LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Trauma Matters: Integrating Genetic and Environmental Components of PTSD.

    Marchese, Shelby / Huckins, Laura M

    Advanced genetics (Hoboken, N.J.)

    2022  Volume 4, Issue 3, Page(s) 2200017

    Abstract: Trauma is ubiquitous, but only a subset of those who experience trauma will develop posttraumatic stress disorder (PTSD). In this review, it is argued that to determine who is at risk of developing PTSD, it is critical to examine the genetic etiology of ... ...

    Abstract Trauma is ubiquitous, but only a subset of those who experience trauma will develop posttraumatic stress disorder (PTSD). In this review, it is argued that to determine who is at risk of developing PTSD, it is critical to examine the genetic etiology of the disorder and individual trauma profiles of those who are susceptible. First, the state of current PTSD genetic research is described, with a particular focus on studies that present evidence for trauma type specificity, or for differential genetic etiology according to gender or race. Next, approaches that leverage non-traditional phenotyping approaches are reviewed to identify PTSD-associated variants and biology, and the relative advantages and limitations inherent in these studies are reflected on. Finally, it is discussed how trauma might influence the heritability of PTSD, through type, risk factors, genetics, and associations with PTSD symptomology.
    Language English
    Publishing date 2022-09-07
    Publishing country United States
    Document type Journal Article
    ISSN 2641-6573
    ISSN (online) 2641-6573
    DOI 10.1002/ggn2.202200017
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article ; Online: Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.

    Hicks, Emily M / Seah, Carina / Cote, Alanna / Marchese, Shelby / Brennand, Kristen J / Nestler, Eric J / Girgenti, Matthew J / Huckins, Laura M

    Translational psychiatry

    2023  Volume 13, Issue 1, Page(s) 129

    Abstract: Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome with genetic and environmental influences. In addition to neuroanatomical and circuit-level disturbances, dysregulation of the brain transcriptome is a key phenotypic ... ...

    Abstract Major depressive disorder (MDD) is a complex and heterogeneous psychiatric syndrome with genetic and environmental influences. In addition to neuroanatomical and circuit-level disturbances, dysregulation of the brain transcriptome is a key phenotypic signature of MDD. Postmortem brain gene expression data are uniquely valuable resources for identifying this signature and key genomic drivers in human depression; however, the scarcity of brain tissue limits our capacity to observe the dynamic transcriptional landscape of MDD. It is therefore crucial to explore and integrate depression and stress transcriptomic data from numerous, complementary perspectives to construct a richer understanding of the pathophysiology of depression. In this review, we discuss multiple approaches for exploring the brain transcriptome reflecting dynamic stages of MDD: predisposition, onset, and illness. We next highlight bioinformatic approaches for hypothesis-free, genome-wide analyses of genomic and transcriptomic data and their integration. Last, we summarize the findings of recent genetic and transcriptomic studies within this conceptual framework.
    MeSH term(s) Humans ; Depressive Disorder, Major ; Transcriptome ; Genome-Wide Association Study ; Brain/metabolism ; Computational Biology ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-04-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-023-02412-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Altered gene expression and PTSD symptom dimensions in World Trade Center responders.

    Marchese, Shelby / Cancelmo, Leo / Diab, Olivia / Cahn, Leah / Aaronson, Cindy / Daskalakis, Nikolaos P / Schaffer, Jamie / Horn, Sarah R / Johnson, Jessica S / Schechter, Clyde / Desarnaud, Frank / Bierer, Linda M / Makotkine, Iouri / Flory, Janine D / Crane, Michael / Moline, Jacqueline M / Udasin, Iris G / Harrison, Denise J / Roussos, Panos /
    Charney, Dennis S / Koenen, Karestan C / Southwick, Steven M / Yehuda, Rachel / Pietrzak, Robert H / Huckins, Laura M / Feder, Adriana

    Molecular psychiatry

    2022  Volume 27, Issue 4, Page(s) 2225–2246

    Abstract: Despite experiencing a significant trauma, only a subset of World Trade Center (WTC) rescue and recovery workers developed posttraumatic stress disorder (PTSD). Identification of biomarkers is critical to the development of targeted interventions for ... ...

    Abstract Despite experiencing a significant trauma, only a subset of World Trade Center (WTC) rescue and recovery workers developed posttraumatic stress disorder (PTSD). Identification of biomarkers is critical to the development of targeted interventions for treating disaster responders and potentially preventing the development of PTSD in this population. Analysis of gene expression from these individuals can help in identifying biomarkers of PTSD. We established a well-phenotyped sample of 371 WTC responders, recruited from a longitudinal WTC responder cohort using stratified random sampling, by obtaining blood, self-reported and clinical interview data. Using bulk RNA-sequencing from whole blood, we examined the association between gene expression and WTC-related PTSD symptom severity on (i) highest lifetime Clinician-Administered PTSD Scale (CAPS) score, (ii) past-month CAPS score, and (iii) PTSD symptom dimensions using a 5-factor model of re-experiencing, avoidance, emotional numbing, dysphoric arousal and anxious arousal symptoms. We corrected for sex, age, genotype-derived principal components and surrogate variables. Finally, we performed a meta-analysis with existing PTSD studies (total N = 1016), using case/control status as the predictor and correcting for these variables. We identified 66 genes significantly associated with total highest lifetime CAPS score (FDR-corrected p < 0.05), and 31 genes associated with total past-month CAPS score. Our more granular analyses of PTSD symptom dimensions identified additional genes that did not reach statistical significance in our analyses with total CAPS scores. In particular, we identified 82 genes significantly associated with lifetime anxious arousal symptoms. Several genes significantly associated with multiple PTSD symptom dimensions and total lifetime CAPS score (SERPINA1, RPS6KA1, and STAT3) have been previously associated with PTSD. Geneset enrichment of these findings has identified pathways significant in metabolism, immune signaling, other psychiatric disorders, neurological signaling, and cellular structure. Our meta-analysis revealed 10 genes that reached genome-wide significance, all of which were downregulated in cases compared to controls (CIRBP, TMSB10, FCGRT, CLIC1, RPS6KB2, HNRNPUL1, ALDOA, NACA, ZNF429 and COPE). Additionally, cellular deconvolution highlighted an enrichment in CD4 T cells and eosinophils in responders with PTSD compared to controls. The distinction in significant genes between total lifetime CAPS score and the anxious arousal symptom dimension of PTSD highlights a potential biological difference in the mechanism underlying the heterogeneity of the PTSD phenotype. Future studies should be clear about methods used to analyze PTSD status, as phenotypes based on PTSD symptom dimensions may yield different gene sets than combined CAPS score analysis. Potential biomarkers implicated from our meta-analysis may help improve therapeutic target development for PTSD.
    MeSH term(s) Anxiety ; Chloride Channels ; Gene Expression ; Humans ; RNA-Binding Proteins ; Self Report ; September 11 Terrorist Attacks/psychology ; Stress Disorders, Post-Traumatic/diagnosis
    Chemical Substances CIRBP protein, human ; CLIC1 protein, human ; Chloride Channels ; RNA-Binding Proteins
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-022-01457-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4812: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

    Nievergelt, Caroline M / Maihofer, Adam X / Atkinson, Elizabeth G / Chen, Chia-Yen / Choi, Karmel W / Coleman, Jonathan R I / Daskalakis, Nikolaos P / Duncan, Laramie E / Polimanti, Renato / Aaronson, Cindy / Amstadter, Ananda B / Andersen, Soren B / Andreassen, Ole A / Arbisi, Paul A / Ashley-Koch, Allison E / Austin, S Bryn / Avdibegoviç, Esmina / Babić, Dragan / Bacanu, Silviu-Alin /
    Baker, Dewleen G / Batzler, Anthony / Beckham, Jean C / Belangero, Sintia / Benjet, Corina / Bergner, Carisa / Bierer, Linda M / Biernacka, Joanna M / Bierut, Laura J / Bisson, Jonathan I / Boks, Marco P / Bolger, Elizabeth A / Brandolino, Amber / Breen, Gerome / Bressan, Rodrigo Affonseca / Bryant, Richard A / Bustamante, Angela C / Bybjerg-Grauholm, Jonas / Bækvad-Hansen, Marie / Børglum, Anders D / Børte, Sigrid / Cahn, Leah / Calabrese, Joseph R / Caldas-de-Almeida, Jose Miguel / Chatzinakos, Chris / Cheema, Sheraz / Clouston, Sean A P / Colodro-Conde, Lucía / Coombes, Brandon J / Cruz-Fuentes, Carlos S / Dale, Anders M / Dalvie, Shareefa / Davis, Lea K / Deckert, Jürgen / Delahanty, Douglas L / Dennis, Michelle F / Desarnaud, Frank / DiPietro, Christopher P / Disner, Seth G / Docherty, Anna R / Domschke, Katharina / Dyb, Grete / Kulenović, Alma Džubur / Edenberg, Howard J / Evans, Alexandra / Fabbri, Chiara / Fani, Negar / Farrer, Lindsay A / Feder, Adriana / Feeny, Norah C / Flory, Janine D / Forbes, David / Franz, Carol E / Galea, Sandro / Garrett, Melanie E / Gelaye, Bizu / Gelernter, Joel / Geuze, Elbert / Gillespie, Charles F / Goleva, Slavina B / Gordon, Scott D / Goçi, Aferdita / Grasser, Lana Ruvolo / Guindalini, Camila / Haas, Magali / Hagenaars, Saskia / Hauser, Michael A / Heath, Andrew C / Hemmings, Sian M J / Hesselbrock, Victor / Hickie, Ian B / Hogan, Kelleigh / Hougaard, David Michael / Huang, Hailiang / Huckins, Laura M / Hveem, Kristian / Jakovljević, Miro / Javanbakht, Arash / Jenkins, Gregory D / Johnson, Jessica / Jones, Ian / Jovanovic, Tanja / Karstoft, Karen-Inge / Kaufman, Milissa L / Kennedy, James L / Kessler, Ronald C / Khan, Alaptagin / Kimbrel, Nathan A / King, Anthony P / Koen, Nastassja / Kotov, Roman / Kranzler, Henry R / Krebs, Kristi / Kremen, William S / Kuan, Pei-Fen / Lawford, Bruce R / Lebois, Lauren A M / Lehto, Kelli / Levey, Daniel F / Lewis, Catrin / Liberzon, Israel / Linnstaedt, Sarah D / Logue, Mark W / Lori, Adriana / Lu, Yi / Luft, Benjamin J / Lupton, Michelle K / Luykx, Jurjen J / Makotkine, Iouri / Maples-Keller, Jessica L / Marchese, Shelby / Marmar, Charles / Martin, Nicholas G / Martínez-Levy, Gabriela A / McAloney, Kerrie / McFarlane, Alexander / McLaughlin, Katie A / McLean, Samuel A / Medland, Sarah E / Mehta, Divya / Meyers, Jacquelyn / Michopoulos, Vasiliki / Mikita, Elizabeth A / Milani, Lili / Milberg, William / Miller, Mark W / Morey, Rajendra A / Morris, Charles Phillip / Mors, Ole / Mortensen, Preben Bo / Mufford, Mary S / Nelson, Elliot C / Nordentoft, Merete / Norman, Sonya B / Nugent, Nicole R / O'Donnell, Meaghan / Orcutt, Holly K / Pan, Pedro M / Panizzon, Matthew S / Pathak, Gita A / Peters, Edward S / Peterson, Alan L / Peverill, Matthew / Pietrzak, Robert H / Polusny, Melissa A / Porjesz, Bernice / Powers, Abigail / Qin, Xue-Jun / Ratanatharathorn, Andrew / Risbrough, Victoria B / Roberts, Andrea L / Rothbaum, Alex O / Rothbaum, Barbara O / Roy-Byrne, Peter / Ruggiero, Kenneth J / Rung, Ariane / Runz, Heiko / Rutten, Bart P F / de Viteri, Stacey Saenz / Salum, Giovanni Abrahão / Sampson, Laura / Sanchez, Sixto E / Santoro, Marcos / Seah, Carina / Seedat, Soraya / Seng, Julia S / Shabalin, Andrey / Sheerin, Christina M / Silove, Derrick / Smith, Alicia K / Smoller, Jordan W / Sponheim, Scott R / Stein, Dan J / Stensland, Synne / Stevens, Jennifer S / Sumner, Jennifer A / Teicher, Martin H / Thompson, Wesley K / Tiwari, Arun K / Trapido, Edward / Uddin, Monica / Ursano, Robert J / Valdimarsdóttir, Unnur / Van Hooff, Miranda / Vermetten, Eric / Vinkers, Christiaan H / Voisey, Joanne / Wang, Yunpeng / Wang, Zhewu / Waszczuk, Monika / Weber, Heike / Wendt, Frank R / Werge, Thomas / Williams, Michelle A / Williamson, Douglas E / Winsvold, Bendik S / Winternitz, Sherry / Wolf, Christiane / Wolf, Erika J / Xia, Yan / Xiong, Ying / Yehuda, Rachel / Young, Keith A / Young, Ross McD / Zai, Clement C / Zai, Gwyneth C / Zervas, Mark / Zhao, Hongyu / Zoellner, Lori A / Zwart, John-Anker / deRoon-Cassini, Terri / van Rooij, Sanne J H / van den Heuvel, Leigh L / Stein, Murray B / Ressler, Kerry J / Koenen, Karestan C

    Nature genetics

    2024  

    Abstract: Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi- ... ...

    Abstract Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 new). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (for example, GRIA1, GRM8 and CACNA1E), developmental, axon guidance and transcription factors (for example, FOXP2, EFNA5 and DCC), synaptic structure and function genes (for example, PCLO, NCAM1 and PDE4B) and endocrine or immune regulators (for example, ESR1, TRAF3 and TANK). Additional top genes influence stress, immune, fear and threat-related processes, previously hypothesized to underlie PTSD neurobiology. These findings strengthen our understanding of neurobiological systems relevant to PTSD pathophysiology, while also opening new areas for investigation.
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1108734-1
    ISSN 1546-1718 ; 1061-4036
    ISSN (online) 1546-1718
    ISSN 1061-4036
    DOI 10.1038/s41588-024-01707-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3613: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 46: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders.

    Nievergelt, Caroline M / Maihofer, Adam X / Atkinson, Elizabeth G / Chen, Chia-Yen / Choi, Karmel W / Coleman, Jonathan Ri / Daskalakis, Nikolaos P / Duncan, Laramie E / Polimanti, Renato / Aaronson, Cindy / Amstadter, Ananda B / Andersen, Soren B / Andreassen, Ole A / Arbisi, Paul A / Ashley-Koch, Allison E / Austin, S Bryn / Avdibegoviç, Esmina / Babic, Dragan / Bacanu, Silviu-Alin /
    Baker, Dewleen G / Batzler, Anthony / Beckham, Jean C / Belangero, Sintia / Benjet, Corina / Bergner, Carisa / Bierer, Linda M / Biernacka, Joanna M / Bierut, Laura J / Bisson, Jonathan I / Boks, Marco P / Bolger, Elizabeth A / Brandolino, Amber / Breen, Gerome / Bressan, Rodrigo Affonseca / Bryant, Richard A / Bustamante, Angela C / Bybjerg-Grauholm, Jonas / Bækvad-Hansen, Marie / Børglum, Anders D / Børte, Sigrid / Cahn, Leah / Calabrese, Joseph R / Caldas-de-Almeida, Jose Miguel / Chatzinakos, Chris / Cheema, Sheraz / Clouston, Sean A P / Colodro-Conde, LucÍa / Coombes, Brandon J / Cruz-Fuentes, Carlos S / Dale, Anders M / Dalvie, Shareefa / Davis, Lea K / Deckert, Jürgen / Delahanty, Douglas L / Dennis, Michelle F / deRoon-Cassini, Terri / Desarnaud, Frank / DiPietro, Christopher P / Disner, Seth G / Docherty, Anna R / Domschke, Katharina / Dyb, Grete / Kulenovic, Alma Dzubur / Edenberg, Howard J / Evans, Alexandra / Fabbri, Chiara / Fani, Negar / Farrer, Lindsay A / Feder, Adriana / Feeny, Norah C / Flory, Janine D / Forbes, David / Franz, Carol E / Galea, Sandro / Garrett, Melanie E / Gelaye, Bizu / Gelernter, Joel / Geuze, Elbert / Gillespie, Charles F / Goci, Aferdita / Goleva, Slavina B / Gordon, Scott D / Grasser, Lana Ruvolo / Guindalini, Camila / Haas, Magali / Hagenaars, Saskia / Hauser, Michael A / Heath, Andrew C / Hemmings, Sian Mj / Hesselbrock, Victor / Hickie, Ian B / Hogan, Kelleigh / Hougaard, David Michael / Huang, Hailiang / Huckins, Laura M / Hveem, Kristian / Jakovljevic, Miro / Javanbakht, Arash / Jenkins, Gregory D / Johnson, Jessica / Jones, Ian / Jovanovic, Tanja / Karstoft, Karen-Inge / Kaufman, Milissa L / Kennedy, James L / Kessler, Ronald C / Khan, Alaptagin / Kimbrel, Nathan A / King, Anthony P / Koen, Nastassja / Kotov, Roman / Kranzler, Henry R / Krebs, Kristi / Kremen, William S / Kuan, Pei-Fen / Lawford, Bruce R / Lebois, Lauren A M / Lehto, Kelli / Levey, Daniel F / Lewis, Catrin / Liberzon, Israel / Linnstaedt, Sarah D / Logue, Mark W / Lori, Adriana / Lu, Yi / Luft, Benjamin J / Lupton, Michelle K / Luykx, Jurjen J / Makotkine, Iouri / Maples-Keller, Jessica L / Marchese, Shelby / Marmar, Charles / Martin, Nicholas G / MartÍnez-Levy, Gabriela A / McAloney, Kerrie / McFarlane, Alexander / McLaughlin, Katie A / McLean, Samuel A / Medland, Sarah E / Mehta, Divya / Meyers, Jacquelyn / Michopoulos, Vasiliki / Mikita, Elizabeth A / Milani, Lili / Milberg, William / Miller, Mark W / Morey, Rajendra A / Morris, Charles Phillip / Mors, Ole / Mortensen, Preben Bo / Mufford, Mary S / Nelson, Elliot C / Nordentoft, Merete / Norman, Sonya B / Nugent, Nicole R / O'Donnell, Meaghan / Orcutt, Holly K / Pan, Pedro M / Panizzon, Matthew S / Pathak, Gita A / Peters, Edward S / Peterson, Alan L / Peverill, Matthew / Pietrzak, Robert H / Polusny, Melissa A / Porjesz, Bernice / Powers, Abigail / Qin, Xue-Jun / Ratanatharathorn, Andrew / Risbrough, Victoria B / Roberts, Andrea L / Rothbaum, Barbara O / Rothbaum, Alex O / Roy-Byrne, Peter / Ruggiero, Kenneth J / Rung, Ariane / Runz, Heiko / Rutten, Bart P F / de Viteri, Stacey Saenz / Salum, Giovanni Abrahão / Sampson, Laura / Sanchez, Sixto E / Santoro, Marcos / Seah, Carina / Seedat, Soraya / Seng, Julia S / Shabalin, Andrey / Sheerin, Christina M / Silove, Derrick / Smith, Alicia K / Smoller, Jordan W / Sponheim, Scott R / Stein, Dan J / Stensland, Synne / Stevens, Jennifer S / Sumner, Jennifer A / Teicher, Martin H / Thompson, Wesley K / Tiwari, Arun K / Trapido, Edward / Uddin, Monica / Ursano, Robert J / Valdimarsdóttir, Unnur / van den Heuvel, Leigh Luella / Van Hooff, Miranda / van Rooij, Sanne Jh / Vermetten, Eric / Vinkers, Christiaan H / Voisey, Joanne / Wang, Zhewu / Wang, Yunpeng / Waszczuk, Monika / Weber, Heike / Wendt, Frank R / Werge, Thomas / Williams, Michelle A / Williamson, Douglas E / Winsvold, Bendik S / Winternitz, Sherry / Wolf, Erika J / Wolf, Christiane / Xia, Yan / Xiong, Ying / Yehuda, Rachel / Young, Ross McD / Young, Keith A / Zai, Clement C / Zai, Gwyneth C / Zervas, Mark / Zhao, Hongyu / Zoellner, Lori A / Zwart, John-Anker / Stein, Murray B / Ressler, Kerry J / Koenen, Karestan C

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi- ... ...

    Abstract Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed a multi-ancestry meta-analysis of genome-wide association studies across 1,222,882 individuals of European ancestry (137,136 cases) and 58,051 admixed individuals with African and Native American ancestry (13,624 cases). We identified 95 genome-wide significant loci (80 novel). Convergent multi-omic approaches identified 43 potential causal genes, broadly classified as neurotransmitter and ion channel synaptic modulators (e.g.,
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.31.23294915
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top