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Article: Fibrose pulmonaire et cancer pulmonaire : entre complémentarités et spécificités.

Rey Cobo, Juliana / Vraka, Argyro / Mansouri, Nahal / Messe, Romain

2022 Volume 18, Issue 804, Page(s) 2162–2168

Abstract: Lung cancer is the leading cause of cancer mortality in the developed world. Diffuse fibrosing interstitial lung disease (ILD) consist of a heterogeneous group that includes idiopathic pulmonary fibrosis (IPF). Diffuse ILD is a risk factor for the ... ...

Title translation	Pulmonary fibrosis and lung cancer: between complementarities and specificities.
Abstract	Lung cancer is the leading cause of cancer mortality in the developed world. Diffuse fibrosing interstitial lung disease (ILD) consist of a heterogeneous group that includes idiopathic pulmonary fibrosis (IPF). Diffuse ILD is a risk factor for the development of lung cancer which on its own is associated with an increased risk of morbidity and mortality. Despite common mechanisms between fibrogenesis and carcinogenesis, the underlying pathogenesis of lung cancer and fibrosis overlap is poorly understood. The clinical management of these patients remains a medical challenge requiring a multidisciplinary approach, particularly in view of the risk of acute exacerbation of fibrosing ILD following most lung cancer treatments, leading to a considerable negative outcome on overall prognosis.
MeSH term(s)	Humans ; Lung Diseases, Interstitial ; Idiopathic Pulmonary Fibrosis/etiology ; Idiopathic Pulmonary Fibrosis/therapy ; Lung/pathology ; Lung Neoplasms/complications ; Prognosis ; Disease Progression
Language	French
Publishing date	2022-11-12
Publishing country	Switzerland
Document type	English Abstract ; Journal Article
ZDB-ID	2177010-4
ISSN	1660-9379
ISSN	1660-9379
DOI	10.53738/REVMED.2022.18.804.2162
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Article ; Online: Impact of COVID-19 on long-term lung function in lung transplant recipients: A single-center retrospective cohort study.

Touilloux, Brice / Papadimitriou-Olivgeris, Matthaios / Bongard, Cédric / Mansouri, Nahal / Ioakeim, Foteini / Manuel, Oriol / Koutsokera, Angela / Aubert, John-David / Casutt, Alessio

Transplant infectious disease : an official journal of the Transplantation Society

2023 Volume 25, Issue 5, Page(s) e14151

Abstract: Available data are limited concerning long-term lung function (LF) evolution after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in lung transplant (LT) recipients. The aim of this study is to determine the effect of first SARS- ... ...

Abstract	Available data are limited concerning long-term lung function (LF) evolution after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in lung transplant (LT) recipients. The aim of this study is to determine the effect of first SARS-CoV-2 infection on long-term LF in LT recipients. We analyzed spirometry results of LT recipients followed at our institution (March 2020 to July 2022) at 3, 6, and 12 months after first SARS-CoV-2 infection. Overall, 42 LT patients of our cohort (70%) with COVID-19 were included for long-term LF analysis. Forced expiratory volume in 1 s (FEV
MeSH term(s)	Humans ; Lung Transplantation/adverse effects ; COVID-19 ; Transplant Recipients ; Retrospective Studies ; SARS-CoV-2 ; Lung
Language	English
Publishing date	2023-09-25
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.14151
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Zs.A 5100: Show issues

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Article ; Online: Immunologic Features in Coronavirus Disease 2019: Functional Exhaustion of T Cells and Cytokine Storm.

Mahmoudi, Shima / Rezaei, Mitra / Mansouri, Nahal / Marjani, Majid / Mansouri, Davood

Journal of clinical immunology

2020 Volume 40, Issue 7, Page(s) 974–976

MeSH term(s)	Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Cell Proliferation ; Cell Survival/immunology ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Cytokines/blood ; Cytokines/immunology ; Cytokines/metabolism ; Humans ; Lymphocyte Count ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Severity of Illness Index ; T-Lymphocytes/immunology
Chemical Substances	Cytokines
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	Netherlands
Document type	Letter
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-020-00824-4
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Article ; Online: Longevity of immunity following COVID-19 vaccination: a comprehensive review of the currently approved vaccines.

Jamshidi, Elham / Asgary, Amirhossein / Shafiekhani, Paria / Khajeamiri, Yasaman / Mohamed, Kawthar / Esmaily, Hadi / Jamal Rahi, Sahand / Mansouri, Nahal

Human vaccines & immunotherapeutics

2022 Volume 18, Issue 5, Page(s) 2037384

Abstract: It is unknown how long the immunity following COVID-19 vaccination lasts. The current systematic review provides a perspective on the persistence of various antibodies for available vaccines.Both the BNT162b2 and the mRNA-1273 induce the production of ... ...

Abstract	It is unknown how long the immunity following COVID-19 vaccination lasts. The current systematic review provides a perspective on the persistence of various antibodies for available vaccines.Both the BNT162b2 and the mRNA-1273 induce the production of IgA antibodies, reflecting the possible prevention of the asymptomatic spread. The mRNA-1273 vaccine's antibodies were detectable until 6 months, followed by the AZD1222, 3 months, the Ad26.COV2.S and the BNT162b2 vaccines within 2 months.The BNT162b2 produced anti-spike IgGs 11 days after the first dose and peaked at day 21, whereas the AZD1222 induced a neutralizing effect 22 days after the first dose.These vaccines induce T-cell mediated immune responses too. Each one of the AZD1222, Ad26.COV2.S, mRNA-1273 mediates T-cell response immunity at days 14-22, 15, and 43 after the first dose, respectively. Whereas for the BNT162b1 and BNT162b2 vaccines, T-cell immunity is induced 7 days and 12 weeks after the booster dose, respectively.
MeSH term(s)	2019-nCoV Vaccine mRNA-1273 ; Ad26COVS1 ; Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Humans ; Vaccination
Chemical Substances	Ad26COVS1 ; Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-04-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2664176-8
ISSN	2164-554X ; 2164-5515
ISSN (online)	2164-554X
ISSN	2164-5515
DOI	10.1080/21645515.2022.2037384
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Article: ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly.

Reddy, Karosham Diren / Bizymi, Nikoleta / Schweikert, Anja / Ananth, Sachin / Lim, Clarice X / Lodge, Katharine M / Joannes, Audrey / Ubags, Niki / van der Does, Anne M / Cloonan, Suzanne M / Mailleux, Arnaud / Mansouri, Nahal / Reynaert, Niki L / Heijink, Irene H / Cuevas-Ocaña, Sara

ERJ open research

2024 Volume 10, Issue 2

Abstract: Early career members of Assembly 3 (Basic and Translational Sciences) of the European Respiratory Society (ERS) summarise the key messages discussed during six selected sessions that took place at the ERS International Congress 2023 in Milan, Italy. ... ...

Abstract	Early career members of Assembly 3 (Basic and Translational Sciences) of the European Respiratory Society (ERS) summarise the key messages discussed during six selected sessions that took place at the ERS International Congress 2023 in Milan, Italy. Aligned with the theme of the congress, the first session covered is "Micro- and macro-environments and respiratory health", which is followed by a summary of the "Scientific year in review" session. Next, recent advances in experimental methodologies and new technologies are discussed from the "Tissue modelling and remodelling" session and a summary provided of the translational science session, "What did you always want to know about omics analyses for clinical practice?", which was organised as part of the ERS Translational Science initiative's aims. The "Lost in translation: new insights into cell-to-cell crosstalk in lung disease" session highlighted how next-generation sequencing can be integrated with laboratory methods, and a final summary of studies is presented from the "From the transcriptome landscape to innovative preclinical models in lung diseases" session, which links the transcriptome landscape with innovative preclinical models. The wide range of topics covered in the selected sessions and the high quality of the research discussed demonstrate the strength of the basic and translational science being presented at the international respiratory conference organised by the ERS.
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2827830-6
ISSN	2312-0541
ISSN	2312-0541
DOI	10.1183/23120541.00875-2023
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Successful Treatment of Covid-19 Associated Cytokine Release Syndrome with Colchicine. A Case Report and Review of Literature.

Mansouri, Nahal / Marjani, Majid / Tabarsi, Payam / von Garnier, Christophe / Mansouri, Davood

Immunological investigations

2020 Volume 50, Issue 8, Page(s) 884–890

Abstract: We describe the case of a 42 year old, healthy patient with Covid-19 who despite improvement in his respiratory symptoms developed a mild to moderate cytokine release syndrome (CRS) and an associated monoarticular gout flare. Since the patient refused ... ...

Abstract	We describe the case of a 42 year old, healthy patient with Covid-19 who despite improvement in his respiratory symptoms developed a mild to moderate cytokine release syndrome (CRS) and an associated monoarticular gout flare. Since the patient refused admission to the hospital and had stable vital signs, we chose to treat him with a safe anti-inflammatory and non-immunosuppressive therapy. To hit two birds with one stone, we considered colchicine, as it has systemic anti-inflammatory effects and is also effective in gout flare. Unexpectedly, 48 hours after treatment, not only did his ongoing fever and toe pain disappear, he also had significant improvements in his general state of health and all his inflammatory markers including fibrinogen, ferritin, D-dimer, and IL-6 levels normalized. To our knowledge, the use of colchicine in Covid-19 and CRS has not been reported. This observation merits the consideration of colchicine as a safe, inexpensive and oral medication for the treatment of mild to moderate CRS in Covid-19 patients. More importantly, in Covid-19 patients with early lung involvement colchicine may be an appropriate candidate to prevent CRS in adjunction with routine antiviral agents. Indeed, multicenter, randomized controlled studies are required to evaluate the benefits of this therapy.
MeSH term(s)	Administration, Oral ; Adult ; COVID-19/complications ; COVID-19/drug therapy ; COVID-19/immunology ; COVID-19/virology ; Colchicine/administration & dosage ; Cytokine Release Syndrome/diagnosis ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Cytokine Release Syndrome/virology ; Gout/diagnosis ; Gout/drug therapy ; Gout/immunology ; Gout/virology ; Humans ; Male ; SARS-CoV-2/immunology ; Treatment Outcome
Chemical Substances	Colchicine (SML2Y3J35T)
Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	632565-8
ISSN	1532-4311 ; 0882-0139
ISSN (online)	1532-4311
ISSN	0882-0139
DOI	10.1080/08820139.2020.1789655
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Article ; Online: Personalized predictions of adverse side effects of the COVID-19 vaccines

Jamshidi, Elham / Asgary, Amirhossein / Kharrazi, Ali Yazdizadeh / Tavakoli, Nader / Zali, Alireza / Mehrazi, Maryam / Jamshidi, Masoud / Farrokhi, Babak / Maher, Ali / von Garnier, Christophe / Rahi, Sahand Jamal / Mansouri, Nahal

Heliyon. 2023 Jan., v. 9, no. 1 p.e12753-

2023

Abstract: Misconceptions about adverse side effects are thought to influence public acceptance of the Coronavirus disease 2019 (COVID-19) vaccines negatively. To address such perceived disadvantages of vaccines, a novel machine learning (ML) approach was designed ... ...

Abstract	Misconceptions about adverse side effects are thought to influence public acceptance of the Coronavirus disease 2019 (COVID-19) vaccines negatively. To address such perceived disadvantages of vaccines, a novel machine learning (ML) approach was designed to generate personalized predictions of the most common adverse side effects following injection of six different COVID-19 vaccines based on personal and health-related characteristics. Prospective data of adverse side effects following COVID-19 vaccination in 19943 participants from Iran and Switzerland was utilized. Six vaccines were studied: The AZD1222, Sputnik V, BBIBP-CorV, COVAXIN, BNT162b2, and the mRNA-1273 vaccine. The eight side effects were considered as the model output: fever, fatigue, headache, nausea, chills, joint pain, muscle pain, and injection site reactions. The total input parameters for the first and second dose predictions were 46 and 54 features, respectively, including age, gender, lifestyle variables, and medical history. The performances of multiple ML models were compared using Area Under the Receiver Operating Characteristic Curve (ROC-AUC). The total number of people receiving the first dose of the AZD1222, Sputnik V, BBIBP-CorV, COVAXIN, BNT162b2, and mRNA-1273 were 6022, 7290, 5279, 802, 277, and 273, respectively. For the second dose, the numbers were 2851, 5587, 3841, 599, 242 and 228. The Logistic Regression model for predicting different side effects of the first dose achieved ROC-AUCs of 0.620–0.686, 0.685–0.716, 0.632–0.727, 0.527–0.598, 0.548–0.655, 0.545–0.712 for the AZD1222, Sputnik V, BBIBP-CorV, COVAXIN, BNT162b2 and mRNA-1273 vaccines, respectively. The second dose models yielded ROC-AUCs of 0.777–0.867, 0.795–0.848, 0.857–0.906, 0.788–0.875, 0.683–0.850, and 0.486–0.680, respectively. Using a large cohort of recipients vaccinated with COVID-19 vaccines, a novel and personalized strategy was established to predict the occurrence of the most common adverse side effects with high accuracy. This technique can serve as a tool to inform COVID-19 vaccine selection and generate personalized factsheets to curb concerns about adverse side effects.
Keywords	COVID-19 infection ; fever ; gender ; headache ; injection site ; lifestyle ; medical history ; models ; muscles ; nausea ; people ; regression analysis ; vaccination ; vaccines ; Iran ; Switzerland ; COVID-19 ; Artificial intelligence ; Machine learning ; Symptom ; Vaccine ; Adverse side effects ; Sputnik V ; AZD1222 ; AstraZeneca ; Sinopharm ; Moderna ; Pfizer ; Covaxin ; AI ; LR ; ML ; RF ; ROC ; MLP ; KNN
Language	English
Dates of publication	2023-01
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e12753
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Delayed Diagnosis of Chronic Necrotizing Granulomatous Skin Lesions due to TAP2 Deficiency

Darazam, Ilad Alavi / Hakamifard, Atousa / Momenilandi, Mana / Materna, Marie / Gharehbagh, Farid Javandoust / Shahrooei, Mohammad / Olyaei, Nasrin Alipour / Zerehpoosh, Farahnaz Bidari / Fayand, Antoine / Hatami, Firouze / Lotfollahi, Legha / Mansouri, Nahal / Casanova, Jean-Laurent / Béziat, Vivien / Mansouri, Davood

J Clin Immunol. 2023 Jan., v. 43, no. 1, p. 217-228

2023 , Page(s) 217–228

Abstract: Major histocompatibility complex class I (MHC-I) deficiency, also known as bare lymphocyte syndrome type 1 (BLS-1), is a rare autosomal recessively inherited immunodeficiency disorder with remarkable clinical and biological heterogeneity. Transporter ... ...

Abstract	Major histocompatibility complex class I (MHC-I) deficiency, also known as bare lymphocyte syndrome type 1 (BLS-1), is a rare autosomal recessively inherited immunodeficiency disorder with remarkable clinical and biological heterogeneity. Transporter associated with antigen processing (TAP) is a member of the ATP-binding cassette superfamily of transporters and consists of two subunits, TAP1 or TAP2. Any defect resulting from a mutation or deletion of these two subunits may adversely affect the peptide translocation in the endoplasmic reticulum, which is an important process for properly assembling MHC-I molecules. To date, only 12 TAP2-deficient patients were reported in the literature. Herein, we described two Iranian cases with 2 and 3 decades of delayed diagnosis of chronic necrotizing granulomatous skin lesions due to TAP2 deficiency without pulmonary involvement. Segregation analysis in family members identified 3 additional homozygous asymptomatic carriers. In both asymptomatic and symptomatic carriers, HLA-I expression was only 4–15% of the one observed in healthy controls. We performed the first deep immunophenotyping in TAP2-deficient patients. While total CD8 T cell counts were normal as previously reported, the patients showed strongly impaired naïve CD8 T cell counts. Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cell counts were increased.
Keywords	CD8-positive T-lymphocytes ; antigens ; endoplasmic reticulum ; homozygosity ; immunophenotyping ; immunosuppression ; major histocompatibility complex ; mutation ; peptides
Language	English
Dates of publication	2023-01
Size	p. 217-228
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	779361-3
ISSN	1573-2592 ; 0271-9142
ISSN (online)	1573-2592
ISSN	0271-9142
DOI	10.1007/s10875-022-01374-7
Database	NAL-Catalogue (AGRICOLA)

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Article: Immunologic Features in Coronavirus Disease 2019: Functional Exhaustion of T Cells and Cytokine Storm

Mahmoudi, Shima / Rezaei, Mitra / Mansouri, Nahal / Marjani, Majid / Mansouri, Davood

J Clin Immunol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #637037
Database	COVID19

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Article ; Online: Using Machine Learning to Predict Mortality for COVID-19 Patients on Day 0 in the ICU.

Jamshidi, Elham / Asgary, Amirhossein / Tavakoli, Nader / Zali, Alireza / Setareh, Soroush / Esmaily, Hadi / Jamaldini, Seyed Hamid / Daaee, Amir / Babajani, Amirhesam / Sendani Kashi, Mohammad Ali / Jamshidi, Masoud / Jamal Rahi, Sahand / Mansouri, Nahal

Frontiers in digital health

2022 Volume 3, Page(s) 681608

Abstract: Rationale: ...

Abstract	Rationale:
Language	English
Publishing date	2022-01-13
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-253X
ISSN (online)	2673-253X
DOI	10.3389/fdgth.2021.681608
Database	MEDical Literature Analysis and Retrieval System OnLINE

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