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  1. Book: The human microbiota and microbiome

    Marchesi, Julian R.

    (Advances in molecular and cellular microbiology ; 25)

    2014  

    Author's details ed. by Julian R. Marchesi
    Series title Advances in molecular and cellular microbiology ; 25
    Collection
    Keywords Metagenome / physiology ; Gastrointestinal Tract / microbiology
    Language English
    Size IX, 197 S. : Ill., graph. Darst.
    Publisher CABI Publ
    Publishing place Wallingford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017354287
    ISBN 978-1-78064-049-5 ; 1-78064-049-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 2229 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Advancing microbiome research.

    Marchesi, Julian R

    Microbiology (Reading, England)

    2018  Volume 164, Issue 8, Page(s) 1005–1006

    MeSH term(s) Biomedical Research/methods ; High-Throughput Nucleotide Sequencing ; Humans ; Microbiota/physiology
    Language English
    Publishing date 2018-06-26
    Publishing country England
    Document type Editorial
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/mic.0.000688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Advancing microbiome research.

    Marchesi, Julian R

    Immunology

    2018  

    Language English
    Publishing date 2018-06-25
    Publishing country England
    Document type Editorial
    ZDB-ID 80124-0
    ISSN 1365-2567 ; 0019-2805 ; 0953-4954
    ISSN (online) 1365-2567
    ISSN 0019-2805 ; 0953-4954
    DOI 10.1111/imm.12973
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  4. Article ; Online: Moving beyond DNA: towards functional analysis of the vaginal microbiome by non-sequencing-based methods.

    Correia, Gonçalo Ds / Marchesi, Julian R / MacIntyre, David A

    Current opinion in microbiology

    2023  Volume 73, Page(s) 102292

    Abstract: Over the last two decades, sequencing-based methods have revolutionised our understanding of niche-specific microbial complexity. In the lower female reproductive tract, these approaches have enabled identification of bacterial compositional structures ... ...

    Abstract Over the last two decades, sequencing-based methods have revolutionised our understanding of niche-specific microbial complexity. In the lower female reproductive tract, these approaches have enabled identification of bacterial compositional structures associated with health and disease. Application of metagenomics and metatranscriptomics strategies have provided insight into the putative function of these communities but it is increasingly clear that direct measures of microbial and host cell function are required to understand the contribution of microbe-host interactions to pathophysiology. Here we explore and discuss current methods and approaches, many of which rely upon mass-spectrometry, being used to capture functional insight into the vaginal mucosal interface. In addition to improving mechanistic understanding, these methods offer innovative solutions for the development of diagnostic and therapeutic strategies designed to improve women's health.
    MeSH term(s) Female ; Humans ; Microbiota/genetics ; Metagenomics/methods ; Host Microbial Interactions ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2023.102292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Moving beyond DNA: towards functional analysis of the vaginal microbiome by non-sequencing-based methods

    Correia, Gonçalo DS / Marchesi, Julian R / MacIntyre, David A

    Current Opinion in Microbiology. 2023 June, v. 73 p.102292-

    2023  

    Abstract: Over the last two decades, sequencing-based methods have revolutionised our understanding of niche-specific microbial complexity. In the lower female reproductive tract, these approaches have enabled identification of bacterial compositional structures ... ...

    Abstract Over the last two decades, sequencing-based methods have revolutionised our understanding of niche-specific microbial complexity. In the lower female reproductive tract, these approaches have enabled identification of bacterial compositional structures associated with health and disease. Application of metagenomics and metatranscriptomics strategies have provided insight into the putative function of these communities but it is increasingly clear that direct measures of microbial and host cell function are required to understand the contribution of microbe-host interactions to pathophysiology. Here we explore and discuss current methods and approaches, many of which rely upon mass-spectrometry, being used to capture functional insight into the vaginal mucosal interface. In addition to improving mechanistic understanding, these methods offer innovative solutions for the development of diagnostic and therapeutic strategies designed to improve women's health.
    Keywords DNA ; female reproductive system ; mass spectrometry ; metagenomics ; microbiology ; microbiome ; pathophysiology ; therapeutics ; transcriptomics
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2023.102292
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Intestinal microbiota transplantation: do not forget the metabolites.

    Mullish, Benjamin H / McDonald, Julie A K / Marchesi, Julian R

    The lancet. Gastroenterology & hepatology

    2022  Volume 7, Issue 7, Page(s) 594

    MeSH term(s) Fecal Microbiota Transplantation ; Gastrointestinal Microbiome ; Humans ; Microbiota
    Language English
    Publishing date 2022-06-16
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00101-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Chronic diarrhea, bile acids, and Clostridia.

    Walters, Julian Rf / Marchesi, Julian R

    The Journal of clinical investigation

    2019  Volume 130, Issue 1, Page(s) 77–79

    Abstract: Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with ... ...

    Abstract Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast growth factor 19 (FGF19). In this issue of the JCI, Zhao et al. investigated BA metabolism, including fecal BAs, serum BAs, and FGF19, in patients and controls. They identified associations between fecal bacterial BA metabolism and specific microbiota, especially Clostridium scindens. These findings have been tested in a mouse model using microbiota transplants and antibiotic treatment. This group of organisms has potential as a biomarker for BAD and to be a target for therapy.
    MeSH term(s) Animals ; Bile ; Bile Acids and Salts ; Clostridiales ; Diarrhea ; Fibroblast Growth Factors ; Humans ; Irritable Bowel Syndrome ; Mice ; Microbiota
    Chemical Substances Bile Acids and Salts ; Fibroblast Growth Factors (62031-54-3)
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI133117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Gut Microbiota Modulation of Efficacy and Toxicity of Cancer Chemotherapy and Immunotherapy.

    Chrysostomou, Despoina / Roberts, Lauren A / Marchesi, Julian R / Kinross, James M

    Gastroenterology

    2022  Volume 164, Issue 2, Page(s) 198–213

    Abstract: Accumulating evidence supports not only the functional role of the gut microbiome in cancer development and progression but also its role in defining the efficacy and toxicity of chemotherapeutic agents (5-fluorouracil, cyclophosphamide, irinotecan, ... ...

    Abstract Accumulating evidence supports not only the functional role of the gut microbiome in cancer development and progression but also its role in defining the efficacy and toxicity of chemotherapeutic agents (5-fluorouracil, cyclophosphamide, irinotecan, oxaliplatin, gemcitabine, methotrexate) and immunotherapeutic compounds (anti-programmed death-ligand 1/anti-programmed cell death protein 1 and anti-cytotoxic T-lymphocyte-associated antigen 4). This evidence is supported in numerous in vitro, animal, and clinical studies that highlight the importance of microbial mechanisms in defining therapeutic responses. The microbiome therefore shapes oncologic outcomes and is now being leveraged for the development of novel personalized therapeutic approaches in cancer treatment. However, if the microbiome is to be successfully translated into next-generation oncologic treatments, a new multimodal model of the oncomicrobiome must be conceptualized that incorporates gut microbial cometabolism of pharmacologic agents into cancer care. The objective of this review is therefore to outline the current knowledge of oncologic pharmacomicrobiomics and to describe how the multiparametric functions of the gut microbiome influence treatment response across cancer types. The secondary objective is to propose innovative approaches for modulating the gut microbiome in clinical environments that improve therapy efficacy and diminish toxic effects derived from antineoplastic agents for patient benefit.
    MeSH term(s) Animals ; Gastrointestinal Microbiome ; Immunotherapy/adverse effects ; Neoplasms ; Antineoplastic Agents/adverse effects ; Microbiota
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.10.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Identification of a Sub-Clinical

    Nishigaki, Alice / Previdelli, Renato / Alexander, James L / Balarajah, Sharmili / Roberts, Lauren / Marchesi, Julian R

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 17

    Abstract: Stool sampling is a useful tool for diagnosing gastrointestinal disease in veterinary medicine. The sub-clinical disease burden ... ...

    Abstract Stool sampling is a useful tool for diagnosing gastrointestinal disease in veterinary medicine. The sub-clinical disease burden of
    Language English
    Publishing date 2023-09-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13172807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The potential of fecal microbiota transplantation in oncology

    Lythgoe, Mark P. / Ghani, Rohma / Mullish, Benjamin H. / Marchesi, Julian R. / Krell, Jonathan

    Trends in microbiology. 2022 Jan., v. 30, no. 1

    2022  

    Abstract: Immune checkpoint inhibitors (ICPIs) are efficacious treatments for several cancers. However, most patients fail to demonstrate durable complete responses. The gut microbiome composition influences the ICPI response. Two recent proof-of-concept studies ... ...

    Abstract Immune checkpoint inhibitors (ICPIs) are efficacious treatments for several cancers. However, most patients fail to demonstrate durable complete responses. The gut microbiome composition influences the ICPI response. Two recent proof-of-concept studies have demonstrated the utility of fecal microbiota transplantation to transform ICPI responsiveness in refractory patients, providing intriguing evidence for the future of microbiota modulation within oncology.
    Keywords cancer therapy ; intestinal microorganisms ; patients
    Language English
    Dates of publication 2022-01
    Size p. 10-12.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1158963-2
    ISSN 1878-4380 ; 0966-842X
    ISSN (online) 1878-4380
    ISSN 0966-842X
    DOI 10.1016/j.tim.2021.10.003
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