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  1. Article ; Online: Persistent symptoms after COVID-19 in children and adolescents from Argentina.

    Seery, Vanesa / Raiden, Silvina / Penedo, Juan Martín Gómez / Borda, Mauricio / Herrera, Largión / Uranga, Macarena / Marcó Del Pont, María / Chirino, Carina / Erramuspe, Constanza / Alvarez, Laura Silvana / Lenoir, Melisa / Morales, Laura Daniela / Davenport, Carolina / Huespe Auchter, Soledad / Monsalvo, Liliana / Sastoque, Laura / Gavazzi, Magalí / Russo, Constanza / Sananez, Inés /
    Pando, María de Los Ángeles / Laufer, Natalia / Muiños, Roberto / Ferrero, Fernando / Geffner, Jorge / Arruvito, Lourdes

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2023  Volume 129, Page(s) 49–56

    Abstract: Objectives: Although long COVID-19 is widely recognized in adults, less information is available about this condition in children, especially in developing countries. Here, we studied the long-term symptoms of SARS-CoV-2 infection beyond 3 months and ... ...

    Abstract Objectives: Although long COVID-19 is widely recognized in adults, less information is available about this condition in children, especially in developing countries. Here, we studied the long-term symptoms of SARS-CoV-2 infection beyond 3 months and the associated risk factors in a pediatric population.
    Methods: This observational study included 639 Argentinian children and adolescents with previously confirmed COVID-19 from June 2020-June 2021 and 577 children without previous COVID-19. Parents completed a survey about symptoms that their child had for >3 months after the diagnosis of SARS-CoV-2 infection.
    Results: At least one persistent symptom was observed more frequently in children with previous COVID-19 than in the non-COVID-19 group (34% vs 13%, P <0.0001). SARS-CoV-2 infection increased the risk of headache, dizziness, loss of taste, dyspnea, cough, fatigue, muscle pain, and loss of weight by three- to seven-fold. The loss of smell was only reported in infected children. After controlling for the other variables, older age, symptomatic COVID-19, and comorbidities were independent predictors of long-term symptoms.
    Conclusions: One-third of children experienced persistent symptoms after COVID-19. Older age, symptomatic infection, and comorbidities were shown to be risk factors for long COVID-19. Pediatric long COVID-19 is a new condition that requires further investigation.
    MeSH term(s) Adult ; Humans ; Adolescent ; Child ; Argentina/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; Cough/epidemiology ; Cough/etiology
    Language English
    Publishing date 2023-02-02
    Publishing country Canada
    Document type Observational Study ; Journal Article
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2023.01.031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Antibody response against SARS-CoV-2 variants of concern in children infected with pre-Omicron variants: An observational cohort study.

    Seery, Vanesa / Raiden, Silvina / Russo, Constanza / Borda, Mauricio / Herrera, Largión / Uranga, Macarena / Varese, Augusto / Marcó Del Pont, María / Chirino, Carina / Erramuspe, Constanza / Álvarez, Laura Silvana / Lenoir, Melisa / Morales, Laura Daniela / Davenport, Carolina / Alarcón Flores, Alexsa / Huespe Auchter, Soledad / Ruiz, Yanina / Monsalvo, Liliana / Sastoque, Laura /
    Gavazzi, Magalí / Mazzitelli, Ignacio / Di Diego, Facundo / Longueira, Yesica / Mazzitelli, Bianca / Sananez, Inés / De Carli, Norberto / Biglione, Mirna Marcela / Gómez Penedo, Juan Martín / Ceballos, Ana / Laufer, Natalia / Ferrero, Fernando / Geffner, Jorge / Arruvito, Lourdes

    EBioMedicine

    2022  Volume 83, Page(s) 104230

    Abstract: Background: Despite that pediatric COVID-19 is usually asymptomatic or mild, SARS-CoV-2 infection typically results in the development of an antibody response. Contradictory observations have been reported when the antibody response of children and ... ...

    Abstract Background: Despite that pediatric COVID-19 is usually asymptomatic or mild, SARS-CoV-2 infection typically results in the development of an antibody response. Contradictory observations have been reported when the antibody response of children and adults were compared in terms of strength, specificity and perdurability.
    Methods: This observational study includes three cohorts infected with SARS-CoV-2 between March 2020-July 2021: unvaccinated infected children (n=115), unvaccinated infected adults (n=62), and vaccinated infected children (n=76). Plasma anti-spike IgG antibodies and neutralising activity against Wuhan, Delta and Omicron variants after 7-17 months post-infection were analysed.
    Findings: More than 95% of unvaccinated infected children and adults remained seropositive when evaluated at 382-491 and 386-420 days after infection, respectively. Anti-spike IgG titers and plasma neutralising activity against Wuhan, Delta and Omicron variants were higher in children compared to adults. No differences were found when unvaccinated infected children were stratified by age, gender or presence/absence of symptoms in the acute phase of SARS-CoV-2 infection, but a slight decrease in the antibody response was observed in those with comorbidities. Vaccination of previously infected children with two doses of the inactivated BBIBP-CorV or the mRNA vaccines, BNT162b2 and/or mRNA-1273, further increased anti-spike IgG titers and neutralising activity against Wuhan, Delta and Omicron variants.
    Interpretation: Unvaccinated infected children mount a more potent and sustained antibody response compared with adults, which is significantly increased after vaccination. Further studies including not only the analysis of the immune response but also the effectiveness to prevent reinfections by the different Omicron lineages are required to optimise vaccination strategy in children.
    Funding: National Agency for Scientific and Technological Promotion from Argentina (PICTO-COVID-SECUELAS-00007 and PMO-BID-PICT2018-2548).
    MeSH term(s) Adult ; Antibodies, Neutralizing ; Antibodies, Viral ; Antibody Formation ; BNT162 Vaccine ; COVID-19 ; Child ; Cohort Studies ; Humans ; Immunoglobulin G ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-08-18
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2022.104230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  3. Article ; Online: A poor and delayed anti-SARS-CoV2 IgG response is associated to severe COVID-19 in children.

    Sananez, Inés / Raiden, Silvina C / Algieri, Silvia C / Uranga, Macarena / Grisolía, Nicolás A / Filippo, Daniela / De Carli, Norberto / Lalla, Sandra Di / Cairoli, Héctor / Chiolo, María J / Meregalli, Claudia N / Cohen, Emilia / Mosquera, Graciela / Marcó Del Pont, María / Giménez, Lorena I / Gregorio, Gabriela / Sarli, Mariam / Alcalde, Ana L / Davenport, Carolina /
    Bruera, María J / Simaz, Nancy / Pérez, Mariela F / Nivela, Valeria / Bayle, Carola / Alvarez, Laura / Revetria, María / Tuccillo, Patricia / Agosta, María T / Pérez, Hernán / Nova, Susana Villa / Suárez, Patricia / Takata, Eugenia M / García, Mariela / Lattner, Jorge / Rolón, María J / Coll, Patricia / Salvatori, Melina / Piccardo, Claudio / Russo, Constanza / Varese, Augusto / Seery, Vanesa / Holgado, María P / Polo, María L / Ceballos, Ana / Nuñez, Myriam / Penedo, Juan Martín Gómez / Ferrero, Fernando / Geffner, Jorge / Arruvito, Lourdes

    EBioMedicine

    2021  Volume 72, Page(s) 103615

    Abstract: Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19). ... ...

    Abstract Background: Most children and youth develop mild or asymptomatic disease during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, a very small number of patients suffer severe Coronavirus induced disease 2019 (COVID-19). The reasons underlying these different outcomes remain unknown.
    Methods: We analyzed three different cohorts: children with acute infection (n=550), convalescent children (n=138), and MIS-C (multisystem inflammatory syndrome in children, n=42). IgG and IgM antibodies to the spike protein of SARS-CoV-2, serum-neutralizing activity, plasma cytokine levels, and the frequency of circulating Follicular T helper cells (cTfh) and plasmablasts were analyzed by conventional methods.
    Findings: Fifty-eight percent of the children in the acute phase of infection had no detectable antibodies at the time of sampling while a seronegative status was found in 25% and 12% of convalescent and MIS-C children, respectively. When children in the acute phase of the infection were stratified according disease severity, we found that contrasting with the response of children with asymptomatic, mild and moderate disease, children with severe COVID-19 did not develop any detectable response. A defective antibody response was also observed in the convalescent cohort for children with severe disease at the time of admission. This poor antibody response was associated to both, a low frequency of cTfh and a high plasma concentration of inflammatory cytokines.
    Interpretation: A weak and delayed kinetic of antibody response to SARS-CoV-2 together with a systemic pro-inflammatory profile characterize pediatric severe COVID-19. Because comorbidities are highly prevalent in children with severe COVID-19, further studies are needed to clarify their contribution in the weak antibody response observed in severe disease.
    Funding: National Agency for Scientific and Technological Promotion from Argentina (IP-COVID-19-0277 and PMO-BID-PICT2018-2548).
    MeSH term(s) Antibodies, Viral/blood ; Antibody Formation ; Argentina ; COVID-19/blood ; COVID-19/complications ; COVID-19/immunology ; Child ; Child, Preschool ; Cytokines/blood ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Infant ; Male ; SARS-CoV-2/immunology ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/immunology
    Chemical Substances Antibodies, Viral ; Cytokines ; Immunoglobulin G ; Immunoglobulin M
    Language English
    Publishing date 2021-10-11
    Publishing country Netherlands
    Document type Journal Article ; Observational Study
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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