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Article ; Online: Parkinson's Disease: A Prionopathy?

Vascellari, Sarah / Manzin, Aldo

International journal of molecular sciences

2021 Volume 22, Issue 15

Abstract: The principal pathogenic event in Parkinson's disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal ... ...

Abstract	The principal pathogenic event in Parkinson's disease is characterized by the conformational change of α-synuclein, which form pathological aggregates of misfolded proteins, and then accumulate in intraneuronal inclusions causing dopaminergic neuronal loss in specific brain regions. Over the last few years, a revolutionary theory has correlated Parkinson's disease and other neurological disorders with a shared mechanism, which determines α-synuclein aggregates and progresses in the host in a prion-like manner. In this review, the main characteristics shared between α-synuclein and prion protein are compared and the cofactors that influence the remodeling of native protein structures and pathogenetic mechanisms underlying neurodegeneration are discussed.
MeSH term(s)	Animals ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Humans ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Prion Diseases/metabolism ; Prion Diseases/pathology ; Protein Aggregates ; alpha-Synuclein/metabolism ; tau Proteins/metabolism
Chemical Substances	MAPT protein, human ; Protein Aggregates ; SNCA protein, human ; alpha-Synuclein ; tau Proteins
Language	English
Publishing date	2021-07-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22158022
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Physico-Chemical Investigation and Antimicrobial Efficacy of Ozonated Oils: The Case Study of Commercial Ozonated Olive and Sunflower Seed Refined Oils.

Puxeddu, Silvia / Scano, Alessandra / Scorciapino, Mariano Andrea / Delogu, Ilenia / Vascellari, Sarah / Ennas, Guido / Manzin, Aldo / Angius, Fabrizio

Molecules (Basel, Switzerland)

2024 Volume 29, Issue 3

Abstract: Drug resistance represents one of the great plagues of our time worldwide. This largely limits the treatment of common infections and requires the development of new antibiotics or other alternative approaches. Noteworthy, the indiscriminate use of ... ...

Abstract	Drug resistance represents one of the great plagues of our time worldwide. This largely limits the treatment of common infections and requires the development of new antibiotics or other alternative approaches. Noteworthy, the indiscriminate use of antibiotics is mostly responsible for the selection of mutations that confer drug resistance to microbes. In this regard, recently, ozone has been raising interest for its unique biological properties when dissolved in natural oils. Ozonated oils have been reported to act in a non-specific way on microorganisms hindering the acquisition of advantageous mutations that result in resistance. Here, we focused on the antimicrobial effect of two commercial olive (OOO) and sunflower seeds (OSO) oils. Nuclear magnetic resonance spectroscopy and thermal analysis showed the change in the chemical composition of the oils after ozonation treatment. Different ozonated oil concentrations were then used to evaluate their antimicrobial profile against
MeSH term(s)	Animals ; Olea ; Helianthus ; Staphylococcus aureus ; Escherichia coli ; Anti-Infective Agents/pharmacology ; Plant Oils/pharmacology ; Plant Oils/chemistry ; Oils, Volatile/pharmacology ; Anti-Bacterial Agents/pharmacology ; Seeds ; Microbial Sensitivity Tests ; Mammals
Chemical Substances	Anti-Infective Agents ; Plant Oils ; Oils, Volatile ; Anti-Bacterial Agents
Language	English
Publishing date	2024-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules29030679
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Article: SARS-CoV-2 and Its Variants: The Pandemic of Unvaccinated.

Angius, Fabrizio / Pala, Giuseppe / Manzin, Aldo

Frontiers in microbiology

2021 Volume 12, Page(s) 749634

Language	English
Publishing date	2021-09-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2021.749634
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Article ; Online: Hylin-a1: A Pan-Inhibitor against Emerging and Re-Emerging Respiratory Viruses.

Chianese, Annalisa / Zannella, Carla / Monti, Alessandra / Doti, Nunzianna / Sanna, Giuseppina / Manzin, Aldo / De Filippis, Anna / Galdiero, Massimiliano

International journal of molecular sciences

2023 Volume 24, Issue 18

Abstract: Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health and social care system worldwide, leading to high mortality and morbidity among the human populations. In light of the limited efficacy of current vaccines and ... ...

Abstract	Pandemic and epidemic outbreaks of respiratory viruses are a challenge for public health and social care system worldwide, leading to high mortality and morbidity among the human populations. In light of the limited efficacy of current vaccines and antiviral drugs against respiratory viral infections and the emergence and re-emergence of new viruses, novel broad-spectrum antiviral drugs are needed for the prevention and treatment of these infections. Antimicrobial peptides with an antiviral effect, also known as AVPs, have already been reported as potent inhibitors of viral infections by affecting different stages of the virus lifecycle. In the present study, we analyzed the activity of the AVP Hylin-a1, secreted by the frog
MeSH term(s)	Humans ; Animals ; Influenza A Virus, H1N1 Subtype ; COVID-19 ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Anura ; Coronavirus 229E, Human
Chemical Substances	hylin ; Antiviral Agents
Language	English
Publishing date	2023-09-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241813888
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Article: Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation

Deledda, Andrea / Annunziata, Giuseppe / Tenore, Gian Carlo / Palmas, Vanessa / Manzin, Aldo / Velluzzi, Fernanda

Antioxidants. 2021 Apr. 29, v. 10, no. 5

2021

Abstract: It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related ... ...

Abstract	It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests that the global dietary patterns may represent a tool in counteracting oxidative stress, thus preventing the onset of diseases related to oxidative stress. More specifically, dietary patterns based on the regular consumption of fruits and vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines in many countries for their health-promoting effects. Such patterns, indeed, result in being rich in specific components, such as fiber, minerals, vitamins and antioxidants, whose beneficial effects on human health have been widely reported. This suggests a potential nutraceutical power of specific dietary components. In this manuscript, we summarize the most relevant evidence reporting the impact of dietary antioxidants on gut microbiota composition, inflammation and obesity, and we underline that antioxidants are implicated in a complex interplay between gut microbiota, inflammation and obesity, thus suggesting their possible role in the development and modulation of chronic diseases related to oxidative stress and in the maintenance of wellness. Do all roads lead to Rome?
Keywords	Mediterranean diet ; dietary supplements ; health promotion ; human health ; inflammation ; intestinal microorganisms ; obesity ; oxidative stress
Language	English
Dates of publication	2021-0429
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10050708
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bichromonol, a dimeric coumarin with anti-HIV activity from the stem bark of Hypericum roeperianum

Fobofou, Serge A. T. / Franke, Katrin / Brandt, Wolfgang / Manzin, Aldo / Madeddu, Silvia / Serreli, Gabriele / Sanna, Giuseppina / Wessjohann, Ludger A.

Natural Product Research. 2023 June 18, v. 37, no. 12 p.1947-1953

2023

Abstract: Infectious diseases caused by viruses like HIV and SARS-COV-2 (COVID-19) pose serious public health threats. In search for new antiviral small molecules from chemically underexplored Hypericum species, a previously undescribed atropisomeric C8-C8’ linked ...

Abstract	Infectious diseases caused by viruses like HIV and SARS-COV-2 (COVID-19) pose serious public health threats. In search for new antiviral small molecules from chemically underexplored Hypericum species, a previously undescribed atropisomeric C8-C8’ linked dimeric coumarin named bichromonol (1) was isolated from the stem bark of Hypericum roeperianum. The structure was elucidated by MS data and NMR spectroscopy. The absolute configuration at the biaryl axis was determined by comparing the experimental ECD spectrum with those calculated for the respective atropisomers. Bichromonol was tested in cell-based assays for cytotoxicity against MT-4 (CC₅₀ = 54 µM) cells and anti-HIV activity in infected MT-4 cells. It exhibits significant activity at EC₅₀ = 6.6–12.0 µM against HIV-1 wild type and its clinically relevant mutant strains. Especially, against the resistant variants A17 and EFVᴿ, bichromonol is more effective than the commercial drug nevirapine and might thus have potential to serve as a new anti-HIV lead.
Keywords	COVID-19 infection ; Hypericum ; Severe acute respiratory syndrome coronavirus 2 ; antiretroviral agents ; antiretroviral properties ; bark ; coumarin ; cytotoxicity ; lead ; mutants ; nuclear magnetic resonance spectroscopy ; public health ; research ; Antiviral ; bioactive compounds ; dimeric coumarins ; drug discovery ; medicinal plants
Language	English
Dates of publication	2023-0618
Size	p. 1947-1953.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2110094
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Article ; Online: Humoral responses to wild type and ancient BA.1 SARS-CoV-2 variant after heterologous priming vaccination with ChAdOx1 nCoV-19 and BNT162b2 booster dose.

Sanna, Giuseppina / Marongiu, Alessandra / Firinu, Davide / Piras, Cristina / Palmas, Vanessa / Galdiero, Massimiliano / Atzori, Luigi / Caria, Paola / Campagna, Marcello / Perra, Andrea / Costanzo, Giulia / Coghe, Ferdinando / Littera, Roberto / Chessa, Luchino / Manzin, Aldo

Clinical and experimental medicine

2024 Volume 24, Issue 1, Page(s) 12

Abstract: Several countries have recommended a booster dose of Pfizer BNT162b2 vaccine for subjects under the age of 60, who have already received the first dose of ChAdOx1. This is due to several ChAdOx1 vaccine-associated adverse vascular events and ... ...

Abstract	Several countries have recommended a booster dose of Pfizer BNT162b2 vaccine for subjects under the age of 60, who have already received the first dose of ChAdOx1. This is due to several ChAdOx1 vaccine-associated adverse vascular events and thrombocytopenia. Neutralization assay and quantitative IgG anti-SARS-CoV-2 Spike antibody (anti-S-IgG) were conducted to investigate the long-term responses to vaccine treatment in a cohort of Sardinian participants, who have received heterologous Prime-Boost Vaccination via ChAdOx1 vector vaccine and a booster dose via BNT162b2. The obtained results were compared with those of a cohort of healthcare workers (HCW) who received homologous BNT162b2 (BNT/BNT/BNT) vaccination. One month (T2) and five months after the second and before the third dose (T3), anti-spike antibody or neutralizing titers in the subjects vaccinated with ChAdOx1-S/BNT162b2 were significantly higher than those who experienced the ChAdOx1-S/ChAdOx1-S or BNT162b2/BNT162b2 schedule. These results suggest that a ChAdOx1-S/BNT162b2 regimen provides a more robust antibody response than either of the homologous regimens. However, the anti-spike antibodies or neutralizing titers after the third injection (mRNA vaccine) of ChAdOx1-S as a second dose and BNT162b2 were not statistically different. Homologous and heterologous vaccination provided a strong antibody response. Neutralizing activities were also described against the Omicron BA.1 variant in a sub-group (40) representative of the three vaccination regimens among our cohort.
MeSH term(s)	Humans ; BNT162 Vaccine ; ChAdOx1 nCoV-19 ; SARS-CoV-2/genetics ; COVID-19/prevention & control ; Vaccination ; Antibodies, Viral ; Immunoglobulin G
Chemical Substances	BNT162 Vaccine ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Antibodies, Viral ; Immunoglobulin G
Language	English
Publishing date	2024-01-20
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-023-01276-x
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Article: Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation.

Deledda, Andrea / Annunziata, Giuseppe / Tenore, Gian Carlo / Palmas, Vanessa / Manzin, Aldo / Velluzzi, Fernanda

Antioxidants (Basel, Switzerland)

2021 Volume 10, Issue 5

Abstract	It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests that the global dietary patterns may represent a tool in counteracting oxidative stress, thus preventing the onset of diseases related to oxidative stress. More specifically, dietary patterns based on the regular consumption of fruits and vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines in many countries for their health-promoting effects. Such patterns, indeed, result in being rich in specific components, such as fiber, minerals, vitamins and antioxidants, whose beneficial effects on human health have been widely reported. This suggests a potential nutraceutical power of specific dietary components. In this manuscript, we summarize the most relevant evidence reporting the impact of dietary antioxidants on gut microbiota composition, inflammation and obesity, and we underline that antioxidants are implicated in a complex interplay between gut microbiota, inflammation and obesity, thus suggesting their possible role in the development and modulation of chronic diseases related to oxidative stress and in the maintenance of wellness. Do all roads lead to Rome?
Language	English
Publishing date	2021-04-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox10050708
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bovine Viral Diarrhea Virus (BVDV): A Preliminary Study on Antiviral Properties of Some Aromatic and Medicinal Plants

Madeddu, Silvia / Marongiu, Alessandra / Sanna, Giuseppina / Zannella, Carla / Falconieri, Danilo / Porcedda, Silvia / Manzin, Aldo / Piras, Alessandra

Pathogens. 2021 Mar. 29, v. 10, no. 4

2021

Abstract: Plant products provide an alternative and successful source of lead compounds for the pharmaceutical industry. The present study was aimed to evaluate, in cell-based assays, the antiviral properties of essential oils obtained from plants that commonly ... ...

Abstract	Plant products provide an alternative and successful source of lead compounds for the pharmaceutical industry. The present study was aimed to evaluate, in cell-based assays, the antiviral properties of essential oils obtained from plants that commonly grow in Sardinia, Italy, against a broad spectrum of RNA/DNA viruses. The essential oils of Helichrisumitalicum (Roth) G. Don ssp. microphyllum (Willd.) Nyman, Laurus nobilis L., Mirtuscommunis L., Pistacia lentiscus L., Salvia officinalis L., Saturejathymbra L., Lavandula angustifolia Mill., Foeniculum vulgare Mill., and Eucalyptus globulus Labill. were extracted by hydrodistillation and analyzed by gas chromatography mass spectrometry (GC–MS). Interestingly, the essential oil of Salvia officinalis showed moderate activity against bovine viral diarrhea virus (BVDV), an enveloped RNA virus belonging to the Flaviviridae family. BVDV is responsible for several clinical manifestations in bovines, including respiratory, gastroenteric, and reproductive diseases, with a significant economic impact. With the aim to individuate the constituent of the Salvia officinalis responsible for the biological activity, we tested the major components of the oil: camphene, β-pinene, limonene, 1,8-cineole, cis-thujone, camphor, (E)-caryophyllene, and α-humulene. Here, we describe α-humulene as an active component that is non-cytotoxic and active against BVDV (EC₅₀ = 36 µM). Its antiviral effects were evaluated using virucidal cytopathic effect inhibition and viral yield reduction assays. This is the first scientific report showing the anti BVDV effects of Salvia officinalis essential oil and α-humulene as the main active component.
Keywords	Bovine viral diarrhea virus 1 ; DNA ; Eucalyptus globulus ; Foeniculum vulgare ; Laurus nobilis ; Lavandula angustifolia ; Pistacia lentiscus ; RNA ; Salvia officinalis ; camphene ; camphor ; cineole ; cytopathogenicity ; economic impact ; essential oils ; gas chromatography-mass spectrometry ; hydrodistillation ; limonene ; oils ; pharmaceutical industry ; Italy ; Sardinia
Language	English
Dates of publication	2021-0329
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10040403
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Bichromonol, a dimeric coumarin with anti-HIV activity from the stem bark of

Fobofou, Serge A T / Franke, Katrin / Brandt, Wolfgang / Manzin, Aldo / Madeddu, Silvia / Serreli, Gabriele / Sanna, Giuseppina / Wessjohann, Ludger A

Natural product research

2022 Volume 37, Issue 12, Page(s) 1947–1953

Abstract: Infectious diseases caused by viruses like HIV and SARS-COV-2 (COVID-19) pose serious public health threats. In search for new antiviral small molecules from chemically ... ...

Abstract	Infectious diseases caused by viruses like HIV and SARS-COV-2 (COVID-19) pose serious public health threats. In search for new antiviral small molecules from chemically underexplored
MeSH term(s)	Humans ; Hypericum/chemistry ; Plant Bark ; COVID-19 ; SARS-CoV-2 ; Coumarins/chemistry ; Molecular Structure
Chemical Substances	Coumarins
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2110094
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