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  1. AU="Manuel Tisminetzky"
  2. AU="Monaco, Carlo"
  3. AU="Srivastava, Rupesh"
  4. AU="Nathan, Jaimie D"
  5. AU="Schnegelberger, Regina D"
  6. AU=Doshi Paresh
  7. AU="Cecilia Hognon"
  8. AU="Mason, Jeremy K."
  9. AU=Hasumi Hisashi
  10. AU="Swati Sethi"
  11. AU="Martin G. Myers, Jr."
  12. AU="Marcus-Sekura, Carol"
  13. AU="Petagine, Lucy"
  14. AU="Jessa R. Alexander"
  15. AU=Rauner Martina
  16. AU="Richlen, Mindy L"
  17. AU="Merghani, Nada M"
  18. AU=Splitt M P
  19. AU="Zlatanović, Gordana"

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  1. Artikel ; Online: Key performance indicators in extracorporeal membrane oxygenation (ECMO)

    Sean M Bagshaw / Eddy Fan / Gurmeet Singh / Oleksa Rewa / Janice Y Kung / Manuel Tisminetzky / Roman Nepomuceno / Ken Kuljit Singh Parhar

    BMJ Open, Vol 13, Iss

    protocol for a systematic review

    2023  Band 12

    Abstract: Introduction Extracorporeal membrane oxygenation (ECMO) is an intervention used in critically ill patients with severe cardiopulmonary failure that is expensive and resource intensive and requires specialised care. There remains a significant practice ... ...

    Abstract Introduction Extracorporeal membrane oxygenation (ECMO) is an intervention used in critically ill patients with severe cardiopulmonary failure that is expensive and resource intensive and requires specialised care. There remains a significant practice variation in its application. This systematic review will assess the evidence for key performance indicators (KPIs) in ECMO.Methods and analysis We will search Ovid MEDLINE, Ovid EMBASE, Cumulative Index to Nursing and Allied Health Literature and the Cochrane Library including the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials and databases from the National Information Center of Health Services Research and Health Care Technology, for studies involving KPIs in ECMO. We will rate methodological quality using the Newcastle-Ottawa Quality Assessment Scale. Randomized controlled trials (RCTs) will be evaluated with the Cochrane Risk of Bias tool, and qualitative studies will be evaluated using the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN checklist). Grey literature sources will be searched for technical reports, practice guidelines and conference proceedings. We will identify relevant organisations, industry leaders and non-profit organisations that represent key opinion leads in the use of ECMO. We will search the Agency of Healthcare Research and Quality National Quality Measures Clearinghouse for ECMO-related KPIs. Studies will be included if they contain quality measures that occur in critically ill patients and are associated with ECMO. The analysis will be primarily descriptive. Each KPI will be evaluated for importance, scientific acceptability, utility and feasibility using the four criteria proposed by the US Strategic Framework Board for a National Quality Measurement and Reporting System. Finally, KPIs will be evaluated for their potential operational characteristics, their potential to be integrated into electronic medical records and their affordability, if ...
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 170
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag BMJ Publishing Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Association of different positive end-expiratory pressure selection strategies with all-cause mortality in adult patients with acute respiratory distress syndrome

    Manuel Tisminetzky / Jose Dianti / Bruno L. Ferreyro / Federico Angriman / Lorenzo Del Sorbo / Sachin Sud / Daniel Talmor / Eddy Fan / Niall D. Ferguson / Ary Serpa Neto / Neill K. J. Adhikari / Ewan C. Goligher

    Systematic Reviews, Vol 10, Iss 1, Pp 1-

    2021  Band 8

    Abstract: Abstract Background The acute respiratory distress syndrome (ARDS) has high morbidity and mortality. Positive end-expiratory pressure (PEEP) is commonly used in patients with ARDS but the best method to select the optimal PEEP level and reduce all-cause ... ...

    Abstract Abstract Background The acute respiratory distress syndrome (ARDS) has high morbidity and mortality. Positive end-expiratory pressure (PEEP) is commonly used in patients with ARDS but the best method to select the optimal PEEP level and reduce all-cause mortality is unclear. The primary objective of this network meta-analysis is to summarize the available evidence and to compare the effect of different PEEP selection strategies on all-cause mortality in adult patients with ARDS. Methods We will search MEDLINE, Cochrane Central Register of Controlled Trials, PubMed, EMBASE, and LILACS from inception onwards for randomized controlled trials assessing the effect of PEEP selection strategies in adult patients with moderate to severe ARDS. We will exclude studies that did not use a lung-protective ventilation approach as part of the comparator or intervention strategy. The primary outcome will be all-cause mortality (at the longest available follow-up and up to 90 days). Secondary outcomes will include barotrauma, ventilator-free days, intensive care unit and hospital length of stay, and changes in oxygenation. Two reviewers will independently screen all citations, full-text articles, and extract study-data. We will assess the risk of bias for each of the outcomes using version 2 of the Cochrane risk of bias tool for randomized controlled trials. If feasible, Bayesian network meta-analyses will be conducted to obtain pooled estimates of all potential head-to-head comparisons. We will report pairwise and network meta-analysis treatment effect estimates as risk ratios and risk differences, together with the associated 95% credible intervals. We will assess certainty in effect estimates using GRADE methodology. Discussion The present study will inform clinical decision-making for adult patients with ARDS and will improve our understanding of the limitations of the available literature assessing PEEP selection strategies. Finally, this information may also inform the design of future randomized trials, including the selection of interventions, comparators, and predictive enrichment strategies. Trial registration PROSPERO 2020 CRD42020193302 .
    Schlagwörter ARDS ; Acute respiratory distress syndrome ; PEEP ; Positive end-expiratory pressure ; Hypoxemic respiratory failure ; Barotrauma ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-08-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Utilización de membrana de circulación extracorpórea en síndrome de leak capilar idiopático

    Florencia Ortega / Indalecio Carboni Bisso / Ignacio Fernandez Ceballos / Ana Montserrat Rivera / Manuel Tisminetzky / José Dianti / Eduardo San Román / Sonia Villarroel / Sabrina Di Stefano / Marcos Las Heras

    Revista de la Facultad de Ciencias Médicas de Córdoba, Vol 77, Iss

    reporte de un caso

    2020  Band 3

    Abstract: Introducción El Síndrome de Leak Capilar Idiopático (SLCI) o enfermedad de Clarkson es un entidad rara pero potencialmente letal, caracterizada por episodios recurrentes de shock y anasarca secundarios al aumento idiopático de la permeabilidad capilar. ... ...

    Abstract Introducción El Síndrome de Leak Capilar Idiopático (SLCI) o enfermedad de Clarkson es un entidad rara pero potencialmente letal, caracterizada por episodios recurrentes de shock y anasarca secundarios al aumento idiopático de la permeabilidad capilar. En este contexto, el uso de membrana de oxigenación extracorpórea (ECMO) venoarterial como soporte cardiorrespiratorio, es una medida de rescate que busca generar estabilidad hemodinámica a la espera de la desaparición espontánea del leak capilar con el fin de sortear las complicaciones de la fase de reabsorción. Caso Clínico Se presenta el caso de un paciente un paciente de 42 años de edad que presentó SLCI y requirió ECMO durante 8 días como soporte hemodinámico. Cursó 20 días de internación en la unidad de terapia intensiva y se otorgó el alta hospitalaria luego de 43 días. Conclusiones El uso de ECMO en el caso reportado significó una estrategia útil para el manejo del SLCI como puente a la recuperación, tanto en la etapa de leak como en la fase de reabsorción de fluidos. Sin embargo, su indicación se ve limitada a pacientes altamente seleccionados, y todavía requiere un mayor debate entre especialistas sobre los posibles riesgos y beneficios.
    Schlagwörter síndrome de fuga capilar ; oxigenación por membrana extracorpórea ; cuidados críticos ; Medicine ; R ; Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2020-08-01T00:00:00Z
    Verlag Universidad Nacional de Córdoba
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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