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Article ; Online: Combination of JAKinibs with Methotrexate or Anti-Cytokine Biologics in Patients with Severe COVID-19.

Seif, Farhad / Pornour, Majid / Mansouri, Davood

International archives of allergy and immunology

2020 Volume 181, Issue 8, Page(s) 648–649

MeSH term(s)	Betacoronavirus ; Biological Products ; COVID-19 ; Coronavirus Infections ; Humans ; Methotrexate ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Chemical Substances	Biological Products ; Methotrexate (YL5FZ2Y5U1)
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000509198
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Article ; Online: Dynamic Changes of Lymphocyte Subsets in the Course of COVID-19.

Rezaei, Mitra / Marjani, Majid / Mahmoudi, Shima / Mortaz, Esmaeil / Mansouri, Davood

International archives of allergy and immunology

2021 Volume 182, Issue 3, Page(s) 254–262

Abstract: Background: Although the pathophysiology of coronavirus disease 2019 (COVID-19) is not clearly defined, among the proposed mechanisms, immune system dysfunction is more likely than others. The aim of this study was to clarify the characteristics and ... ...

Abstract	Background: Although the pathophysiology of coronavirus disease 2019 (COVID-19) is not clearly defined, among the proposed mechanisms, immune system dysfunction is more likely than others. The aim of this study was to clarify the characteristics and clinical significance of dynamic changes of lymphocyte subsets in the course of COVID-19. Methods: In this prospective study, the levels of peripheral lymphocyte subsets including CD4+, CD8+, CD4+CD25+FOXP3+, CD38+, CD3+HLA-DR+, CD19+, CD20+, and CD16+CD56+ cells were measured by flow cytometry in 52 confirmed hospitalized patients with COVID-19 at the day of admission and after 7 days of care. Clinical response was defined as improvement in symptoms (fever, dyspnea, and cough as well as blood oxygen saturation), and patients who met these criteria after 1 week of admission were classified as early responders; others who survived and finally discharged from the hospital were classified as late responders and patients who died were categorized as nonresponders. Immunophenotyping of studied cell changes on the first day of admission and 7 days after treatment were compared. Besides, the correlation between cellular subset variation and clinical response and outcome were analyzed. Results: Total counts of white blood cell, T cells, CD4+ T cells, CD8+ T cells, CD38+ lymphocytes, and CD3+HLA-DR+ lymphocytes were significantly increased in both early and late responders. No statistically significant difference was observed in CD4+/CD8+ ratio, B cells, FOXP3+Treg lymphocytes, and FOXP3 median fluorescence intensity among studied groups. According to the multivariate analysis, an increase in CD4+ T cells (p = 0.019), CD8+ T cells (p = 0.001), and administration of interferon (p < 0.001) were independent predictors of clinical response. Conclusion: We found an increasing trend in total T cells, T helpers, cytotoxic T cells, activated lymphocytes, and natural killer cells among responders. This trend was not statistically significant among nonresponders. The findings of this study may enhance our knowledge about the pathogenesis of COVID-19.
MeSH term(s)	Adult ; Aged ; COVID-19/immunology ; Female ; Humans ; Lymphocyte Subsets/immunology ; Male ; Middle Aged ; Prospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000514202
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Article ; Online: Genetic, immunologic, and clinical features of 830 patients with Mendelian susceptibility to mycobacterial diseases (MSMD): A systematic review.

Khavandegar, Armin / Mahdaviani, Seyed Alireza / Zaki-Dizaji, Majid / Khalili-Moghaddam, Fereshteh / Ansari, Sarina / Alijani, Saba / Taherzadeh-Ghahfarrokhi, Nooshin / Mansouri, Davood / Casanova, Jean-Laurent / Bustamante, Jacinta / Jamee, Mahnaz

The Journal of allergy and clinical immunology

2024 Volume 153, Issue 5, Page(s) 1432–1444

Abstract: Background: Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare clinical syndrome characterized by vulnerability to weakly virulent mycobacterial species, including Bacillus Calmette-Guérin (BCG) vaccines and environmental mycobacteria.!# ...

Abstract	Background: Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare clinical syndrome characterized by vulnerability to weakly virulent mycobacterial species, including Bacillus Calmette-Guérin (BCG) vaccines and environmental mycobacteria. Objective: We sought to perform a systematic review of the genetic, immunologic, and clinical findings for reported patients with MSMD. Methods: We searched PubMed, Web of Science, and Scopus databases for publications in English relating to MSMD. All full texts were evaluated for eligibility for inclusion. Two reviewers independently selected the publications, with a third reviewer consulted in cases of disagreement. Results: A primary systematic search and searches of other resources identified 16,155 articles. In total, 158 articles from 63 countries were included in qualitative and quantitative analyses. In total, 830 patients-436 males (52.5%), 369 females (44.5%), and 25 patients of unknown sex (3.0%)-from 581 families were evaluated. A positive family history was reported in 347 patients (45.5%). The patients had a mean age of 10.41 ± 0.42 (SEM) years. The frequency of MSMD was highest in Iran, Turkey, and Saudi Arabia. Lymphadenopathy was the most common clinical manifestation of MSMD, reported in 378 (45.5%) cases and multifocal in 35.1%. Fever, organomegaly, and sepsis were the next most frequent findings, reported in 251 (30.2%), 206 (24.8%), and 171 (20.8%) cases, respectively. In total, 299 unique mutations in 21 genes known to be involved in MSMD were reported: 100 missense (34%), 80 indel-frameshift (insertion or deletion, 27%), 53 nonsense (18%), 35 splice site (12%), 10 indel-in frame (2.7%), 6 indel (2%), and 15 large deletion/duplication mutations. Finally, 61% of the reported patients with MSMD had mutations of IL12RB1 (41%) or IFNGR1 (20%). At the time of the report, 177 of the patients (21.3%) were dead and 597 (71.9%) were still alive. Conclusions: MSMD is associated with a high mortality rate, mostly due to impaired control of infection. Preexposure strategies, such as changes in vaccination policy in endemic areas, the establishment of a worldwide registry of patients with MSMD, and precise follow-up over generations in affected families, appear to be vital to decrease MSMD-related mortality.
MeSH term(s)	Humans ; Mycobacterium Infections/genetics ; Mycobacterium Infections/immunology ; Genetic Predisposition to Disease ; Male ; Female ; Child ; BCG Vaccine/immunology
Chemical Substances	BCG Vaccine
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2024.01.021
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Article: Acrocyanosis and digital necrosis are associated with poor prognosis in COVID-19.

Pourdowlat, Guitti / Naderi, Zohre / Seif, Farhad / Mansouri, Davood / Raji, Hanieh

Clinical case reports

2020 Volume 8, Issue 12, Page(s) 2769–2772

Abstract: Acrocyanosis and digital necrosis, which caused by microangiopathic and immunothrombosis phenomenon, may accompanied by microvascular involvement of other organs. Therefore, this finding can play a prognostic role in covid-19 outcome. ...

Abstract	Acrocyanosis and digital necrosis, which caused by microangiopathic and immunothrombosis phenomenon, may accompanied by microvascular involvement of other organs. Therefore, this finding can play a prognostic role in covid-19 outcome.
Language	English
Publishing date	2020-08-30
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.3276
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunologic Features in Coronavirus Disease 2019: Functional Exhaustion of T Cells and Cytokine Storm.

Mahmoudi, Shima / Rezaei, Mitra / Mansouri, Nahal / Marjani, Majid / Mansouri, Davood

Journal of clinical immunology

2020 Volume 40, Issue 7, Page(s) 974–976

MeSH term(s)	Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Cell Proliferation ; Cell Survival/immunology ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Cytokines/blood ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Lymphocyte Count ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severity of Illness Index ; T-Lymphocytes/immunology
Chemical Substances	Cytokines
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-020-00824-4
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Article ; Online: Transient left ventricular clot in COVID-19-related myocarditis is associated with hypereosinophilic syndrome: a case report.

Ziaie, Naghmeh / Maleh, Parviz Amri / Ramandi, Mohammad Mostafa Ansari / Pourkia, Roghayeh / Latifi, Kayvan / Mansouri, Davood

The international journal of cardiovascular imaging

2021 Volume 37, Issue 11, Page(s) 3279–3283

Abstract: Frequent clinical presentations have been reported in patients with Coronavirus disease 2019 (COVID-19). It may be associated with multi-organ and cardiovascular involvements such as myocarditis and clot formation. Hypereosinophilic syndrome (HES) is a ... ...

Abstract	Frequent clinical presentations have been reported in patients with Coronavirus disease 2019 (COVID-19). It may be associated with multi-organ and cardiovascular involvements such as myocarditis and clot formation. Hypereosinophilic syndrome (HES) is a rare disease diagnosed with idiopathic eosinophilia and organ involvement. Here, we report a patient with COVID-19 who presented with clot formation and myocarditis. One month after discharge, regarding persistent peripheral/bone marrow hypereosinophilia and clot in echocardiography, fluorescent in situ hybridization (FISH) analysis was done that showed FIP1L1-CHIC2 fusion (PDGFRɑ rearrangement) in 18% of scored cells and PDGFRβ rearrangement in 12% of scored cells, which confirmed HES diagnosis. Clot formation may be a late manifestation of COVID-19 or myocarditis due to COVID-19, or the first manifestation of HES that COVID-19 might provoke in this rare syndrome.
MeSH term(s)	COVID-19 ; Humans ; Hypereosinophilic Syndrome/complications ; Hypereosinophilic Syndrome/diagnostic imaging ; Hypereosinophilic Syndrome/drug therapy ; In Situ Hybridization, Fluorescence ; Myocarditis/diagnostic imaging ; Myocarditis/etiology ; Oncogene Proteins, Fusion/genetics ; Predictive Value of Tests ; SARS-CoV-2
Chemical Substances	Oncogene Proteins, Fusion
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-021-02317-w
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Article: Combination of JAKinibs with Methotrexate or Anti-Cytokine Biologics in Patients with Severe COVID-19

Seif, Farhad / Pornour, Majid / Mansouri, Davood

Int Arch Allergy Immunol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #598067
Database	COVID19

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Article ; Online: Combination of JAKinibs with Methotrexate or Anti-Cytokine Biologics in Patients with Severe COVID-19

Seif, Farhad / Pornour, Majid / Mansouri, Davood

International Archives of Allergy and Immunology

2020 Volume 181, Issue 8, Page(s) 648–649

Keywords	Immunology ; Immunology and Allergy ; General Medicine ; covid19
Language	English
Publisher	S. Karger AG
Publishing country	ch
Document type	Article ; Online
ZDB-ID	1108932-5
ISSN	1423-0097 ; 1018-2438
ISSN (online)	1423-0097
ISSN	1018-2438
DOI	10.1159/000509198
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Delayed Diagnosis of Chronic Necrotizing Granulomatous Skin Lesions due to TAP2 Deficiency

Darazam, Ilad Alavi / Hakamifard, Atousa / Momenilandi, Mana / Materna, Marie / Gharehbagh, Farid Javandoust / Shahrooei, Mohammad / Olyaei, Nasrin Alipour / Zerehpoosh, Farahnaz Bidari / Fayand, Antoine / Hatami, Firouze / Lotfollahi, Legha / Mansouri, Nahal / Casanova, Jean-Laurent / Béziat, Vivien / Mansouri, Davood

J Clin Immunol. 2023 Jan., v. 43, no. 1, p. 217-228

2023 , Page(s) 217–228

Abstract: Major histocompatibility complex class I (MHC-I) deficiency, also known as bare lymphocyte syndrome type 1 (BLS-1), is a rare autosomal recessively inherited immunodeficiency disorder with remarkable clinical and biological heterogeneity. Transporter ... ...

Abstract	Major histocompatibility complex class I (MHC-I) deficiency, also known as bare lymphocyte syndrome type 1 (BLS-1), is a rare autosomal recessively inherited immunodeficiency disorder with remarkable clinical and biological heterogeneity. Transporter associated with antigen processing (TAP) is a member of the ATP-binding cassette superfamily of transporters and consists of two subunits, TAP1 or TAP2. Any defect resulting from a mutation or deletion of these two subunits may adversely affect the peptide translocation in the endoplasmic reticulum, which is an important process for properly assembling MHC-I molecules. To date, only 12 TAP2-deficient patients were reported in the literature. Herein, we described two Iranian cases with 2 and 3 decades of delayed diagnosis of chronic necrotizing granulomatous skin lesions due to TAP2 deficiency without pulmonary involvement. Segregation analysis in family members identified 3 additional homozygous asymptomatic carriers. In both asymptomatic and symptomatic carriers, HLA-I expression was only 4–15% of the one observed in healthy controls. We performed the first deep immunophenotyping in TAP2-deficient patients. While total CD8 T cell counts were normal as previously reported, the patients showed strongly impaired naïve CD8 T cell counts. Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cell counts were increased.
Keywords	CD8-positive T-lymphocytes ; antigens ; endoplasmic reticulum ; homozygosity ; immunophenotyping ; immunosuppression ; major histocompatibility complex ; mutation ; peptides
Language	English
Dates of publication	2023-01
Size	p. 217-228
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-022-01374-7
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Successful Treatment of Covid-19 Associated Cytokine Release Syndrome with Colchicine. A Case Report and Review of Literature.

Mansouri, Nahal / Marjani, Majid / Tabarsi, Payam / von Garnier, Christophe / Mansouri, Davood

Immunological investigations

2020 Volume 50, Issue 8, Page(s) 884–890

Abstract: We describe the case of a 42 year old, healthy patient with Covid-19 who despite improvement in his respiratory symptoms developed a mild to moderate cytokine release syndrome (CRS) and an associated monoarticular gout flare. Since the patient refused ... ...

Abstract	We describe the case of a 42 year old, healthy patient with Covid-19 who despite improvement in his respiratory symptoms developed a mild to moderate cytokine release syndrome (CRS) and an associated monoarticular gout flare. Since the patient refused admission to the hospital and had stable vital signs, we chose to treat him with a safe anti-inflammatory and non-immunosuppressive therapy. To hit two birds with one stone, we considered colchicine, as it has systemic anti-inflammatory effects and is also effective in gout flare. Unexpectedly, 48 hours after treatment, not only did his ongoing fever and toe pain disappear, he also had significant improvements in his general state of health and all his inflammatory markers including fibrinogen, ferritin, D-dimer, and IL-6 levels normalized. To our knowledge, the use of colchicine in Covid-19 and CRS has not been reported. This observation merits the consideration of colchicine as a safe, inexpensive and oral medication for the treatment of mild to moderate CRS in Covid-19 patients. More importantly, in Covid-19 patients with early lung involvement colchicine may be an appropriate candidate to prevent CRS in adjunction with routine antiviral agents. Indeed, multicenter, randomized controlled studies are required to evaluate the benefits of this therapy.
MeSH term(s)	Administration, Oral ; Adult ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/virology ; Colchicine/administration & dosage ; Cytokine Release Syndrome/diagnosis ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Gout/diagnosis ; Gout/drug therapy ; Gout/immunology ; Gout/virology ; Humans ; Male ; SARS-CoV-2/immunology ; Treatment Outcome
Chemical Substances	Colchicine (SML2Y3J35T)
Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2020.1789655
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