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  1. Book ; Thesis: Untersuchungen im Mausmodell zu den Effekten von Spenderlymphozyteninfusionen nach allogener Knochenmarktransplantation

    Mapara, Markus Y.

    2003  

    Author's details vorgelegt von Markus Y. Mapara
    Language German
    Size 87 Bl. : Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Habil.-Schr., 2003
    HBZ-ID HT013992224
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2004 E 1086 order to use in reading room Magazin

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  2. Article ; Online: Janus Kinase Inhibitors and Cell Therapy.

    Assal, Amer / Mapara, Markus Y

    Frontiers in immunology

    2021  Volume 12, Page(s) 740847

    Abstract: Cellular therapies such as allogeneic hematopoietic stem cell transplantation (HSCT) and immune-effector cell therapy (IECT) continue to have a critical role in the treatment of patients with high risk malignancies and hematologic conditions. These ... ...

    Abstract Cellular therapies such as allogeneic hematopoietic stem cell transplantation (HSCT) and immune-effector cell therapy (IECT) continue to have a critical role in the treatment of patients with high risk malignancies and hematologic conditions. These therapies are also associated with inflammatory conditions such as graft-
    MeSH term(s) Animals ; Cytokine Release Syndrome/drug therapy ; Graft vs Host Disease/drug therapy ; Hematopoietic Stem Cell Transplantation ; Humans ; Janus Kinase Inhibitors/therapeutic use ; Janus Kinases/metabolism ; Signal Transduction
    Chemical Substances Janus Kinase Inhibitors ; Janus Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2021-08-31
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.740847
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  3. Article ; Online: Psychiatric comorbidities in adults with sickle cell disease: A narrative review.

    Mishkin, Adrienne D / Prince, Elizabeth J / Leimbach, Elizabeth J / Mapara, Markus Y / Carroll, C Patrick

    British journal of haematology

    2023  Volume 203, Issue 5, Page(s) 747–759

    Abstract: Although descriptions of quality of life and patient reports of mood in sickle cell disease (SCD) have become more common in the literature, less is known about psychiatric illness prevalence, presentation, and treatment, particularly for adults. We ... ...

    Abstract Although descriptions of quality of life and patient reports of mood in sickle cell disease (SCD) have become more common in the literature, less is known about psychiatric illness prevalence, presentation, and treatment, particularly for adults. We provide a narrative review of what is known about common and debilitating psychiatric conditions such as depression, anxiety, and cognitive impairment, specifically for adults with SCD. We discuss the limitations of the current evidence, make provisional recommendations, and identify opportunities for research and improved care.
    MeSH term(s) Adult ; Humans ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/epidemiology ; Anemia, Sickle Cell/psychology ; Anxiety/epidemiology ; Cognitive Dysfunction/epidemiology ; Comorbidity ; Quality of Life ; Depression/epidemiology
    Language English
    Publishing date 2023-07-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18981
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  4. Article ; Online: Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.

    Ma, Huihui / Lu, Caisheng / Ziegler, Judith / Liu, Ailing / Sepulveda, Antonia / Okada, Hideho / Lentzsch, Suzanne / Mapara, Markus Y

    The Journal of clinical investigation

    2024  Volume 134, Issue 5

    MeSH term(s) Mice ; Animals ; CD4-Positive T-Lymphocytes ; T-Lymphocytes, Regulatory ; Graft vs Host Disease ; Mice, Inbred C57BL ; Mice, Inbred BALB C ; STAT1 Transcription Factor/genetics
    Chemical Substances Stat1 protein, mouse ; STAT1 Transcription Factor
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI180350
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  5. Article ; Online: High-dose melphalan-autologous hematopoietic cell transplantation in systemic AL amyloidosis following daratumumab-based frontline therapy.

    Mellgard, George S / Bhutani, Divaya / Mapara, Markus Y / Maurer, Mathew S / Radhakrishnan, Jai / Lentzsch, Suzanne / Chakraborty, Rajshekhar

    Bone marrow transplantation

    2024  

    Language English
    Publishing date 2024-05-09
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02301-7
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  6. Article ; Online: The quest for the optimal conditioning regimen: some answers, more questions.

    Mapara, Markus Y

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2013  Volume 19, Issue 9, Page(s) 1275–1276

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Female ; HLA Antigens/metabolism ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Transplantation Conditioning/methods ; Vidarabine/analogs & derivatives ; Vidarabine/therapeutic use ; Whole-Body Irradiation/methods
    Chemical Substances Antineoplastic Agents ; HLA Antigens ; Vidarabine (FA2DM6879K) ; fludarabine (P2K93U8740)
    Language English
    Publishing date 2013-09
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2013.07.011
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    Zs.MO 462: Show issues

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  7. Article ; Online: Reprogramming donor T cells for adoptive immunotherapy.

    Mapara, Markus Y

    Immunotherapy

    2013  Volume 5, Issue 12, Page(s) 1287–1289

    MeSH term(s) Gene Transfer Techniques ; Humans ; Immunotherapy, Adoptive/methods ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/immunology ; Kruppel-Like Transcription Factors/metabolism ; Promyelocytic Leukemia Zinc Finger Protein ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; T-Lymphocytes/transplantation
    Chemical Substances Kruppel-Like Transcription Factors ; Promyelocytic Leukemia Zinc Finger Protein ; ZBTB16 protein, human (147855-37-6)
    Language English
    Publishing date 2013-11-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1750-7448
    ISSN (online) 1750-7448
    DOI 10.2217/imt.13.139
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  8. Article ; Online: Amplification of Signal on Cell Surfaces in Molecular Cascades.

    Rudchenko, Sergei / Taylor, Steven / Milosavic, Nenad / Rudchenko, Maria / Wedderhoff Tissi, Betina / Mapara, Markus Y / Stojanovic, Milan N

    Cells

    2023  Volume 12, Issue 24

    Abstract: We can formulate mixtures of oligonucleotide-antibody conjugates to act as molecular cascade-based automata that analyze pairs of cell surface markers (CD markers) on individual cells in a manner consistent with the implementation of Boolean logic-for ... ...

    Abstract We can formulate mixtures of oligonucleotide-antibody conjugates to act as molecular cascade-based automata that analyze pairs of cell surface markers (CD markers) on individual cells in a manner consistent with the implementation of Boolean logic-for example, by producing a fluorescent label only if two markers are present. While traditional methods to characterize cells are based on transducing signals from individual cell surface markers, these cascades can be used to combine into a single signal the presence of two or even more CDs. In our original design, oligonucleotide components irreversibly flowed from one antibody to another, driven by increased hybridizations, leading to the magnitude of the final signal on each cell being determined by the surface marker that was the least abundant. This is a significant limitation to the precise labeling of narrow subpopulations, and, in order to overcome it, we changed our design to accomplish signal amplification to a more abundant cell surface marker. We show the AMPLIFY function on two examples: (1) we amplify the fluorescent label from the CD19 marker onto a fivefold more abundant CD45, and (2) we amplify broadly distributed CD45RA to a more constant marker, CD3. We expect this new function to enable the increasingly complex Boolean analysis of cell surfaces.
    MeSH term(s) Leukocyte Common Antigens ; Antigens, CD19 ; Cell Membrane ; Oligonucleotides
    Chemical Substances Leukocyte Common Antigens (EC 3.1.3.48) ; Antigens, CD19 ; Oligonucleotides
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12242858
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  9. Article ; Online: The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease.

    Fu, Jing / Li, Shirong / Ma, Huihui / Yang, Jun / Pagnotti, Gabriel M / Brown, Lewis M / Weiss, Stephen J / Mapara, Markus Y / Lentzsch, Suzanne

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 4271

    Abstract: Multiple myeloma bone disease is characterized by the development of osteolytic bone lesions. Recent work identified matrix metalloproteinase 13 as a myeloma-derived fusogen that induces osteoclast activation independent of its proteolytic activity. We ... ...

    Abstract Multiple myeloma bone disease is characterized by the development of osteolytic bone lesions. Recent work identified matrix metalloproteinase 13 as a myeloma-derived fusogen that induces osteoclast activation independent of its proteolytic activity. We now identify programmed death-1 homolog, PD-1H, as the bona fide MMP-13 receptor on osteoclasts. Silencing PD-1H or using Pd-1h
    MeSH term(s) Animals ; Mice ; Bone and Bones/pathology ; Carrier Proteins ; Matrix Metalloproteinase 13 ; Multiple Myeloma/genetics ; Multiple Myeloma/pathology ; Osteoclasts/pathology ; Osteolysis/genetics ; Osteolysis/pathology
    Chemical Substances Carrier Proteins ; Matrix Metalloproteinase 13 (EC 3.4.24.-) ; Vsir protein, mouse
    Language English
    Publishing date 2023-07-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39769-8
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  10. Article ; Online: First report of outcomes in patients with stage IIIb AL amyloidosis treated with Dara-VCD front-line therapy.

    Chakraborty, Rajshekhar / Rosenbaum, Cara / Kaur, Gurbakhash / Bhutani, Divaya / Radhakrishnan, Jai / Mapara, Markus Y / Maurer, Mathew / Lentzsch, Suzanne

    British journal of haematology

    2023  Volume 201, Issue 5, Page(s) 913–916

    Abstract: Although Dara-VCD (daratumumab-bortezomib-cyclophosphamide-dexamethasone) has revolutionized the treatment of newly diagnosed Amyloid Light chain (AL) amyloidosis, patients with stage IIIb disease were excluded in the pivotal trial. We performed a ... ...

    Abstract Although Dara-VCD (daratumumab-bortezomib-cyclophosphamide-dexamethasone) has revolutionized the treatment of newly diagnosed Amyloid Light chain (AL) amyloidosis, patients with stage IIIb disease were excluded in the pivotal trial. We performed a multicentre retrospective cohort study to investigate the outcomes of 19 consecutive patients treated with Dara-VCD front-line therapy who had stage IIIb AL at diagnosis. More than two thirds presented with New York Heart Association Class III/IV symptoms, and had a median of two organs involved (range, 2-4). The haematologic overall response rate was 100%, with 17/19 patients (89.5%) achieving a very good partial response (VGPR) or better. Haematologic responses were achieved rapidly, as evidenced by 63% of evaluable patients with involved serum free light chains (iFLC) < 2 mg/dl and the difference between involved and uninvolved serum free light chains (dFLC) <1 mg/dl at three months. Among 18 evaluable patients, 10 (56%) achieved a cardiac organ response and six (33%) cardiac VGPR or better. The median time to first cardiac response was 1.9 months (range, 0.4-7.3). At a median follow-up of 12 months for surviving patients, estimated one-year overall survival was 67.5% [95% confidence interval (CI), 43.8-84.7]. The incidence of grade 3 or higher infections was 21%, with no infection-related mortality thus far. In summary, Dara-VCD has a promising efficacy and safety profile in stage IIIb AL, and should be studied in prospective trials.
    MeSH term(s) Humans ; Bortezomib/adverse effects ; Cyclophosphamide/adverse effects ; Dexamethasone/adverse effects ; Immunoglobulin Light-chain Amyloidosis ; Prospective Studies ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Bortezomib (69G8BD63PP) ; Cyclophosphamide (8N3DW7272P) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-03-10
    Publishing country England
    Document type Journal Article ; Multicenter Study
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18733
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