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  1. Article ; Online: Does life expectancy of patients with hepatocellular carcinoma only depend on the upfront treatment?

    Fuks, David / Marchese, Ugo

    Diagnostic and interventional imaging

    2023  Volume 104, Issue 4, Page(s) 165–166

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/therapy ; Liver Neoplasms/pathology ; Treatment Outcome ; Combined Modality Therapy ; Life Expectancy ; Chemoembolization, Therapeutic ; Catheter Ablation ; Retrospective Studies ; Survival Rate
    Language English
    Publishing date 2023-01-28
    Publishing country France
    Document type Editorial ; Comment
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2023.01.004
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  2. Article ; Online: Highlights, limitations and future challenges of laparoscopic resection for colorectal liver metastases.

    Guilbaud, T / Marchese, U / Gayet, B / Fuks, D

    Journal of visceral surgery

    2019  Volume 156, Issue 4, Page(s) 329–337

    Abstract: The liver is the most common site for metastatic colorectal cancer (CRLM). Despite advances in oncologic treatment, resection of metastases is still the only curative option. Although laparoscopic surgery for primary colorectal cancer is well documented ... ...

    Abstract The liver is the most common site for metastatic colorectal cancer (CRLM). Despite advances in oncologic treatment, resection of metastases is still the only curative option. Although laparoscopic surgery for primary colorectal cancer is well documented and widely used, laparoscopic surgery for liver metastases has developed more slowly. However, in spite of some difficulties, laparoscopic approach demonstrated strong advantages including minimal parietal damage, decreased morbidity (reduced blood loss and need for transfusion, fewer pulmonary complications), and simplification of subsequent iterative hepatectomy. Up to now, more than 9 000 laparoscopic procedures have been reported worldwide and long-term results in colorectal liver metastases seem comparable to the open approach. Only one recent randomized controlled trial has compared the laparoscopic and the open approach. The purpose of the present update was to identify the barriers limiting widespread acceptance of laparoscopic approach, the benefits and the limits of laparoscopic hepatectomies in CRLM.
    MeSH term(s) Blood Loss, Surgical/prevention & control ; Colorectal Neoplasms/pathology ; Embolism, Air/etiology ; Forecasting ; Hemostasis, Surgical ; Hepatectomy/adverse effects ; Hepatectomy/methods ; Humans ; Laparoscopy/adverse effects ; Laparoscopy/instrumentation ; Laparoscopy/methods ; Laparoscopy/trends ; Learning Curve ; Length of Stay ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Postoperative Complications/etiology
    Language English
    Publishing date 2019-05-14
    Publishing country France
    Document type Journal Article ; Review
    ISSN 1878-7886
    ISSN (online) 1878-7886
    DOI 10.1016/j.jviscsurg.2019.04.006
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  3. Article: Comment on: Failure to rescue in patients with distal pancreatectomy: a nationwide analysis of 10,632 patients.

    Marchese, Ugo / Fuks, David / Truant, Stephanie / El Amrani, Mehdi

    Hepatobiliary surgery and nutrition

    2021  Volume 10, Issue 2, Page(s) 229–231

    Language English
    Publishing date 2021-04-23
    Publishing country China (Republic : 1949- )
    Document type Editorial ; Comment
    ZDB-ID 2812398-0
    ISSN 2304-389X ; 2304-3881
    ISSN (online) 2304-389X
    ISSN 2304-3881
    DOI 10.21037/hbsn-21-105
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  4. Article ; Online: Early radiologic intervention for postesophagectomy chylothorax.

    Veziant, Julie / Gaillard, Martin / Barat, Maxime / Leconte, Mahaut / Marchese, Ugo / Dohan, Anthony

    Journal of vascular surgery. Venous and lymphatic disorders

    2022  Volume 10, Issue 1, Page(s) 222–223

    MeSH term(s) Adenocarcinoma/surgery ; Chylothorax/diagnostic imaging ; Chylothorax/therapy ; Early Medical Intervention ; Embolization, Therapeutic ; Esophageal Neoplasms/surgery ; Esophagectomy ; Female ; Humans ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/therapy
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2213-3348
    ISSN (online) 2213-3348
    DOI 10.1016/j.jvsv.2021.10.008
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  5. Article: Multiple Laparoscopic Liver Resection for Colorectal Liver Metastases.

    Nassar, Alexandra / Tzedakis, Stylianos / Dhote, Alix / Strigalev, Marie / Coriat, Romain / Karoui, Mehdi / Dohan, Anthony / Gaillard, Martin / Marchese, Ugo / Fuks, David

    Cancers

    2023  Volume 15, Issue 2

    Abstract: Over the past decades, liver cancer's minimally invasive approach has primarily become as a new standard of oncological care. Colorectal liver metastases (CRLM) are one of the most developed indications of laparoscopic liver resection (LLR). CRLM ... ...

    Abstract Over the past decades, liver cancer's minimally invasive approach has primarily become as a new standard of oncological care. Colorectal liver metastases (CRLM) are one of the most developed indications of laparoscopic liver resection (LLR). CRLM resection is still the best treatment known in terms of survival. As multiple CRLM are found in up to 80% of cases at diagnosis (Manfredi S. and al, Annals of Surgery 2006), a lot of possible technical management approaches are described. With the development of the parenchymal-sparing strategy, multiple concomitant laparoscopic liver resections (LLR) are gaining acceptance. However, no recommendation is available regarding its indications and feasibility. Also, laparoscopic two-stage hepatectomy is developing for bilobar CRLM, and this also does not have established recommendation. The purpose of this paper was to highlight novelty and updates in the field of multiple minimally invasive liver resections. A review of the international literature was performed. The feasibility of laparoscopic concomitant multiple LLR and two-stage hepatectomy for CRLM as well as their outcomes were discussed. These clarifications could further guide the implementation of minimal resection in multiple colorectal liver metastases therapies.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15020435
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  6. Article ; Online: Comparison Between Radial and Femoral Artery Access for Transarterial Chemoembolisation in Patients With Hepatocellular Carcinoma.

    Hedjoudje, Mohamed / Barat, Maxime / Dohan, Anthony / Lucas, Alexandre / Dautry, Raphael / Coriat, Romain / Marchese, Ugo / Pol, Stanislas / Parlati, Lucia / Soyer, Philippe

    Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes

    2023  Volume 75, Issue 1, Page(s) 178–186

    Abstract: Purpose: The purpose of this study was to compare the technical success rate, the selectivity of transarterial chemoembolisation (TACE), the complication rate, the radiation dose given to the patients and the hospitalization stay between TACE performed ... ...

    Abstract Purpose: The purpose of this study was to compare the technical success rate, the selectivity of transarterial chemoembolisation (TACE), the complication rate, the radiation dose given to the patients and the hospitalization stay between TACE performed using femoral artery approach (FAA) and TACE performed using radial artery approach (RAA) in patients with hepatocellular carcinoma (HCC).
    Methods: Between June 2020 and April 2022, 49 patients with HCC who underwent 116 TACEs (75 using FAA and 41 using RAA) were included. Differences in technical success rate, selectivity of micro-catheterization, radiation dose given to the patients, fluoroscopy time, hospitalization stay duration, and complication rate were compared between FAA and RAA using Fisher exact or Student
    Results: No differences in technical success rates were found between RAA (93%; 39/41 TACEs) and FAA (100%; 75/75 TACEs) (
    Conclusions: This study confirms that RAA is a safe approach that does not compromise the technical efficacy and the selectivity of TACE compared to FAA in patients with HCC.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/therapy ; Femoral Artery ; Treatment Outcome ; Chemoembolization, Therapeutic/adverse effects ; Radial Artery ; Retrospective Studies
    Language English
    Publishing date 2023-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 418190-6
    ISSN 1488-2361 ; 0846-5371 ; 0008-2902
    ISSN (online) 1488-2361
    ISSN 0846-5371 ; 0008-2902
    DOI 10.1177/08465371231186524
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 299: Show issues Location:
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  7. Article ; Online: Modified Appleby procedure for locally advanced pancreatic carcinoma: A primer for the radiologist.

    Sindayigaya, Rémy / Barat, Maxime / Tzedakis, Stylianos / Dautry, Raphael / Dohan, Anthony / Belle, Arthur / Coriat, Romain / Soyer, Philippe / Fuks, David / Marchese, Ugo

    Diagnostic and interventional imaging

    2023  Volume 104, Issue 10, Page(s) 455–464

    Abstract: Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent pancreatic neoplasm accounting for more than 90% of pancreatic malignancies. Surgical resection with adequate lymphadenectomy remains the only available curative strategy for patients with ... ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent pancreatic neoplasm accounting for more than 90% of pancreatic malignancies. Surgical resection with adequate lymphadenectomy remains the only available curative strategy for patients with PDAC. Despite improvements in both chemotherapy regimen and surgical care, body/neck PDAC still conveys a poor prognosis because of the vicinity of major vascular structures, including celiac trunk, which favors insidious disease spread at the time of diagnosis. Body/neck PDAC involving the celiac trunk is considered locally advanced PDAC in most guidelines and therefore not eligible for upfront resection. However, a more aggressive surgical approach (i.e., distal pancreatectomy with splenectomy and en-bloc celiac trunk resection [DP-CAR]) was recently proposed to offer hope for cure in selected patients with locally advanced body/neck PDAC responsive to induction therapy at the cost of higher morbidity. The so-called "modified Appleby procedure" is highly demanding and requires optimal preoperative staging as well as appropriate patient preparation for surgery (i.e., preoperative arterial embolization). Herein, we review current evidence regarding DP-CAR indications and outcomes as well as the critical role of diagnostic and interventional radiology in patient preparation before DP-CAR, and early identification and management of DP-CAR complications.
    MeSH term(s) Humans ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/surgery ; Carcinoma, Pancreatic Ductal/diagnostic imaging ; Carcinoma, Pancreatic Ductal/surgery ; Pancreatectomy ; Celiac Artery ; Radiologists ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-06-08
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2648283-6
    ISSN 2211-5684 ; 2211-5684
    ISSN (online) 2211-5684
    ISSN 2211-5684
    DOI 10.1016/j.diii.2023.05.008
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  8. Article ; Online: Assessing textbook outcome after single large hepatocellular carcinoma resection.

    Sindayigaya, Rémy / Tzedakis, Stylianos / Tribillon, Ecoline / Gavignet, Chloé / Mazzotta, Alessandro / Nassar, Alexandra / Marchese, Ugo / Soubrane, Olivier / Fuks, David

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2023  Volume 25, Issue 9, Page(s) 1093–1101

    Abstract: Background: This study aimed to investigate the impact and predictors of an ideal surgical care following SLHCC resection.: Methods: SLHCC patients who underwent LR in two tertiary hepatobiliary centers between 2000 and 2021 were retrieved from ... ...

    Abstract Background: This study aimed to investigate the impact and predictors of an ideal surgical care following SLHCC resection.
    Methods: SLHCC patients who underwent LR in two tertiary hepatobiliary centers between 2000 and 2021 were retrieved from prospectively maintained databases. The quality of surgical care was measured by the textbook outcome (TO). Tumor burden was defined by the tumor burden score (TBS). Factors associated with TO were determined on multivariate analysis. The impact of TO on oncological outcomes was assessed using Cox regressions.
    Results: Overall, 103 SLHCC patients were included. Laparoscopic approach was considered in 65 (63.1%) patients and 79 (76.7%) patients presented with moderate TBS. TO was achieved in 54 (52.4%) patients. Laparoscopic approach was independently associated with TO (OR 2.57; 95% CI 1.03-6.64; p = 0.045). Within 19 (6-38) months of median follow up, patients who achieved TO had better OS compared to non-TO patients (1-year OS: 91.7% vs. 66.9%; 5-year OS: 83.4% vs. 37.0%, p < 0.0001). On multivariate analysis, TO was independently associated with improved OS, especially in non-cirrhotic patients (HR 0.11; 95% CI 0.02-0.52, p = 0.005).
    Conclusions: TO achievement could be a relevant surrogate marker of improved oncological care following SLHCC resection in non-cirrhotic patients.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Hepatectomy/adverse effects ; Retrospective Studies ; Tumor Burden
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2023.05.001
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    Zs.A 6326: Show issues Location:
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  9. Article ; Online: Predictive value of C-reactive protein for postoperative liver-specific surgical site infections.

    Pattou, Maxime / Fuks, David / Guilbaud, Theophile / Le Floch, Bastien / Lelièvre, Oceane / Tribillon, Ecoline / Jeddou, Heithem / Marchese, Ugo / Birnbaum, David Jeremie / Soubrane, Olivier / Sulpice, Laurent / Tzedakis, Stylianos

    Surgery

    2024  Volume 175, Issue 5, Page(s) 1337–1345

    Abstract: Background: C-reactive protein is a useful biological tool to predict infectious complications, but its predictive value in detecting organ-specific surgical site infection after liver resection has never been studied. We aimed to evaluate the ... ...

    Abstract Background: C-reactive protein is a useful biological tool to predict infectious complications, but its predictive value in detecting organ-specific surgical site infection after liver resection has never been studied. We aimed to evaluate the predictive value of c-reactive protein and determine the cut-off values to detect postoperative liver resection-surgical site infection.
    Methods: A multicentric analysis of consecutive patients with liver resection between 2018 and 2021 was performed. The predictive value of postoperative day 1, postoperative day 3, and postoperative day 5 C-reactive protein levels was evaluated using the area under the receiver operating characteristic curve. Cut-off values were determined using the Youden index in a 500-fold bootstrap resampling of 500 patients treated at 3 centers, who comprised the development cohort and were tested in an external independent validation cohort of 166 patients at a fourth center.
    Results: Among the 500 patients who underwent liver resection of the development cohort, liver resection-surgical site infection occurred in 66 patients (13.2%), and the median time to diagnosis was 6.0 days (interquartile range, 4.0-9.0) days. Median C-reactive protein levels were significantly higher on postoperative day 1, postoperative day 3, and postoperative day 5 in the liver resection-surgical site infection group compared with the non-surgical site infection group (50.5 vs 34.5 ng/mL, 148.0 vs 72.5 ng/mL, and 128.4 vs 35.2 ng/mL, respectively; P < .001). Postoperative day 3 and postoperative day 5 C-reactive protein-level area under the curve values were 0.76 (95% confidence interval, 0.64-0.88, P < .001) and 0.82 (95% confidence interval, 0.72-0.92, P < .001), respectively. Postoperative day 3 and postoperative day 5 optimal cut-off values of 100 mg/L and 87.0 mg/L could be used to rule out liver resection-surgical site infection, with a negative predictive value of 87.0% (interquartile range, 70.2-93.8) and 76.0% (interquartile range, 65.0-88.0), respectively, in the validation cohort.
    Conclusion: Postoperative day 3 and postoperative day 5 C-reactive protein levels may be valuable predictive tools for liver resection-surgical site infection and aid in hospital discharge decision-making in the absence of other liver-related complications.
    MeSH term(s) Humans ; Biomarkers ; C-Reactive Protein/metabolism ; Liver/surgery ; Liver/metabolism ; Postoperative Complications/diagnosis ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Predictive Value of Tests ; ROC Curve ; Surgical Wound Infection/diagnosis ; Surgical Wound Infection/epidemiology ; Surgical Wound Infection/etiology
    Chemical Substances Biomarkers ; C-Reactive Protein (9007-41-4)
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2024.01.030
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    Uk I Zs.129: Show issues Location:
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  10. Article ; Online: Clinical care pathways of patients with biliary tract cancer: A French nationwide longitudinal cohort study.

    Tzedakis, Stylianos / Challine, Alexandre / Katsahian, Sandrine / Malka, David / Jaquet, Romain / Marchese, Ugo / Gaillard, Martin / Coriat, Romain / Dhote, Alix / Mallet, Vincent / Jeddou, Heithem / Boudjema, Karim / Fuks, David / Lazzati, Andrea

    European journal of cancer (Oxford, England : 1990)

    2024  Volume 202, Page(s) 114018

    Abstract: Background: Although the incidence of BTC is raising, national healthcare strategies to improve care lack. We aimed to explore patient clinical care pathways and strategies to improve biliary tract cancer (BTC) care.: Methods: We analysed the French ... ...

    Abstract Background: Although the incidence of BTC is raising, national healthcare strategies to improve care lack. We aimed to explore patient clinical care pathways and strategies to improve biliary tract cancer (BTC) care.
    Methods: We analysed the French National Healthcare database of all BTC inpatients between January 1, 2017 and December 31, 2021. Multinomial logistic regression adjusted odds ratios (aOR) were used to identify healthcare organisation factors that influenced access to curative care both overall and in a longitudinal sensibility analysis using optimal matching and hierarchical ascending classification to detect a subgroup of curative-care patients with a high survival over a two-year period.
    Results: A total of 19,825 new BTC patients and three clinical care pathways (CCP) were identified: 'Palliative care' (PC-CCP), 'Non-curative Care' (NCC-CCP) and 'Curative Care' (CC-CCP) involving 7669 (38.7%), 7721 (38.9%) and 4435 (22.4%) patients respectively. Out of 1200 centers involved in BTC treatment, 84%, 11% and 5% were of low- (<15 patients/year), medium- (15-30 patients/year) and high-volume (>30 patients/year) respectively. Among patient, tumor and hospital factors, BTC management in academic (aOR: 2.32; 95%CI: 1.98-2.71), private (2.51; 2.22-2.83), semi-private (2.25; 1.91-2.65) and in high- (2.09; 1.81-2.42) or medium-volume (1.49; 1.33-1.68) centers increased probability to CC-CCP. These results were maintained in a longitudinal cluster of 2363 (53%) CC-CCP patients presenting a higher two-year survival compared with the rest [96.4% (95.1; 97.6) vs. 38.8% (36.3; 41.4), log-rank p < 0.001].
    Conclusions: Among factors subject to healthcare policy improvement, the volume and type of centers managing BTC strongly influenced access to curative care.
    MeSH term(s) Humans ; Longitudinal Studies ; Critical Pathways ; Biliary Tract Neoplasms/epidemiology ; Biliary Tract Neoplasms/therapy ; Biliary Tract Neoplasms/diagnosis ; Retrospective Studies ; Cohort Studies ; Bile Duct Neoplasms/pathology ; Cholangiocarcinoma/pathology
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2024.114018
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