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Article ; Online: Dysbiosis in SARS-CoV-2-Infected Patients.

Marazzato, Massimiliano / Ceccarelli, Giancarlo / d'Ettorre, Gabriella

2020 Volume 160, Issue 6, Page(s) 2195

MeSH term(s)	COVID-19 ; Dysbiosis ; Hospitalization ; Humans ; Mycobiome ; Patient Discharge ; SARS-CoV-2
Language	English
Publishing date	2020-12-30
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2020.12.056
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Article ; Online: SLAB51 Multi-Strain Probiotic Formula Increases Oxygenation in Oxygen-Treated Preterm Infants.

Baldassarre, Maria Elisabetta / Marazzato, Massimiliano / Pensa, Marta / Loverro, Maria Teresa / Quercia, Michele / Lombardi, Francesca / Schettini, Federico / Laforgia, Nicola

Nutrients

2023 Volume 15, Issue 17

Abstract: Preterm infants are at risk of hypoxia and hyperoxia because of the immaturity of their respiratory and antioxidant systems, linked to increased morbidity and mortality. This study aimed to evaluate the efficacy of a single administration of the SLAB51 ... ...

Abstract	Preterm infants are at risk of hypoxia and hyperoxia because of the immaturity of their respiratory and antioxidant systems, linked to increased morbidity and mortality. This study aimed to evaluate the efficacy of a single administration of the SLAB51 probiotic formula in improving oxygenation in respiratory distress syndrome (RDS)-affected premature babies, thus reducing their need for oxygen administration. Additionally, the capability of SLAB51 in activating the factor-erythroid 2-related factor (Nrf2) responsible for antioxidant responses was evaluated in vitro. In two groups of oxygen-treated preterm infants with similar SaO
MeSH term(s)	Infant, Newborn ; Infant ; Humans ; Oxygen ; Hyperoxia ; Antioxidants ; NF-E2-Related Factor 2 ; Infant, Premature ; Probiotics
Chemical Substances	Oxygen (S88TT14065) ; Antioxidants ; NF-E2-Related Factor 2
Language	English
Publishing date	2023-08-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15173685
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Atopic dermatitis-derived

Conte, Antonietta Lucia / Brunetti, Francesca / Marazzato, Massimiliano / Longhi, Catia / Maurizi, Linda / Raponi, Giammarco / Palamara, Anna Teresa / Grassi, Sara / Conte, Maria Pia

Frontiers in cellular and infection microbiology

2023 Volume 13, Page(s) 1194254

Abstract: Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition whose pathogenesis involves genetic predisposition, epidermal barrier dysfunction, alterations in the immune responses and microbial dysbiosis. Clinical studies have shown a ... ...

Abstract	Background: Atopic dermatitis (AD) is a chronic inflammatory skin condition whose pathogenesis involves genetic predisposition, epidermal barrier dysfunction, alterations in the immune responses and microbial dysbiosis. Clinical studies have shown a link between Methods: WGS analyses were performed on 38 Results: Strains isolated from AD patients revealed a high degree of genetic heterogeneity and a shared set of virulence factors and antimicrobial resistance genes, suggesting that no genotype and genomic content are uniquely associated with AD. The same strains were characterized by a lower variability in terms of gene content, indicating that the inflammatory conditions could exert a selective pressure leading to the optimization of the gene repertoire. Furthermore, genes related to specific mechanisms, like post-translational modification, protein turnover and chaperones as well as intracellular trafficking, secretion and vesicular transport, were significantly more enriched in AD strains. Phenotypic analysis revealed that all of our AD strains were strong or moderate biofilm producers, while less than half showed invasive capabilities. Conclusions: We conclude that in AD skin, the functional role played by
MeSH term(s)	Humans ; Dermatitis, Atopic ; Staphylococcus aureus/genetics ; Multilocus Sequence Typing ; Genotype ; Skin
Language	English
Publishing date	2023-06-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2023.1194254
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Article: Women Skin Microbiota Modifications during Pregnancy.

Radocchia, Giulia / Brunetti, Francesca / Marazzato, Massimiliano / Totino, Valentina / Neroni, Bruna / Bonfiglio, Giulia / Conte, Antonietta Lucia / Pantanella, Fabrizio / Ciolli, Paola / Schippa, Serena

Microorganisms

2024 Volume 12, Issue 4

Abstract: Several studies have shown fluctuations in the maternal microbiota at various body sites (gut, oral cavity, and vagina). The skin microbiota plays an important role in our health, but studies on the changes during pregnancy are limited. Quantitative and ... ...

Abstract	Several studies have shown fluctuations in the maternal microbiota at various body sites (gut, oral cavity, and vagina). The skin microbiota plays an important role in our health, but studies on the changes during pregnancy are limited. Quantitative and qualitative variations in the skin microbiota in pregnant woman could indeed play important roles in modifying the immune and inflammatory responses of the host. These alterations could induce inflammatory disorders affecting the individual's dermal properties, and could potentially predict infant skin disorder in the unborn. The present study aimed to characterize skin microbiota modifications during pregnancy. For this purpose, skin samples were collected from 52 pregnant women in the first, second, and third trimester of non-complicated pregnancies and from 17 age- and sex-matched healthy controls. The skin microbiota composition was assessed by next generation sequencing (NGS) of the V3-V4 region of the bacterial rRNA 16S. Our results indicate that from the first to the third trimester of pregnancy, changes occur in the composition of the skin microbiota, microbial interactions, and various metabolic pathways. These changes could play a role in creating more advantageous conditions for fetal growth.
Language	English
Publishing date	2024-04-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms12040808
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Article: Extraintestinal Pathogenic

Longhi, Catia / Maurizi, Linda / Conte, Antonietta Lucia / Marazzato, Massimiliano / Comanducci, Antonella / Nicoletti, Mauro / Zagaglia, Carlo

Antibiotics (Basel, Switzerland)

2022 Volume 11, Issue 3

Abstract: Multiple-antibiotic-resistant (MAR) extra-intestinal ... ...

Abstract	Multiple-antibiotic-resistant (MAR) extra-intestinal pathogenic
Language	English
Publishing date	2022-03-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics11030328
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Article: Insight into the Possible Use of the Predator Bdellovibrio bacteriovorus as a Probiotic

Bonfiglio, Giulia / Neroni, Bruna / Radocchia, Giulia / Marazzato, Massimiliano / Pantanella, Fabrizio / Schippa, Serena

Nutrients. 2020 July 28, v. 12, no. 8

2020

Abstract: The gut microbiota is a complex microbial ecosystem that coexists with the human organism in the intestinal tract. The members of this ecosystem live together in a balance between them and the host, contributing to its healthy state. Stress, aging, and ... ...

Abstract	The gut microbiota is a complex microbial ecosystem that coexists with the human organism in the intestinal tract. The members of this ecosystem live together in a balance between them and the host, contributing to its healthy state. Stress, aging, and antibiotic therapies are the principal factors affecting the gut microbiota composition, breaking the mutualistic relationship among microbes and resulting in the overgrowth of potential pathogens. This condition, called dysbiosis, has been linked to several chronic pathologies. In this review, we propose the use of the predator Bdellovibrio bacteriovorus as a possible probiotic to prevent or counteract dysbiotic outcomes and look at the findings of previous research.
Keywords	Bdellovibrio bacteriovorus ; antibiotics ; dysbiosis ; ecosystems ; humans ; intestinal microorganisms ; intestines ; microbial ecology ; probiotics ; research
Language	English
Dates of publication	2020-0728
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-light
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12082252
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Chronic intestinal pseudo-obstruction: associations with gut microbiota and genes expression of intestinal serotonergic pathway.

Radocchia, Giulia / Marazzato, Massimiliano / Harbi, Karim Ben / Capuzzo, Elena / Pantanella, Fabrizio / De Giorgio, Roberto / Guarino, Matteo / Costanzini, Anna / Zenzeri, Letizia / Parisi, Pasquale / Ferretti, Alessandro / Felici, Enrico / Palamara, Anna Teresa / Di Nardo, Giovanni / Schippa, Serena

BMC microbiology

2024 Volume 24, Issue 1, Page(s) 48

Abstract: Background: Pediatric chronic intestinal pseudo-obstruction (PIPO) is a rare disease characterized by symptoms and radiological signs suggestive of intestinal obstruction, in the absence of lumen-occluding lesions. It results from an extremely severe ... ...

Abstract	Background: Pediatric chronic intestinal pseudo-obstruction (PIPO) is a rare disease characterized by symptoms and radiological signs suggestive of intestinal obstruction, in the absence of lumen-occluding lesions. It results from an extremely severe impairment of propulsive motility. The intestinal endocrine system (IES) jointly with the enteric nervous system (ENS) regulates secreto-motor functions via different hormones and bioactive messengers/neurotransmitters. The neurotransmitter 5-hydroxytryptamine (5-HT) (or serotonin) is linked to intestinal peristalsis and secretory reflexes. Gut microbiota and its interplay with ENS affect 5-HT synthesis, release, and the subsequent serotonin receptor activation. To date, the interplay between 5-HT and gut microbiota in PIPO remains largely unclear. This study aimed to assess correlations between mucosa associated microbiota (MAM), intestinal serotonin-related genes expression in PIPO. To this purpose, biopsies of the colon, ileum and duodenum have been collected from 7 PIPO patients, and 7 age-/sex-matched healthy controls. After DNA extraction, the MAM was assessed by next generation sequencing (NGS) of the V3-V4 region of the bacterial RNA 16 S, on an Illumina Miseq platform. The expression of genes implicated in serotoninergic pathway (TPH1, SLC6A4, 5-HTR3 and 5-HTR4) was established by qPCR, and correlations with MAM and clinical parameters of PIPO have been evaluated. Results: Our results revealed that PIPO patients exhibit a MAM with a different composition and with dysbiosis, i.e. with a lower biodiversity and fewer less connected species with a greater number of non-synergistic relationships, compared to controls. qPCR results revealed modifications in the expression of serotonin-related intestinal genes in PIPO patients, when compared to controls. Correlation analysis do not reveal any kind of connection. Conclusions: For the first time, we report in PIPO patients a specific MAM associated to underlying pathology and an altered intestinal serotonin pathway. A possible dysfunction of the serotonin pathway, possibly related to or triggered by an altered microbiota, may contribute to dysmotility in PIPO patients. The results of our pilot study provide the basis for new biomarkers and innovative therapies targeting the microbiota or serotonin pathways in PIPO patients.
MeSH term(s)	Humans ; Child ; Serotonin/metabolism ; Gastrointestinal Microbiome ; Pilot Projects ; Intestines ; Intestinal Pseudo-Obstruction/genetics ; Intestinal Pseudo-Obstruction/diagnosis ; Serotonin Plasma Membrane Transport Proteins
Chemical Substances	Serotonin (333DO1RDJY) ; SLC6A4 protein, human ; Serotonin Plasma Membrane Transport Proteins
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2041505-9
ISSN	1471-2180 ; 1471-2180
ISSN (online)	1471-2180
ISSN	1471-2180
DOI	10.1186/s12866-024-03200-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insight into the Possible Use of the Predator

Bonfiglio, Giulia / Neroni, Bruna / Radocchia, Giulia / Marazzato, Massimiliano / Pantanella, Fabrizio / Schippa, Serena

Nutrients

2020 Volume 12, Issue 8

Abstract	The gut microbiota is a complex microbial ecosystem that coexists with the human organism in the intestinal tract. The members of this ecosystem live together in a balance between them and the host, contributing to its healthy state. Stress, aging, and antibiotic therapies are the principal factors affecting the gut microbiota composition, breaking the mutualistic relationship among microbes and resulting in the overgrowth of potential pathogens. This condition, called dysbiosis, has been linked to several chronic pathologies. In this review, we propose the use of the predator
MeSH term(s)	Bdellovibrio bacteriovorus ; Dysbiosis/microbiology ; Dysbiosis/therapy ; Ecosystem ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; Humans ; Probiotics/therapeutic use ; Symbiosis
Language	English
Publishing date	2020-07-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12082252
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?

Radocchia, Giulia / Neroni, Bruna / Marazzato, Massimiliano / Capuzzo, Elena / Zuccari, Simone / Pantanella, Fabrizio / Zenzeri, Letizia / Evangelisti, Melania / Vassallo, Francesca / Parisi, Pasquale / Di Nardo, Giovanni / Schippa, Serena

Microorganisms. 2021 Dec. 10, v. 9, no. 12

2021

Abstract: Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome characterized by severe impairment of gastrointestinal (GI) motility, and its symptoms are suggestive of partial or complete intestinal obstruction in the absence of any lesion ... ...

Abstract	Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome characterized by severe impairment of gastrointestinal (GI) motility, and its symptoms are suggestive of partial or complete intestinal obstruction in the absence of any lesion restricting the intestinal lumen. Diagnosis and therapy of CIPO patients still represent a significant challenge for clinicians, despite their efforts to improve diagnostic workup and treatment strategies for this disease. The purpose of this review is to better understand what is currently known about the relationship between CIPO patients and intestinal microbiota, with a focus on the role of the enteric nervous system (ENS) and the intestinal endocrine system (IES) in intestinal motility, underling the importance of further studies to deeply understand the causes of gut motility dysfunction in these patients.
Keywords	endocrine system ; gastrointestinal motility ; intestinal microorganisms ; intestinal obstruction ; intestines ; nervous system ; therapeutics
Language	English
Dates of publication	2021-1210
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9122549
Database	NAL-Catalogue (AGRICOLA)

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Article: Oxygen Sparing Effect of Bacteriotherapy in COVID-19

Ceccarelli, Giancarlo / Marazzato, Massimiliano / Celani, Luigi / Lombardi, Francesca / Piccirilli, Alessandra / Mancone, Massimo / Trinchieri, Vito / Pugliese, Francesco / Mastroianni, Claudio M. / d’Ettorre, Gabriella

Nutrients. 2021 Aug. 23, v. 13, no. 8

2021

Abstract: Background: We previously reported that severe COVID-19 patients had higher chances of survival and a reduced risk of developing respiratory failure when administered with the probiotic formulation SLAB51. This study aimed to investigate further ... ...

Abstract	Background: We previously reported that severe COVID-19 patients had higher chances of survival and a reduced risk of developing respiratory failure when administered with the probiotic formulation SLAB51. This study aimed to investigate further bacteriotherapy mechanisms and how early they are activated. Methods: We performed an analysis on the blood oxygenation parameters collected in sixty-nine severe COVID-19 patients requiring non-invasive oxygen therapy and presenting a CT lung involvement ≥50%. Twenty-nine patients received low-molecular-weight heparin, azithromycin and Remdesivir. In addition, forty subjects received SLAB51. Blood gas analyses were performed before the beginning of treatments and at 24 h. Results: The patients receiving only standard therapy needed significantly increased oxygen amounts during the 24 h observation period. Furthermore, they presented lower blood levels of pO₂, O₂Hb and SaO₂ than the group also supplemented with oral bacteriotherapy. In vitro data suggest that SLAB51 can reduce nitric oxide synthesis in intestinal cells. Conclusions: SARS-CoV-2 infected patients may present lesions in the lungs compromising their gas exchange capability. The functionality of the organs essential for these patients’ survival depends mainly on the levels of pO₂, O₂Hb and SaO₂. SLAB51 contains enzymes that could reduce oxygen consumption in the intestine, making it available for the other organs.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; azithromycin ; blood ; blood gases ; gas exchange ; heparin ; intestines ; lungs ; nitric oxide ; oxygen ; oxygen consumption ; probiotics ; risk reduction ; therapeutics
Language	English
Dates of publication	2021-0823
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13082898
Database	NAL-Catalogue (AGRICOLA)

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