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Article ; Online: COVID-19 Concerns and Personality of Commerce Workers

Ana María Rodríguez-López / Susana Rubio-Valdehita

Sustainability, Vol 13, Iss 12908, p

Its Influence on Burnout

2021 Volume 12908

Abstract: We analyze burnout in a sample of commercial workers in Spain and its relationship with sociodemographic variables, personality, and concern about the influence of the COVID-19 pandemic on their jobs through a cross-sectional design. Participants ( n = ... ...

Abstract	We analyze burnout in a sample of commercial workers in Spain and its relationship with sociodemographic variables, personality, and concern about the influence of the COVID-19 pandemic on their jobs through a cross-sectional design. Participants ( n = 614) answered an online survey, including questions about sociodemographic data, concern, NEO-FFI (personality), and MBI (burnout syndrome). The survey took place from October 2020 to May 2021. We assessed the relationships between sociodemographic variables, pandemic concern, and personality as predictors of burnout by hierarchical regression analysis and then tested using SEM (structural equation models). The proposed model showed adequate goodness-of-fit indices. The results of the present study suggest that the COVID-19 pandemic had little effect to the development of burnout syndrome in commerce employees. However, in agreement with previous literature, the present study shows that personality has a significant role in predicting burnout. Neuroticism, introversion, conscientiousness, and agreeableness were strong predictors for burnout dimensions. In addition, we found that personality directly affected the pandemic concern: individuals with high levels of Neuroticism and low levels of extraversion, agreeableness, and conscientiousness have more pandemic concerns. In conclusion, personality is an important factor that affects the level of workers’ concern about the influence of the pandemic on their job and the development of burnout syndrome. Furthermore, although we found significant differences between groups formed by various sociodemographic characteristics, the conclusion regarding this type of variable is that their ability to predict burnout is deficient.
Keywords	burnout ; personality ; COVID-19 ; pandemic ; commerce sector ; Spain ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	150
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Concern about the Effects of the Pandemic Caused by COVID-19 in the Retail Sector in Spain. Differences between Men and Women

Susana Rubio-Valdehita / Ana María Rodríguez-López / Angélica Marín

Medical Sciences Forum, Vol 4, Iss 9, p

2021 Volume 9

Abstract: This study analyzed differences between men and women from a sample of retail workers in their perception of the effects that COVID-19 can have on the workplace. Participants ( n = 467) answered an online survey including questions about sociodemographic ...

Abstract	This study analyzed differences between men and women from a sample of retail workers in their perception of the effects that COVID-19 can have on the workplace. Participants ( n = 467) answered an online survey including questions about sociodemographic data and perception of COVID-19. We obtained data throughout October-December 2020. The results showed that participants exhibit deep concern about the COVID-19 pandemic and its influence at the work level. Both genders exhibited deep concern about the pandemic and about how the COVID-19 had affected them at the workplace. However, women have more uncertainty in their work. They have noticed more changes at the psychosomatic level, they are more afraid that their employment situation will be affected by the pandemic, and they consider that their situation will worsen. In conclusion, while the COVID-19 pandemic has similarly affected men and women in terms of their work, expectations about the future effects of the crisis caused by COVID-19 are worse for women than for men.
Keywords	perception ; economic impact ; COVID-19 ; pandemic ; retail sector ; Spain ; Medicine ; R
Subject code	300
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Broad functional profiling of fission yeast proteins using phenomics and machine learning

María Rodríguez-López / Nicola Bordin / Jon Lees / Harry Scholes / Shaimaa Hassan / Quentin Saintain / Stephan Kamrad / Christine Orengo / Jürg Bähler

eLife, Vol

2023 Volume 12

Abstract: Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe for broad cues on protein functions. We assayed colony- ... ...

Abstract	Many proteins remain poorly characterized even in well-studied organisms, presenting a bottleneck for research. We applied phenomics and machine-learning approaches with Schizosaccharomyces pombe for broad cues on protein functions. We assayed colony-growth phenotypes to measure the fitness of deletion mutants for 3509 non-essential genes in 131 conditions with different nutrients, drugs, and stresses. These analyses exposed phenotypes for 3492 mutants, including 124 mutants of ‘priority unstudied’ proteins conserved in humans, providing varied functional clues. For example, over 900 proteins were newly implicated in the resistance to oxidative stress. Phenotype-correlation networks suggested roles for poorly characterized proteins through ‘guilt by association’ with known proteins. For complementary functional insights, we predicted Gene Ontology (GO) terms using machine learning methods exploiting protein-network and protein-homology data (NET-FF). We obtained 56,594 high-scoring GO predictions, of which 22,060 also featured high information content. Our phenotype-correlation data and NET-FF predictions showed a strong concordance with existing PomBase GO annotations and protein networks, with integrated analyses revealing 1675 novel GO predictions for 783 genes, including 47 predictions for 23 priority unstudied proteins. Experimental validation identified new proteins involved in cellular aging, showing that these predictions and phenomics data provide a rich resource to uncover new protein functions.
Keywords	cell phenotype ; functional genomics ; unknown protein ; computational prediction ; gene ontology ; machine learning ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	006
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Influence of the CoViD-19 Pandemic on Mental Workload and Burnout of Fashion Retailing Workers in Spain

Ana María Rodríguez-López / Susana Rubio-Valdehita / Eva María Díaz-Ramiro

International Journal of Environmental Research and Public Health, Vol 18, Iss 983, p

2021 Volume 983

Abstract: This study analyzed the levels of mental workload and the presence of burnout on a sample of fashion retailing workers from Spain and its relationship with the current CoViD-19 (Coronavirus disease-19) pandemic. We established a cross-sectional design. ... ...

Abstract	This study analyzed the levels of mental workload and the presence of burnout on a sample of fashion retailing workers from Spain and its relationship with the current CoViD-19 (Coronavirus disease-19) pandemic. We established a cross-sectional design. Participants ( n = 360) answered an online survey including questions about sociodemographic data, perception of CoViD-19, CarMen-Q questionnaire (workload), and MBI (burnout syndrome). The survey campaign took place in October and November 2020. The results showed that participants exhibited deep concern about the CoViD-19 pandemic and its influence in the workplace. Although the mental workload was near the middle point of the scale, participants showed moderate to high burnout levels, revealing that the sample was at risk of experiencing higher burnout levels over time as the pandemic and associated economic crisis continued. The multiple regression analysis results indicated that environmental changes, work overload, somatic symptoms, insomnia, negative job expectations, and uncertainty constituted significant mental workload predictors. Insomnia, somatic symptoms, and negative job expectations constituted significant predictors for burnout. Differences between job positions and genders in mental workload and burnout were found. In conclusion, the uncertainty at work derived from the CoViD-19 pandemic harms fashion retailing workers’ psychological well-being in Spain.
Keywords	mental workload ; burnout ; CoViD-19 ; pandemic ; fashion retailing sector ; Spain ; Medicine ; R
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Inflammatory Response, Immunosuppression and Arginase Activity after Cardiac Surgery Using Cardiopulmonary Bypass

José María Rodríguez-López / José Luis Iglesias-González / Francisco Santiago Lozano-Sánchez / Miguel Ángel Palomero-Rodríguez / Pilar Sánchez-Conde

Journal of Clinical Medicine, Vol 11, Iss 14, p

2022 Volume 4187

Abstract: Background: Major surgeries suppress patients’ cellular immunity for several days, but the mechanisms underlying this T-cell dysfunction are not well understood. A decreased L-Arginine (L-Arg) level may inhibit T-cell function. Arginase 1 (Arg 1) is ... ...

Abstract	Background: Major surgeries suppress patients’ cellular immunity for several days, but the mechanisms underlying this T-cell dysfunction are not well understood. A decreased L-Arginine (L-Arg) level may inhibit T-cell function. Arginase 1 (Arg 1) is induced after traumatic injury, leading to molecular changes in T cells, including decreased expression of cell surface T-cell receptors (TCRs) and a loss in CD3ζ chain expression. In this study, we examined the temporal patterns of CD3ζ expression and Arg 1 activity in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). Methods: We determined the CD3ζ chain expression; the Arg 1 activity; and the leukocyte, neutrophil and lymphocyte levels of patients on the day before surgery and at 24, 48 and 72 h after surgery. Results: Fifty adult patients scheduled for elective cardiac surgery with CPB were eligible for enrolment. Arginase activity was significantly increased between the day before surgery and at 24, 48 and 72 h after surgery ( p < 0.01), and CD3ζ expression was significantly decreased between the day before surgery and at 24, 48 and 72 h after surgery ( p < 0.001). We observed significant leukocytosis, neutrophilia and lymphopenia after surgery. Conclusions: The decreased CD3ζ chain expression could be due to the increased Arg 1 activity secondary to the activation of neutrophils in cardiac surgery under CPB. These findings could explain the limited immune-system-mediated organ damage resulting from systemic inflammatory response to major cardiac surgery with CPB.
Keywords	arginase activity ; CD3ζ chain expression ; immunosuppression ; cardiac surgery ; cardiopulmonary bypass ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2022-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pyphe, a python toolbox for assessing microbial growth and cell viability in high-throughput colony screens

Stephan Kamrad / María Rodríguez-López / Cristina Cotobal / Clara Correia-Melo / Markus Ralser / Jürg Bähler

eLife, Vol

2020 Volume 9

Abstract: Microbial fitness screens are a key technique in functional genomics. We present an all-in-one solution, pyphe, for automating and improving data analysis pipelines associated with large-scale fitness screens, including image acquisition and ... ...

Abstract	Microbial fitness screens are a key technique in functional genomics. We present an all-in-one solution, pyphe, for automating and improving data analysis pipelines associated with large-scale fitness screens, including image acquisition and quantification, data normalisation, and statistical analysis. Pyphe is versatile and processes fitness data from colony sizes, viability scores from phloxine B staining or colony growth curves, all obtained with inexpensive transilluminating flatbed scanners. We apply pyphe to show that the fitness information contained in late endpoint measurements of colony sizes is similar to maximum growth slopes from time series. We phenotype gene-deletion strains of fission yeast in 59,350 individual fitness assays in 70 conditions, revealing that colony size and viability provide complementary, independent information. Viability scores obtained from quantifying the redness of phloxine-stained colonies accurately reflect the fraction of live cells within colonies. Pyphe is user-friendly, open-source and fully documented, illustrated by applications to diverse fitness analysis scenarios.
Keywords	genetic screen ; phenomics ; python software ; microbial fitness ; high-throughput phenotyping ; cell viability ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	eLife Sciences Publications Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Efecto biológico y social de los factores asociados al riesgo cardiovascular en la población adulta joven, revisión documental

Danna María Rodríguez López / Alejandro Gutiérrez Escobar / Nicolás Cortes Gómez / Pedro Antonio Calero Saa

Sabia Revista Científica, Vol 6, Iss 1, Pp 177-

2020 Volume 190

Abstract: Introducción: Las enfermedades cardiovasculares para la Organización Mundial de la Salud (OMS) representan uno de los más grandes problemas en materia de salud pública a nivel mundial, las cuales son consideradas como una de las primeras causas de ... ...

Abstract	Introducción: Las enfermedades cardiovasculares para la Organización Mundial de la Salud (OMS) representan uno de los más grandes problemas en materia de salud pública a nivel mundial, las cuales son consideradas como una de las primeras causas de mortalidad ocasionando 17 millones de muertes por año (1). Según estudios realizados, la población adulto joven tiende a encaminarse hacia la adquisión de conductas y estilos de vida poco saludables, debido a que el ámbito académico produce cambios en estas conductas con complicaciones, tales como, comer entre horas, alto consumo de comidas rápidas, poco tiempo para comer, disminución en la realización de actividad física e incremento de consumo de alcohol y tabaco (2). Objetivos: Conocer acerca de las variables relacionadas con los efectos biológicos y sociales de factores de riesgo cardiovascular en la población adulta joven. Materiales y métodos: se realizó una revisión documental de la literatura existente en el período 2010-2020 de acuerdo a los criterios de inclusión y exclusión propuestos. Resultados y conclusiones: Los resultados encontrados indican que los componentes sociales representan mayor influencia en el desarrollo de los factores de riesgo afectando directamente la dimensión biológica.
Keywords	riesgo cardiovascular ; obesidad ; tabaquismo ; consumo de alcohol ; hábitos alimenticios ; enfermedades cardiovasculares ; adulto joven ; Education ; L ; Social Sciences ; H
Language	Spanish
Publishing date	2020-01-01T00:00:00Z
Publisher	Universidad del Pacífico
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Genetic effects on molecular network states explain complex traits

Matthias Weith / Jan Großbach / Mathieu Clement‐Ziza / Ludovic Gillet / María Rodríguez‐López / Samuel Marguerat / Christopher T Workman / Paola Picotti / Jürg Bähler / Ruedi Aebersold / Andreas Beyer

Molecular Systems Biology, Vol 19, Iss 8, Pp n/a-n/a (2023)

2023

Abstract: Abstract The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules, but ... ...

Abstract	Abstract The complexity of many cellular and organismal traits results from the integration of genetic and environmental factors via molecular networks. Network structure and effect propagation are best understood at the level of functional modules, but so far, no concept has been established to include the global network state. Here, we show when and how genetic perturbations lead to molecular changes that are confined to small parts of a network versus when they lead to modulation of network states. Integrating multi‐omics profiling of genetically heterogeneous budding and fission yeast strains with an array of cellular traits identified a central state transition of the yeast molecular network that is related to PKA and TOR (PT) signaling. Genetic variants affecting this PT state globally shifted the molecular network along a single‐dimensional axis, thereby modulating processes including energy and amino acid metabolism, transcription, translation, cell cycle control, and cellular stress response. We propose that genetic effects can propagate through large parts of molecular networks because of the functional requirement to centrally coordinate the activity of fundamental cellular processes.
Keywords	complex traits ; network effects ; PKA signaling ; QTL mapping ; TOR signaling ; Biology (General) ; QH301-705.5 ; Medicine (General) ; R5-920
Subject code	006
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Estudio de la presencia y uso de redes sociales de las agencias de comunicación que más facturan en España / Study about the social network presence and use of the communication agencies with the largest turnover in Spain

María Rodríguez López / Daniel Robles Álvarez

Revista Internacional de Relaciones Públicas, Vol 5, Iss 10, Pp 213-

2015 Volume 236

Abstract: Las agencias de comunicación son empresas que se mueven en el terreno de las relaciones públicas, la publicidad, la comunicación audiovisual y el periodismo. Estas empresas deberían ser líderes en el uso de las nuevas herramientas de comunicación. En ... ...

Abstract	Las agencias de comunicación son empresas que se mueven en el terreno de las relaciones públicas, la publicidad, la comunicación audiovisual y el periodismo. Estas empresas deberían ser líderes en el uso de las nuevas herramientas de comunicación. En este artículo se han estudiado las agencias de comunicación que más facturan en España para comprobar si, efectivamente, hacen un buen uso de las nuevas tecnologías de la comunicación, especialmente de las redes sociales. Hemos descubierto que las empresas aquí estudiadas deberían tener más actividad en redes sociales y en el mundo online en general. No crean contenidos específicos para sus diferentes redes, consiguen poco feedback por parte de sus seguidores, si bien es cierto que todas tienen perfiles en Facebook, Twitter, además de blogs. / Communication agencies are companies that are in contact with public relations, advertising, media and journalism industries. These companies should be leaders in the use of new communication tools. In this article we will study if the communication agencies with the largest turnover in Spain make a good use of new communication tools, especially social networks. We have discovered these companies should have more activity in social networks and in the online world in general. They do not create specific contents for their different networks and get little feedback of from their followers. However, all of them have a profile on Facebook, Twitter and blogs.
Keywords	Comunicación ; Consultorías de Comunicación ; España ; Facturación ; Redes Sociales ; Communication ; Communication Agencies ; Spain ; Billing ; Social Networks ; Political science ; J
Language	English
Publishing date	2015-12-01T00:00:00Z
Publisher	IIPR
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1

María Rodríguez-López / Suam Gonzalez / Olivia Hillson / Edward Tunnacliffe / Sandra Codlin / Victor A. Tallada / Jürg Bähler / Charalampos Rallis

Cell Reports, Vol 30, Iss 10, Pp 3240-3249.e

2020 Volume 4

Abstract: Summary: Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well ... ...

Abstract	Summary: Target of Rapamycin Complex 1 (TORC1) signaling promotes growth and aging. Inhibition of TORC1 leads to reduced protein translation, which promotes longevity. TORC1-dependent post-transcriptional regulation of protein translation has been well studied, while analogous transcriptional regulation is less understood. Here we screen fission yeast mutants for resistance to Torin1, which inhibits TORC1 and cell growth. Cells lacking the GATA factor Gaf1 (gaf1Δ) grow normally even in high doses of Torin1. The gaf1Δ mutation shortens the chronological lifespan of non-dividing cells and diminishes Torin1-mediated longevity. Expression profiling and genome-wide binding experiments show that upon TORC1 inhibition, Gaf1 directly upregulates genes for small-molecule metabolic pathways and indirectly represses genes for protein translation. Surprisingly, Gaf1 binds to and downregulates the tRNA genes, so it also functions as a transcription factor for RNA polymerase III. Thus, Gaf1 controls the transcription of both protein-coding and tRNA genes to inhibit translation and growth downstream of TORC1. : TORC1 signaling promotes protein translation and cellular aging. Rodríguez-López et al. show that this role of TORC1 is partly mediated via the transcription factor Gaf1. When TORC1 is blocked, Gaf1 extends the cellular lifespan by inhibiting the transcription not only of protein-coding genes but also of tRNA genes functioning in translation. Keywords: S. pombe, cell growth, aging, transcription factor, RNA polymerase III, protein translation, vacuole, TOR, GATA6, tRNA
Keywords	Biology (General) ; QH301-705.5
Subject code	570 ; 612
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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