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Article ; Online: HLA-A02:05:01:10, -A26:01:01:30, -C07:01:01:75 and -C07:04:01:12 identified in Spanish donors.

Marin, Luis A / Rada, Ramon / Ontañon, Jesús

2020 Volume 96, Issue 2, Page(s) 207–208

Abstract: Four new HLA-A*02:05:01:10, A*26:01:01:30, C*07:01:01:75 and C*07:04:01:12 alleles detected in Spanish individuals. ...

Abstract	Four new HLA-A02:05:01:10, A26:01:01:30, C07:01:01:75 and C07:04:01:12 alleles detected in Spanish individuals.
MeSH term(s)	Alleles ; HLA-A Antigens/genetics ; High-Throughput Nucleotide Sequencing ; Humans ; Tissue Donors
Chemical Substances	HLA-A Antigens
Language	English
Publishing date	2020-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.13851
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Article: Simulating seasonal to multi-decadal variation in lake thermal response to meteorological forcing using the UCLAKE 1-dimensional model code

Morales-Marín, Luis A / French, Jon R / Burningham, Helene / Evans, Chris / Burden, Annette

Limnologica. 2021 May, v. 88

2021

Abstract: Lake temperature responses to climate forcing are of interest on account of the important linkages between water temperature and ecosystem processes. This paper describes a new 1-dimensional (1D) numerical model code and its application to investigations ...

Abstract	Lake temperature responses to climate forcing are of interest on account of the important linkages between water temperature and ecosystem processes. This paper describes a new 1-dimensional (1D) numerical model code and its application to investigations of multi-scale linkages between the vertical temperature structure and meteorological forcing. UCLAKE is implemented as highly portable open-source software, based on computationally efficient algorithms, and able to resolve sub-daily (e.g., hourly) dynamics while retaining the efficiency to simulate multi-decadal time scales.A UCLAKE model is calibrated and validated against thermistor profile time series for a small upland lake in North Wales, UK. Some of the challenges in 1D model calibration are explored and a sensitivity analysis reveals a dependence of optimal parameter set values on water column depth and time. An exploratory 52-year hindcast simulation demonstrates the computational efficiency of UCLAKE for multi-decadal studies of trends in lake temperature that vary with depth. A supplementary application of UCLAKE to Windermere, in the English Lake District, demonstrates its performance for larger and deeper lakes.
Keywords	climate ; computer software ; ecosystems ; highlands ; lakes ; mathematical models ; thermistors ; time series analysis ; water temperature
Language	English
Dates of publication	2021-05
Publishing place	Elsevier GmbH
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	3380-7
ISSN	0075-9511
ISSN	0075-9511
DOI	10.1016/j.limno.2021.125874
Database	NAL-Catalogue (AGRICOLA)

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Article: On the Mismatches between the Monetary and Social Values of Air Purification in the Colombian Andean Region: A Case Study

Suarez, Andres / Ruiz-Agudelo, Cesar / Castro-Escobar, Edisson / Flórez-Yepes, Gloria Y. / Vargas-Marín, Luis A.

Forests. 2021 Sept. 17, v. 12, no. 9

2021

Abstract: There is growing interest in air quality and air purification, due to current high pollution levels, their effects on human health, and implications for urban economies. Since the improvement of air quality carries important economic value, air-related ... ...

Abstract	There is growing interest in air quality and air purification, due to current high pollution levels, their effects on human health, and implications for urban economies. Since the improvement of air quality carries important economic value, air-related benefits have been evaluated monetarily from two perspectives: the first relates to air quality improvements, while the second values air purification as an ecosystem function. This research opted for the second perspective, given that the study area (two Colombian municipalities) does not suffer from poor air quality conditions, but stakeholders prioritized this function as highly important to them. Contingent valuation methods were applied in order to identify the population’s probability of willingness to maintain the air purification function. Although individuals (n = 245) attribute a yearly monetary value of USD 1.5 million to air purification, it was found that, despite the high level of social importance that respondents assigned to air purification (mean = 4.7/5), this had no correlation with payment values (rho = 0.0134, p = 0.8350); that is, households do not really recognize the monetary value of all the benefits they receive or the benefits they would lose if the service suffers changes. Hence, it is posed that monetary values do not necessarily reflect the social importance that individuals assign to ecosystem services, and attention is called to the need to integrate social and monetary values into decision-making processes, so as to encompass the complexity of ecosystem services and conciliate conflicting valuation language.
Keywords	air ; air quality ; case studies ; contingent valuation ; decision making ; ecological function ; ecosystems ; human health ; pollution ; probability ; stakeholders ; Andes region
Language	English
Dates of publication	2021-0917
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2527081-3
ISSN	1999-4907
ISSN	1999-4907
DOI	10.3390/f12091274
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Article ; Online: Recognizing, normalizing and articulating: An approach to highlight plural values of water ecosystem services in Colombia

Suárez, Andrés / Ruiz-Agudelo, Cesar Augusto / Arias-Arévalo, Paola / Flórez-Yepes, Gloria Y. / Arciniegas, Nicolas / Vargas-Marín, Luis A. / Marulanda, Alejandro / Ramirez, Jesica / Castro-Escobar, Edisson / Bastidas, Juan C. / Blanco Zabala, David

Heliyon. 2022 Sept., v. 8, no. 9 p.e10622-

2022

Abstract: The dialectical relationship between ecosystems and society is complex; therefore, holistic approaches are required to address this complexity. This view also stands out in the ecosystem services valuation field, where different scholars and global ... ...

Abstract	The dialectical relationship between ecosystems and society is complex; therefore, holistic approaches are required to address this complexity. This view also stands out in the ecosystem services valuation field, where different scholars and global platforms have drawn attention to the need to incorporate plural valuation initiatives at decision-making. In this sense, through a comprehensive design, we conducted a multi-layered valuation of ecosystem services, and we highlighted multiple values in two areas of the province of Caldas, Colombia. We proposed a three-phase valuation process called Recognizing, Normalizing and Articulating values. Then, in cooperation with the regional environmental authority, we obtained different water-related ecosystem services values. Our results showed some warnings: first, we found mismatches between ecosystem services values; second, people assigned high values to ecosystems but the actual capacity of ecosystems to support ES is low. Finally, monetary values were marginal compared to social and ecological values. We conclude by saying that the more strata are assessed, the more values appear in the valuation scenarios, and those values could be conflicting. Our results have political implications, since they highlight the need to incorporate plural values as a fundamental tool for planning and land use in real scenarios where conflicts of interest and values are evident.
Keywords	decision making ; ecosystems ; land use ; people ; politics ; Colombia ; Nature contributions to people ; Plural valuation ; Social participation ; Integration: decision making
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10622
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Article: Recognizing, normalizing and articulating: An approach to highlight plural values of water ecosystem services in Colombia.

Suarez, Andres / Ruiz-Agudelo, Cesar Augusto / Arias-Arévalo, Paola / Flórez-Yepes, Gloria Y / Arciniegas, Nicolas / Vargas-Marín, Luis A / Marulanda, Alejandro / Ramirez, Jesica / Castro-Escobar, Edisson / Bastidas, Juan C / Blanco, David

Heliyon

2022 Volume 8, Issue 9, Page(s) e10622

Abstract	The dialectical relationship between ecosystems and society is complex; therefore, holistic approaches are required to address this complexity. This view also stands out in the ecosystem services valuation field, where different scholars and global platforms have drawn attention to the need to incorporate plural valuation initiatives at decision-making. In this sense, through a comprehensive design, we conducted a multi-layered valuation of ecosystem services, and we highlighted multiple values in two areas of the province of Caldas, Colombia. We proposed a three-phase valuation process called
Language	English
Publishing date	2022-09-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2022.e10622
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Article ; Online: Bispectral index and suppression ratio after cardiac arrest: are they useful as bedside tools for rational treatment escalation plans?

Arbas-Redondo, Emilio / Rosillo-Rodríguez, Sandra O / Merino-Argos, Carlos / Marco-Clement, Irene / Rodríguez-Sotelo, Laura / Martínez-Marín, Luis A / Martín-Polo, Lorena / Vélez-Salas, Andrea / Caro-Codón, Juan / García-Arribas, Daniel / Armada-Romero, Eduardo / López-De-Sa, Esteban

Revista espanola de cardiologia (English ed.)

2022 Volume 75, Issue 12, Page(s) 992–1000

Abstract: Introduction and objectives: Myocardial dysfunction contributes to early mortality (24-72 hours) among survivors of a cardiac arrest (CA). The benefits of mechanical support in refractory shock should be balanced against the patient's potential for ... ...

Abstract	Introduction and objectives: Myocardial dysfunction contributes to early mortality (24-72 hours) among survivors of a cardiac arrest (CA). The benefits of mechanical support in refractory shock should be balanced against the patient's potential for neurological recovery. To date, these early treatment decisions have been taken based on limited information leading mainly to undertreatment. Therefore, there is a need for early, reliable, accessible, and simple tools that offer information on the possibilities of neurological improvement. Methods: We collected data from bispectral index (BIS) and suppression ratio (SR) monitoring of adult comatose survivors of CA managed with targeted temperature management (TTM). Neurological status was assessed according to the Cerebral Performance Category (CPC) scale. Results: We included 340 patients. At the first full neurological evaluation, 211 patients (62.1%) achieved good outcome or CPC 1-2. Mean BIS values were significantly higher and median SR lower in patients with CPC 1-2. An average BIS> 26 during first 12 hours of TTM predicted good outcome with 89.5% sensitivity and 75.8% specificity (AUC of 0.869), while average SR values> 24 during the first 12 hours of TTM predicted poor outcome (CPC 3-5) with 91.5% sensitivity and 81.8% specificity (AUC, 0.906). Hourly BIS and SR values exhibited good predictive performance (AUC> 0.85), as soon as hour 2 for SR and hour 4 for BIS. Conclusions: BIS/SR are associated with patients' potential for neurological recovery after CA. This finding could help to create awareness of the possibility of a better outcome in patients who might otherwise be wrongly considered as nonviable and to establish personalized treatment escalation plans.
MeSH term(s)	Adult ; Humans ; Prognosis ; Heart Arrest ; Hypothermia, Induced/adverse effects ; Out-of-Hospital Cardiac Arrest
Language	Spanish
Publishing date	2022-05-12
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2592481-3
ISSN	1885-5857 ; 1885-5857
ISSN (online)	1885-5857
ISSN	1885-5857
DOI	10.1016/j.rec.2022.03.004
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Article ; Online: Geometrically controlled snapping transitions in shells with curved creases.

Bende, Nakul Prabhakar / Evans, Arthur A / Innes-Gold, Sarah / Marin, Luis A / Cohen, Itai / Hayward, Ryan C / Santangelo, Christian D

Proceedings of the National Academy of Sciences of the United States of America

2015 Volume 112, Issue 36, Page(s) 11175–11180

Abstract: Curvature and mechanics are intimately connected for thin materials, and this coupling between geometry and physical properties is readily seen in folded structures from intestinal villi and pollen grains to wrinkled membranes and programmable ... ...

Abstract	Curvature and mechanics are intimately connected for thin materials, and this coupling between geometry and physical properties is readily seen in folded structures from intestinal villi and pollen grains to wrinkled membranes and programmable metamaterials. While the well-known rules and mechanisms behind folding a flat surface have been used to create deployable structures and shape transformable materials, folding of curved shells is still not fundamentally understood. Shells naturally deform by simultaneously bending and stretching, and while this coupling gives them great stability for engineering applications, it makes folding a surface of arbitrary curvature a nontrivial task. Here we discuss the geometry of folding a creased shell, and demonstrate theoretically the conditions under which it may fold smoothly. When these conditions are violated we show, using experiments and simulations, that shells undergo rapid snapping motion to fold from one stable configuration to another. Although material asymmetry is a proven mechanism for creating this bifurcation of stability, for the case of a creased shell, the inherent geometry itself serves as a barrier to folding. We discuss here how two fundamental geometric concepts, creases and curvature, combine to allow rapid transitions from one stable state to another. Independent of material system and length scale, the design rule that we introduce here explains how to generate snapping transitions in arbitrary surfaces, thus facilitating the creation of programmable multistable materials with fast actuation capabilities.
Language	English
Publishing date	2015-09-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1509228112
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Article ; Online: Heart failure in COVID-19 patients: prevalence, incidence and prognostic implications.

Rey, Juan R / Caro-Codón, Juan / Rosillo, Sandra O / Iniesta, Ángel M / Castrejón-Castrejón, Sergio / Marco-Clement, Irene / Martín-Polo, Lorena / Merino-Argos, Carlos / Rodríguez-Sotelo, Laura / García-Veas, Jose M / Martínez-Marín, Luis A / Martínez-Cossiani, Marcel / Buño, Antonio / Gonzalez-Valle, Luis / Herrero, Alicia / López-Sendón, José L / Merino, José L

European journal of heart failure

2020 Volume 22, Issue 12, Page(s) 2205–2215

Abstract: Aims: Data on the impact of COVID-19 in chronic heart failure (CHF) patients and its potential to trigger acute heart failure (AHF) are lacking. The aim of this work was to study characteristics, cardiovascular outcomes and mortality in patients with ... ...

Abstract	Aims: Data on the impact of COVID-19 in chronic heart failure (CHF) patients and its potential to trigger acute heart failure (AHF) are lacking. The aim of this work was to study characteristics, cardiovascular outcomes and mortality in patients with confirmed COVID-19 infection and a prior diagnosis of heart failure (HF). Further aims included the identification of predictors and prognostic implications for AHF decompensation during hospital admission and the determination of a potential correlation between the withdrawal of HF guideline-directed medical therapy (GDMT) and worse outcomes during hospitalization. Methods and results: Data for a total of 3080 consecutive patients with confirmed COVID-19 infection and follow-up of at least 30 days were analysed. Patients with a previous history of CHF (n = 152, 4.9%) were more prone to the development of AHF (11.2% vs. 2.1%; P < 0.001) and had higher levels of N-terminal pro brain natriuretic peptide. In addition, patients with previous CHF had higher mortality rates (48.7% vs. 19.0%; P < 0.001). In contrast, 77 patients (2.5%) were diagnosed with AHF, which in the vast majority of cases (77.9%) developed in patients without a history of HF. Arrhythmias during hospital admission and CHF were the main predictors of AHF. Patients developing AHF had significantly higher mortality (46.8% vs. 19.7%; P < 0.001). Finally, the withdrawal of beta-blockers, mineralocorticoid receptor antagonists and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was associated with a significant increase in in-hospital mortality. Conclusions: Patients with COVID-19 have a significant incidence of AHF, which is associated with very high mortality rates. Moreover, patients with a history of CHF are prone to developing acute decompensation after a COVID-19 diagnosis. The withdrawal of GDMT was associated with higher mortality.
MeSH term(s)	Acute Disease/epidemiology ; Adrenergic beta-Antagonists/therapeutic use ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Angiotensin Receptor Antagonists/therapeutic use ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Arrhythmias, Cardiac/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Chronic Disease/epidemiology ; Deprescriptions ; Disease Progression ; Female ; Heart Failure/complications ; Heart Failure/drug therapy ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Hospital Mortality ; Humans ; Incidence ; Male ; Middle Aged ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prevalence ; Prognosis ; Risk Factors ; SARS-CoV-2 ; Spain/epidemiology
Chemical Substances	Adrenergic beta-Antagonists ; Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors ; Mineralocorticoid Receptor Antagonists ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Keywords	covid19
Language	English
Publishing date	2020-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.1990
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Article ; Online: Effect of antiretroviral therapy on inflammatory markers of endothelial dysfunction in HIV treatment-naïve infected patients.

Mata-Marín, José A / Méndez-Cruz, René / Arroyo-Anduiza, Carla I / Mata-Marín, Luis A / Gaytán-Martínez, Jesús / Asbún-Bojalil, Juan

Journal of medical virology

2013 Volume 85, Issue 8, Page(s) 1321–1326

Abstract: The aim of this study was to evaluate the effect of antiretroviral therapy on inflammatory markers of endothelial dysfunction in HIV treatment-naïve infected patients. This was a prospective cohort study in HIV treatment-naïve infected patients. The ... ...

Abstract	The aim of this study was to evaluate the effect of antiretroviral therapy on inflammatory markers of endothelial dysfunction in HIV treatment-naïve infected patients. This was a prospective cohort study in HIV treatment-naïve infected patients. The patients were assigned to a untreated group or a treatment group according to the therapeutic strategy received. Patients in the treatment group received efavirenz or lopinavir/ritonavir, each given with zidovudine and lamivudine. HIV RNA, CD4(+) cell count, and the levels of hsCRP, sCD40L, sICAM-1, sVCAM-1, and sE-selectin were measured before and 12 weeks after treatment. Fifty patients were enrolled: 13 in the untreated group and 37 in the treatment group; 48 (96%) completed the follow-up. The mean (± SD) age was 33 ± 9 years, and 38 (79%) were men. The median pretreatment CD4(+) cell counts were 263 cells/ml (IQR 118-341) in the treatment group and 658 cells/ml (IQR 475-887) in the untreated group. In the treatment group, the median serum sVCAM-1 and sICAM-1 levels decreased by a small but significant amount (1,400 and 228 ng/ml, respectively, P<0.05) from before to after the 12 weeks. These levels did not change in the untreated group. Antiretroviral therapy is associated with a decrease in sVCAM-1 and sICAM-1 levels after 12 weeks of treatment.
MeSH term(s)	Adult ; Anti-Retroviral Agents/therapeutic use ; CD4 Lymphocyte Count ; Cohort Studies ; Cytokines/blood ; Endothelial Cells/immunology ; Endothelial Cells/pathology ; Female ; HIV Infections/drug therapy ; HIV Infections/pathology ; Humans ; Inflammation/pathology ; Male ; Prospective Studies ; Viral Load
Chemical Substances	Anti-Retroviral Agents ; Cytokines
Language	English
Publishing date	2013-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.23624
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Article: Heart failure in COVID-19 patients: prevalence, incidence and prognostic implications

Eur. j. heart fail

Abstract: AIMS: Data on the impact of COVID-19 in chronic heart failure (CHF) patients and its potential to trigger acute heart failure (AHF) are lacking. The aim of this work was to study characteristics, cardiovascular outcomes and mortality in patients with ... ...

Abstract	AIMS: Data on the impact of COVID-19 in chronic heart failure (CHF) patients and its potential to trigger acute heart failure (AHF) are lacking. The aim of this work was to study characteristics, cardiovascular outcomes and mortality in patients with confirmed COVID-19 infection and a prior diagnosis of heart failure (HF). Further aims included the identification of predictors and prognostic implications for AHF decompensation during hospital admission and the determination of a potential correlation between the withdrawal of HF guideline-directed medical therapy (GDMT) and worse outcomes during hospitalization. METHODS AND RESULTS: Data for a total of 3080 consecutive patients with confirmed COVID-19 infection and follow-up of at least 30 days were analysed. Patients with a previous history of CHF (n = 152, 4.9%) were more prone to the development of AHF (11.2% vs. 2.1%; P < 0.001) and had higher levels of N-terminal pro brain natriuretic peptide. In addition, patients with previous CHF had higher mortality rates (48.7% vs. 19.0%; P < 0.001). In contrast, 77 patients (2.5%) were diagnosed with AHF, which in the vast majority of cases (77.9%) developed in patients without a history of HF. Arrhythmias during hospital admission and CHF were the main predictors of AHF. Patients developing AHF had significantly higher mortality (46.8% vs. 19.7%; P < 0.001). Finally, the withdrawal of beta-blockers, mineralocorticoid receptor antagonists and angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was associated with a significant increase in in-hospital mortality. CONCLUSIONS: Patients with COVID-19 have a significant incidence of AHF, which is associated with very high mortality rates. Moreover, patients with a history of CHF are prone to developing acute decompensation after a COVID-19 diagnosis. The withdrawal of GDMT was associated with higher mortality.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #726285
Database	COVID19

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