson M / Kambach, Grace / Kanishka, Fnu / Levin, Yuriy / Masarik, John F / Meyer, Stephanie D / Milroy, Lauren / Morris, Keeley J / Olmstead, John / Olsen, Nina S / Omoike, Enaholo / Patel, Komal / Pettinger, Amanda / Pike, Melissa A / Reed, Isaiah G / Slocum, Elizabeth / Sutton, Melissa / Tilakaratne, Buddhi P / Vest, Hailey / Vostok, Johanna / Wang, Jennifer S / Watson-Lewis, Lydia / Wienkes, Haley N / Hagen, Melissa Briggs / Silk, Benjamin J / Scobie, Heather M

    MMWR. Morbidity and mortality weekly report

    2023  Band 72, Heft 25, Seite(n) 683–689

    Abstract: Although reinfections with SARS-CoV-2 have occurred in the United States with increasing frequency, U.S. epidemiologic trends in reinfections and associated severe outcomes have not been characterized. Weekly counts of SARS-CoV-2 reinfections, total ... ...

    Abstract Although reinfections with SARS-CoV-2 have occurred in the United States with increasing frequency, U.S. epidemiologic trends in reinfections and associated severe outcomes have not been characterized. Weekly counts of SARS-CoV-2 reinfections, total infections, and associated hospitalizations and deaths reported by 18 U.S. jurisdictions during September 5, 2021-December 31, 2022, were analyzed overall, by age group, and by five periods of SARS-CoV-2 variant predominance (Delta and Omicron [BA.1, BA.2, BA.4/BA.5, and BQ.1/BQ.1.1]). Among reported reinfections, weekly trends in the median intervals between infections and frequencies of predominant variants during previous infections were calculated. As a percentage of all infections, reinfections increased substantially from the Delta (2.7%) to the Omicron BQ.1/BQ.1.1 (28.8%) periods; during the same periods, increases in the percentages of reinfections among COVID-19-associated hospitalizations (from 1.9% [Delta] to 17.0% [Omicron BQ.1/BQ.1.1]) and deaths (from 1.2% [Delta] to 12.3% [Omicron BQ.1/BQ.1.1]) were also substantial. Percentages of all COVID-19 cases, hospitalizations, and deaths that were reinfections were consistently higher across variant periods among adults aged 18-49 years compared with those among adults aged ≥50 years. The median interval between infections ranged from 269 to 411 days by week, with a steep decline at the start of the BA.4/BA.5 period, when >50% of reinfections occurred among persons previously infected during the Alpha variant period or later. To prevent severe COVID-19 outcomes, including those following reinfection, CDC recommends staying up to date with COVID-19 vaccination and receiving timely antiviral treatments, when eligible.
    Mesh-Begriff(e) Adolescent ; Adult ; Humans ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Vaccines ; Hospitalization/trends ; Reinfection/epidemiology ; SARS-CoV-2 ; Hospital Mortality
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-06-23
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7225a3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: COVID-19 Incidence and Mortality Among Unvaccinated and Vaccinated Persons Aged ≥12 Years by Receipt of Bivalent Booster Doses and Time Since Vaccination - 24 U.S. Jurisdictions, October 3, 2021-December 24, 2022.

    Johnson, Amelia G / Linde, Lauren / Ali, Akilah R / DeSantis, Allison / Shi, Minchan / Adam, Carolyn / Armstrong, Brandy / Armstrong, Brett / Asbell, Madison / Auche, Steven / Bayoumi, Nagla S / Bingay, Boudu / Chasse, Melisse / Christofferson, Scott / Cima, Michael / Cueto, Kevin / Cunningham, Spencer / Delgadillo, Janelle / Dorabawila, Vajeera /
    Drenzek, Cherie / Dupervil, Brandi / Durant, Tonji / Fleischauer, Aaron / Hamilton, Ross / Harrington, Pauline / Hicks, Liam / Hodis, Jeffrey D / Hoefer, Dina / Horrocks, Sam / Hoskins, Mikhail / Husain, Sofia / Ingram, L Amanda / Jara, Amanda / Jones, Amanda / Kanishka, F N U / Kaur, Ramandeep / Khan, Saadiah I / Kirkendall, Samantha / Lauro, Priscilla / Lyons, Shelby / Mansfield, Joshua / Markelz, Amanda / Masarik, John / McCormick, Donald / Mendoza, Erica / Morris, Keeley J / Omoike, Enaholo / Patel, Komal / Pike, Melissa A / Pilishvili, Tamara / Praetorius, Kevin / Reed, Isaiah G / Severson, Rachel L / Sigalo, Nekabari / Stanislawski, Emma / Stich, Sarah / Tilakaratne, Buddhi P / Turner, Kathryn A / Wiedeman, Caleb / Zaldivar, Allison / Silk, Benjamin J / Scobie, Heather M

    MMWR. Morbidity and mortality weekly report

    2023  Band 72, Heft 6, Seite(n) 145–152

    Abstract: On September 1, 2022, CDC recommended an updated (bivalent) COVID-19 vaccine booster to help restore waning protection conferred by previous vaccination and broaden protection against emerging variants for persons aged ≥12 years (subsequently extended to ...

    Abstract On September 1, 2022, CDC recommended an updated (bivalent) COVID-19 vaccine booster to help restore waning protection conferred by previous vaccination and broaden protection against emerging variants for persons aged ≥12 years (subsequently extended to persons aged ≥6 months).* To assess the impact of original (monovalent) COVID-19 vaccines and bivalent boosters, case and mortality rate ratios (RRs) were estimated comparing unvaccinated and vaccinated persons aged ≥12 years by overall receipt of and by time since booster vaccination (monovalent or bivalent) during Delta variant and Omicron sublineage (BA.1, BA.2, early BA.4/BA.5, and late BA.4/BA.5) predominance.
    Mesh-Begriff(e) Humans ; Aged ; COVID-19 Vaccines ; COVID-19/epidemiology ; COVID-19/prevention & control ; Incidence ; SARS-CoV-2 ; Vaccination
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-02-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm7206a3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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