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  1. Article ; Online: Throbbing headache is not always migraine; it can be serious

    Marcelle G. Meseeha / Maximos Attia

    Journal of Community Hospital Internal Medicine Perspectives, Vol 6, Iss 5, Pp 1-

    2016  Volume 4

    Abstract: Cerebral venous thrombosis (CVT) is a rare but serious venous thrombotic disorder in the general population. It has an estimated annual incidence of about 4–5 cases per 1 million persons. It is more common in females than males. We describe below a case ... ...

    Abstract Cerebral venous thrombosis (CVT) is a rare but serious venous thrombotic disorder in the general population. It has an estimated annual incidence of about 4–5 cases per 1 million persons. It is more common in females than males. We describe below a case of a 49-year-old female patient who presented to the emergency room with 1 day history of right-sided throbbing headache associated with vomiting. Computed tomography (CT) scan of the head without contrast showed venous sinus thrombosis involving the posterior sagittal sinus, extending into the dominant right transverse sinus, which was confirmed by CT head with intravenous contrast. The patient was immediately started on anticoagulation with therapeutic low-molecular-weight heparin that was transitioned to warfarin. Follow-up CT head 3 months later showed resolution of the thrombus and recanalization of the affected veins. A high level of suspicion for a rare disorder like CVT should be considered as part of the differential diagnosis of headache, which is a commonly encountered problem, because immediate anticoagulation treatment can prevent fatal complications.
    Keywords cerebral venous thrombosis ; headache ; oral contraceptive pills ; sinus infection ; anticoagulation ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2016-10-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Topiramate as a rare cause of reversible Fanconi syndrome and acute kidney injury

    Marcelle G. Meseeha / Maximos N. Attia / Victor O. Kolade

    Journal of Community Hospital Internal Medicine Perspectives, Vol 6, Iss 1, Pp 1-

    a case report and literature review

    2016  Volume 4

    Abstract: Topiramate (TPM) is a sulfa-derivative monosaccharide that has been used for multiple indications in the last several years. We describe a 53-year-old woman with known chronic kidney disease stage 2 and baseline creatinine of 1 mg/dL who developed acute ... ...

    Abstract Topiramate (TPM) is a sulfa-derivative monosaccharide that has been used for multiple indications in the last several years. We describe a 53-year-old woman with known chronic kidney disease stage 2 and baseline creatinine of 1 mg/dL who developed acute kidney injury and proximal renal tubular dysfunction while on TPM for depression. The Naranjo Adverse Drug Reaction Probability Scale indicated a probable relationship (score of 6) between TPM and acute kidney injury as well as proximal tubular dysfunction; these renal conditions resolved on withdrawal of TPM. To our knowledge, this is the first report of such a scenario. Patients receiving TPM therapy should be closely monitored for evidence of kidney dysfunction and electrolyte abnormalities.
    Keywords acute kidney injury ; drug-related side effects ; topiramate ; proximal renal tubular dysfunction ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2016-02-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Celiac disease unmasked by acute severe iron deficiency anemia

    Marcelle G. Meseeha / Maximos N. Attia / Victor O. Kolade

    Journal of Community Hospital Internal Medicine Perspectives, Vol 6, Iss 3, Pp 1-

    2016  Volume 3

    Abstract: The prevalence of celiac disease (CD) appears to be increasing in the United States. However, the proportion of new CD cases with atypical presentations is also rising. We present the case of a 49-year-old woman who was diagnosed with CD in the setting ... ...

    Abstract The prevalence of celiac disease (CD) appears to be increasing in the United States. However, the proportion of new CD cases with atypical presentations is also rising. We present the case of a 49-year-old woman who was diagnosed with CD in the setting of new, severe iron-deficiency anemia, 13 years into treatment of diarrhea-predominant irritable bowel syndrome associated with chronic mildly elevated liver function tests. While CD and iron deficiency anemia are common, this is a rare presentation of CD.
    Keywords iron deficiency anemia ; celiac disease ; irritable bowel syndrome ; elevated liver enzymes ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2016-07-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Partially reversible bortezomib-induced cardiotoxicity

    Marcelle G. Meseeha / Victor O. Kolade / Maximos N. Attia

    Journal of Community Hospital Internal Medicine Perspectives, Vol 5, Iss 6, Pp 1-

    an unusual cause of acute cardiomyopathy

    2015  Volume 3

    Abstract: Chemotherapy-associated cardiotoxicity can present as a spectrum from arrhythmia to acute congestive heart failure. Unlike anthracyclines, proteasome inhibitors – for example, bortezomib – are not notorious for causing cardiotoxicity in absence of pre- ... ...

    Abstract Chemotherapy-associated cardiotoxicity can present as a spectrum from arrhythmia to acute congestive heart failure. Unlike anthracyclines, proteasome inhibitors – for example, bortezomib – are not notorious for causing cardiotoxicity in absence of pre-existing cardiac dysfunction or without concomitant use of other cardiotoxic agents. We describe a 66-year-old woman with end-stage renal disease who developed acute dyspnea hours after a third treatment with bortezomib for IgG kappa myeloma. The Naranjo adverse drug reaction probability scale indicated a probable relationship (score of 5) between bortezomib and acute left ventricular dysfunction. Patients receiving proteasome inhibitors should be closely monitored for evidence of cardiac dysfunction during treatment.
    Keywords bortezomib ; proteasome inhibitors ; cardiotoxicity ; multiple myeloma ; heart failure ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2015-12-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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