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  1. Article: Robotic Intraoperative Tracheobronchial Repair during Minimally Invasive 3-Stage Esophagectomy.

    Marano, Alessandra / Palagi, Silvia / Pellegrino, Luca / Borghi, Felice

    Journal of chest surgery

    2020  Volume 54, Issue 2, Page(s) 154–157

    Abstract: Tracheobronchial injury (TBI) is an uncommon but potentially fatal event. Iatrogenic lesions during bronchoscopy, endotracheal intubation, or thoracic surgery are considered the most common causes of TBI. When TBI is detected during surgery, concomitant ... ...

    Abstract Tracheobronchial injury (TBI) is an uncommon but potentially fatal event. Iatrogenic lesions during bronchoscopy, endotracheal intubation, or thoracic surgery are considered the most common causes of TBI. When TBI is detected during surgery, concomitant surgical treatment is recommended. Herein we present a case of successful robotic primary repair of iatrogenic tracheal and left bronchial branch tears during a robot-assisted hybrid 3-stage esophagectomy after neoadjuvant chemoradiotherapy. A robotic approach can facilitate the repair of this injury while reducing both the potential risk of conversion to open surgery and the associated increased risk of postoperative respiratory complications.
    Language English
    Publishing date 2020-10-28
    Document type Case Reports
    ISSN 2765-1606
    ISSN 2765-1606
    DOI 10.5090/jcs.20.055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Robot-assisted esophagectomy with robot-sewn intrathoracic anastomosis (Ivor Lewis): surgical technique and early results.

    Marano, Alessandra / Salomone, Sara / Pellegrino, Luca / Geretto, Paolo / Robella, Manuela / Borghi, Felice

    Updates in surgery

    2022  Volume 75, Issue 4, Page(s) 941–952

    Abstract: Esophagectomy is the selected treatment for nonmetastatic esophageal and esophagogastric junction cancer, although high perioperative morbidity and mortality incur. Robot-assisted minimally invasive esophagectomy (RAMIE) effectively reduces ... ...

    Abstract Esophagectomy is the selected treatment for nonmetastatic esophageal and esophagogastric junction cancer, although high perioperative morbidity and mortality incur. Robot-assisted minimally invasive esophagectomy (RAMIE) effectively reduces cardiopulmonary complications compared to open esophagectomy and offers a technical advantage, especially for lymph node dissection and intrathoracic anastomosis. This article aims at describing our initial experience of Ivor Lewis RAMIE, focusing on the technique's main steps and robotic-sewn esophagogastrostomy. Prospectively collected data from all consecutive patients who underwent Ivor Lewis RAMIE for cancer was reviewed. Reconstruction was performed with a gastric conduit pull-up and a robotic-sewn intrathoracic anastomosis. Intraoperative and postoperative complications were recorded as prescribed by the Esophagectomy Complications Consensus Group (ECCG). Thirty patients underwent Ivor Lewis RAMIE with complete mediastinal lymph node dissection and robot-sewn anastomosis. No intraoperative complications nor conversion occurred. Pulmonary complications totaled 26.7%. Anastomotic leakage (ECCG, type III) and conduit necrosis (ECCG, type III) both occurred in one patient (3.3%). Chylothorax appeared in 2 patients (6.7%) (ECCG, Type IIA). Anastomotic stricture, successfully treated with endoscopic dilatations, occurred in 8 cases (26.7%). Median overall postoperative stay was 11 days (range, 6-51 days). 30 day and 90 day mortality was 0%. R0 resection was performed in 96.7% of patients with a median number of 47 retrieved lymph nodes. RAMIE with robot-sewn intrathoracic anastomosis appears to be feasible, safe and effective, with favorable perioperative results. Nevertheless, further high-quality studies are needed to define the best anastomotic technique for Ivor Lewis RAMIE.
    MeSH term(s) Humans ; Esophagectomy/methods ; Robotics ; Robotic Surgical Procedures/methods ; Esophageal Neoplasms/pathology ; Retrospective Studies ; Anastomosis, Surgical/methods ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Treatment Outcome
    Language English
    Publishing date 2022-12-12
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01439-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Abdominal wall endometriosis misdiagnosed as a desmoid tumor: A case report.

    Girardi, Martina / Marano, Alessandra / Fortunato, Mirella / Gelarda, Enrico / Giuffrida, Maria Carmela

    International journal of surgery case reports

    2022  Volume 93, Page(s) 106979

    Abstract: Introduction: Abdominal wall masses have different aetiologies. Diagnosis includes desmoid tumors (DTs) and other benign and malignant lesions, among which abdominal wall endometriosis (AWE). Diagnosis is challenging if symptoms are aspecific, and the ... ...

    Abstract Introduction: Abdominal wall masses have different aetiologies. Diagnosis includes desmoid tumors (DTs) and other benign and malignant lesions, among which abdominal wall endometriosis (AWE). Diagnosis is challenging if symptoms are aspecific, and the contribution of imaging may be weak. We present a case of AWE that according to clinical history and imaging was misdiagnosed as DT.
    Presentation of case: A healthy 35-year-old female presented, 4 years after a cesarean delivery, a rapidly growing painless subumbilical mass within the right rectus abdominis muscle. Ultrasound and magnetic resonance imaging suspected a DT. The patient underwent complete resection of the mass and pathological examination revealed foci of endometriosis in the muscle. Patient's post-operative course was uneventful and at 18-month follow-up, no recurrence has been detected.
    Discussion: The current case highlights differences in clinical presentation and imaging in case of AWE and DTs, underlining possible pitfalls in diagnosis. In young women with previous gynaecological abdominal surgery, AWE is the most likely disease when a mass in the region of the scar appears. Differential diagnosis is complex and rare entities like DTs should nevertheless be taken into consideration. A complete surgical resection with negative margins is considered the primary treatment for AWE and for selected DTs. Final pathology of the tumor can state the precise diagnosis.
    Conclusion: Since AWE and DTs share similar clinical signs and aspecific imaging exams, both diseases should be considered in case of abdominal wall mass in female patients of childbearing age and history of uterine-related surgery.
    Language English
    Publishing date 2022-03-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.106979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Combined laparoscopic-endoscopic resection of a bleeding giant duodenal Brunner's gland hamartoma.

    Marano, Alessandra / Sacco, Marco / Rorato, Lisa Marie / Caronna, Stefania / Di Giovanni, Fabrizia / Santarelli, Mauro / De Angelis, Claudio Giovanni

    Endoscopy

    2023  Volume 55, Issue S 01, Page(s) E983–E984

    MeSH term(s) Humans ; Brunner Glands/surgery ; Duodenum ; Laparoscopy
    Language English
    Publishing date 2023-08-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/a-2134-9639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  5. Article ; Online: Small noncoding RNAs and sperm nuclear basic proteins reflect the environmental impact on germ cells.

    Ferrero, Giulio / Festa, Rosaria / Follia, Laura / Lettieri, Gennaro / Tarallo, Sonia / Notari, Tiziana / Giarra, Antonella / Marinaro, Carmela / Pardini, Barbara / Marano, Alessandra / Piaggeschi, Giulia / Di Battista, Carla / Trifuoggi, Marco / Piscopo, Marina / Montano, Luigi / Naccarati, Alessio

    Molecular medicine (Cambridge, Mass.)

    2024  Volume 30, Issue 1, Page(s) 12

    Abstract: Background: Molecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of spermatozoa and to identify early alterations due to environmental pollution.: Methods: Here, we present a ... ...

    Abstract Background: Molecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of spermatozoa and to identify early alterations due to environmental pollution.
    Methods: Here, we present a multilevel molecular profiling by small RNA sequencing and sperm nuclear basic protein analysis of male germ cells from 33 healthy young subjects residing in low and high-polluted areas.
    Results: Although sperm motility and sperm concentration were comparable between samples from the two sites, those from the high-pollution area had a higher concentration of immature/immune cells, a lower protamine/histone ratio, a reduced ability of sperm nuclear basic proteins to protect DNA from oxidative damage, and an altered copper/zinc ratio in sperm. Sperm levels of 32 microRNAs involved in intraflagellar transport, oxidative stress response, and spermatogenesis were different between the two areas. In parallel, a decrease of Piwi-interacting RNA levels was observed in samples from the high-polluted area.
    Conclusions: This comprehensive analysis provides new insights into pollution-driven epigenetic alterations in sperm not detectable by spermiogram.
    MeSH term(s) Male ; Humans ; RNA, Small Untranslated/genetics ; RNA, Small Untranslated/metabolism ; Semen ; Sperm Motility ; Spermatozoa/metabolism ; Environment ; Nuclear Proteins
    Chemical Substances sperm basic nuclear proteins ; RNA, Small Untranslated ; Nuclear Proteins
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1283676-x
    ISSN 1528-3658 ; 1076-1551
    ISSN (online) 1528-3658
    ISSN 1076-1551
    DOI 10.1186/s10020-023-00776-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4456: Show issues Location:
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  6. Book: Robotic surgery

    Spinoglio, Giuseppe / Marano, Alessandra / Formisano, Giampaolo

    current applications and new trends

    (Updates in surgery,)

    2015  

    Author's details Giuseppe Spinoglio, editor ; in collaboration with Alessandra Marano and Giampaolo Formisano ; forewords by Giorgio De Toma, Francesco Corcione
    Series title Updates in surgery,
    MeSH term(s) Robotic Surgical Procedures ; Robotics
    Language English
    Size xix, 238 pages :, illustrations ;, 25 cm.
    Document type Book
    ISBN 9788847057135 ; 8847057132 ; 9788847057142 ; 8847057140
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article: Robotic approach to large tailgut cyst with malignant transformation: A case report.

    Marano, Alessandra / Giuffrida, Maria Carmela / Peluso, Chiara / Testa, Valentina / Bosio, Paolo / Borghi, Felice

    International journal of surgery case reports

    2020  Volume 77S, Page(s) S57–S60

    Abstract: Introduction: Tailgut cysts (TGC) are rare congenital retrorectal lesions deriving from vestiges of the hindgut. The risk of malignant transformation is relatively high. Thus early diagnosis and a complete removal of the mass are of paramount importance. ...

    Abstract Introduction: Tailgut cysts (TGC) are rare congenital retrorectal lesions deriving from vestiges of the hindgut. The risk of malignant transformation is relatively high. Thus early diagnosis and a complete removal of the mass are of paramount importance. We present a case of successful robotic exeresis of a large TGC adenocarcinoma.
    Presentation of case: A healthy 35-year-old woman was found to have a retrorectal TGC with suspected malignant transformation. The patient underwent complete robotic resection of the mass and pathology confirmed a TGC adenocarcinoma. The patient's post-operative course was unremarkable. At 24 months, the patient has not experienced any recurrence nor complained functional disorders.
    Discussion: The current case highlights the importance of TGC as a differential diagnosis of presacral masses, underscoring that malignant transformation can occur and may result in mortality and morbidity if radical surgery is not performed. Diagnosing TGC adenocarcinoma can be challenging because of its relatively low incidence. Biopsy is not recommended while magnetic resonance imaging (MRI) is indispensable in the evaluation of this lesion as the presence of intracystic vegetations could indicate a malignant transformation. Surgery is the mainstay of treatment and minimally invasive techniques have the potential to minimize morbidity and enhance recovery. Amongst these, the robotic approach can make the dissection of large lesions easier, reducing their manipulation and preventing nerve injuries.
    Conclusion: Robot-assisted resection of a TGC adenocarcinoma is safe and feasible. This approach can be particularly useful in the pelvis providing acceptable functional and oncological outcomes.
    Language English
    Publishing date 2020-09-24
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.09.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Robotic Wedge Resection for Unfavorably Located Gastric Gastrointestinal Stromal Tumors: Perioperative and Long-Term Oncological Outcomes.

    Di Maria Grimaldi, Simone / Marano, Alessandra / Pellegrino, Luca / Geretto, Paolo / Palagi, Silvia / Borghi, Felice

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2020  Volume 31, Issue 7, Page(s) 772–778

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Adult ; Aged ; Feasibility Studies ; Gastrectomy/methods ; Gastrectomy/mortality ; Gastrointestinal Stromal Tumors/mortality ; Gastrointestinal Stromal Tumors/pathology ; Gastrointestinal Stromal Tumors/surgery ; Humans ; Length of Stay ; Male ; Middle Aged ; Operative Time ; Retrospective Studies ; Robotic Surgical Procedures/methods ; Robotic Surgical Procedures/mortality ; Stomach/pathology ; Stomach/surgery ; Stomach Neoplasms/mortality ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Survival Rate ; Treatment Outcome
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Evaluation Study ; Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2020.0660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3246: Show issues Location:
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  9. Article ; Online: Impacts of Environmental Pollution on Brain Tumorigenesis.

    Pagano, Cristina / Navarra, Giovanna / Coppola, Laura / Savarese, Beatrice / Avilia, Giorgio / Giarra, Antonella / Pagano, Giovanni / Marano, Alessandra / Trifuoggi, Marco / Bifulco, Maurizio / Laezza, Chiara

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Pollutants consist of several components, known as direct or indirect mutagens, that can be associated with the risk of tumorigenesis. The increased incidence of brain tumors, observed more frequently in industrialized countries, has generated a deeper ... ...

    Abstract Pollutants consist of several components, known as direct or indirect mutagens, that can be associated with the risk of tumorigenesis. The increased incidence of brain tumors, observed more frequently in industrialized countries, has generated a deeper interest in examining different pollutants that could be found in food, air, or water supply. These compounds, due to their chemical nature, alter the activity of biological molecules naturally found in the body. The bioaccumulation leads to harmful effects for humans, increasing the risk of the onset of several pathologies, including cancer. Environmental components often combine with other risk factors, such as the individual genetic component, which increases the chance of developing cancer. The objective of this review is to discuss the impact of environmental carcinogens on modulating the risk of brain tumorigenesis, focusing our attention on certain categories of pollutants and their sources.
    MeSH term(s) Humans ; Air Pollutants/analysis ; Environmental Pollution ; Air Pollution/analysis ; Environmental Monitoring ; Carcinogenesis ; Brain Neoplasms ; Cell Transformation, Neoplastic ; Brain ; Environmental Exposure
    Chemical Substances Air Pollutants
    Language English
    Publishing date 2023-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24055045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Impact of Hydrophobic Chains in Five-Coordinate Glucoconjugate Pt(II) Anticancer Agents.

    Annunziata, Alfonso / Imbimbo, Paola / Cucciolito, Maria Elena / Ferraro, Giarita / Langellotti, Vincenzo / Marano, Alessandra / Melchiorre, Massimo / Tito, Gabriella / Trifuoggi, Marco / Monti, Daria Maria / Merlino, Antonello / Ruffo, Francesco

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: This study describes new platinum(II) cationic five-coordinate complexes ( ...

    Abstract This study describes new platinum(II) cationic five-coordinate complexes (
    MeSH term(s) Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Crystallography, X-Ray ; Dimethyl Sulfoxide ; DNA ; Hydrophobic and Hydrophilic Interactions ; Muramidase ; Platinum Compounds/chemistry ; Platinum Compounds/pharmacology
    Chemical Substances Antineoplastic Agents ; carbene (2465-56-7) ; Dimethyl Sulfoxide (YOW8V9698H) ; DNA (9007-49-2) ; ethylene (91GW059KN7) ; Muramidase (EC 3.2.1.17) ; Platinum Compounds
    Language English
    Publishing date 2023-01-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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