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  1. Article: Communication molecules (ncRNAs) mediate tumor-associated macrophage polarization and tumor progression.

    Yao, Min / Mao, Xuhua / Zhang, Zherui / Cui, Feilun / Shao, Shihe / Mao, Boneng

    Frontiers in cell and developmental biology

    2024  Volume 12, Page(s) 1289538

    Abstract: Non-coding RNAs play important roles in tumor cells and macrophages and participate in their communication as messengers. Non-coding RNAs have an impact in tumor cell proliferation, migration, and apoptosis, and they also regulate the differentiation and ...

    Abstract Non-coding RNAs play important roles in tumor cells and macrophages and participate in their communication as messengers. Non-coding RNAs have an impact in tumor cell proliferation, migration, and apoptosis, and they also regulate the differentiation and regulation of immune cells. In macrophages, they stimulate the polarization of macrophages into M1 or M2 by regulating proteins related to signaling pathways; in tumor cells, non-coding RNAs can enter macrophages through exosomes and affect the latter polarization. The polarization of macrophages further regulates the biological functions of cancer cells. The direction of macrophage polarization determines tumor progression, angiogenesis and drug resistance. This often creates a feedback loop. Non-coding RNAs act as bridges between tumor cells and macrophages to regulate the balance of the tumor microenvironment. We reviewed the signaling pathways related to macrophage polarization and the regulatory mechanisms of non-coding RNA in tumor-associated macrophages M1 and M2, and discussed the potential applications and prospects of exosome engineering.
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2024.1289538
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Bifidobacterium animalis

    Lin, Chunxiu / Lin, Yugui / Wang, Shunhe / Wang, Jialiang / Mao, Xuhua / Zhou, Yonghua / Zhang, Hao / Chen, Wei / Wang, Gang

    Food & function

    2024  Volume 15, Issue 1, Page(s) 236–254

    Abstract: Bifidobacterium ... ...

    Abstract Bifidobacterium animalis
    MeSH term(s) Rats ; Animals ; Bifidobacterium animalis ; Bifidobacterium/metabolism ; Intestines ; Salmonella ; Probiotics ; Salmonella Infections
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d3fo03686c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  3. Article ; Online: Acute myeloid leukemia with blue-green neutrophilic inclusions have different outcomes: two cases and review of the literature.

    Zhao, Jiahao / Qiao, Guohong / Tong, Laigen / Feng, Xinghua / Mao, Xuhua / Huang, Jin / Sun, Yaoxiang

    Clinical chemistry and laboratory medicine

    2023  Volume 62, Issue 6, Page(s) e140–e143

    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/diagnosis ; Neutrophils/pathology ; Male ; Inclusion Bodies/pathology ; Female ; Middle Aged ; Adult ; Aged
    Language English
    Publishing date 2023-12-29
    Publishing country Germany
    Document type Case Reports ; Letter ; Review
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2023-1065
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Tumor-derived CircRNA_102191 promotes gastric cancer and facilitates M2 macrophage polarization.

    Yao, Min / Mao, Xuhua / Zhang, Zherui / Xi, Yue / Gan, Haining / Cui, Feilun / Shao, Shihe

    Cell cycle (Georgetown, Tex.)

    2023  Volume 22, Issue 18, Page(s) 2003–2017

    Abstract: Background: Gastric cancer is a common malignant tumor of the digestive tract and the fourth leading cause of death from cancer-related diseases. In recent years, many studies have found that circular RNAs play an important role in cancer. Tumor- ... ...

    Abstract Background: Gastric cancer is a common malignant tumor of the digestive tract and the fourth leading cause of death from cancer-related diseases. In recent years, many studies have found that circular RNAs play an important role in cancer. Tumor-associated macrophages (TAMs) are also critical for tumor progression.
    Objective: This study examined the role of circRNA_102191 in gastric cancer progression.
    Methods: The relative mRNA levels were determined by qRT-PCR. Western blotting and ELISA were used to detect the protein levels. In vitro proliferation was assessed using CCK8 and clonogenic assays. The migration and invasion of cell lines were assessed by transwell-based assays. The interactions between molecules were detected using a luciferase reporter assay. M0 macrophages were induced with PMA. M1 macrophages were induced with LPS and IFN-γ, and M2 macrophages were induced with IL-4.
    Results: The expression of circRNA_102191 was enhanced significantly in gastric cancer cell lines and clinical tumor tissues. CircRNA_102191 promotes gastric cancer cell progression by regulating miR-493-3p and its downstream target gene XPR1. CircRNA_102191 can enhance the EMT process of gastric cancer cells by promoting the M2 polarization of macrophages.
    Conclusion: CircRNA_102191 promotes the biological function of gastric cancer cells by regulating the miR-493-3p/XPR1 axis and M2 macrophage polarization.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; RNA, Circular/genetics ; RNA, Circular/metabolism ; Stomach Neoplasms/pathology ; Macrophages/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics
    Chemical Substances MicroRNAs ; RNA, Circular ; MIRN493 microRNA, human
    Language English
    Publishing date 2023-11-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2023.2271341
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Bifidobacterium longum

    Kong, Qingmin / Chen, Qian / Mao, Xuhua / Wang, Gang / Zhao, Jianxin / Zhang, Hao / Chen, Wei

    Nutrients

    2022  Volume 14, Issue 8

    Abstract: The kynurenine pathway (KP) is abnormal in autistic patients and model animals. According to studies on the brain-gut axis, probiotics can help ameliorate the metabolic abnormalities of the KP in patients and model animals with neurological diseases. ... ...

    Abstract The kynurenine pathway (KP) is abnormal in autistic patients and model animals. According to studies on the brain-gut axis, probiotics can help ameliorate the metabolic abnormalities of the KP in patients and model animals with neurological diseases. This study was aimed at evaluating the ability of
    MeSH term(s) Animals ; Autistic Disorder ; Bifidobacterium longum/metabolism ; Glutamic Acid ; Humans ; Kynurenine/metabolism ; Neuroinflammatory Diseases ; Neurotransmitter Agents ; Quinolinic Acid/metabolism ; Rats ; gamma-Aminobutyric Acid
    Chemical Substances Neurotransmitter Agents ; Kynurenine (343-65-7) ; Glutamic Acid (3KX376GY7L) ; gamma-Aminobutyric Acid (56-12-2) ; Quinolinic Acid (F6F0HK1URN)
    Language English
    Publishing date 2022-04-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu14081615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Helicobacter pylori

    Xi, Yue / Zhang, Xiao-Li / Luo, Qing-Xin / Gan, Hai-Ning / Liu, Yu-Shi / Shao, Shi-He / Mao, Xu-Hua

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1187638

    Abstract: One of the most prevalent malignant tumors of the digestive tract is gastric cancer (GC). Age, high salt intake, ...

    Abstract One of the most prevalent malignant tumors of the digestive tract is gastric cancer (GC). Age, high salt intake,
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1187638
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bifidobacterium breve

    Lan, Yuming / Lu, Junjie / Qiao, Guohong / Mao, Xuhua / Zhao, Jianxin / Wang, Gang / Tian, Peijun / Chen, Wei

    Nutrients

    2023  Volume 15, Issue 21

    Abstract: Psychobiotics, a newly identified category of probiotics primarily targeting the gut-brain axis, exhibit tremendous potential in improving sleep quality. In this study, the clinical trial was registered in advance (identifier: NO. ChiCTR2300067806). ... ...

    Abstract Psychobiotics, a newly identified category of probiotics primarily targeting the gut-brain axis, exhibit tremendous potential in improving sleep quality. In this study, the clinical trial was registered in advance (identifier: NO. ChiCTR2300067806). Forty participants who were diagnosed with stress-induced insomnia were chosen and randomly divided into two groups: one received CCFM1025 at a dose of 5 × 10
    MeSH term(s) Humans ; Bifidobacterium breve ; Sleep Quality ; Hypothalamo-Hypophyseal System ; Pituitary-Adrenal System ; Sleep Initiation and Maintenance Disorders ; Probiotics/therapeutic use ; Double-Blind Method
    Language English
    Publishing date 2023-11-06
    Publishing country Switzerland
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15214700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Molecular features, biological behaviors and clinical implications of m

    Zhan, Mengyao / Song, Huan / Tian, Dan / Wen, Qin / Shi, Xinling / Wang, Yuting / Mao, Xuhua / Wang, Jianming

    Cancer biology & therapy

    2023  Volume 24, Issue 1, Page(s) 2223382

    Abstract: Epitranscriptome studies have shown that critical RNA modifications drive tumorigenicity; however, the role of 5-methylcytosine ( ... ...

    Abstract Epitranscriptome studies have shown that critical RNA modifications drive tumorigenicity; however, the role of 5-methylcytosine (m
    MeSH term(s) Humans ; Methylation ; Gastrointestinal Neoplasms/genetics ; Pancreatic Neoplasms ; Liver Neoplasms ; RNA ; Prognosis
    Chemical Substances RNA (63231-63-0)
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.1080/15384047.2023.2223382
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Clustering and recent transmission of

    Xu, Guisheng / Mao, Xuhua / Wang, Jianming / Pan, Hongqiu

    Infection and drug resistance

    2018  Volume 11, Page(s) 323–330

    Abstract: Purpose: The objectives of the present study were to characterize the clinical isolates prevailing in the northeast of Jiangsu and to investigate the mode of transmission. The study also aimed to explore the extent to which : Patients and methods: We ...

    Abstract Purpose: The objectives of the present study were to characterize the clinical isolates prevailing in the northeast of Jiangsu and to investigate the mode of transmission. The study also aimed to explore the extent to which
    Patients and methods: We consecutively enrolled 912 culture-confirmed pulmonary tuberculosis (TB) cases from 1 January 2013 to 31 December 2014 in Lianyungang City, which is located in the center of China's vast ocean area and the northeast of Jiangsu province. Isolates were genotyped using 15-locus mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing. The Hunter-Gaston discrimination index (HGDI) was used to estimate the discriminatory power and diversity of molecular markers.
    Results: Among 741 successfully genotyped isolates, 144 (19.43%) strains formed 46 clusters, while 597 (80.57%) isolates had the unique MIRU pattern. The total HGDI for all 15 loci was 0.999. The average cluster size was 3 (2-13) patients. The estimated proportion of recent transmission was 13.34%. Patients with unfavorable treatment outcomes were infected with clustered strains at a higher proportion than were those with favorable treatment outcomes (adjusted OR: 1.78, 95% CI: 1.14-2.85,
    Conclusion: The probability of recent TB transmission was relatively low in the study site, while the cases mainly arose from the activation of previous infection. Spatial analysis showed that strains forming larger clusters had the characteristics of regional aggregation.
    Language English
    Publishing date 2018-03-06
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S156534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway.

    Song, Huan / Tian, Dan / Sun, Jian / Mao, Xuhua / Kong, Weimin / Xu, Dian / Ji, Ye / Qiu, Beibei / Zhan, Mengyao / Wang, Jianming

    Cell death & disease

    2022  Volume 13, Issue 4, Page(s) 361

    Abstract: Extensive changes of circRNA expression underscore their essential contributions to multiple hallmarks of cancers; however, their functions and mechanisms of action in esophageal squamous cell carcinoma (ESCC) remain undetermined. Here, we adopted a ... ...

    Abstract Extensive changes of circRNA expression underscore their essential contributions to multiple hallmarks of cancers; however, their functions and mechanisms of action in esophageal squamous cell carcinoma (ESCC) remain undetermined. Here, we adopted a three-stage approach by first screening for significantly differentially expressed circRNAs in ESCC and performing an external validation study, followed by the functional analyses. The properties of circRNAs were evaluated using Sanger sequencing, RNase R digestion, actinomycin D treatment, subcellular localization analysis, and fluorescence in situ hybridization. Target transcripts were predicted using online tools and verified by dual-luciferase, RNA immunoprecipitation, qRT-PCR, and western blot. Biotin-labeled RNA-protein pull-down, mass spectrometry, and RNA immunoprecipitation were employed to identify proteins interacting with circRNAs. Gain- and loss-of-function experiments were performed to uncover the roles of circRNAs, their target genes, and binding proteins in the proliferation, metastasis, and invasion. We observed that circFAM120B (hsa_circ_0001666) was frequently downregulated in cancer tissues and patient plasma, and its expression level was related to overall survival in ESCC patients. Overexpression of circFAM120B inhibited the proliferation, metastasis, and invasion of ESCC while silencing it enhanced malignant phenotypes. Mechanistically, circFAM120B was predominantly located in the cytoplasm, guarantying its sponging for miR-661 to restore the expression of PPM1L, a tumor suppressor. We observed that circFAM120B could reduce the stability of RNA-dependent protein kinase (PKR) by promoting its ubiquitination-dependent degradation and subsequently regulating the p38 MAPK signaling pathway, resulting in the repression of EMTs in ESCC cells. Our findings suggest that circFAM120B is a promising biomarker of ESCC, which acts as a tumor suppressor via the circFAM120B/miR-661/PPM1L axis and PKR/p38 MAPK/EMT pathway, supporting its significance as a candidate therapeutic target.
    MeSH term(s) Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Esophageal Neoplasms/pathology ; Esophageal Squamous Cell Carcinoma/pathology ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; In Situ Hybridization, Fluorescence ; MicroRNAs/metabolism ; RNA, Circular/genetics ; p38 Mitogen-Activated Protein Kinases/genetics ; p38 Mitogen-Activated Protein Kinases/metabolism
    Chemical Substances MIRN661 microRNA, human ; MicroRNAs ; RNA, Circular ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24)
    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-022-04818-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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