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Article ; Online: Pathological features of gastric‑type endocervical adenocarcinoma: A report of two cases.

Zhou, Jiahui / Zhang, Xiangning / Mao, Weibo / Zhu, Yiling / Yan, Liping / Jiang, Jiangle / Zhang, Min

2024 Volume 27, Issue 4, Page(s) 149

Abstract: Gastric-type endocervical adenocarcinoma (GEA) is an uncommon form of uterine cervical adenocarcinoma with an unfavorable prognosis. The tumor consists of glands exhibiting a morphological resemblance to gastric cells and occasionally manifests features ... ...

Abstract	Gastric-type endocervical adenocarcinoma (GEA) is an uncommon form of uterine cervical adenocarcinoma with an unfavorable prognosis. The tumor consists of glands exhibiting a morphological resemblance to gastric cells and occasionally manifests features akin to pancreaticobiliary mucinous adenocarcinoma. GEA differs from the typical cervical cancer, particularly in its lack of association with the human papillomavirus. Immunophenotypic analysis suggests intestinal differentiation. The present study reports two cases of GEA occurring in postmenopausal individuals who were diagnosed in Lishui Central Hospital (Lishui, China) between January 2015 and January 2023. Microscopic examination revealed cysts lined with mucinous cells within the tumors. Immunohistochemical assays confirmed the positivity of the tumors for cytokeratin 7, mucin (MUC)5AC, and mutant tumor protein p53, while the results were negative for tumor suppressor p16, and in one case for paired box protein 8, consistent with characteristics of mucinous adenocarcinoma originating from the gastrointestinal tract. Programmed death-ligand 1 expression was also negative. The proto-oncogene K-ras was identified using amplification refractory mutation system polymerase chain reaction. Both cases were negative for mutations in codons 12 and 13 of exon 2, codon 61 of exon 3 and codon 146 of exon 4, but were positive for wild-type K-ras. Clinical follow-up revealed a potential association between histopathological features and resistance to chemotherapeutic drugs. The infrequency of this tumor type may contribute to diagnostic challenges.
Language	English
Publishing date	2024-02-09
Publishing country	Greece
Document type	Case Reports
ZDB-ID	2573196-8
ISSN	1792-1082 ; 1792-1074
ISSN (online)	1792-1082
ISSN	1792-1074
DOI	10.3892/ol.2024.14282
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development of TSHR-CAR NK-92 cells for Differentiated Thyroid Cancer.

Zhou, Jiahui / Zhang, Chengcheng / Mao, Weibo / Zhu, Yiling / Zhao, Huan / Han, Ruozhen / Peng, You / Pan, Gang / Fang, Yang

Molecular and cellular endocrinology

2024 Volume 589, Page(s) 112251

Abstract: Differentiated thyroid cancer (DTC) is the predominant type of thyroid cancer, with some patients experiencing relapse, distant metastases, or refractoriness, revealing limited treatment options. Chimeric antigen receptor (CAR)-modified Natural Killer ( ... ...

Abstract	Differentiated thyroid cancer (DTC) is the predominant type of thyroid cancer, with some patients experiencing relapse, distant metastases, or refractoriness, revealing limited treatment options. Chimeric antigen receptor (CAR)-modified Natural Killer (NK) cells are revolutionary therapeutic agents effective against various resistant cancers. Thyroid-stimulating hormone receptor (TSHR) expression in DTC provides a unique tumor-specific target for CAR therapy. Here, we developed an innovative strategy for treating DTC using modified NK-92 cells armed with a TSHR-targeted CAR. The modified cells showed enhanced cytotoxicity against TSHR-positive DTC cell lines and exhibited elevated degranulation and cytokine release. After undergoing irradiation, the cells effectively halted their proliferative capacity while maintaining potent targeted killing ability. Transfer of these irradiation-treated cells into NSG mice with DTC tumors resulted in profound tumor suppression. NK-92 cells modified with TSHR-CAR offer a promising, off-the-shelf option for advancing DTC immunotherapy.
Language	English
Publishing date	2024-04-24
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	187438-x
ISSN	1872-8057 ; 0303-7207
ISSN (online)	1872-8057
ISSN	0303-7207
DOI	10.1016/j.mce.2024.112251
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Book ; Online: Joint-Relation Transformer for Multi-Person Motion Prediction

Xu, Qingyao / Mao, Weibo / Gong, Jingze / Xu, Chenxin / Chen, Siheng / Xie, Weidi / Zhang, Ya / Wang, Yanfeng

2023

Abstract: Multi-person motion prediction is a challenging problem due to the dependency of motion on both individual past movements and interactions with other people. Transformer-based methods have shown promising results on this task, but they miss the explicit ... ...

Abstract	Multi-person motion prediction is a challenging problem due to the dependency of motion on both individual past movements and interactions with other people. Transformer-based methods have shown promising results on this task, but they miss the explicit relation representation between joints, such as skeleton structure and pairwise distance, which is crucial for accurate interaction modeling. In this paper, we propose the Joint-Relation Transformer, which utilizes relation information to enhance interaction modeling and improve future motion prediction. Our relation information contains the relative distance and the intra-/inter-person physical constraints. To fuse relation and joint information, we design a novel joint-relation fusion layer with relation-aware attention to update both features. Additionally, we supervise the relation information by forecasting future distance. Experiments show that our method achieves a 13.4% improvement of 900ms VIM on 3DPW-SoMoF/RC and 17.8%/12.0% improvement of 3s MPJPE on CMU-Mpcap/MuPoTS-3D dataset.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	629
Publishing date	2023-08-09
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation of a Polypyrrole/Graphene Oxide Composite Electrode by Electrochemical Codeposition for Capacitor Deionization.

Xue, Juanqin / Sun, Qixin / Zhang, Yujie / Mao, Weibo / Li, Fagen / Yin, Chengxian

ACS omega

2020 Volume 5, Issue 19, Page(s) 10995–11004

Abstract: In this paper, a polypyrrole/graphene oxide (PPy/GO) composite electrode, applied to the capacitive deionization process for removing heavy metal ions, was prepared by one-step electrochemical codeposition. The PPy/GO composite electrode has a dense ... ...

Abstract	In this paper, a polypyrrole/graphene oxide (PPy/GO) composite electrode, applied to the capacitive deionization process for removing heavy metal ions, was prepared by one-step electrochemical codeposition. The PPy/GO composite electrode has a dense sheet structure, and PPy is spherical and uniformly distributed on the surface of GO sheets. The experimental results show that the PPy/GO composite electrode has a higher capacitance (186.67 F/g) and a lower charge transfer resistance (1.626 Ω·cm
Language	English
Publishing date	2020-05-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.0c00817
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Article ; Online: Malignant changes in adenomyosis in patients with endometrial adenocarcinoma: A case series.

Mao, Xuemei / Zheng, Wei / Mao, Weibo

Medicine

2017 Volume 96, Issue 43, Page(s) e8336

Abstract: The aim of the study is to describe the clinical characteristics and prognosis of malignant transformation of adenomyosis in patients with endometrial cancer.In this retrospective descriptive study, the clinical data of patients with endometrial cancer ( ... ...

Abstract	The aim of the study is to describe the clinical characteristics and prognosis of malignant transformation of adenomyosis in patients with endometrial cancer.In this retrospective descriptive study, the clinical data of patients with endometrial cancer (n = 127) who were admitted at our hospital between January 2006 and December 2013 were evaluated.Among the 127 patients with endometrial cancer, 24 patients had endometrial cancer concurrently with adenomyosis. Among these 24 patients, 3 were diagnosed with malignant transformation of adenomyosis. Postoperative pathological investigations in the cancer+adenomyosis group revealed endometrial adenocarcinoma of Grade I (n = 21) and II (n = 3). The patients with malignant transformation of adenomyosis were relatively younger than the other patients. In those 3 patients, both the estrogen and progesterone receptors were strongly expressed in eutopic endometrium and were weakly positive in ectopic endometrium.Although adenomyosis is usually benign, it might also be a precursor of malignant disease. As the incidence of adenomyosis malignant transformation is low, and its clinical manifestations are nonspecific, it may only be confirmed by postoperative pathological examination. Further investigations on larger sample size may provide additional data about prognosis of adenomyosis malignant transformation.
MeSH term(s)	Adenocarcinoma/epidemiology ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Adenomyosis/epidemiology ; Adenomyosis/pathology ; Adult ; Age Factors ; Cell Transformation, Neoplastic/pathology ; China/epidemiology ; Choristoma/metabolism ; Choristoma/pathology ; Endometrial Neoplasms/epidemiology ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/surgery ; Endometrium/pathology ; Female ; Humans ; Hysterectomy/methods ; Hysterectomy/statistics & numerical data ; Incidence ; Middle Aged ; Myometrium/pathology ; Neoplasm Grading ; Receptors, Estrogen/analysis ; Receptors, Progesterone/analysis ; Retrospective Studies ; Risk Factors
Chemical Substances	Receptors, Estrogen ; Receptors, Progesterone
Language	English
Publishing date	2017-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000008336
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Article: Application of artificial neural networks in detection and diagnosis of gastrointestinal and liver tumors.

Mao, Wei-Bo / Lyu, Jia-Yu / Vaishnani, Deep K / Lyu, Yu-Man / Gong, Wei / Xue, Xi-Ling / Shentu, Yang-Ping / Ma, Jun

World journal of clinical cases

2020 Volume 8, Issue 18, Page(s) 3971–3977

Abstract: As a form of artificial intelligence, artificial neural networks (ANNs) have the advantages of adaptability, parallel processing capabilities, and non-linear processing. They have been widely used in the early detection and diagnosis of tumors. In this ... ...

Abstract	As a form of artificial intelligence, artificial neural networks (ANNs) have the advantages of adaptability, parallel processing capabilities, and non-linear processing. They have been widely used in the early detection and diagnosis of tumors. In this article, we introduce the development, working principle, and characteristics of ANNs and review the research progress on the application of ANNs in the detection and diagnosis of gastrointestinal and liver tumors.
Language	English
Publishing date	2020-09-11
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v8.i18.3971
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Article: MicroRNA‐155‐5p suppresses PD‐L1 expression in lung adenocarcinoma

Huang, Jiansheng / Weng, Qiaoyou / Shi, Yang / Mao, Weibo / Zhao, Zhigang / Wu, Rongzhen / Ren, Jianmin / Fang, Shiji / Lu, Chenying / Du, Yongzhong / Ji, Jiansong

FEBS Open Bio. 2020 June, v. 10, no. 6

2020

Abstract: MiR‐155‐5p is a key oncogenic microRNA that maintains immune homeostasis and mediates cross‐talk between inflammation and tumorigenesis. High expression of programmed death ligand‐1 (PD‐L1) also plays an important role in immune tolerance in tumors. The ... ...

Abstract	MiR‐155‐5p is a key oncogenic microRNA that maintains immune homeostasis and mediates cross‐talk between inflammation and tumorigenesis. High expression of programmed death ligand‐1 (PD‐L1) also plays an important role in immune tolerance in tumors. The present study aimed to explore the relationship between miR‐155‐5p and PD‐L1 in lung adenocarcinoma (LUAD) cells A549 and H1650. The expression levels of miR‐155‐5p and PD‐L1 in LUAD patients were detected by a quantitative reverse transcriptase‐polymerase chain reaction (qRT‐PCR) and mimics of miR‐155‐5p were used to model increased expression in A549 or H1650 cells. After 24 h, we measured levels of PD‐L1 by qRT‐PCR, western blotting and flow cytometry. In addition, we identified two sites in the PD‐L1 3′‐UTR (5′‐AGCAUUA‐3′ and 5′‐GCAUUAA‐3′) that can be bound by miR‐155‐5p using TargetScan (http://www.targetscan.org). Compared to normal tissue, miR‐155‐5p was overexpressed in tumor tissue (P = 0.0456), whereas the expression of PD‐L1 was not significantly different (P = 0.1349). The expression levels of miR‐155‐5p and PD‐L1 were negatively correlated (r = −0.6409, P = 0.0459 and r = −0.7544, P = 0.0117). Exogenous overexpression of miR‐155‐5p decreased the mRNA, total protein and membrane protein expression levels of PD‐L1 both in A549 and H1650 cells (P < 0.05). Taken together, our data suggest that miR‐155‐5p may suppress the expression of PD‐L1 in LUAD.
Keywords	adenocarcinoma ; carcinogenesis ; death ; flow cytometry ; homeostasis ; immunosuppression ; inflammation ; lungs ; membrane proteins ; microRNA ; protein content ; protein synthesis ; reverse transcriptase polymerase chain reaction
Language	English
Dates of publication	2020-06
Size	p. 1065-1071.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2651702-4
ISSN	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.12853
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: FusionFormer

Hu, Chunyong / Zheng, Hang / Li, Kun / Xu, Jianyun / Mao, Weibo / Luo, Maochun / Wang, Lingxuan / Chen, Mingxia / Peng, Qihao / Liu, Kaixuan / Zhao, Yiru / Hao, Peihan / Liu, Minzhe / Yu, Kaicheng

A Multi-sensory Fusion in Bird's-Eye-View and Temporal Consistent Transformer for 3D Object Detection

2023

Abstract: Multi-sensor modal fusion has demonstrated strong advantages in 3D object detection tasks. However, existing methods that fuse multi-modal features require transforming features into the bird's eye view space and may lose certain information on Z-axis, ... ...

Abstract	Multi-sensor modal fusion has demonstrated strong advantages in 3D object detection tasks. However, existing methods that fuse multi-modal features require transforming features into the bird's eye view space and may lose certain information on Z-axis, thus leading to inferior performance. To this end, we propose a novel end-to-end multi-modal fusion transformer-based framework, dubbed FusionFormer, that incorporates deformable attention and residual structures within the fusion encoding module. Specifically, by developing a uniform sampling strategy, our method can easily sample from 2D image and 3D voxel features spontaneously, thus exploiting flexible adaptability and avoiding explicit transformation to the bird's eye view space during the feature concatenation process. We further implement a residual structure in our feature encoder to ensure the model's robustness in case of missing an input modality. Through extensive experiments on a popular autonomous driving benchmark dataset, nuScenes, our method achieves state-of-the-art single model performance of 72.6% mAP and 75.1% NDS in the 3D object detection task without test time augmentation.
Keywords	Computer Science - Computer Vision and Pattern Recognition
Subject code	629
Publishing date	2023-09-11
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Heterogeneity in effects of genetically determined adiposity on insulin resistance and type 2 diabetes: The atherosclerosis risk in communities study.

Liu, Tingting / Li, Changwei / Shen, Luqi / Shen, Ye / Mao, Weibo / Li, Shengxu

Journal of diabetes and its complications

2018 Volume 32, Issue 3, Page(s) 330–334

Abstract: Background: A recent genome-wide association study has identified 12 genetic variants robustly associated with body fat percentage (BF%) with diverse cardiometabolic consequences. We developed three genetic risk scores (GRSs) according to the ... ...

Abstract	Background: A recent genome-wide association study has identified 12 genetic variants robustly associated with body fat percentage (BF%) with diverse cardiometabolic consequences. We developed three genetic risk scores (GRSs) according to the associations of the 12 individual variants with type 2 diabetes (T2D) and test the GRSs' associations with insulin resistance and T2D in the Atherosclerosis Risk in Communities Study. Methods: In 6895 European-American participants, we calculated GRS-I as the number of BF%-increasing alleles from variants associated with increased risk of T2D, GRS-D from variants associated with decreased risk of T2D, and GRS-ALL from all 12 variants. Linear and logistic regression models were used to evaluate associations of the GRSs with insulin resistance and risk of T2D, respectively, adjusted for age, sex, smoking, and drinking, and additionally for body mass index (BMI). Results: GRS-D was significantly associated with decreased levels of fasting insulin (P = 0.014) and homeostasis assessment of insulin resistance (P = 0.023). While GRS-I was not associated with insulin resistance measures, it was with T2D (P = 0.002). Further adjustment for BMI did not substantially change the above associations. GRS-ALL was inversely associated with insulin resistance after controlling for covariates including BMI; GRS-ALL was not associated with T2D. Conclusion: Genetically determined BF% has differential effects on cardiometabolic risk, which may partly explain the heterogeneity in obesity-induced cardiometabolic risk and have implications for developing new strategies mitigating obesity-induced cardiometabolic consequences.
MeSH term(s)	Adiposity/genetics ; Atherosclerosis/etiology ; Body Mass Index ; Cohort Studies ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; European Continental Ancestry Group/genetics ; Female ; Genetic Predisposition to Disease/genetics ; Genome-Wide Association Study ; Humans ; Insulin Resistance/genetics ; Male ; Middle Aged
Language	English
Publishing date	2018-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1105840-7
ISSN	1873-460X ; 1056-8727
ISSN (online)	1873-460X
ISSN	1056-8727
DOI	10.1016/j.jdiacomp.2017.12.012
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Zs.A 2225: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (1.OG)
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Article ; Online: MicroRNA-155-5p suppresses PD-L1 expression in lung adenocarcinoma.

Huang, Jiansheng / Weng, Qiaoyou / Shi, Yang / Mao, Weibo / Zhao, Zhigang / Wu, Rongzhen / Ren, Jianmin / Fang, Shiji / Lu, Chenying / Du, Yongzhong / Ji, Jiansong

FEBS open bio

2020 Volume 10, Issue 6, Page(s) 1065–1071

Abstract: MiR-155-5p is a key oncogenic microRNA that maintains immune homeostasis and mediates cross-talk between inflammation and tumorigenesis. High expression of programmed death ligand-1 (PD-L1) also plays an important role in immune tolerance in tumors. The ... ...

Abstract	MiR-155-5p is a key oncogenic microRNA that maintains immune homeostasis and mediates cross-talk between inflammation and tumorigenesis. High expression of programmed death ligand-1 (PD-L1) also plays an important role in immune tolerance in tumors. The present study aimed to explore the relationship between miR-155-5p and PD-L1 in lung adenocarcinoma (LUAD) cells A549 and H1650. The expression levels of miR-155-5p and PD-L1 in LUAD patients were detected by a quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) and mimics of miR-155-5p were used to model increased expression in A549 or H1650 cells. After 24 h, we measured levels of PD-L1 by qRT-PCR, western blotting and flow cytometry. In addition, we identified two sites in the PD-L1 3'-UTR (5'-AGCAUUA-3' and 5'-GCAUUAA-3') that can be bound by miR-155-5p using TargetScan (http://www.targetscan.org). Compared to normal tissue, miR-155-5p was overexpressed in tumor tissue (P = 0.0456), whereas the expression of PD-L1 was not significantly different (P = 0.1349). The expression levels of miR-155-5p and PD-L1 were negatively correlated (r = -0.6409, P = 0.0459 and r = -0.7544, P = 0.0117). Exogenous overexpression of miR-155-5p decreased the mRNA, total protein and membrane protein expression levels of PD-L1 both in A549 and H1650 cells (P < 0.05). Taken together, our data suggest that miR-155-5p may suppress the expression of PD-L1 in LUAD.
MeSH term(s)	A549 Cells ; Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/immunology ; Adenocarcinoma of Lung/pathology ; B7-H1 Antigen/genetics ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Lung/pathology ; Lung Neoplasms/genetics ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; MicroRNAs/metabolism ; Tumor Escape/genetics
Chemical Substances	B7-H1 Antigen ; CD274 protein, human ; MIRN155 microRNA, human ; MicroRNAs
Language	English
Publishing date	2020-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2651702-4
ISSN	2211-5463 ; 2211-5463
ISSN (online)	2211-5463
ISSN	2211-5463
DOI	10.1002/2211-5463.12853
Database	MEDical Literature Analysis and Retrieval System OnLINE

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