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Article ; Online: The Influence of GFRαl Inhibition on Proliferation and Apoptosis of Spermatogenic Cells

Mao, Jianmin / Liu, Peng / Han, Wenjun / Mo, Ran / Guo, Shishuai / Sun, Jianming

Cytol. Genet.. 2022 Dec., v. 56, no. 6 p.567-573

2022

Abstract: The role of the GFRαl receptor in the regulation of cell differentiation and spermatogenesis is poorly investigated. The influence of GFRα1 on the apoptosis and proliferation of spermatogenic cells are not fully elucidated. In this study, GC-1 spg cells ... ...

Abstract	The role of the GFRαl receptor in the regulation of cell differentiation and spermatogenesis is poorly investigated. The influence of GFRα1 on the apoptosis and proliferation of spermatogenic cells are not fully elucidated. In this study, GC-1 spg cells were cultured and then assigned to a control cell (control group) transfected with empty adenovirus AdH1-siRNA and an inhibited cells (inhibited group) with GFRα1 interfering adenovirus (AdH1-siRNA/GFRα1). The GFRal inhibition was determined by employing western blot and qRT-PCR analysis. Furthermore, we used CCK8 for determining the proliferation of the GFRα1 interfering adenovirus (AdH1-siRNA/GFRα1). Transfected cells, employing flow cytometry and Caspase 3, Bax and Bcl-2 expression analysis to determine their apoptosis. This study demonstrated that after transfection, the inhibited cells presented lower proliferation and invasion and higher apoptosis. According to these findings, the inhibition of GFRαl might reduce spermatogenesis and remarkably affect spermatogenic cells proliferation.
Keywords	Western blotting ; apoptosis ; caspase-3 ; cell differentiation ; flow cytometry ; spermatogenesis ; transfection
Language	English
Dates of publication	2022-12
Size	p. 567-573.
Publishing place	Pleiades Publishing
Document type	Article ; Online
ZDB-ID	390717-x
ISSN	1934-9440 ; 0095-4527
ISSN (online)	1934-9440
ISSN	0095-4527
DOI	10.3103/S0095452722060081
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Article ; Online: Electroacupuncture regulates sperm motility in patients with asthenozoospermia: study protocol for a randomized sham-controlled clinical trial.

Huang, Hai / Li, Zhihao / Han, Wenjun / Liu, Juan / Sun, Jianming / Mao, Jianmin / Liu, Peng

Minerva medica

2022 Volume 114, Issue 6, Page(s) 906–909

MeSH term(s)	Humans ; Male ; Asthenozoospermia/therapy ; Sperm Motility ; Electroacupuncture ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2022-05-18
Publishing country	Italy
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
DOI	10.23736/S0026-4806.22.08175-7
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Article: Simplified Chinese version of the international prostate symptom score and the benign prostatic hyperplasia impact index: cross-cultural adaptation, reliability, and validity for patients with benign prostatic hyperplasia.

Dun, Rong-Liang / Mao, Jian-Min / Yu, Chao / Zhang, Qiang / Hu, Xiao-Hua / Zhu, Wen-Jing / Qi, Guang-Chong / Peng, Yu

Prostate international

2022 Volume 10, Issue 3, Page(s) 162–168

Abstract: Background: The aim of this study was to translate and cross-culturally adapt the international prostate symptom score (IPSS) and benign prostatic hyperplasia impact index (BII) into simplified Chinese for mainland Chinese patients with benign prostatic ...

Abstract	Background: The aim of this study was to translate and cross-culturally adapt the international prostate symptom score (IPSS) and benign prostatic hyperplasia impact index (BII) into simplified Chinese for mainland Chinese patients with benign prostatic hyperplasia (BPH). Methods: The original English IPSS and BII were translated into simplified Chinese versions based on cross-cultural adaptation guidelines. Internal consistency was evaluated with Cronbach's α, then test-retest reliability with intraclass correlation coefficients (ICCs) in stable patients. The validity of these two adaptations was tested by the correlation between the IPSS and BII with visual prostate symptom score (VPSS) and 36 items Short Form Health Survey (SF-36). The floor and ceiling effects were calculated by the proportion of participants who obtained the highest and lowest possible score. Results: A total of 105 native Chinese-speaking patients with BPH were enrolled. Cronbach's α was over 0.75 for the simplified Chinese IPSS (IPSS 0.815; IPSS-symptom 0.782) and 0.709 for the simplified Chinese BII, indicating acceptable internal consistency. The ICCs for the test-retest reliability were over 0.75 (IPSS, Conclusions: This study indicates that the simplified Chinese IPSS and BII are reliable and valid measurements of the symptom and quality of life among Chinese patients with BPH, which is likely to be widely used in this population.
Language	English
Publishing date	2022-05-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2711928-2
ISSN	2287-903X ; 2287-8882
ISSN (online)	2287-903X
ISSN	2287-8882
DOI	10.1016/j.prnil.2022.04.001
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Article: TRIM52 positively mediates NF-κB to promote the growth of human benign prostatic hyperplasia cells through affecting TRAF2 ubiquitination

Sun, Jianming / Liu, Peng / Mao, Jianmin / Han, Wenjun / Jiang, Xiaomei / Gu, Yin

Life sciences. 2020 Oct. 15, v. 259

2020

Abstract: Benign prostatic hyperplasia (BPH) is a progressive disease, which severely affects men's health. Here, we sought to analyze the functions and mechanism of action of the tripartite motif protein 52 (TRIM52), a novel prostate basal cell biomarker in BPH ... ...

Abstract	Benign prostatic hyperplasia (BPH) is a progressive disease, which severely affects men's health. Here, we sought to analyze the functions and mechanism of action of the tripartite motif protein 52 (TRIM52), a novel prostate basal cell biomarker in BPH.Immunohistochemistry assay was performed in sectioned human BPH tissues, BPH-1 cells, and prostate RWPE-1 cells, to detect the expressions of TRIM52 and NF-κB. Western blotting and qRT-PCR analyses were conducted to measure the relative protein and mRNA expression levels, respectively. Further, lentiviral transfection was performed in BPH-1 and RWPE-1 cells to study the overexpression and siRNA knockdown of TRIM52. Dual-luciferase reporter assay was applied to evaluate the relationship between NF-κB and TRIM52. Furthermore, CCK-8 assay and flow cytometry were employed to analyze cell proliferation and apoptosis.TRIM52 and NF-κB levels were elevated in BPH tissues, and TRIM52 expression positively correlated with NF-κB expression. TRIM52 silencing suppressed the growth of BPH-1 cells and decreased the promoter activity of NF-κB. Moreover, the NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-κB promoter activity in oeTRIM52 transfected RWPE-1 cells. Silencing TRIM52 also inhibited TRAF2 ubiquitination in BPH-1 cells. Further, NF-κB promoter activity in siNC transfected cells was enhanced by the recombinant protein TNF-α and inhibited by siTRIM52.TRIM52 accelerated the growth of BPH-1 cells by upregulating NF-κB, and TRIM52 could promote TRAF2 ubiquitination. These findings might contribute to the understanding of the biological functions and action mechanisms of TRIM52 in BPH.
Keywords	bioluminescence assay ; biomarkers ; cell proliferation ; flow cytometry ; humans ; hyperplasia ; mechanism of action ; recombinant proteins ; transfection ; ubiquitination
Language	English
Dates of publication	2020-1015
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-light
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118380
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Article ; Online: TRIM52 positively mediates NF-κB to promote the growth of human benign prostatic hyperplasia cells through affecting TRAF2 ubiquitination.

Sun, Jianming / Liu, Peng / Mao, Jianmin / Han, Wenjun / Jiang, Xiaomei / Gu, Yin

Life sciences

2020 Volume 259, Page(s) 118380

Abstract: Aims: Benign prostatic hyperplasia (BPH) is a progressive disease, which severely affects men's health. Here, we sought to analyze the functions and mechanism of action of the tripartite motif protein 52 (TRIM52), a novel prostate basal cell biomarker ... ...

Abstract	Aims: Benign prostatic hyperplasia (BPH) is a progressive disease, which severely affects men's health. Here, we sought to analyze the functions and mechanism of action of the tripartite motif protein 52 (TRIM52), a novel prostate basal cell biomarker in BPH. Materials and methods: Immunohistochemistry assay was performed in sectioned human BPH tissues, BPH-1 cells, and prostate RWPE-1 cells, to detect the expressions of TRIM52 and NF-κB. Western blotting and qRT-PCR analyses were conducted to measure the relative protein and mRNA expression levels, respectively. Further, lentiviral transfection was performed in BPH-1 and RWPE-1 cells to study the overexpression and siRNA knockdown of TRIM52. Dual-luciferase reporter assay was applied to evaluate the relationship between NF-κB and TRIM52. Furthermore, CCK-8 assay and flow cytometry were employed to analyze cell proliferation and apoptosis. Key findings: TRIM52 and NF-κB levels were elevated in BPH tissues, and TRIM52 expression positively correlated with NF-κB expression. TRIM52 silencing suppressed the growth of BPH-1 cells and decreased the promoter activity of NF-κB. Moreover, the NF-κB inhibitor, pyrrolidine dithiocarbamate (PDTC), suppressed TRIM52-induced proliferation of RWPE-1 cells and inhibited NF-κB promoter activity in oeTRIM52 transfected RWPE-1 cells. Silencing TRIM52 also inhibited TRAF2 ubiquitination in BPH-1 cells. Further, NF-κB promoter activity in siNC transfected cells was enhanced by the recombinant protein TNF-α and inhibited by siTRIM52. Significance: TRIM52 accelerated the growth of BPH-1 cells by upregulating NF-κB, and TRIM52 could promote TRAF2 ubiquitination. These findings might contribute to the understanding of the biological functions and action mechanisms of TRIM52 in BPH.
MeSH term(s)	Blotting, Western ; Disease Progression ; Flow Cytometry ; Humans ; Male ; NF-kappa B/metabolism ; Prostatic Hyperplasia/metabolism ; Prostatic Hyperplasia/pathology ; Reverse Transcriptase Polymerase Chain Reaction ; TNF Receptor-Associated Factor 2/metabolism ; Tripartite Motif Proteins/metabolism ; Ubiquitination
Chemical Substances	NF-kappa B ; PSMD2 protein, human ; TNF Receptor-Associated Factor 2 ; TRIM52 protein, human ; Tripartite Motif Proteins
Language	English
Publishing date	2020-09-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2020.118380
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Article ; Online: A systematic review of cross-cultural adaptation of the National Institutes of Health Chronic Prostatitis Symptom Index.

Dun, Rong-Liang / Tsai, Jennifer / Hu, Xiao-Hua / Mao, Jian-Min / Zhu, Wen-Jing / Qi, Guang-Chong / Peng, Yu

Health and quality of life outcomes

2021 Volume 19, Issue 1, Page(s) 159

Abstract: Background: The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to accurately assess the pain, urinary symptoms, and quality of life related to chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). This ... ...

Abstract	Background: The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to accurately assess the pain, urinary symptoms, and quality of life related to chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). This study aimed to evaluate the cross-cultural adaptations of the NIH-CPSI. Method: PubMed, Embase, CINAHL, and SciELO databases were searched from their established year to September 2020. Cross-cultural adaptations and the quality control of measurement properties of adaptations were conducted by two reviewers independently according to the Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures and the Quality Criteria for Psychometric Properties of Health Status Questionnaire. Results: Area total of 21 papers with 16 adaptations, and six studies of the original version of the NIH-CPSI were enrolled in the systematic review. Back translation was the weakest process for the quality assessment of the cross-cultural adaptations of the NIH-CPSI. Internal consistency was analyzed for most of the adaptations, but none of them met the standard. Only 11 adaptations reported test reliability, then only the Arabic-Egyptian, Chinese-Mainland, Danish, Italian, Persian, and Turkish adaptations met the criterion. Most adaptations reported the interpretability, but only the Danish adaptation reported the agreement. The other measurement properties, including responsiveness, and floor as well as ceiling effects were not reported in any of the adaptations. Conclusions: The overall quality of the NIH-CPSI cross-cultural adaptations was not organized as expected. Only the Portuguese-Brazilian, Italian, and Spanish adaptations reached over half the process for the cross-cultural adaptation. Only the Turkish adaptations finished half of the measurement properties of cross-cultural adaptations.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Chronic Pain/physiopathology ; Chronic Pain/psychology ; Cross-Cultural Comparison ; Health Status ; Humans ; Male ; Middle Aged ; National Institutes of Health (U.S.) ; Prostatitis/physiopathology ; Prostatitis/psychology ; Psychometrics ; Quality of Life/psychology ; Reproducibility of Results ; Self Report/statistics & numerical data ; Surveys and Questionnaires/standards ; Surveys and Questionnaires/statistics & numerical data ; Symptom Assessment/standards ; Translations ; United States
Language	English
Publishing date	2021-05-31
Publishing country	England
Document type	Journal Article ; Systematic Review
ISSN	1477-7525
ISSN (online)	1477-7525
DOI	10.1186/s12955-021-01796-8
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Article: Sheng Jing Decoction Can Promote Spermatogenesis and Increase Sperm Motility of the Oligozoospermia Mouse Model.

Yan, Guang / Tian, Fang / Liu, Peng / Sun, Jianming / Mao, Jianmin / Han, Wenjun / Mo, Ran / Guo, Shishuai / Yu, Quanyao

Evidence-based complementary and alternative medicine : eCAM

2021 Volume 2021, Page(s) 3686494

Abstract: Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the ... ...

Abstract	Sheng Jing Decoction (SJD), as a traditional Chinese medicine prescription, is mainly be used to treat male infertility. However, the pharmacological functions and molecular mechanisms of SJD are poorly understood. In this study, we investigated the functions of SJD on spermatogenesis and sperm motility and explored the potential mechanisms involved. Here, we demonstrated that high, medium, and low doses of SJD are effective in restoring the impairments of the whole body and testicular tissue by cyclophosphamide inducing and to rescue the damage of testicular tissue cells including Sertoli cells and germ cells. SJD can partly restore the decrease in sperm concentration, sperm vitality, sperm motility, and normal sperm morphology rate in oligozoospermic mouse models. Ki67 staining analyses confirm SJD can promote testicular tissue cell proliferation. Real-time RT-PCR analyses also reveal that SJD can upregulate the expression of proliferation-associated gene
Language	English
Publishing date	2021-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2021/3686494
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Article: Protective Effect of Melatonin for Renal Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis.

Dun, Rong-Liang / Lan, Tian-Ying / Tsai, Jennifer / Mao, Jian-Min / Shao, Yi-Qun / Hu, Xiao-Hua / Zhu, Wen-Jing / Qi, Guang-Chong / Peng, Yu

Frontiers in physiology

2022 Volume 12, Page(s) 791036

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-01-13
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2021.791036
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Article: Traditional Chinese Herb Combined with Surgery versus Surgery for Varicocele Infertility: A Systematic Review and Meta-Analysis.

Dun, Rong-Liang / Yao, Min / Yang, Long / Cui, Xue-Jun / Mao, Jian-Min / Peng, Yu / Qi, Guang-Chong

Evidence-based complementary and alternative medicine : eCAM

2015 Volume 2015, Page(s) 689056

Abstract: Objective. The objective of this study was to conduct a systematic review to assess the effectiveness and safety of traditional Chinese herb combined with surgery for male varicocele infertility compared to surgery. Methods. Randomized controlled trials ( ...

Abstract	Objective. The objective of this study was to conduct a systematic review to assess the effectiveness and safety of traditional Chinese herb combined with surgery for male varicocele infertility compared to surgery. Methods. Randomized controlled trials (RCTs) data of traditional Chinese herbs combined with surgery for male varicocele fertility versus surgery were collected by searching the Cochrane Library, Embase, PubMed, and Chinese databases. The risk of bias was assessed using Cochrane Handbook. Study outcomes were presented as risk ratios (RRs) for dichotomous data. Results. Seventeen of 72 potentially relevant trials met the inclusion criteria. The methodological qualities of the RCTs were low. Compared with the surgery group, the traditional Chinese herb combined with surgery group had superiority in pregnancy rate at 3-month (RR = 1.76, and P = 0.008), 6-month (RR = 1.58, and P = 0.0005), and 2-year (RR = 1.58, and P = 0.0005) follow-ups. No RCT was found to describe the side effects. Conclusion. On considering the low methodological quality of RCTs, there was no enough evidence on traditional Chinese herb with surgery for male varicocele infertility, and more high-quality RCTs of large sample sizes are required.
Language	English
Publishing date	2015-01-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2015/689056
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Article: Breast cancer detection by mapping hemoglobin concentration and oxygen saturation.

Cheng, Xuefeng / Mao, Jian-min / Bush, Robin / Kopans, Daniel B / Moore, Richard H / Chorlton, Maryann

Applied optics

2003 Volume 42, Issue 31, Page(s) 6412–6421

Abstract: Near-infrared (NIR) spectroscopic imaging technology provides a new modality for measuring changes in total hemoglobin concentration (HbT) and blood oxygen saturation (SO2) in human tissue. The technology can be used to detect breast cancer because ... ...

Abstract	Near-infrared (NIR) spectroscopic imaging technology provides a new modality for measuring changes in total hemoglobin concentration (HbT) and blood oxygen saturation (SO2) in human tissue. The technology can be used to detect breast cancer because cancers may cause greater vascularization and greater oxygen consumption than in normal tissue. Based on the NIR technology, ViOptix, Inc., has developed an optical device that provides two-dimensional mapping of HbT and SO2 in human tissue. As an adjunctive tool to mammography, the device was preliminarily tested in a clinical trial with 50 mammogram-positive patients at the Massachusetts General Hospital. The results of the clinical trial demonstrate that the device can reach as much as 92% diagnostic sensitivity and 67% specificity in detecting ductal carcinoma. These results may indicate that the NIR technology can potentially be used as an adjunct to mammography for breast cancer detection to reduce the number of biopsies performed.
MeSH term(s)	Adult ; Biomarkers, Tumor/analysis ; Breast Neoplasms/diagnosis ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carcinoma, Ductal/diagnosis ; Carcinoma, Ductal/metabolism ; Carcinoma, Ductal/pathology ; Diagnosis, Computer-Assisted/instrumentation ; Diagnosis, Computer-Assisted/methods ; Equipment Failure Analysis ; Female ; Hemoglobins/analysis ; Hemoglobins/metabolism ; Humans ; Oxygen/analysis ; Oxygen/metabolism ; Pilot Projects ; Reproducibility of Results ; Sensitivity and Specificity ; Spectrophotometry, Infrared/instrumentation ; Spectrophotometry, Infrared/methods
Chemical Substances	Biomarkers, Tumor ; Hemoglobins ; Oxygen (S88TT14065)
Language	English
Publishing date	2003-11-24
Publishing country	United States
Document type	Clinical Trial ; Journal Article ; Validation Studies
ISSN	1559-128X
ISSN	1559-128X
DOI	10.1364/ao.42.006412
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