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Article: Los exosomas de las células presentadoras de antígeno y su papel en la regulación de las respuestas inmunológicas.

Maravillas-Montero, José Luis / Martínez-Cortés, Ismael

Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)

2017 Volume 64, Issue 4, Page(s) 463–476

Abstract: Cells release several biomolecules to the extracellular environment using them as a communication alternative with neighbor cells. Besides these molecules, cells also release more complex elements, like vesicles; structures composed of a lipidic bilayer ... ...

Title translation	Regulation of immune responses by exosomes derived from antigen presenting cells.
Abstract	Cells release several biomolecules to the extracellular environment using them as a communication alternative with neighbor cells. Besides these molecules, cells also release more complex elements, like vesicles; structures composed of a lipidic bilayer with transmembrane proteins that protect a hydrophilic content. Exosomes are a small subtype of vesicles (30-150 nm), produced by many cell types, such as tumor cells, neurons, epithelial cells and immune cells. Included in this last group, antigen presenting cells produce exosomes that contain different types of molecules depending on their activation and/or maturation state. In recent years there has been an exponential interest in exosomes due to the recent evidences that show the immunomodulatory properties of these vesicles and therefore, their great potential in diagnostic approaches and development of therapies for different inflammation-associated pathologies.
MeSH term(s)	Adaptive Immunity ; Antigen-Presenting Cells/cytology ; Antigen-Presenting Cells/immunology ; Exosome Multienzyme Ribonuclease Complex/immunology ; Exosomes/immunology ; Humans
Chemical Substances	Exosome Multienzyme Ribonuclease Complex (EC 3.1.-)
Language	Spanish
Publishing date	2017-12-14
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	639125-4
ISSN	0002-5151
ISSN	0002-5151
DOI	10.29262/ram.v64i4.285
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Article ; Online: Size Determination and Phenotypic Analysis of Urinary Extracellular Vesicles using Flow Cytometry.

Navarro-Hernandez, Itze Cecilia / Acevedo-Ochoa, Ernesto / Juárez-Vega, Guillermo / Meza-Sánchez, David Eduardo / Hernández-Hernández, José Manuel / Maravillas-Montero, José Luis

Journal of visualized experiments : JoVE

2021 , Issue 170

Abstract: Extracellular vesicles, EVs, are a heterogeneous complex of lipidic membranes, secreted by any cell type, in any fluid such as urine. EVs can be of different sizes ranging from 40-100 nm in diameter such as in exosomes to 100-1000 nm in microvesicles. ... ...

Abstract	Extracellular vesicles, EVs, are a heterogeneous complex of lipidic membranes, secreted by any cell type, in any fluid such as urine. EVs can be of different sizes ranging from 40-100 nm in diameter such as in exosomes to 100-1000 nm in microvesicles. They can also contain different molecules that can be used as biomarkers for the prognosis and diagnosis of many diseases. Many techniques have been developed to characterize these vesicles. One of these is flow cytometry. However, there are no existing reports to show how to quantify the concentration of EVs and differentiate them by size, along with biomarker detection. This work aims to describe a procedure for the isolation, quantification, and phenotypification of urinary extracellular vesicles, uEVs, using a conventional cytometer for the analysis without any modification to its configuration. The method's limitations include staining a maximum of four different biomarkers per sample. The method is also limited by the amount of EVs available in the sample. Despite these limitations, with this protocol and its subsequent analysis, we can obtain more information on the enrichment of EVs markers and the abundance of these vesicles present in urine samples, in diseases involving kidney and brain damage.
MeSH term(s)	Biomarkers/urine ; Cell Size ; Extracellular Vesicles/metabolism ; Flow Cytometry/methods ; Humans ; Phenotype
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/61695
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Article: Impact of Tyrosine Kinase Inhibitors on the Immune Response to SARS-CoV-2 Vaccination in Patients with Non-Small Cell Lung Cancer.

Hernández-Pedro, Norma / Arroyo-Hernández, Marisol / Barrios-Bernal, Pedro / Romero-Nuñez, Eunice / Sosa-Hernandez, Victor A / Ávila-Ríos, Santiago / Maravillas-Montero, José Luis / Pérez-Padilla, Rogelio / de Miguel-Perez, Diego / Rolfo, Christian / Arrieta, Oscar

Vaccines

2023 Volume 11, Issue 10

Abstract: Immune dysregulation and cancer treatment may affect SARS-CoV-2 vaccination protection. Antibody production by B-cells play a vital role in the control and clearance of the SARS-CoV-2 virus. This study prospectively explores B-cell seroconversion ... ...

Abstract	Immune dysregulation and cancer treatment may affect SARS-CoV-2 vaccination protection. Antibody production by B-cells play a vital role in the control and clearance of the SARS-CoV-2 virus. This study prospectively explores B-cell seroconversion following SARS-CoV-2 immunization in healthy individuals and non-small cell lung cancer (NSCLC) patients undergoing oncological treatment. 92 NSCLC patients and 27 healthy individuals' blood samples were collected after receiving any COVID-19 vaccine. Serum and mononuclear cells were isolated, and a serum surrogate virus neutralization test kit evaluated SARS-CoV-2 antibodies. B-cell subpopulations on mononuclear cells were characterized by flow cytometry. Patients were compared based on vaccination specifications and target mutation oncological treatment. A higher percentage of healthy individuals developed more SARS-CoV-2 neutralizing antibodies than NSCLC patients (63% vs. 54.3%;
Language	English
Publishing date	2023-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2703319-3
ISSN	2076-393X
ISSN	2076-393X
DOI	10.3390/vaccines11101612
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Article: A Review Study of the Participation of Late Domains in Sorting and Transport of Viral Factors to Exosomes.

Velázquez-Cervantes, Manuel Adrián / Benítez-Zeferino, Yazmín Rocío / Flores-Pliego, Arturo / Helguera-Repetto, Addy Cecilia / Meza-Sánchez, David Eduardo / Maravillas-Montero, José Luis / León-Reyes, Guadalupe / Mancilla-Ramírez, Javier / Cerna-Cortés, Jorge Francisco / Baeza-Ramírez, María Isabel / León-Juaárez, Moises

Life (Basel, Switzerland)

2023 Volume 13, Issue 9

Abstract: Cellular communication depends heavily on the participation of vesicular systems generated by most cells of an organism. Exosomes play central roles in this process. Today, these vesicles have been characterized, and it has been determined that the cargo ...

Abstract	Cellular communication depends heavily on the participation of vesicular systems generated by most cells of an organism. Exosomes play central roles in this process. Today, these vesicles have been characterized, and it has been determined that the cargo they transport is not within a random system. In fact, it depends on various molecular signals and the recruitment of proteins that participate in the biogenesis of exosomes. It has also been shown that multiple viruses can recruit these vesicles to transport viral factors such as genomes or proteins. It has been shown that the late domains present in viral proteins are critical for the exosomal selection and biogenesis systems to recognize these viral proteins and introduce them into the exosomes. In this review, the researchers discuss the evidence related to the characterization of these late domains and their role in exosome recruitment during viral infection.
Language	English
Publishing date	2023-08-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13091842
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Article ; Online: Prokaryotic Expression of the Immunoglobulin's Domains of CRTAM to Characterize a Monoclonal Antibody.

Barragan-Galvez, Juan Carlos / Gonzalez-Orozco, Maria / Hernandez-Flores, Araceli / Maravillas-Montero, Jose Luis / Chavez-Guerrero, Yedhani / Ortiz-Navarrete, Vianney

The protein journal

2020 Volume 39, Issue 3, Page(s) 224–231

Abstract: Class-I restricted T cell-associated molecule (CRTAM) is a member of the immunoglobulin superfamily, and it is closely related to nectin-like protein. CRTAM is expressed in activated CD8 T cells, NKT cells, NK cells and in a subpopulation CD4 T cells. In ...

Abstract	Class-I restricted T cell-associated molecule (CRTAM) is a member of the immunoglobulin superfamily, and it is closely related to nectin-like protein. CRTAM is expressed in activated CD8 T cells, NKT cells, NK cells and in a subpopulation CD4 T cells. In this study, we produce as recombinant proteins, the Ig-domains of CRTAM (IgV-IgC), the IgV, and the IgC. These proteins were successfully purified in the soluble fraction only if the stalk region was included. The recombinant CRTAM recognizes its ligand nectin-like 2 in a cell-free system. We also demonstrate that the IgC domain of CRTAM is recognized by the anti-hCRTAM monoclonal antibody C8 with a 0.62 nM affinity. In conclusion, the stalk region of CRTAM provides solubility for the expression of its Ig-domains as recombinant proteins.
MeSH term(s)	Animals ; Antibodies, Monoclonal/biosynthesis ; Antibodies, Monoclonal/chemistry ; Binding Sites ; Cell Adhesion Molecule-1/genetics ; Cell Adhesion Molecule-1/immunology ; Cell Adhesion Molecule-1/metabolism ; Cell-Free System/chemistry ; Cloning, Molecular ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Female ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; Humans ; Hybridomas/chemistry ; Immunoglobulin Domains/genetics ; Immunoglobulins/genetics ; Immunoglobulins/immunology ; Immunoglobulins/metabolism ; Jurkat Cells ; Mice ; Mice, Inbred BALB C ; Protein Binding ; Recombinant Proteins/genetics ; Recombinant Proteins/immunology ; Recombinant Proteins/metabolism
Chemical Substances	Antibodies, Monoclonal ; CADM1 protein, human ; Cell Adhesion Molecule-1 ; Immunoglobulins ; Recombinant Proteins ; class-I restricted T cell-associated molecule
Language	English
Publishing date	2020-03-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2143071-8
ISSN	1875-8355 ; 1572-3887
ISSN (online)	1875-8355
ISSN	1572-3887
DOI	10.1007/s10930-020-09896-y
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Article ; Online: Isthmin 1 is Expressed by Progenitor-Like Cells in the Lung: Phenotypical Analysis of Isthmin 1

Rivera-Torruco, Guadalupe / Martínez-Mendiola, Carolina A / Angeles-Floriano, Tania / Jaimes-Ortega, Gustavo Alberto / Maravillas-Montero, José Luis / García-Contreras, Rodolfo / González, Yolanda / Juárez, Esmeralda / Nava, Porfirio / Ortiz-Navarrete, Vianney / Medina-Contreras, Oscar / Licona-Limón, Paula / Valle-Rios, Ricardo

Journal of immunology research

2022 Volume 2022, Page(s) 2909487

Abstract: The process by which blood cells are generated has been widely studied in homeostasis and during pathogen-triggered inflammatory response. Recently, murine lungs have been shown to be a significant source of hematopoietic progenitors in a process known ... ...

Abstract	The process by which blood cells are generated has been widely studied in homeostasis and during pathogen-triggered inflammatory response. Recently, murine lungs have been shown to be a significant source of hematopoietic progenitors in a process known as extramedullary hematopoiesis. Using multiparametric flow cytometry, we have identified mesenchymal, endothelial, and hematopoietic progenitor cells that express the secreted small protein Isthmin 1 (ISM1). Further characterization of hematopoietic progenitor cells indicated that ISM1
MeSH term(s)	Animals ; Hematopoiesis ; Hematopoietic Stem Cells ; Homeostasis ; Intercellular Signaling Peptides and Proteins/metabolism ; Lung/metabolism ; Mice ; Mice, Inbred C57BL ; Proteins ; Sepsis/metabolism
Chemical Substances	Intercellular Signaling Peptides and Proteins ; Proteins ; isthmin protein, mouse
Language	English
Publishing date	2022-04-01
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2022/2909487
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Article ; Online: Peripheral expansion of myeloid-derived suppressor cells is related to disease activity and damage accrual in inflammatory myopathies.

Torres-Ruiz, Jiram / Absalón-Aguilar, Abdiel / Reyes-Islas, Juan Alberto / Cassiano-Quezada, Fabiola / Mejía-Domínguez, Nancy R / Pérez-Fragoso, Alfredo / Maravillas-Montero, José Luis / Núñez-Álvarez, Carlos / Juárez-Vega, Guillermo / Culebro-Bermejo, Alejandro / Gómez-Martín, Diana

Rheumatology (Oxford, England)

2022 Volume 62, Issue 2, Page(s) 775–784

Abstract: Objective: To assess the proportion of myeloid-derived suppressor cells (MDSCs), their expression of arginase-1 and programmed cell death ligand 1 (PD-L1) and their relationship with the clinical phenotype of patients with idiopathic inflammatory ... ...

Abstract	Objective: To assess the proportion of myeloid-derived suppressor cells (MDSCs), their expression of arginase-1 and programmed cell death ligand 1 (PD-L1) and their relationship with the clinical phenotype of patients with idiopathic inflammatory myopathies (IIMs). Methods: We recruited 37 IIM adult patients and 10 healthy donors in Mexico City. We evaluated their clinical features, the proportion of MDSCs and their expression of PD-L1 and arginase-1 by flow cytometry. Polymorphonuclear (PMN)-MDSCs were defined as CD33dim, CD11b+ and CD66b+ while monocytic (M)-MDSCs were CD33+, CD11b+, HLA-DR- and CD14+. Serum cytokines were analysed with a multiplex assay. We compared the quantitative variables with the Kruskal-Wallis and Mann-Whitney U tests and assessed correlations with Spearman's ρ. Results: Most patients had dermatomyositis [n = 30 (81.0%)]. IIM patients had a peripheral expansion of PMN-MDSCs and M-MDSCs with an enhanced expression of arginase-1 and PD-L1. Patients with active disease had a decreased percentage {median 1.75% [interquartile range (IQR) 0.31-5.50 vs 10.71 [3.16-15.58], P = 0.011} of M-MDSCs and a higher absolute number of PD-L1+ M-MDSCs [median 23.21 cells/mm3 (IQR 11.16-148.9) vs 5.95 (4.66-102.7), P = 0.046] with increased expression of PD-L1 [median 3136 arbitrary units (IQR 2258-4992) vs 1961 (1885-2335), P = 0.038]. PD-L1 expression in PMN-MDSCs correlated with the visual analogue scale of pulmonary disease activity (r = 0.34, P = 0.040) and damage (r = 0.36, P = 0.031), serum IL-5 (r = 0.55, P = 0.003), IL-6 (r = 0.46, P = 0.003), IL-8 (r = 0.53, P = 0.018), IL-10 (r = 0.48, P = 0.005) and GM-CSF (r = 0.48, P = 0.012). M-MDSCs negatively correlated with the skeletal Myositis Intention to Treat Index (r = -0.34, P = 0.038) and positively with IL-6 (r = 0.40, P = 0.045). Conclusion: MDSCs expressing arginase-1 and PD-L1 are expanded in IIM and correlate with disease activity, damage accrual and serum cytokines.
MeSH term(s)	Myeloid-Derived Suppressor Cells ; Arginase/genetics ; Arginase/metabolism ; Interleukin-6/metabolism ; B7-H1 Antigen/metabolism ; Cytokines/metabolism
Chemical Substances	Arginase (EC 3.5.3.1) ; Interleukin-6 ; B7-H1 Antigen ; Cytokines
Language	English
Publishing date	2022-06-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/keac374
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Article ; Online: Mycobacterium tuberculosis

Pérez-Noriega, Flaubert Alexis / Salinas-Lara, Citlaltepetl / Sánchez-Garibay, Carlos / Torres-Ruíz, José Jiram / Maravillas-Montero, José Luis / Castañón-Arreola, Mauricio / Hernández-Campos, María Elena / Rodríguez-Balderas, Cesar / Basurto-López, Beatriz Victoria / Peñafiel-Salgado, Carlos / Espinosa-García, Ana Paola / Choreño-Parra, José Alberto / Tena-Suck, Martha Lilia / Soto-Rojas, Luis O / León-Marroquín, Elsa Y / Romero-López, José Pablo / Castillejos-López, Manuel

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: Tuberculosis (TB) of the central nervous system (CNS) presents high mortality due to brain damage and inflammation events. The formation and deposition of immune complexes (ICs) in the brain microvasculature ... ...

Abstract	Tuberculosis (TB) of the central nervous system (CNS) presents high mortality due to brain damage and inflammation events. The formation and deposition of immune complexes (ICs) in the brain microvasculature during
MeSH term(s)	Male ; Animals ; Mice ; Mycobacterium tuberculosis ; Antigen-Antibody Complex ; Disease Models, Animal ; Tuberculosis/microbiology ; Antigens, Bacterial ; Vasculitis ; Cell Wall
Chemical Substances	Antigen-Antibody Complex ; Antigens, Bacterial
Language	English
Publishing date	2023-01-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021242
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Article ; Online: Conformational changes in myeloperoxidase induced by ubiquitin and NETs containing free ISG15 from systemic lupus erythematosus patients promote a pro-inflammatory cytokine response in CD4

Carrillo-Vázquez, Daniel Alberto / Jardón-Valadez, Eduardo / Torres-Ruiz, Jiram / Juárez-Vega, Guillermo / Maravillas-Montero, José Luis / Meza-Sánchez, David Eduardo / Domínguez-López, María Lilia / Varela, Jorge Carlos Alcocer / Gómez-Martín, Diana

Journal of translational medicine

2020 Volume 18, Issue 1, Page(s) 429

Abstract: Background: Neutrophil extracellular traps (NETs) from patients with systemic lupus erythematosus (SLE) are characterized by lower ubiquitylation and myeloperoxidase (MPO) as a substrate. The structural and functional effect of such modification and if ... ...

Abstract	Background: Neutrophil extracellular traps (NETs) from patients with systemic lupus erythematosus (SLE) are characterized by lower ubiquitylation and myeloperoxidase (MPO) as a substrate. The structural and functional effect of such modification and if there are additional post-translational modifications (PTMs) are unknown. Methods: To assess the expression and functional role of PTMs in NETs of patients with SLE; reactivation, proliferation and cytokine production was evaluated by flow cytometry using co-cultures with dendritic cells (DC) and CD4 Results: Fifteen patients with SLE and ten healthy controls were included. In the co-cultures of CD4 Conclusion: The ubiquitylated MPO has a differential effect on the induction of reactivation of CD4
MeSH term(s)	CD4-Positive T-Lymphocytes ; Cytokines ; Extracellular Traps ; Humans ; Lupus Erythematosus, Systemic ; Peroxidase ; Ubiquitin ; Ubiquitins
Chemical Substances	Cytokines ; Ubiquitin ; Ubiquitins ; ISG15 protein, human (60267-61-0) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2020-11-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-020-02604-5
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Article ; Online: A Novel Mutation in the FSH Receptor (I423T) Affecting Receptor Activation and Leading to Primary Ovarian Failure.

Zariñán, Teresa / Mayorga, Julio / Jardón-Valadez, Eduardo / Gutiérrez-Sagal, Rubén / Maravillas-Montero, José Luis / Mejía-Domínguez, Nancy R / Martínez-Luis, Iván / Yacini-Torres, Omar G / Cravioto, Ma-Del-Carmen / Reiter, Eric / Ulloa-Aguirre, Alfredo

The Journal of clinical endocrinology and metabolism

2020 Volume 106, Issue 2, Page(s) e534–e550

Abstract: Context: Follicle-stimulating hormone (FSH) plays an essential role in gonadal function. Loss-of-function mutations in the follicle-stimulating hormone receptor (FSHR) are an infrequent cause of primary ovarian failure.: Objective: To analyze the ... ...

Abstract	Context: Follicle-stimulating hormone (FSH) plays an essential role in gonadal function. Loss-of-function mutations in the follicle-stimulating hormone receptor (FSHR) are an infrequent cause of primary ovarian failure. Objective: To analyze the molecular physiopathogenesis of a novel mutation in the FSHR identified in a woman with primary ovarian failure, employing in vitro and in silico approaches, and to compare the features of this dysfunctional receptor with those shown by the trafficking-defective D408Y FSHR mutant. Methods: Sanger sequencing of the FSHR cDNA was applied to identify the novel mutation. FSH-stimulated cyclic adenosine monophosphate (cAMP) production, ERK1/2 phosphorylation, and desensitization were tested in HEK293 cells. Receptor expression was analyzed by immunoblotting, receptor-binding assays, and flow cytometry. Molecular dynamics simulations were performed to determine the in silico behavior of the mutant FSHRs. Results: A novel missense mutation (I423T) in the second transmembrane domain of the FSHR was identified in a woman with normal pubertal development but primary amenorrhea. The I423T mutation slightly impaired plasma membrane expression of the mature form of the receptor and severely impacted on cAMP/protein kinase A signaling but much less on β-arrestin-dependent ERK1/2 phosphorylation. Meanwhile, the D408Y mutation severely affected membrane expression, with most of the FSH receptor located intracellularly, and both signal readouts tested. Molecular dynamics simulations revealed important functional disruptions in both mutant FSHRs, mainly the loss of interhelical connectivity in the D408Y FSHR. Conclusions: Concurrently, these data indicate that conformational differences during the inactive and active states account for the distinct expression levels, differential signaling, and phenotypic expression of the I423T and D408Y mutant FSHRs.
MeSH term(s)	Adult ; Amenorrhea/genetics ; Amenorrhea/metabolism ; Amino Acid Substitution ; Family ; Female ; Follicle Stimulating Hormone/pharmacology ; HEK293 Cells ; Humans ; Isoleucine/genetics ; Loss of Function Mutation/genetics ; Models, Molecular ; Mutation, Missense ; Pedigree ; Primary Ovarian Insufficiency/genetics ; Primary Ovarian Insufficiency/metabolism ; Receptors, FSH/agonists ; Receptors, FSH/chemistry ; Receptors, FSH/genetics ; Receptors, FSH/metabolism ; Threonine/genetics
Chemical Substances	FSHR protein, human ; Receptors, FSH ; Isoleucine (04Y7590D77) ; Threonine (2ZD004190S) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2020-10-29
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgaa782
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