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Article ; Online: Conditional uncertainty: Misinterpretations of "significant" p values.

Messinger Cayetano, Shari / Mantero, Alejandro

2021 Volume 36, Issue 11, Page(s) 4332–4334

Abstract: Misapplication of p values can lead to very misleading conclusions. The frequent insignificance of a "significant" p ... ...

Abstract	Misapplication of p values can lead to very misleading conclusions. The frequent insignificance of a "significant" p value
MeSH term(s)	Humans ; Probability ; Research Design ; Uncertainty
Language	English
Publishing date	2021-08-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	639059-6
ISSN	1540-8191 ; 0886-0440
ISSN (online)	1540-8191
ISSN	0886-0440
DOI	10.1111/jocs.15963
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Zs.A 2221: Show issues

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Article: Unsupervised random forests.

Mantero, Alejandro / Ishwaran, Hemant

Statistical analysis and data mining

2021 Volume 14, Issue 2, Page(s) 144–167

Abstract: sidClustering is a new random forests unsupervised machine learning algorithm. The first step in sidClustering involves what is called sidification of the features: staggering the features to have mutually exclusive ranges (called the staggered ... ...

Abstract	sidClustering is a new random forests unsupervised machine learning algorithm. The first step in sidClustering involves what is called sidification of the features: staggering the features to have mutually exclusive ranges (called the staggered interaction data [SID] main features) and then forming all pairwise interactions (called the SID interaction features). Then a multivariate random forest (able to handle both continuous and categorical variables) is used to predict the SID main features. We establish uniqueness of sidification and show how multivariate impurity splitting is able to identify clusters. The proposed sidClustering method is adept at finding clusters arising from categorical and continuous variables and retains all the important advantages of random forests. The method is illustrated using simulated and real data as well as two in depth case studies, one from a large multi-institutional study of esophageal cancer, and the other involving hospital charges for cardiovascular patients.
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2416076-3
ISSN	1932-1872 ; 1932-1864
ISSN (online)	1932-1872
ISSN	1932-1864
DOI	10.1002/sam.11498
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Article ; Online: Increasing Rates of Pancreatic and Hepatocellular Cancers Parallel Increasing Obesity Rates.

Kumar, Shria / Moghaddam, Saltenat / Goldberg, David S / Mantero, Alejandro / Crane, Tracy E

Pancreas

2023 Volume 51, Issue 9, Page(s) 1116–1117

Abstract: Objectives: Gastrointestinal (GI) cancers are now the second leading cause of cancer death in the United States, and six are convincingly associated with obesity. We interrogate the association of a state's obesity prevalence with cancer incidence.: ... ...

Abstract	Objectives: Gastrointestinal (GI) cancers are now the second leading cause of cancer death in the United States, and six are convincingly associated with obesity. We interrogate the association of a state's obesity prevalence with cancer incidence. Methods: We use data from US Cancer Statistics for each of the 6 cancers of interest from 2011 to 2018. Age-adjusted incidences were calculated, and the Behavioral Risk Factor Surveillance System was used to identify prevalence of obesity in each state. A generalized estimating equation model was used to relate the rate of cancer with the rate of obesity. Results: Increased state-level prevalence of obesity was significantly associated with increasing state-level incidence of pancreatic and hepatocellular cancers. The rate of colorectal cancer was not associated with increasing obesity in 2011-2014 but from 2015 to 2018 was inversely associated with increasing rates of obesity. State-level prevalence of obesity was not associated with esophageal, gastric, or gallbladder cancers. Conclusions: Weight management interventions may reduce risk of pancreatic and hepatocellular cancers.
MeSH term(s)	Humans ; United States/epidemiology ; Liver Neoplasms/epidemiology ; Carcinoma, Hepatocellular/epidemiology ; Obesity/complications ; Obesity/epidemiology ; Gastrointestinal Neoplasms/epidemiology ; Incidence ; Risk Factors
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000002153
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Article: Contextualizing covid-19 spread: a county level analysis, urban versus rural, and implications for preparing for the next wave.

Rao, J Sunil / Zhang, Hang / Mantero, Alejandro

medRxiv : the preprint server for health sciences

2020

Abstract: Paraphrasing [Morano and Holt, 2017], contextual determinants of health including social, environmental, healthcare and others, are a so-called deck of cards one is dealt. The ability to modify health outcomes varies then based upon how one's hand is ... ...

Abstract	Paraphrasing [Morano and Holt, 2017], contextual determinants of health including social, environmental, healthcare and others, are a so-called deck of cards one is dealt. The ability to modify health outcomes varies then based upon how one's hand is played. It is thus of great interest to understand how these determinants associate with the emerging pandemic covid-19. To this end, we conducted a deep-dive analysis into this problem using a recently curated public dataset on covid-19 that connects infection spread over time to a rich collection of contextual determinants for all counties of the U.S and Washington, D.C. Using random forest machine learning methodology, we identified a relevant constellation of contextual factors of disease spread which manifest differently for urban and rural counties. The findings also have clear implications for better preparing for the next wave of disease.
Keywords	covid19
Language	English
Publishing date	2020-04-29
Publishing country	United States
Document type	Preprint
DOI	10.1101/2020.04.24.20078204
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Article ; Online: Use of Livers With Fibrosis Based on Donor Hospital Biopsy: Missed Opportunities?

Narasimman, Manasa / Mantero, Alejandro / Ronquillo, Nemencio / Chyou, Darius / Goldberg, David

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

2021 Volume 28, Issue 4, Page(s) 717–721

MeSH term(s)	Biopsy ; Fibrosis ; Hospitals ; Humans ; Liver/pathology ; Liver/surgery ; Liver Transplantation/adverse effects
Language	English
Publishing date	2021-11-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2006866-9
ISSN	1527-6473 ; 1527-6465
ISSN (online)	1527-6473
ISSN	1527-6465
DOI	10.1002/lt.26335
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Zs.A 4702: Show issues

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Article ; Online: Frontal lobe position after single-layer cadaveric dermal matrix repair of large anterior skull base defects.

Levine, Corinna G / Al-Rasheedi, Abdullah N / Mantero, Alejandro / Al-Bar, Mohammad / Casiano, Roy R

World journal of otorhinolaryngology - head and neck surgery

2022 Volume 8, Issue 1, Page(s) 36–41

Abstract: Objective: Endoscopic repair of large anterior skull base (ASB) defects has excellent results when using multilayered repairs with a nasoseptal flap. However, in extensive intranasal tumors, a nasoseptal flap may not always be available. One alternative ...

Abstract	Objective: Endoscopic repair of large anterior skull base (ASB) defects has excellent results when using multilayered repairs with a nasoseptal flap. However, in extensive intranasal tumors, a nasoseptal flap may not always be available. One alternative option is a flexible single-layer ASB repair. Initial studies indicate low cerebrospinal fluid leak rates with a single-layer repair. However, the level of frontal lobe support, particularly the propensity for a significant inferior displacement of the frontal lobe, is not known. The goal of this study is to determine the frontal lobe position after single-layer acellular dermal allograft repair in large ASB defects. Study design: Retrospective cohort study. Setting: Tertiary care medical center. Subjects and methods: This cohort study compares the frontal lobe position in adults who underwent endoscopic endonasal ASB tumor resection and single-layer cadaveric dermal matrix repair (ASB cohort) with control subjects without intracranial abnormalities (control cohort). The ASB cohort includes subjects with an ASB defect of ≥5 cm anterior/posterior and ≥1.5 cm wide and who had imaging at least 2 months after surgery. The frontal lobe position is measured on sagittal CT/MRI using a reference line from the base of the sella to the nasion. A value of zero indicates that the inferior-most aspect of the frontal lobe is at the level of the nasion-sellar line. A positive value indicates that the frontal lobe is inferior to the nasion-sellar line. The ASB cohort frontal lobe position is compared with the control cohort using the Mann-Whitney Results: The ASB cohort includes 47 subjects who are 57% male with an average age of 60 years (range: 31-89 years). The most common ASB pathology is esthesioneuroblastoma ( Conclusions: Single-layer acellular dermal graft repair maintains frontal lobe support and position in large ASB defects.
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Journal Article
ISSN	2589-1081
ISSN (online)	2589-1081
DOI	10.1002/wjo2.23
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Article ; Online: Mechanisms of energy dissipation and relationship with tissue composition in human meniscus.

Morejon, A / Mantero, A M A / Best, T M / Jackson, A R / Travascio, F

Osteoarthritis and cartilage

2022 Volume 30, Issue 4, Page(s) 605–612

Abstract: Objective: The human meniscus is essential in maintaining proper knee joint function. The meniscus absorbs shock, distributes loads, and stabilizes the knee joint to prevent the onset of osteoarthritis. The extent of its shock-absorbing role can be ... ...

Abstract	Objective: The human meniscus is essential in maintaining proper knee joint function. The meniscus absorbs shock, distributes loads, and stabilizes the knee joint to prevent the onset of osteoarthritis. The extent of its shock-absorbing role can be estimated by measuring the energy dissipated by the meniscus during cyclic mechanical loading. Methods: Samples were prepared from the central and horn regions of medial and lateral human menisci from 8 donors (both knees for total of 16 samples). Cyclic compression tests at several compression strains and frequencies yielded the energy dissipated per tissue volume. A GEE regression model was used to investigate the effects of compression, meniscal side and region, and water content on energy dissipation in order to account for repeated measures within samples. Results: Energy dissipation by the meniscus increased with compressive strain from ∼0.1 kJ/m Conclusion: The extent of energy dissipated by the meniscus is inversely related to loading frequency and meniscal water content.
MeSH term(s)	Humans ; Knee ; Knee Joint ; Menisci, Tibial ; Meniscus ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2022-01-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1167809-4
ISSN	1522-9653 ; 1063-4584
ISSN (online)	1522-9653
ISSN	1063-4584
DOI	10.1016/j.joca.2022.01.001
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Zs.A 3828: Show issues

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Article: Early Detection of Myocardial Damage: A Multimodality Approach.

Novo, Giuseppina / Nugara, Cinzia / Fava, Antonella / Mantero, Antonio / Citro, Rodolfo

Journal of cardiovascular echography

2020 Volume 30, Issue Suppl 1, Page(s) S4–S10

Abstract: Cardiovascular diseases are possible complications of antineoplastic treatment and may lead to premature morbidity and mortality among cancer survivors. A symptom-based follow-up is ineffective, and there are growing evidences that early detection of ... ...

Abstract	Cardiovascular diseases are possible complications of antineoplastic treatment and may lead to premature morbidity and mortality among cancer survivors. A symptom-based follow-up is ineffective, and there are growing evidences that early detection of myocardial damage in patients treated with antineoplastic drugs is the key point to prevent the occurrence of damage and improve the prognosis of these patients. Different techniques have been proposed to monitor cardiac function in oncologic patients such as cardiac imaging (echocardiography, nuclear imaging, and cardiac magnetic resonance) and biomarkers (troponin and natriuretic peptides). The European Association of Cardiovascular Imaging/American Society of Echocardiography consensus document encourages an integrated approach to early detect cardiotoxicity.
Language	English
Publishing date	2020-04-10
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2734045-4
ISSN	2347-193X ; 2211-4122
ISSN (online)	2347-193X
ISSN	2211-4122
DOI	10.4103/jcecho.jcecho_2_19
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Article ; Online: Rapid improvement in organ procurement organization performance: Potential for change and impact of new leadership.

Niroomand, Elaheh / Mantero, Alejandro / Narasimman, Manasa / Delgado, Cindy / Goldberg, David

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2020 Volume 20, Issue 12, Page(s) 3567–3573

Abstract: Recently proposed rulemaking from Centers for Medicare and Medicaid Services would change how organ procurement organizations (OPOs) are evaluated. The proposals include using national inpatient death data to define a standardized denominator to ... ...

Abstract	Recently proposed rulemaking from Centers for Medicare and Medicaid Services would change how organ procurement organizations (OPOs) are evaluated. The proposals include using national inpatient death data to define a standardized denominator to calculate comparable donation rates among OPOs. Based on these objective metrics, OPOs not performing at a prespecified threshold will be required to rapidly improve performance to avoid decertification. We sought to determine whether rapid OPO improvement was possible based on objective donation metrics, and whether leadership change was associated with rapid improvement. We evaluated United Network for Organ Sharing and Centers for Disease Control and Prevention (CDC) data from 2011 to 2018, and measured donation rates using CDC data on inpatient deaths from causes consistent with donation, based on the location of deaths. During the two 4-year cycles, we found that an OPO's ranking relative to other OPOs was fairly static, with more than 90% of the OPOs at risk of flagging at the end of each 4-year cycle (2014, 2018) being in the bottom 75% of OPOs in the preceding 3 years. In multivariable logistic regression models, leadership changes were only statistically significantly associated with an improvement in OPO rankings during the 2011-2014 cycle. These data demonstrate that rapid improvements in OPO performance are uncommon, and while leadership changes increase the odds of rapid improvement, they do not guarantee improvement.
MeSH term(s)	Aged ; Centers for Medicare and Medicaid Services, U.S. ; Humans ; Leadership ; Medicare ; Tissue Donors ; Tissue and Organ Procurement ; United States
Language	English
Publishing date	2020-07-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16085
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Zs.A 5542: Show issues

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Article: Eastern European and Asian-born populations are prone to gastric cancer: an epidemiologic analysis of foreign-born populations and gastric cancer.

Kumar, Shria / Mantero, Alejandro / Delgado, Cindy / Dominguez, Barbara / Nuchovich, Nadine / Goldberg, David S

Annals of gastroenterology

2021 Volume 34, Issue 5, Page(s) 669–674

Abstract: Background: The highest incidence of gastric cancer is in East Asia, corresponding to a high prevalence of : Methods: We evaluated total and foreign-born populations in metropolitan statistical areas (MSAs). Cardia and non-cardia gastric ... ...

Abstract	Background: The highest incidence of gastric cancer is in East Asia, corresponding to a high prevalence of Methods: We evaluated total and foreign-born populations in metropolitan statistical areas (MSAs). Cardia and non-cardia gastric adenocarcinomas diagnosed between 2006 and 2016 were identified using the Surveillance, Epidemiology, and End Results Program. Generalized linear regression models determined whether the incidence of gastric cancer in each MSA was associated with specific foreign-born populations. Results: Among 32 MSAs, we identified 55,937 patients with gastric adenocarcinoma. A greater percentage of Eastern European-born individuals in an MSA was associated with a higher incidence of cardia cancers (coefficient 1.32, P=0.02). Evaluating Asian-born populations alone, a greater percentage of Japanese-born individuals was associated with a higher incidence of non-cardia cancers (coefficient 2.48, P=0.03), whereas Korean or Chinese origin was not associated with a significantly higher risk. Conclusions: On a population level, a greater percentage of Eastern European-born individuals is associated with a higher incidence of cardia gastric adenocarcinomas. Among Asian-born individuals, Korean or Chinese origin was not associated with a significantly higher risk, but a greater percent of persons born in other Asian countries, including Japan, was associated with a higher incidence of non-cardia gastric adenocarcinomas in an MSA.
Language	English
Publishing date	2021-06-03
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2032850-3
ISSN	1108-7471
ISSN	1108-7471
DOI	10.20524/aog.2021.0640
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Zs.A 2455: Show issues

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