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  1. Article ; Online: Role of Dendritic Cells in Inflammation

    Marcello Chieppa

    International Journal of Molecular Sciences, Vol 21, Iss 4432, p

    2020  Volume 4432

    Abstract: From the first manuscript describing “A Novel Cell Type in Peripheral Lymphoid Organs of Mice” [.] ...

    Abstract From the first manuscript describing “A Novel Cell Type in Peripheral Lymphoid Organs of Mice” [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Coronavirus Disease (COVID-19–SARS-CoV-2) and Nutrition

    Hellas Cena / Marcello Chieppa

    Frontiers in Immunology, Vol

    Is Infection in Italy Suggesting a Connection?

    2020  Volume 11

    Abstract: Novel coronavirus disease (COVID-19) was declared a global pandemic on March 11, 2020. The outbreak first occurred in Wuhan, Hubei, China, in December 2019 and hit Italy heavily in February 2020. Several countries are adopting complete or partial ... ...

    Abstract Novel coronavirus disease (COVID-19) was declared a global pandemic on March 11, 2020. The outbreak first occurred in Wuhan, Hubei, China, in December 2019 and hit Italy heavily in February 2020. Several countries are adopting complete or partial lockdown to contain the growth of COVID-19 infection. These measures may affect people's mental health and well-being but are necessary to avoid spreading the pandemic. There has been a gradual increase in studies exploring prevention and control measures, and we recommend paying close attention to nutrition, which may contribute to modulating some important consequences of COVID-19 infection, as such pro-inflammatory cytokine storm.
    Keywords COVID-19 ; nutrition ; polyphenols ; diabetes ; incidence ; cytokine storm ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Immune Cells and Microbiota Response to Iron Starvation

    Marcello Chieppa / Gianluigi Giannelli

    Frontiers in Medicine, Vol

    2018  Volume 5

    Abstract: Metal ions are essential for life on Earth, mostly as crucial components of all living organisms; indeed, they are necessary for bioenergetics functions as crucial redox catalysts. Due to the essential role of iron in biological processes, body iron ... ...

    Abstract Metal ions are essential for life on Earth, mostly as crucial components of all living organisms; indeed, they are necessary for bioenergetics functions as crucial redox catalysts. Due to the essential role of iron in biological processes, body iron content is finely regulated and is the battlefield of a tug-of-war between the host and the microbiota.
    Keywords iron-chelating agents ; microbiota ; inflammation ; inflammatory bowel disease ; immune cells ; Medicine (General) ; R5-920
    Language English
    Publishing date 2018-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Editorial: Innate Immune Cells and Inflammatory Mediators in Mucosal Pathologies.

    Maria, Leite-de-Moraes / Marcello, Chieppa / Mònica, Vermeulen

    Frontiers in immunology

    2020  Volume 11, Page(s) 1679

    MeSH term(s) Animals ; Host-Pathogen Interactions ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Mucous Membrane/immunology ; Mucous Membrane/metabolism ; Mucous Membrane/pathology ; Signal Transduction
    Chemical Substances Inflammation Mediators
    Language English
    Publishing date 2020-07-28
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Deletion of TNF in Winnie- APC Min/+ Mice Reveals Its Dual Role in the Onset and Progression of Colitis-Associated Colorectal Cancer

    Giulio Verna / Marina Liso / Elisabetta Cavalcanti / Raffaele Armentano / Alessandro Miraglia / Vladia Monsurrò / Marcello Chieppa / Stefania De Santis

    International Journal of Molecular Sciences, Vol 23, Iss 15145, p

    2022  Volume 15145

    Abstract: Colorectal cancer (CRC) is among the best examples for depicting the relationship between inflammation and cancer. The introduction of new therapeutics targeting inflammatory mediators showed a marked decrease in the overall risk of CRC, although their ... ...

    Abstract Colorectal cancer (CRC) is among the best examples for depicting the relationship between inflammation and cancer. The introduction of new therapeutics targeting inflammatory mediators showed a marked decrease in the overall risk of CRC, although their chemopreventive potential is still debated. Specifically, a monoclonal antibody that blocks tumor necrosis factor (TNF), infliximab, increases CRC risk in inflammatory bowel disease patients. To address the axis between TNF and CRC development and progression, we depleted the Tnf from our previously established murine model of colitis-associated cancer (CAC), the Winnie- Apc Min/+ line. We characterized the new Winnie- APC Min/+- TNF-KO line through macroscopical and microscopical analyses. Surprisingly, the latter demonstrated that the deletion of Tnf in Winnie- Apc Min/+ mice resulted in an initial reduction in dysplastic lesion incidence in 5-week-old mice followed by a faster disease progression at 8 weeks. Histological data were confirmed by the molecular profiling obtained from both the real-time PCR analysis of the whole tissue and the RNA sequencing of the macrodissected tumoral lesions from Winnie- APC Min/+- TNF-KO distal colon at 8 weeks. Our results highlight that TNF could exert a dual role in CAC, supporting the promotion of neoplastic lesions onset in the early stage of the disease while inducing their reduction during disease progression.
    Keywords colon cancer ; inflammation ; animal models ; ulcerative colitis ; TNF ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Beyond Just Bacteria

    Ravichandra Vemuri / Esaki M. Shankar / Marcello Chieppa / Rajaraman Eri / Kylie Kavanagh

    Microorganisms, Vol 8, Iss 4, p

    Functional Biomes in the Gut Ecosystem Including Virome, Mycobiome, Archaeome and Helminths

    2020  Volume 483

    Abstract: Gut microbiota refers to a complex network of microbes, which exerts a marked influence on the host’s health. It is composed of bacteria, fungi, viruses, and helminths. Bacteria, or collectively, the bacteriome, comprises a significant proportion of the ... ...

    Abstract Gut microbiota refers to a complex network of microbes, which exerts a marked influence on the host’s health. It is composed of bacteria, fungi, viruses, and helminths. Bacteria, or collectively, the bacteriome, comprises a significant proportion of the well-characterized microbiome. However, the other communities referred to as ‘dark matter’ of microbiomes such as viruses (virome), fungi (mycobiome), archaea (archaeome), and helminths have not been completely elucidated. Development of new and improved metagenomics methods has allowed the identification of complete genomes from the genetic material in the human gut, opening new perspectives on the understanding of the gut microbiome composition, their importance, and potential clinical applications. Here, we review the recent evidence on the viruses, fungi, archaea, and helminths found in the mammalian gut, detailing their interactions with the resident bacterial microbiota and the host, to explore the potential impact of the microbiome on host’s health. The role of fecal virome transplantations, pre-, pro-, and syn-biotic interventions in modulating the microbiome and their related concerns are also discussed.
    Keywords gut microbiota ; virome ; fecal virome transplants ; mycobiome ; archaeome ; helminths ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells

    Giulio Verna / Marina Liso / Elisabetta Cavalcanti / Giusy Bianco / Veronica Di Sarno / Angelo Santino / Pietro Campiglia / Marcello Chieppa

    International Journal of Molecular Sciences, Vol 22, Iss 8349, p

    2021  Volume 8349

    Abstract: Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory ... ...

    Abstract Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to the basolateral side. This results in DCs activation, but the response of pDCs is still poorly characterized. In the present study, we compared mDCs and pDCs responses to LPS administration. We present a broad panel of DCs secreted factors, including cytokines, chemokines, and growth factors. Our recent studies demonstrated the anti-inflammatory effects of quercetin administration, but to date, there is no evidence about quercetin’s effects on pDCs. The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs ( Slpi , Hmox1, and AP-1 ).
    Keywords quercetin ; dendritic cells ; plasmacytoid ; cytokines ; slpi ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: miR-369-3p modulates inducible nitric oxide synthase and is involved in regulation of chronic inflammatory response

    Viviana Scalavino / Marina Liso / Elisabetta Cavalcanti / Isabella Gigante / Antonio Lippolis / Mauro Mastronardi / Marcello Chieppa / Grazia Serino

    Scientific Reports, Vol 10, Iss 1, Pp 1-

    2020  Volume 10

    Abstract: Abstract Dendritic cells are the most important antigen-presenting cells that link the innate and acquired immune system. In our previous study, we identified that the upregulation of miR-369-3p suppresses the LPS-induced inflammatory response, reducing ... ...

    Abstract Abstract Dendritic cells are the most important antigen-presenting cells that link the innate and acquired immune system. In our previous study, we identified that the upregulation of miR-369-3p suppresses the LPS-induced inflammatory response, reducing C/EBP-β, TNFα and IL-6 production. With the aim of gaining further insight into the biological function of miR-369-3p during acute inflammatory response, in the present study we identified novel gene targets of miR-369-3p and demonstrated the suppressive ability of these genes on the inflammatory dendritic cells. Bioinformatic analyses revealed that iNOS is a potential target of miR-369-3p. We demonstrated that the ectopic induction of miR-369-3p markedly reduced iNOS mRNA and protein as well as NO production. Moreover, we found that the upregulation of miR-369-3p decreased the release of TNFα, IL-6, IL-12, IL-1α, IL-1β in response to LPS, and increased the production of anti-inflammatory cytokines such as IL-10 and IL-1RA. In addition, LPS-induced nuclear translocation of NF-kB was inhibited by miR-369-3p. Levels of miR-369-3p were decreased in human inflamed regions of human intestine obtained from IBD patients. Our results provide novel additional information on miR-369-3p as a potential core of the signaling regulating the inflammatory response. These findings suggest that miR-369-3p should be considered as a potential target for the future development of new molecular therapeutic approaches.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Chemical profiling of bioactive constituents in hop cones and pellets extracts by online comprehensive two‐dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron resonance mass spectrometry

    Sommella, Eduardo / Francesco Pagano / Emanuela Salviati / Marcello Chieppa / Alessia Bertamino / Michele Manfra / Marina Sala / Ettore Novellino / Pietro Campiglia

    Journal of separation science. 2018 Apr., v. 41, no. 7

    2018  

    Abstract: Humulus lupulus L. (hop) is highly interesting from a nutraceutical perspective. The hop phytocomplex contains a wide range of bioactive metabolites, and its characterization is challenging. To tackle such a task, for the first time we applied and ... ...

    Abstract Humulus lupulus L. (hop) is highly interesting from a nutraceutical perspective. The hop phytocomplex contains a wide range of bioactive metabolites, and its characterization is challenging. To tackle such a task, for the first time we applied and compared a combined approach consisting of online comprehensive two‐dimensional liquid chromatography with tandem mass spectrometry and direct infusion Fourier transform ion cyclotron mass spectrometry. A reversed phase × reversed phase approach with a shifted gradient in the second dimension ensured selectivity and two‐dimensional space coverage. Hyphenation with an ion trap time‐of‐flight analyzer led to the identification of 83 compounds in 70 min, comprising a novel quercetin derivative and six unknown bitter acids. On the other hand, the direct infusion method was able to identify 40 analytes (except isomers) with high mass accuracy (≤ 0.1 ppm) in less than 1 min analysis time. The developed approach can be used in a complementary way, combining the separation capability and high informative spectra of two‐dimensional liquid chromatography tandem mass spectrometry with the ultra‐high mass accuracy of direct infusion, for potential compound discovery or the accurate profiling of bioactive compounds in different hop cultivars as well as for monitoring processing and storage of hop‐based products.
    Keywords Humulus lupulus ; bioactive compounds ; bitter acids ; comprehensive two-dimensional liquid chromatography ; cultivars ; functional foods ; isomers ; liquid chromatography ; metabolites ; pellets ; quercetin ; tandem mass spectrometry
    Language English
    Dates of publication 2018-04
    Size p. 1548-1557.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.201701242
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Iron Overload Mimicking Conditions Skews Bone Marrow Dendritic Cells Differentiation into MHCII low CD11c + CD11b + F4/80 + Cells

    Giulio Verna / Marina Liso / Stefania De Santis / Manuela Dicarlo / Elisabetta Cavalcanti / Alberto Crovace / Annamaria Sila / Pietro Campiglia / Angelo Santino / Antonio Lippolis / Grazia Serino / Alessio Fasano / Marcello Chieppa

    International Journal of Molecular Sciences, Vol 21, Iss 4, p

    2020  Volume 1353

    Abstract: Iron overload is an undesired effect of frequent blood transfusions or genetic diseases. Myelodysplastic syndrome (MDS) patients become transfusion dependent, but due to the combination of ineffective haematopoiesis and repeated blood transfusions they ... ...

    Abstract Iron overload is an undesired effect of frequent blood transfusions or genetic diseases. Myelodysplastic syndrome (MDS) patients become transfusion dependent, but due to the combination of ineffective haematopoiesis and repeated blood transfusions they are often subject to iron overload. In this study, we demonstrate that iron-overload mimicking condition alters bone marrow progenitor differentiation towards dendritic cells (DCs). Cells cultured in iron-enriched culture medium for seven days fail to differentiate into conventional CD11c + MHCII hi DCs and fail to efficiently respond to LPS (Lipopolysaccharides). Cells appear smaller than control DCs but vital and able to perform FITC-dextran (Fluorescein isothiocyanate-dextran) endocytosis. At molecular level, cells cultured in iron-enriched conditions show increased ARG1 and PU.1 , and decreased IRF8 expression.
    Keywords dendritic cells ; inflammation ; iron overload ; bone marrow ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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