Article ; Online: Identification of T cell responses to the nonstructural glycoproteins in survivors of Crimean-Congo hemorrhagic fever in South Africa.
2023 Volume 95, Issue 10, Page(s) e29154
Abstract: Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is listed as a priority pathogen by the World Health Organization due to the severity of disease, propensity for spread to nonendemic regions, and absence of a vaccine or specific treatment. The ... ...
| Abstract | Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is listed as a priority pathogen by the World Health Organization due to the severity of disease, propensity for spread to nonendemic regions, and absence of a vaccine or specific treatment. The immune correlates of protection are not clearly defined and hence the importance of investigating host immune responses in survivors. We have previously shown that survivors generate memory T cell responses that are long-lived and this study aimed to further define specific viral proteins targeted by the T cell response. The NS |
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| MeSH term(s) | Humans ; Hemorrhagic Fever, Crimean ; South Africa ; Leukocytes, Mononuclear ; T-Lymphocytes ; Glycoproteins ; Mucins ; Peptide Library ; Survivors | |||||
| Chemical Substances | Glycoproteins ; Mucins ; Peptide Library | |||||
| Language | English | |||||
| Publishing date | 2023-10-09 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 752392-0 | |||||
| ISSN | 1096-9071 ; 0146-6615 | |||||
| ISSN (online) | 1096-9071 | |||||
| ISSN | 0146-6615 | |||||
| DOI | 10.1002/jmv.29154 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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