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  1. Article ; Online: Mitigating phthalate toxicity: The protective role of humic acid and clay in zebrafish larvae.

    Mansuri, Abdulkhalik / Trivedi, Charvi / Parikh, Aashi / Kumar, Ashutosh

    Chemosphere

    2024  Volume 354, Page(s) 141756

    Abstract: This research study aimed to explore the mitigating effects of humic acid and clay on the toxicity induced by three different phthalates (DBP, DEP, DEHP) on zebrafish larvae growth. Prolonged exposure to DBP resulted in a concerning 87.33% mortality rate, ...

    Abstract This research study aimed to explore the mitigating effects of humic acid and clay on the toxicity induced by three different phthalates (DBP, DEP, DEHP) on zebrafish larvae growth. Prolonged exposure to DBP resulted in a concerning 87.33% mortality rate, significantly reduced to 7.3% when co-administered with humic acid. A similar reduction in mortality was observed for the other two phthalates (DEP and DEHP). Additionally, the introduction of phthalates with humic acid, clay, or their combination led to a significant decrease in the malformation rate in larvae. High-Performance Liquid Chromatography (HPLC) analysis of phthalates in treatments revealed a noteworthy decline in their concentration when combined with humic acid and clay. This suggests a reduced bioavailability of phthalates to larvae, aligning with diminished toxicity, lower mortality, fewer malformations, and improved organ development, as well as less oxidative stress. Furthermore, measurements of larval length and morphological scoring affirmed the protective role of humic acid and clay in promoting the normal growth of zebrafish. This study underscores the potential of environment modulators, such as humic acid and clay, as effective bioremediation agents against phthalate toxicity. The generation of reactive oxygen species (ROS), indicative of oxidative stress, was markedly higher in larvae treated solely with phthalates compared to the control. Conversely, larvae treated with a combination of phthalates and humic acid or clay exhibited a significant decrease in ROS generation, signaling a decline in oxidative stress. Histopathological analysis of adult fish subjected to various treatments revealed significant damage to vital organs like the liver and intestine when treated with phthalates alone. However, when phthalates were introduced with humic acid, clay, or both, the morphology closely resembled that of the control, reinforcing the protective role of humic acid and clay in zebrafish development against administered phthalates.
    MeSH term(s) Animals ; Zebrafish ; Diethylhexyl Phthalate/toxicity ; Clay ; Humic Substances ; Reactive Oxygen Species ; Larva ; Phthalic Acids/toxicity
    Chemical Substances phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C) ; Clay (T1FAD4SS2M) ; Humic Substances ; Reactive Oxygen Species ; Phthalic Acids
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2024.141756
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2540: Show issues Location:
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  2. Article ; Online: Fabrication, assessment, and potential anti-bacterial activity of sandalwood oil nanoemulsion and its hand rub sanitizer.

    Meghani, Nikita / Mansuri, Abdulkhalik / Chaudhari, Ramesh / Kumar, Ashutosh

    Environmental science and pollution research international

    2023  

    Abstract: In the last decade, extensive research has been performed on developing hand sanitizers that can be used to eradicate the diseases that are caused due to poor hand hygiene. Essential oils possess antibacterial and antifungal properties and thus have ... ...

    Abstract In the last decade, extensive research has been performed on developing hand sanitizers that can be used to eradicate the diseases that are caused due to poor hand hygiene. Essential oils possess antibacterial and antifungal properties and thus have great potential to replace the available antibacterial agents. In the present study, sandalwood oil-based nanoemulsion (NE) and sanitizer have been formulated and well characterized for their properties. Antibacterial activity was assessed using growth inhibition studies, agar cup, viability assay, etc. The sandalwood oil NE synthesized had oil to surfactant ratio of 1:0.5 (2.5% sandalwood oil and 0.5% Tween 80) and was observed to have a droplet diameter of 118.3 ± 0.92 nm, the zeta potential of - 18.8 ± 2.01 mV, and stability of 2 months. The antibacterial activity of sandalwood NE and sanitizer was evaluated against microorganisms. The antibacterial activity was assessed using the zone of inhibition value of sanitizer, which was in the range of 19 to 25 mm against all microorganisms. Morphological analysis showed distant changes in membrane shape and size and microorganisms' morphology. The synthesized NE was thermodynamically stable and efficient enough to be used in sanitizer, and the formulated sanitizer showed great antibacterial efficacy.
    Language English
    Publishing date 2023-04-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-26945-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Radiofrequency thermocoagulation of haemorrhoids: learning curve of a novel approach.

    Butnari, Valentin / Mansuri, Ahmer / Kaul, Sandeep / Shatkar, Veeranna / Boulton, Richard

    Journal of surgical case reports

    2023  Volume 2023, Issue 3, Page(s) rjad115

    Abstract: Haemorrhoidal disease (HD) is a common condition that often requires surgical treatment. In comparison with other traditional techniques, radiofrequency thermocoagulation (RFTC) has multiple advantages to traditional repairs and can be a good alternative ...

    Abstract Haemorrhoidal disease (HD) is a common condition that often requires surgical treatment. In comparison with other traditional techniques, radiofrequency thermocoagulation (RFTC) has multiple advantages to traditional repairs and can be a good alternative in surgical management of HD. We retrospectively analysed 20 patients with Grades 2 (
    Language English
    Publishing date 2023-03-17
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: New insight into long-term effects of phthalates microplastics in developing zebrafish: Evidence from genomic alteration and organ development.

    Mansuri, Abdulkhalik / Kansara, Krupa / Raiyani, Dixit / Mazmudar, Dhairya / Kumar, Ashutosh

    Environmental toxicology and pharmacology

    2023  Volume 99, Page(s) 104087

    Abstract: The plasticizer leaches from the microplastics are one of the significant concerns related to plastic pollution. These plasticizers are known to be endocrine disrupters; however, little is known about their long-term effect on the development of aquatic ... ...

    Abstract The plasticizer leaches from the microplastics are one of the significant concerns related to plastic pollution. These plasticizers are known to be endocrine disrupters; however, little is known about their long-term effect on the development of aquatic vertebrates. Hence, the present study has been conducted to provide a holistic understanding of the effect of the three most common plasticizers, dibutyl phthalate (DBP), diethyl phthalate (DEP), and di-ethylhexyl phthalate (DEHP) leaching out from the microplastics in zebrafish development. Zebrafish larvae were exposed to different phthalates at different concentrations. The phthalates have shown significantly higher mortality and morphological changes in the larva upon exposure compared to the control. A significant change in the genes related to cardiovascular development (krit1, fbn2b), dorsoventral axis development (chrd, smad5), tail formation (pkd2, wnt3a, wnt8a), and floorplate development (foxa2) were also observed under the effects of the phthalates in comparison to control.
    MeSH term(s) Animals ; Zebrafish/genetics ; Plasticizers/toxicity ; Plastics ; Microplastics ; Diethylhexyl Phthalate ; Phthalic Acids/toxicity ; Dibutyl Phthalate/toxicity ; Genomics ; Zebrafish Proteins/genetics ; Smad5 Protein
    Chemical Substances phthalic acid (6O7F7IX66E) ; Plasticizers ; Plastics ; Microplastics ; Diethylhexyl Phthalate (C42K0PH13C) ; Phthalic Acids ; Dibutyl Phthalate (2286E5R2KE) ; smad5 protein, zebrafish ; Zebrafish Proteins ; Smad5 Protein
    Language English
    Publishing date 2023-02-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1318302-3
    ISSN 1872-7077 ; 1382-6689
    ISSN (online) 1872-7077
    ISSN 1382-6689
    DOI 10.1016/j.etap.2023.104087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4490: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Development of food-grade antimicrobials of fenugreek oil nanoemulsion—bioactivity and toxicity analysis

    Mansuri, Abdulkhalik / Chaudhari, Ramesh / Nasra, Simran / Meghani, Nikita / Ranjan, Shivendu / Kumar, Ashutosh

    Environ Sci Pollut Res. 2023 Feb., v. 30, no. 10 p.24907-24918

    2023  

    Abstract: Antimicrobials of natural origin are proving to be an effective solution to emerging antimicrobial resistance and its physiological side effects. Recent studies have demonstrated that essential oils encapsulated in the form of nanoemulsions have better ... ...

    Abstract Antimicrobials of natural origin are proving to be an effective solution to emerging antimicrobial resistance and its physiological side effects. Recent studies have demonstrated that essential oils encapsulated in the form of nanoemulsions have better antimicrobial activity than the oil itself, possibly due to its high stability, solubility, sustained release, and increased bioavailability. In the present study, fenugreek oil—a well-known antimicrobial and antioxidant—has been used to fabricate nanoemulsion (NE), with an objective to meet potential alternative to synthesized antimicrobials. A combination of three different components, water, fenugreek oil, and Tween 80, has been used to prepare the nanoemulsions of different size and one of the most stable nanoemulsion with lowest concentration of surfactant Tween 80 was used to assess its bioactivity, antimicrobial properties, and toxicity against human hepatic cell line. Among all the formulations, nano-emulsion with 2.5% oil concentration, 30 min sonication (hydrodynamic size 135.2 nm, zeta potential 36.8 mV, PDI 0.135, and pH 5.12), was selected for all studies. The nanoemulsion showed potential antibacterial activity against all the microbial strains (Escherichia coli, Bacillus subtilis, Staphylococcus aureus, and Pseudomonas aeruginosa) used in this study. Interestingly, the nanoemulsion showed potential antibacterial activity against P. aeruginosa, known to show resistance against ampicillin. The toxicity evaluation in human hepatic cell line (WRL-68) indicated no significant toxicity of nanoemulsion up to the concentration of 800 µg/ml. The synthesized nanoemulsion thus has a translational potential as a food-grade non-toxic natural nanoantimicrobials.
    Keywords Bacillus subtilis ; Escherichia coli ; Pseudomonas aeruginosa ; Staphylococcus aureus ; ampicillin ; antibacterial properties ; antibiotic resistance ; bioavailability ; cell lines ; fenugreek ; humans ; hydrodynamics ; nanoemulsions ; oils ; pH ; polysorbates ; solubility ; sonication ; surfactants ; toxicity ; zeta potential
    Language English
    Dates of publication 2023-02
    Size p. 24907-24918.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-19116-y
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Stopping the Unstoppable: Unconventional Methods to Prevent the Biofilm Growth.

    Jain, Neha / Mansuri, Abdulkhalik

    Current drug discovery technologies

    2019  Volume 17, Issue 4, Page(s) 515–522

    Abstract: Biofilms are consortia of microorganisms encased in extracellular matrix that protect cells from adverse conditions. A biofilm matrix is typically composed of extracellular DNA, cellulose and proteinaceous amyloid fibers. The matrix aids in adhesion to ... ...

    Abstract Biofilms are consortia of microorganisms encased in extracellular matrix that protect cells from adverse conditions. A biofilm matrix is typically composed of extracellular DNA, cellulose and proteinaceous amyloid fibers. The matrix aids in adhesion to abiotic and biotic surface including medical devices and host tissues. The presence of biofilm makes bacteria more resilient and non-responsive to most current treatment regimes at disposal. Therefore, biofilm-associated infections are serious threat in hospital settings and pose a huge burden on economy. Inhibition of matrix components (cellulose and/or amyloid formation) has emerged as a lucrative alternative strategy to cure biofilm-related infections and combat antibiotic resistance. Here we review the current and emerging therapeutic interventions to mitigate persistent infections due to biofilms. The successful implementation of these interventions will have a huge impact on alleviating the current financial burden on healthcare services.
    Language English
    Publishing date 2019-07-29
    Publishing country United Arab Emirates
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1875-6220
    ISSN (online) 1875-6220
    DOI 10.2174/1570163816666190726153441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Laparoscopic right hemicolectomy with complete mesocolic excision and D3 lymphadenectomy using the open book approach: a video vignette.

    Butnari, Valentin / Mansuri, Ahmer / Momotaz, Sultana / Osilli, Dixon / Boulton, Richard / Huang, Joseph / Rajendran, Nirooshun / Kaul, Sandeep

    Journal of minimally invasive surgery

    2024  Volume 27, Issue 1, Page(s) 47–50

    Abstract: According to the concept of total mesorectal excision for rectal cancer, Hohenberger translated this concept to colonic cancer by introducing complete mesocolic excision (CME). The concept of this surgical technique was further elucidated by Benz et al. ... ...

    Abstract According to the concept of total mesorectal excision for rectal cancer, Hohenberger translated this concept to colonic cancer by introducing complete mesocolic excision (CME). The concept of this surgical technique was further elucidated by Benz et al. in the form of an open book approach. This article presents and demonstrates in a video a case of laparoscopic right hemicolectomy with CME and D3 lymphadenectomy using open book approach in the treatment of a T3N1M0 distal ascending colonic adenocarcinoma. The final pathology report confirmed moderately differentiated adenocarcinoma with a maximum tumor size of 55 mm and 0/60 lymph nodes. The mesocolic fascia was intact and R0 was achieved. The final staging was pT3pN0pM0. However, D3 lymphadenectomy is not universally adopted due to concerns of higher morbidity we believe that with adequate training and supervision CME with D3 LDN is feasible and safe to be offered to all right-sided colorectal cancers with curative intent treatment.
    Language English
    Publishing date 2024-03-16
    Publishing country Korea (South)
    Document type Journal Article
    ISSN 2234-5248
    ISSN (online) 2234-5248
    DOI 10.7602/jmis.2024.27.1.47
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Comparison of early surgical outcomes of robotic and laparoscopic colorectal cancer resection reported by a busy district general hospital in England.

    Butnari, Valentin / Sultana, Momotaz / Mansuri, Ahmer / Rao, Christopher / Kaul, Sandeep / Boulton, Richard / Huang, Joseph / Rajendran, Nirooshun

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9227

    Abstract: Robotic platforms provide a stable tool with high-definition views and improved ergonomics compared to laparoscopic approaches. The aim of this retrospective study was to compare the intra- and short-term postoperative results of oncological resections ... ...

    Abstract Robotic platforms provide a stable tool with high-definition views and improved ergonomics compared to laparoscopic approaches. The aim of this retrospective study was to compare the intra- and short-term postoperative results of oncological resections performed robotically (RCR) and laparoscopically (LCR) at a single centre. Between February 2020 and October 2022, retrospective data on RCR were compared to LCR undertaken during the same period. Parameters compared include total operative time, length of stay (LOS), re-admission rates, 30-day morbidity. 100 RCR and 112 LCR satisfied inclusion criteria. There was no difference between the two group's demographic and tumour characteristics. Overall, median operative time was shorter in LCR group [200 vs. 247.5 min, p < 0.005], but this advantage was not observed with pelvic and muti-quadrant resections. There was no difference in the rate of conversion [5(5%) vs. 5(4.5%), p > 0.95]. With respect to perioperative outcomes, there was no difference in the overall morbidity, or mortality between RCR and LCR, in particular requirement for blood transfusion [3(3%) vs. 5(4.5%), p 0.72], prolonged ileus [9(9%) vs. 15(13.2%), p 0.38], surgical site infections [5(4%) vs. 5(4.4%), p > 0.95], anastomotic leak [7(7%) vs. 5(4.4%), p 0.55], and re-operation rate [9(9%) vs. 7(6.3%), p 0.6]. RCR had shorter LOS by one night, but this did not reach statistical significance. No difference was observed in completeness of resection but there was a statically significant increase in lymph node harvest in the robotic series. Robotic approach to oncological colorectal resections is safe, with comparable intra- and peri-operative morbidity and mortality to laparoscopic surgery.
    MeSH term(s) Humans ; Laparoscopy/methods ; Robotic Surgical Procedures/methods ; Robotic Surgical Procedures/adverse effects ; Male ; Female ; Colorectal Neoplasms/surgery ; Colorectal Neoplasms/mortality ; Aged ; England/epidemiology ; Middle Aged ; Retrospective Studies ; Length of Stay ; Operative Time ; Treatment Outcome ; Hospitals, General ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Aged, 80 and over ; Hospitals, District ; Adult
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article ; Comparative Study
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57110-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Spatiotemporal dynamics of DNA nanocage uptake in zebrafish embryos for targeted tissue bioimaging applications.

    Kansara, Krupa / Mansuri, Abdulkhalik / Rajwar, Anjali / Vaswani, Payal / Singh, Ramesh / Kumar, Ashutosh / Bhatia, Dhiraj

    Nanoscale advances

    2023  Volume 5, Issue 9, Page(s) 2558–2564

    Abstract: Three-dimensional DNA nanocages have attracted significant attention for various biomedical applications including targeted ... ...

    Abstract Three-dimensional DNA nanocages have attracted significant attention for various biomedical applications including targeted bioimaging
    Language English
    Publishing date 2023-04-17
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d2na00905f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Late-Onset Hyponatremia in Premature Infants.

    Marin, Terri / Dowell, Samuel H / Wright, Kristen / Mansuri, Asifhusen / Mann, Paul C

    The Journal of perinatal & neonatal nursing

    2023  Volume 37, Issue 4, Page(s) 325–331

    Abstract: Late-onset hyponatremia (LOH) frequently affects premature infants 2 or more weeks of age due to inadequate sodium intake and excessive kidney loss. Late-onset hyponatremia typically occurs in infants who are physiologically stable and is defined as ... ...

    Abstract Late-onset hyponatremia (LOH) frequently affects premature infants 2 or more weeks of age due to inadequate sodium intake and excessive kidney loss. Late-onset hyponatremia typically occurs in infants who are physiologically stable and is defined as serum sodium of 132 mEq/L or less or between 133 and 135 mEq/L if receiving sodium supplementation. Recent evidence suggests that spot urine sodium levels may improve the recognition of LOH, as low levels of excreted urine reflect a total body sodium deficit and negative balance. Untreated LOH may result in poor somatic growth, neurodevelopmental delay, higher incidence of bronchopulmonary dysplasia, and more severe retinopathy of prematurity. The primary prevention of LOH is to maintain serum sodium between 135 and 145 mEq/L; however, there are currently no formal protocols guiding sodium supplementation. The purpose of this article is to present on overview of LOH pathophysiology and its effect on somatic growth, neurodevelopment outcomes, and other related sequelae. We further discuss general management strategies and describe a protocol for sodium supplementation that is presently undergoing an evaluation for effectiveness.
    MeSH term(s) Humans ; Infant ; Infant, Newborn ; Bronchopulmonary Dysplasia ; Hyponatremia/diagnosis ; Hyponatremia/etiology ; Hyponatremia/therapy ; Infant, Premature ; Sodium
    Chemical Substances Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1036365-8
    ISSN 1550-5073 ; 0893-2190
    ISSN (online) 1550-5073
    ISSN 0893-2190
    DOI 10.1097/JPN.0000000000000737
    Database MEDical Literature Analysis and Retrieval System OnLINE

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