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Article ; Online: Successful stem cell transplantation after nelarabine, pegylated asparaginase, vincristine, doxorubicin, and prednisone in refractory early T-cell precursor acute lymphoblastic leukemia

Marcela Espinoza / Pablo Ramírez / Yuho Najima / Jorge Rojas-Vallejos

Medwave, Vol 23, Iss 04, Pp e2664-e

A case report

2023 Volume 2664

Abstract: Early T-cell precursor Acute Lymphoblastic Leukemia (ALL) has a dismal prognosis. Nelarabine is a purine nucleoside analog that increases the apoptosis rate in T-cell lymphoblasts. We present a 30-year-old patient diagnosed with T-cell ALL. He was a high- ...

Abstract	Early T-cell precursor Acute Lymphoblastic Leukemia (ALL) has a dismal prognosis. Nelarabine is a purine nucleoside analog that increases the apoptosis rate in T-cell lymphoblasts. We present a 30-year-old patient diagnosed with T-cell ALL. He was a high-risk patient because of an early precursor phenotype and a complex karyotype that had been refractory to three previous lines of treatment. He started a course of nelarabine (1500 mg/m for three days), pegylated-asparaginase, doxorubicin, vincristine, and prednisone (Nelarabine Peg-Asp AdmVP). He reached complete remission and received an allogeneic sibling hematopoietic stem cell transplant with fludarabine, total body irradiation, and cyclophosphamide as the conditioning regimen. He developed a pulmonary mycosis, which resolved, and grade-2 neurotoxicity in his upper and lower limbs. He was discharged after 40 days and to date remains with 23 months of complete remission. The Nelarabine Peg-Asp AdmVP regimen seems to be effective and safe. Further research is needed to establish it as an induction treatment in refractory early T-cell precursor acute lymphoblastic leucemia.
Keywords	nelarabine ; early t-cell ; acute lymphoblastic leukemia ; neurotoxicity ; hematology ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Medwave Estudios Limitada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The short-term impact of urban air pollution on student achievement

Jorge Rojas-Vallejos / Carmen Gloria Jiménez Bucarey / Marcela Espinoza / Luis Araya-Castillo

Desarrollo y Sociedad, Vol 87, Iss 1, Pp 11-

2021 Volume 32

Abstract: Goal: The relationship between air pollution and human health has been widely studied in medicine and economics. However, only a few recent articles have estimated the direct impact of air pollution on academic achievement. Methodology: We collect daily ... ...

Abstract	Goal: The relationship between air pollution and human health has been widely studied in medicine and economics. However, only a few recent articles have estimated the direct impact of air pollution on academic achievement. Methodology: We collect daily air pollution data from all monitoring stations in the city of Santiago, Chile, and combine it with academic results recorded by the National Learning Outcome Assessment System of (SIMCE in Spanish) for fourth grade students over the past decade, to create a unique pooled cross-sectional dataset. Results: Applying different econometric strategies, we find that certain air pollutants have a negative impact on the test scores of the cohort. Our estimated effects are negative and statistically significant, ranging between 0.02 and 0.06 standard deviations. Conclusions: These results seem to be small, but are equivalent to around 30% of a successful educational policy that specifically targets performance. Recommendations: Public policy must consider the positive externalities of reducing air pollution.
Keywords	government policy ; academic performance ; pollutants ; chile ; Economic history and conditions ; HC10-1085 ; Economics as a science ; HB71-74
Subject code	333
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Universidad de los Andes (Bogotá)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin

Marcela Espinoza-Monje / Jorge Campos / Eduardo Alvarez Villamil / Alonso Jerez / Stefania Dentice Maidana / Mariano Elean / Susana Salva / Haruki Kitazawa / Julio Villena / Apolinaria García-Cancino

Microorganisms, Vol 9, Iss 1486, p

Its Beneficial Role in the Pathogenesis of Acne Vulgaris

2021 Volume 1486

Abstract: Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes . ... ...

Abstract	Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes . The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes , and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes . Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.
Keywords	Weissella viridescens UCO-SMC3 ; probiotic ; immunobiotic ; skin immunity ; acne vulgaris ; Cutibacterium acnes ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nutritional assessment as predictor of complications after hematopoietic stem cell transplantation

Marcela Espinoza / Javiera Perelli / Roberto Olmos / Pablo Bertin / Verónica Jara / Pablo Ramírez

Revista Brasileira de Hematologia e Hemoterapia, Vol 38, Iss 1, Pp 7-

2016 Volume 14

Abstract: ABSTRACT Introduction: Nutritional support is pivotal in patients submitted to hematopoietic stem cell transplantation. Nutritional status has been associated with time of engraftment and infection rates. In order to evaluate the association between ... ...

Abstract	ABSTRACT Introduction: Nutritional support is pivotal in patients submitted to hematopoietic stem cell transplantation. Nutritional status has been associated with time of engraftment and infection rates. In order to evaluate the association between nutritional parameters and clinical outcomes after transplantation a cohort of transplant patients was retrospectively evaluated. Methods: All 50 patients transplanted between 2011 and 2014 were included. The nutritional status before transplantation, ten days after transplantation and before discharge was assessed including anthropometry, body mass index, albumin, prealbumin and total urinary nitrogen. Results: The median follow-up time was 41 months and the median age of patients was 41 years. Thirty-two underwent allogeneic and 18 autologous transplants. Diagnoses included acute leukemias (n = 27), lymphoma (n = 7), multiple myeloma (n = 13), and aplastic anemia (n = 3). Thirty-seven patients developed mucositis (three Grade 1, 15 Grade 2, 18 Grade 3 and one Grade 4), and twenty-two allogeneic, and five autologous transplant patients required total parenteral nutrition. Albumin and total urinary nitrogen were associated with length of hospital stay and platelet and neutrophil engraftment. None of the nutritional parameters evaluated were associated with overall survival. Non-relapse mortality was 14% and overall survival was 79% at 41 months of follow-up. Conclusions: After hematopoietic stem cell transplantation, high catabolism was associated with longer length of hospital stay, the need of total parenteral nutrition and platelet and neutrophil engraftment times. Nutritional parameters were not associated with overall survival.
Keywords	Hematopoietic cell transplantation ; Nutrition ; Outcomes ; Internal medicine ; RC31-1245 ; Medicine ; R
Subject code	610
Language	English
Publishing date	2016-02-01T00:00:00Z
Publisher	Sociedade Brasileira de Hematologia e Hemoterapia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Retrospective study comparing low-dose versus standard dose of bortezomib in patients with multiple myeloma

Marcela Espinoza Zelada / Nicole Befferman Cordova / Mauricio Ocqueteau Tachin / Pablo Ramírez Villanueva / Mauricio Galleguillos M. / Mauricio Sarmiento Maldonado

Medwave, Vol 15, Iss 02, p e

2015 Volume 6098

Abstract: INTRODUCTION Bortezomib is a selective inhibitor of the proteosoma that is used in multiple myeloma. In combination with other antineoplastic drugs, it has a well-documented impact in progression-free survival rates and overall survival rates with ... ...

Abstract	INTRODUCTION Bortezomib is a selective inhibitor of the proteosoma that is used in multiple myeloma. In combination with other antineoplastic drugs, it has a well-documented impact in progression-free survival rates and overall survival rates with standard doses (1.3-1.5 mg/m2). However, up to 88% of patients on standard doses have unwanted side effects (neutropenia, neuropathy or anemia. Standard dose (1.3 mg/m2) is used in almost all patients and low dose (0.7-0.8 mg/m2) is reserved for patients with kidney disease and neuropathy. OBJECTIVE We aim to describe clinical, cytological, and cytometric outcomes, as well as overall survival and side effects of low dose versus standard dose of bortezomib in our institution. METHODS Retrospective, descriptive study based on data recovered from clinical charts of 48 multiple myeloma patients treated in our hospital between 2011 and 2013. We included data on age, gender, type of multiple myeloma, serum albumin, serum creatinine, beta 2 microglobulin, calcemia, imaging studies, disease stage, pre-and post-therapy bone marrow studies, adverse events and rate of progression. We also recorded events like date of death or of the last medical appointment. RESULTS Forty-eight multiple myeloma patients were treated with bortezomib-cyclophosphamide-dexamethasone. Twenty-one patients received low dose and 27 patients were treated with the standard dose. No statistical differences between the two groups were found for clinical response (p=0.6), cytological response (p=0.28), flow cytometric response (p= 0.3), rate of adverse effects and overall survival rates. CONCLUSION This retrospective analysis suggests that lower doses of bortezomib have similar effects in disease control measured by flow cytometry and cytology compared to standard doses in multiple myeloma patients.
Keywords	Medicine ; R ; Medicine (General) ; R5-920
Subject code	610 ; 616
Language	English
Publishing date	2015-03-01T00:00:00Z
Publisher	Medwave Estudios Limitada
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women.

Poveda, Gina Ferrer / Carrillo, Katia Sáez / Monje, Marcela Espinoza / Cruz, Carlos Alvarez / Cancino, Apolinaria García

Revista da Associacao Medica Brasileira (1992)

2014 Volume 60, Issue 4, Page(s) 306–310

Abstract: Objective: the aim of this research was to determine the prevalence of Helicobacter pylori infection on Chilean pregnant women and its relationship with the appearance and severity of hyperemesis and dyspepsia.: Methods: quantitative study of ... ...

Abstract	Objective: the aim of this research was to determine the prevalence of Helicobacter pylori infection on Chilean pregnant women and its relationship with the appearance and severity of hyperemesis and dyspepsia. Methods: quantitative study of prevalence in a transversal cut with variable analysis. The sample was taken from 274 Chilean pregnant women from the Bío Bío province through vein puncture between June and December, 2005. Pregnant women were informed of this study, interviewed and signed an informed consent. The samples were processed using ImmunoComb II Helicobacter pylori IgG kit. Statistical analysis was performed by means of the Statistical Package for Social Sciences (SPSS) Program. Results: out of the total number of pregnant women, 68.6% showed infection by Helicobacter pylori. 79.6% of the total sample had symptoms of dyspepsia, and 72.5% of this group presented Helicobacter pylori infection. 12.4% showed pregnancy hyperemesis; among them, 79.4% were infected with Helicobacter pylori. 73.4% of the pregnant women that showed gastric discomfort during the first three months had Helicobacter pylori infection. 53.7% of them continued with gastric discomfort after the first three months; of those, 95.8% were infected. Helicobacter pylori infection was present only in 1.5% of pregnant women without gastric discomfort. Conclusion: both, gastric discomfort of pregnant women and the continuity of severe symptoms of dyspepsia and hyperemesis after the first three months of gestation are significantly correlated with Helicobacter pylori infection.
MeSH term(s)	Chile/epidemiology ; Cross-Sectional Studies ; Dyspepsia/epidemiology ; Dyspepsia/microbiology ; Female ; Helicobacter Infections/epidemiology ; Helicobacter pylori ; Humans ; Hyperemesis Gravidarum/epidemiology ; Hyperemesis Gravidarum/microbiology ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/microbiology ; Prevalence ; Severity of Illness Index
Language	English
Publishing date	2014-08-22
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2027973-5
ISSN	1806-9282 ; 0104-4230
ISSN (online)	1806-9282
ISSN	0104-4230
DOI	10.1590/1806-9282.60.04.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Helicobacter pylori infection and gastrointestinal symptoms on Chilean pregnant women

Gina Ferrer Poveda / Katia Sáez Carrillo / Marcela Espinoza Monje / Carlos Alvarez Cruz / Apolinaria García Cancino

Revista da Associação Médica Brasileira, Vol 60, Iss 4, Pp 306-

2014 Volume 310

Abstract	Objective: the aim of this research was to determine the prevalence of Helicobacter pylori infection on Chilean pregnant women and its relationship with the appearance and severity of hyperemesis and dyspepsia. Methods: quantitative study of prevalence in a transversal cut with variable analysis. The sample was taken from 274 Chilean pregnant women from the Bío Bío province through vein puncture between June and December, 2005. Pregnant women were informed of this study, interviewed and signed an informed consent. The samples were processed using ImmunoComb II Helicobacter pylori IgG kit. Statistical analysis was performed by means of the Statistical Package for Social Sciences (SPSS) Program. Results: out of the total number of pregnant women, 68.6% showed infection by Helicobacter pylori. 79.6% of the total sample had symptoms of dyspepsia, and 72.5% of this group presented Helicobacter pylori infection. 12.4% showed pregnancy hyperemesis; among them, 79.4% were infected with Helicobacter pylori. 73.4% of the pregnant women that showed gastric discomfort during the first three months had Helicobacter pylori infection. 53.7% of them continued with gastric discomfort after the first three months; of those, 95.8% were infected. Helicobacter pylori infection was present only in 1.5% of pregnant women without gastric discomfort. Conclusion: both, gastric discomfort of pregnant women and the continuity of severe symptoms of dyspepsia and hyperemesis after the first three months of gestation are significantly correlated with Helicobacter pylori infection.
Keywords	Helicobacter pylori ; gravidez ; hiperêmese ; dispepsia ; Medicine (General) ; R5-920 ; Medicine ; R
Subject code	150
Language	Portuguese
Publishing date	2014-07-01T00:00:00Z
Publisher	Associação Médica Brasileira
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evaluación de la nitazoxanida en dosis única y por tres días en parasitosis intestinal Nitazoxanide vs albendazole against intestinal parasites in a single dose and for three days

Uri Belkind-Valdovinos / Jaime Belkind-Gerson / Domingo Sánchez-Francia / Mónica Marcela Espinoza-Ruiz / Eduardo Lazcano-Ponce

Salud Pública de México, Vol 46, Iss 4, Pp 333-

2004 Volume 340

Abstract: OBJETIVO: Evaluar la utilidad de nitazoxanida en dosis habitual con esquema de tres días y en dosis única, para la erradicación masiva de parásitos intestinales en la población pediátrica, comparando su efecto con el del albendazol en dosis única. ... ...

Abstract	OBJETIVO: Evaluar la utilidad de nitazoxanida en dosis habitual con esquema de tres días y en dosis única, para la erradicación masiva de parásitos intestinales en la población pediátrica, comparando su efecto con el del albendazol en dosis única. MATERIAL Y MÉTODOS: Se realizó un ensayo clínico aleatorizado, en tres comunidades rurales de la región central de México, durante el periodo 2001-2003, para incluir tres posibles alternativas de tratamiento en 786 sujetos de entre 5 y 11 años de edad, de los cuales 92 tuvieron un examen parasitológico positivo (15.1%). El grupo 1 incluyó 27 pacientes que recibieron 400 mg de albendazol en dosis única; el grupo 2 incluyó 34 pacientes a quienes se administró nitazoxanida en dosis de 15 mg/kg/día durante tres días consecutivos; y el grupo 3 incluyó 31 pacientes que recibieron 1.2 g de nitazoxanida en dosis única. Se evaluó diferencia de proporciones mediante prueba exacta de Fisher. RESULTADOS: No existieron diferencias estadísticamente significativas en la efectividad de los tres esquemas de tratamiento: (80.5%) con albendazol, comparado con las dos alternativas adicionales de nitazoxanida (67.6% y 71%, respectivamente). Se observó una mayor prevalencia de efectos secundarios con nitazoxanida por kg /día (26.5%) y en dosis única (32.2%), en comparación con la dosis única de albendazol (7.4%). CONCLUSIONES: Las evidencias en cuanto a la efectividad y elevada prevalencia de efectos secundarios de la nitazoxanida no justifican aún su utilización como quimiopreventivo masivo para el control de parasitosis intestinal en áreas endémicas. En países con elevada prevalencia de parasitosis intestinal las medidas de prevención primaria que continúan vigentes, y que deben priorizarse, están relacionadas con sanidad pública, introducción de agua potable y drenaje, cloración de agua y manejo adecuado de excretas de animales domésticos, así como educación para la salud. OBJETIVE: To assess the efectiveness of the usual dose of nitazoxanide administered for three days and as a single ...
Keywords	parasitosis intestinal ; nitazoxanida ; albendazol ; ensayo clínico ; México ; intestinal parasitosis ; nitazoxanide ; albendazole ; clinical trial ; Mexico ; Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2004-08-01T00:00:00Z
Publisher	Instituto Nacional de Salud Pública
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Valores de referencia para proteína transportadora de hormona de crecimiento en una población pediátrica normal Normative values of growth hormone binding protein (GHBP) for a Chilean pediatric population

Teresa E Salazar C / M Verónica Méricq / Marcela Espinoza F / Germán Iñiguez V / Pilar Carvallo de SQ / Fernando Cassorla G

Revista Médica de Chile, Vol 129, Iss 4, Pp 382-

2001 Volume 389

Abstract: Circulating concentrations of the high affinity growth hormone binding protein (GHBP) may be a marker of GH receptor density as well as GH sensiffvity. Goal: To determine values of GHBP for a normal Chilean pediatric population. Methods: We determined ... ...

Abstract	Circulating concentrations of the high affinity growth hormone binding protein (GHBP) may be a marker of GH receptor density as well as GH sensiffvity. Goal: To determine values of GHBP for a normal Chilean pediatric population. Methods: We determined GHBP levels in 73 males and 73 females between 4 to 15.5 years and 4 to 16.8 years respectively, divided in 7 groups according to age and puberal status. Results: The population was normally distributed in weight, height and body mass index (BMI). GHBP activity increased up to Tanner IV in males and Tanner III in females, and decreased slightly thereafter in Tanner V and IV respectively. There was a significant difference between GHBP levels of preschool children and those found in Tanner II to V in both sexes (p<0.05). In adition, we found a positive correlation between GHBP vs weight, height and BMI (p<0.001) in males and females. Conclusion: The availability of this methodology allows us to establish the normative value of GHBP in our population and provides useful information to interpret GH circulating levels in children with growth disorders.(Rev Méd Chile 2001; 129: 382-9)
Keywords	Growth ; Pediatrics ; Somatotropin ; Somatropin ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	590
Language	Spanish
Publishing date	2001-04-01T00:00:00Z
Publisher	Sociedad Médica de Santiago
Document type	Article ; Online
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