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Article ; Online: Nerve Growth Factor and Brain-Derived Neurotrophic Factor as Potential Biomarkers of Mirabegron Efficacy in Patients with Overactive Bladder Syndrome.

Beta, Anastasia / Giannouli, Aikaterini / Rizos, Demetrios / Mantzou, Aimilia / Deligeoroglou, Efthymios / Bakas, Panagiotis

International urogynecology journal

2024

Abstract: Introduction: Overactive Bladder Syndrome (OAB) significantly impacts quality of life, necessitating improved diagnostic tools and treatment monitoring. This study explores the potential of neurotrophins, nerve growth factor (NGF), and brain-derived ... ...

Abstract	Introduction: Overactive Bladder Syndrome (OAB) significantly impacts quality of life, necessitating improved diagnostic tools and treatment monitoring. This study explores the potential of neurotrophins, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) as urinary biomarkers in patients with OAB undergoing mirabegron therapy, a β3-adrenergic agonist. This investigation is aimed at providing insights into the potential of neurotrophins to enhance OAB diagnosis and assess treatment efficacy. Materials and methods: Urinary NGF and BDNF levels were measured in 15 healthy controls and 30 patients with OAB. Patients were treated with mirabegron 50 mg once daily. Urinary NGF and BDNF levels were measured by enzyme-linked immunosorbent assay method and normalized by urinary creatinine levels (NGF/Cre and BDNF/Cre). The urinary NGF/Cre and BDNF/Cre levels were compared between controls and patients with OAB and subsequently at baseline and 3 months after mirabegron treatment. Treatment efficacy was assessed with the Indevus Urgency Severity Scale (IUSS) questionnaire. Results: Urinary NGF/Cre and BDNF/Cre levels were significantly higher in patients with OAB than in the controls (p < 0.001 and p = 0.03 respectively). Moreover, NGF/Cre and BDNF/Cre levels significantly decreased post-mirabegron treatment (p < 0.001 and p = 0.005 respectively). Patients with improvement of OAB symptoms after treatment showed lower levels of NGF/Cre at the 3-month evaluation than those with no improvement (p = 0.05). Conclusion: Although both NGF/Cre and BDNF/Cre levels were significantly decreased after mirabegron treatment, only NGF/Cre levels were associated with treatment response.
Language	English
Publishing date	2024-05-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1050631-7
ISSN	1433-3023 ; 0937-3462
ISSN (online)	1433-3023
ISSN	0937-3462
DOI	10.1007/s00192-024-05809-0
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Article: Association of Plasma Irisin Levels with Circulating Endothelial Microparticles (EMPs) and Endothelial Progenitor Cells (EPCs) in Children Born Prematurely.

Markopoulou, Panagiota / Koutroumpa, Arsinoi / Mantzou, Aimilia / Margeli, Alexandra / Papanikolaou, Eleni / Siahanidou, Tania

Metabolites

2023 Volume 13, Issue 1

Abstract: Prematurity has been linked with endothelial dysfunction in later life. The purpose of this study was to evaluate the association between plasma irisin, an adipomyokine reported to protect the functional integrity of vascular endothelium, and circulating ...

Abstract	Prematurity has been linked with endothelial dysfunction in later life. The purpose of this study was to evaluate the association between plasma irisin, an adipomyokine reported to protect the functional integrity of vascular endothelium, and circulating endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs), consisting early biomarkers of endothelial dysfunction, in preterm-born children. We studied 131 prepubertal children; 61 preterm and 70 born at term (controls). Plasma irisin was determined by ELISA. Circulating CD62E(+), CD144(+) and CD31(+)/CD42b(-) EMPs, and CD34(+)/VEGFR-2(+)/CD45(-) and CD34(+)/VEGFR-2(+)/CD45dim EPCs, were determined by flow cytometry. Body mass index, waist-to-hip ratio, neck circumference, systolic and diastolic blood pressure, and biochemical parameters (glucose, lipids, insulin, HOMA-IR) were also evaluated. Plasma irisin was significantly lower (
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13010120
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Article: Neuroendocrine System Adaptation during Consecutive Extrinsic Stimuli: A Pilot Dynamic Study.

Geronikolou, Styliani A / Vasdekis, Vasilis / Mantzou, Aimilia / Davos, Constantinos / Cokkinos, Dennis V / Chrousos, George P

Children (Basel, Switzerland)

2023 Volume 10, Issue 2

Abstract: This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic-pituitary-adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive ... ...

Abstract	This pilot repeated measures study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic-pituitary-adrenal (HPA) axis, and/or their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. Twenty healthy schoolchildren and adolescents aged 11-14 years (12.5 ± 1.5) were consecutively exposed to an oral task (#2) and an arithmetic task (#3) (Trier Social Stress Test for Children (TSST-C)), lasting 5 min each, and a three-minute cellular phone call (#4). Salivary cortisol (SC) was sampled at baseline (#1) and immediately after each exposure (#2, 3, and 4). Baseline serum high-sensitivity C-reactive protein (hsCRP) and cortisol levels were also assessed. ANS dynamics and complexity were measured using Sample Entropy (SampEn) at each experimental time period (#1-4). Baseline serum hCRP and cortisol correlated negatively to each other, while the ANS and HPA axis acute reactions to the three consecutive stimuli differed over time. The ANS adaptation to these stimuli included complexity modulation, which was not dependent on baseline hsCRP or cortisol, and weakened during the third stimulation. However, baseline hsCRP and cortisol had a weakening and an increasing effect on the HPA axis over time, respectively. We conclude that low-level inflammation and baseline morning cortisol level have no effect on ANS dynamics but influence the HPA axis response to consecutive external stimuli.
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10020248
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Article: High frequency of autoimmune thyroiditis in euthyroid girls with premature adrenarche.

Kyritsi, Eleni Magdalini / Vasilakis, Ioannis-Anargyros / Kosteria, Ioanna / Mantzou, Aimilia / Gryparis, Alexandros / Kassi, Eva / Kaltsas, Gregory / Kanaka-Gantenbein, Christina

Frontiers in pediatrics

2023 Volume 11, Page(s) 1064177

Abstract: Objective: The purpose of this study was to investigate the frequency of autoimmune thyroiditis (AT) among euthyroid prepubertal girls presenting with premature adrenarche (PA). We also aimed to identify the clinical, metabolic, and endocrine profile of ...

Abstract	Objective: The purpose of this study was to investigate the frequency of autoimmune thyroiditis (AT) among euthyroid prepubertal girls presenting with premature adrenarche (PA). We also aimed to identify the clinical, metabolic, and endocrine profile of girls with AT and concurrent PA and compare them to girls with AT without PA, PA alone and healthy controls. Methods: Ninety-one prepubertal girls aged 5-10 years, who attended our department for AT, PA and normal variants of growth and puberty were recruited for the study: 73 girls had PA, 6 AT without PA and 12 were referred for investigation of growth. All girls underwent clinical examination, detailed biochemical and hormonal screen. Standard dose Synachten stimulation test (SDSST) and oral glucose tolerance test (OGTT) were performed in all girls with PA. The whole study population was divided in 4 groups: Group PA-/AT+ included 6 girls with AT without PA; Group PA+/AT- PA subjects without AT; Group PA+/AT+ girls with PA and concomitant AT; Group PA-/AT- twelve healthy girls without PA nor AT (controls). Results: Among 73 girls presenting with PA 19 had AT (26%). BMI, systolic blood pressure (SBP) and the presence of goiter significantly differed between the four groups ( Conclusion: A high frequency of AT among euthyroid prepubertal girls with PA was observed. The combination of PA with AT even in euthyroid state may be associated with a greater degree of insulin resistance, than PA alone.
Language	English
Publishing date	2023-03-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2023.1064177
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Article ; Online: Differences in segmental hair cortisol concentration analysis among children and adolescents with overweight and obesity, their parents, and normal weight peers.

Kitani, Rosa-Anna / Nicolaides, Nicolas C / Mantzou, Aimilia / Chatzidaki, Evi / Michou, Maria / Polychronaki, Nektaria / Letsou, Konstantina / Pervanidou, Panagiota / Kanaka-Gantenbein, Christina

Hormones (Athens, Greece)

2023 Volume 22, Issue 4, Page(s) 623–632

Abstract: Purpose: Dysregulation of the stress system via incidental long exposure to glucocorticoids (GCs) can lead to weight gain. In addition, family and maternal stress can also have an impact on children's weight. Hair is used in several studies to evaluate ... ...

Abstract	Purpose: Dysregulation of the stress system via incidental long exposure to glucocorticoids (GCs) can lead to weight gain. In addition, family and maternal stress can also have an impact on children's weight. Hair is used in several studies to evaluate cortisol (GC) levels in children and adolescents with excess weight as a retrospective stress biomarker, depending on the hair length the cortisol measurement depicting different time periods. We aimed to investigate whether there is a difference among segmental hair cortisol concentration (HCC) analysis between children and adolescents with overweight and obesity, their mothers, and normal weight peers. Methods: This study recruited 25 children aged 6-14 years with a body mass index (BMI) ≥ 85th centile and their mothers, as well as 20 children of the same age with a BMI < 85th centile. Hair cortisol concentration was measured using electrochemiluminescence immunoassay. Results: Segmental HCC analysis exhibited gradually decreasing values in all participants as segments of hair were more distantly located from the scalp. A positive correlation was found between BMI z-score and HCC of the first segment of hair in children and adolescents with elevated BMI (b = 1.84, p = 0.033), as well as with maternal HCC / of an only child (b = 15.77, p = 0.01). There were no associations between mother-child dyads and children and adolescents of different BMI groups, even though minors with excess weight exhibited higher HCC levels in all segments of hair in comparison to their normal weight counterparts. Conclusions: Hair cortisol of all participants exhibited a gradually declining concentration. More studies with larger samples and more sensitive methods of analysis are warranted in order to draw firmer conclusions.
MeSH term(s)	Humans ; Adolescent ; Overweight ; Hydrocortisone/analysis ; Retrospective Studies ; Obesity ; Hair/chemistry ; Parents ; Weight Gain
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2023-09-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2075912-5
ISSN	2520-8721 ; 1109-3099
ISSN (online)	2520-8721
ISSN	1109-3099
DOI	10.1007/s42000-023-00482-2
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Article ; Online: Diurnal production of cortisol and prediction of treatment response in rheumatoid arthritis: a 6-month, real-life prospective cohort study.

Yavropoulou, Maria P / Filippa, Maria G / Vlachogiannis, Nikolaos I / Fragoulis, George E / Laskari, Katerina / Mantzou, Aimilia / Panopoulos, Stylianos / Fanouriakis, Antonis / Bournia, Vasiliki-Kalliopi / Evangelatos, Gerasimos / Papapanagiotou, Aggeliki / Tektonidou, Maria G / Chrousos, George P / Sfikakis, Petros P

RMD open

2024 Volume 10, Issue 1

Abstract: Objectives: A reduced adrenal reserve-associated cortisol production relative to the enhanced needs of chronic inflammation (: Methods: Diurnal cortisol production (measured at: 08-12:00/18:00-22:00) was assessed by electrochemiluminescence ... ...

Abstract	Objectives: A reduced adrenal reserve-associated cortisol production relative to the enhanced needs of chronic inflammation ( Methods: Diurnal cortisol production (measured at: 08-12:00/18:00-22:00) was assessed by electrochemiluminescence immunoassay in 28 consecutive patients with moderately/highly active RA, as well as 3 and 6 months after treatment initiation or/escalation. Twenty-eight COVID-19 patients and 28 age-matched healthy individuals (HC) served as controls. Results: Saliva diurnal cortisol production in patients with RA was similar to that of HC, despite 12-fold higher serum C reactive protein (CRP) levels, and lower than COVID-19 patients (area under the curve: RA: 87.0±37.6 vs COVID-19: 146.7±14.3, p<0.001), having similarly high CRP. Moreover, a disturbed circadian cortisol rhythm at baseline was evident in 15 of 28 of patients with RA vs 4 of 28 and 20 of 28 of HC and COVID-19 patients, respectively. Treatment-induced minimal disease activity (MDA) at 6 months was achieved by 16 of 28 patients. Despite comparable demographics and clinical characteristics at baseline, non-MDA patients had lower baseline morning cortisol and higher adrenocorticotropic hormone (ACTH) levels compared with patients on MDA (cortisol: 10.9±4.0 vs 18.4±8.2 nmol/L, respectively, p=0.005 and ACTH: 4.8±3.3 vs 2.4±0.4 pmol/L, respectively, p=0.047). Baseline morning cortisol <13.9 nmol/L predicted non-MDA at 6 months (75% sensitivity, 92% specificity, p=0.006). Prospective measurements revealed that individualised diurnal cortisol production remained largely unchanged from baseline to 3 and 6 months. Conclusions: An impaired adrenal reserve is present in patients with RA. Further studies to confirm that assessment of diurnal cortisol production may be useful in guiding treatment decisions and/or predicting treatment response in RA are warranted. Trial registration number: NCT05671627.
MeSH term(s)	Humans ; Hydrocortisone/metabolism ; Prospective Studies ; Arthritis, Rheumatoid/drug therapy ; Adrenocorticotropic Hormone/metabolism ; Adrenocorticotropic Hormone/pharmacology ; COVID-19
Chemical Substances	Hydrocortisone (WI4X0X7BPJ) ; Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2812592-7
ISSN	2056-5933 ; 2056-5933
ISSN (online)	2056-5933
ISSN	2056-5933
DOI	10.1136/rmdopen-2023-003575
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Article: Measurement of Calprotectin and PTH in the Amniotic Fluid of Early Second Trimester Pregnancies and Their Impact on Fetuses with Growth Disorders: Are Their Levels Related to Oxidative Stress?

Maroudias, George / Vrachnis, Dionysios / Fotiou, Alexandros / Loukas, Nikolaos / Mantzou, Aimilia / Pergialiotis, Vasileiοs / Valsamakis, George / Machairiotis, Nikolaos / Stavros, Sofoklis / Panagopoulos, Periklis / Vakas, Panagiotis / Kanaka-Gantenbein, Christina / Drakakis, Petros / Vrachnis, Nikolaos

Journal of clinical medicine

2024 Volume 13, Issue 3

Abstract: ... ...

Abstract	Background
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13030855
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Article: Second Trimester Amniotic Fluid Angiotensinogen Levels Linked to Increased Fetal Birth Weight and Shorter Gestational Age in Term Pregnancies.

Vrachnis, Dionysios / Fotiou, Alexandros / Mantzou, Aimilia / Pergialiotis, Vasilios / Antsaklis, Panagiotis / Valsamakis, George / Stavros, Sofoklis / Machairiotis, Nikolaos / Iavazzo, Christos / Kanaka-Gantenbein, Christina / Mastorakos, George / Drakakis, Petros / Vrachnis, Nikolaos / Antonakopoulos, Nikolaos

Life (Basel, Switzerland)

2024 Volume 14, Issue 2

Abstract: Background: Despite the considerable progress made in recent years in fetal assessment, the etiology of fetal growth disturbances is not as yet well understood. In an effort to enhance our knowledge in this area, we investigated the associations of the ... ...

Abstract	Background: Despite the considerable progress made in recent years in fetal assessment, the etiology of fetal growth disturbances is not as yet well understood. In an effort to enhance our knowledge in this area, we investigated the associations of the amniotic fluid angiotensinogen of the renin-angiotensin system with fetal growth abnormalities. Methods: We collected amniotic fluid samples from 70 pregnant women who underwent amniocentesis during their early second trimester. Birth weight was documented upon delivery, after which the embryos corresponding to the respective amniotic fluid samples were categorized into three groups as follows: small for gestational age (SGA), appropriate for gestational age (AGA), and large for gestational age (LGA). Amniotic fluid angiotensinogen levels were determined by using ELISA kits. Results: Mean angiotensinogen values were 3885 ng/mL (range: 1625-5375 ng/mL), 4885 ng/mL (range: 1580-8460 ng/mL), and 4670 ng/mL (range: 1995-7250 ng/mL) in the SGA, LGA, and AGA fetuses, respectively. The concentrations in the three groups were not statistically significantly different. Although there were wide discrepancies between the mean values of the subgroups, the large confidence intervals in the three groups negatively affected the statistical analysis. However, multiple regression analysis revealed a statistically significant negative correlation between the angiotensinogen levels and gestational age and a statistically significant positive correlation between the birth weight and angiotensinogen levels. Discussion: Our findings suggest that fetal growth abnormalities did not correlate with differences in the amniotic fluid levels of angiotensinogen in early second trimester pregnancies. However, increased angiotensinogen levels were found to be consistent with a smaller gestational age at birth and increased BMI of neonates.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14020206
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Article ; Online: Coagulation Profile in Neonates with Congenital Heart Disease: A Pilot Study.

Papadogeorgou, Paraskevi / Valsami, Serena / Boutsikou, Maria / Pergantou, Eleni / Mantzou, Aimilia / Papassotiriou, Ioannis / Iliodromiti, Zoi / Sokou, Rozeta / Bouza, Elena / Politou, Marianna / Iacovidou, Nicoletta / Boutsikou, Theodora

Medicina (Kaunas, Lithuania)

2024 Volume 60, Issue 2

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Infant, Newborn ; Child ; Humans ; Infant ; von Willebrand Factor/metabolism ; ADAMTS13 Protein ; Pilot Projects ; Heart Defects, Congenital/complications ; Hemostatics
Chemical Substances	von Willebrand Factor ; ADAMTS13 Protein (EC 3.4.24.87) ; Hemostatics
Language	English
Publishing date	2024-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina60020268
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Article ; Online: Serum Neuron-Specific Enolase as a Biomarker of Neonatal Brain Injury-New Perspectives for the Identification of Preterm Neonates at High Risk for Severe Intraventricular Hemorrhage.

Metallinou, Dimitra / Karampas, Grigorios / Pavlou, Maria-Loukia / Louma, Maria-Ioanna / Mantzou, Aimilia / Sarantaki, Antigoni / Nanou, Christina / Gourounti, Kleanthi / Tzeli, Maria / Pantelaki, Nikoletta / Tzamakos, Evangelos / Boutsikou, Theodora / Lykeridou, Aikaterini / Iacovidou, Nicoletta

Biomolecules

2024 Volume 14, Issue 4

Abstract: Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case-control study aimed at investigating the levels and prognostic value of serum neuron- ...

Abstract	Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case-control study aimed at investigating the levels and prognostic value of serum neuron-specific enolase (NSE) during the first 3 days of life in preterm neonates (<34 weeks) that later developed brain injury in the form of either periventricular leukomalacia (PVL) or intraventricular hemorrhage (IVH) during their hospitalization. Participants were recruited from one neonatal intensive care unit, and on the basis of birth weight and gestational age, we matched each case (
MeSH term(s)	Humans ; Phosphopyruvate Hydratase/blood ; Infant, Newborn ; Biomarkers/blood ; Infant, Premature/blood ; Male ; Female ; Case-Control Studies ; Prospective Studies ; Brain Injuries/blood ; Brain Injuries/diagnosis ; Leukomalacia, Periventricular/blood ; Leukomalacia, Periventricular/diagnostic imaging ; Cerebral Hemorrhage/blood ; Cerebral Hemorrhage/diagnostic imaging ; Cerebral Hemorrhage/diagnosis ; Cerebral Intraventricular Hemorrhage/blood ; Cerebral Intraventricular Hemorrhage/diagnostic imaging ; Gestational Age ; Prognosis
Chemical Substances	Phosphopyruvate Hydratase (EC 4.2.1.11) ; Biomarkers ; ENO2 protein, human (EC 4.2.1.11)
Language	English
Publishing date	2024-04-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom14040434
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