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  1. AU="Marchesi, Pietro"
  2. AU="Kim Je Hyoung"
  3. AU="Huber, Ingrid"
  4. AU="Hasuko, K."
  5. AU="Yao, Weigen"
  6. AU="Huang, Xiao-Fan"
  7. AU=Zuo Chuantian
  8. AU="Varchetta, Veronica"
  9. AU="Zhang, Lingye"
  10. AU="Venko, Katja"
  11. AU="Kasthuri, Thirupathi"
  12. AU="Pirtskhalava, Tamar"
  13. AU="Saridakis, E N"
  14. AU="Vithana, Eranga N"
  15. AU="Suárez-Lledó, M"
  16. AU="Olivo-Marston, Susan"
  17. AU="Denise P Momesso"
  18. AU="Obrecht-Sturm, Denise"

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  1. Artikel ; Online: Triple dissociation of visual, auditory and motor processing in mouse primary visual cortex.

    Oude Lohuis, Matthijs N / Marchesi, Pietro / Olcese, Umberto / Pennartz, Cyriel M A

    Nature neuroscience

    2024  Band 27, Heft 4, Seite(n) 758–771

    Abstract: Primary sensory cortices respond to crossmodal stimuli-for example, auditory responses are found in primary visual cortex (V1). However, it remains unclear whether these responses reflect sensory inputs or behavioral modulation through sound-evoked body ... ...

    Abstract Primary sensory cortices respond to crossmodal stimuli-for example, auditory responses are found in primary visual cortex (V1). However, it remains unclear whether these responses reflect sensory inputs or behavioral modulation through sound-evoked body movement. We address this controversy by showing that sound-evoked activity in V1 of awake mice can be dissociated into auditory and behavioral components with distinct spatiotemporal profiles. The auditory component began at approximately 27 ms, was found in superficial and deep layers and originated from auditory cortex. Sound-evoked orofacial movements correlated with V1 neural activity starting at approximately 80-100 ms and explained auditory frequency tuning. Visual, auditory and motor activity were expressed by different laminar profiles and largely segregated subsets of neuronal populations. During simultaneous audiovisual stimulation, visual representations remained dissociable from auditory-related and motor-related activity. This three-fold dissociability of auditory, motor and visual processing is central to understanding how distinct inputs to visual cortex interact to support vision.
    Mesh-Begriff(e) Animals ; Mice ; Acoustic Stimulation ; Primary Visual Cortex ; Photic Stimulation ; Visual Perception/physiology ; Auditory Cortex/physiology ; Auditory Perception/physiology
    Sprache Englisch
    Erscheinungsdatum 2024-02-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-023-01564-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Offline orbitofrontal cortex reactivation depends on recency of place-reward changes and coheres with hippocampal replay.

    Rusu, Silviu I / Bos, Jeroen J / Marchesi, Pietro / Lankelma, Jan V / Ferreira Pica, Ildefonso / Gentet, Luc J / Joëls, Marian / Pennartz, Cyriel

    iScience

    2024  Band 27, Heft 3, Seite(n) 109205

    Abstract: The orbitofrontal cortex, one of the key neocortical areas in valuation and emotion, is critical for cognitive flexibility but its role in the consolidation of recently acquired information remains unclear. Here, we demonstrate orbitofrontal offline ... ...

    Abstract The orbitofrontal cortex, one of the key neocortical areas in valuation and emotion, is critical for cognitive flexibility but its role in the consolidation of recently acquired information remains unclear. Here, we demonstrate orbitofrontal offline replay in the context of a place-reward association task on a maze with varying goal locations. When switches in place-reward coupling were applied, replay was enhanced relative to sessions with stable contingencies. Moreover, replay strength was positively correlated with the subsequent overnight change in behavioral performance. Interrogating relationships between orbitofrontal and hippocampal activity, we found that orbitofrontal and hippocampal replay could occur independently but became coordinated during a type of cortical state with strong spiking activity. These findings reveal a structured form of offline orbitofrontal ensemble activity that is correlated with cognitive flexibility required to adapt to changing task contingencies, and becomes associated with hippocampal replay only during a specific state of high cortical excitability.
    Sprache Englisch
    Erscheinungsdatum 2024-02-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109205
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Functional (ir)Relevance of Posterior Parietal Cortex during Audiovisual Change Detection.

    Oude Lohuis, Matthijs N / Marchesi, Pietro / Pennartz, Cyriel M A / Olcese, Umberto

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Band 42, Heft 26, Seite(n) 5229–5245

    Abstract: The posterior parietal cortex (PPC) plays a key role in integrating sensory inputs from different modalities to support adaptive behavior. Neuronal activity in PPC reflects perceptual decision-making across behavioral tasks, but the mechanistic ... ...

    Abstract The posterior parietal cortex (PPC) plays a key role in integrating sensory inputs from different modalities to support adaptive behavior. Neuronal activity in PPC reflects perceptual decision-making across behavioral tasks, but the mechanistic involvement of PPC is unclear. In an audiovisual change detection task, we tested the hypothesis that PPC is required to arbitrate between the noisy inputs from the two different modalities and help decide in which modality a sensory change occurred. In trained male mice, we found extensive single-neuron and population-level encoding of task-relevant visual and auditory stimuli, trial history, as well as upcoming behavioral responses. However, despite these rich neural correlates, which would theoretically be sufficient to solve the task, optogenetic inactivation of PPC did not affect visual or auditory performance. Thus, despite neural correlates faithfully tracking sensory variables and predicting behavioral responses, PPC was not relevant for audiovisual change detection. This functional dissociation questions the role of sensory- and task-related activity in parietal associative circuits during audiovisual change detection. Furthermore, our results highlight the necessity to dissociate functional correlates from mechanistic involvement when exploring the neural basis of perception and behavior.
    Sprache Englisch
    Erscheinungsdatum 2022-06-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.2150-21.2022
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  4. Artikel ; Online: Coherent mapping of position and head direction across auditory and visual cortex.

    Mertens, Paul E C / Marchesi, Pietro / Ruikes, Thijs R / Oude Lohuis, Matthijs / Krijger, Quincy / Pennartz, Cyriel M A / Lansink, Carien S

    Cerebral cortex (New York, N.Y. : 1991)

    2023  Band 33, Heft 12, Seite(n) 7369–7385

    Abstract: Neurons in primary visual cortex (V1) may not only signal current visual input but also relevant contextual information such as reward expectancy and the subject's spatial position. Such contextual representations need not be restricted to V1 but could ... ...

    Abstract Neurons in primary visual cortex (V1) may not only signal current visual input but also relevant contextual information such as reward expectancy and the subject's spatial position. Such contextual representations need not be restricted to V1 but could participate in a coherent mapping throughout sensory cortices. Here, we show that spiking activity coherently represents a location-specific mapping across auditory cortex (AC) and lateral, secondary visual cortex (V2L) of freely moving rats engaged in a sensory detection task on a figure-8 maze. Single-unit activity of both areas showed extensive similarities in terms of spatial distribution, reliability, and position coding. Importantly, reconstructions of subject position based on spiking activity displayed decoding errors that were correlated between areas. Additionally, we found that head direction, but not locomotor speed or head angular velocity, was an important determinant of activity in AC and V2L. By contrast, variables related to the sensory task cues or to trial correctness and reward were not markedly encoded in AC and V2L. We conclude that sensory cortices participate in coherent, multimodal representations of the subject's sensory-specific location. These may provide a common reference frame for distributed cortical sensory and motor processes and may support crossmodal predictive processing.
    Mesh-Begriff(e) Rats ; Animals ; Reproducibility of Results ; Neurons/physiology ; Auditory Cortex/physiology ; Visual Cortex/physiology
    Sprache Englisch
    Erscheinungsdatum 2023-03-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhad045
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Neural correlates of object identity and reward outcome in the sensory cortical-hippocampal hierarchy: coding of motivational information in perirhinal cortex.

    Fiorilli, Julien / Marchesi, Pietro / Ruikes, Thijs / Huis In 't Veld, Gerjan / Buckton, Rhys / Quintero, Mariana D / Reiten, Ingrid / Bjaalie, Jan G / Pennartz, Cyriel M A

    Cerebral cortex (New York, N.Y. : 1991)

    2024  Band 34, Heft 2

    Abstract: Neural circuits support behavioral adaptations by integrating sensory and motor information with reward and error-driven learning signals, but it remains poorly understood how these signals are distributed across different levels of the ... ...

    Abstract Neural circuits support behavioral adaptations by integrating sensory and motor information with reward and error-driven learning signals, but it remains poorly understood how these signals are distributed across different levels of the corticohippocampal hierarchy. We trained rats on a multisensory object-recognition task and compared visual and tactile responses of simultaneously recorded neuronal ensembles in somatosensory cortex, secondary visual cortex, perirhinal cortex, and hippocampus. The sensory regions primarily represented unisensory information, whereas hippocampus was modulated by both vision and touch. Surprisingly, the sensory cortices and the hippocampus coded object-specific information, whereas the perirhinal cortex did not. Instead, perirhinal cortical neurons signaled trial outcome upon reward-based feedback. A majority of outcome-related perirhinal cells responded to a negative outcome (reward omission), whereas a minority of other cells coded positive outcome (reward delivery). Our results highlight a distributed neural coding of multisensory variables in the cortico-hippocampal hierarchy. Notably, the perirhinal cortex emerges as a crucial region for conveying motivational outcomes, whereas distinct functions related to object identity are observed in the sensory cortices and hippocampus.
    Mesh-Begriff(e) Rats ; Animals ; Perirhinal Cortex ; Hippocampus/physiology ; Visual Perception/physiology ; Parietal Lobe ; Reward
    Sprache Englisch
    Erscheinungsdatum 2024-01-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhae002
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Multisensory task demands temporally extend the causal requirement for visual cortex in perception.

    Oude Lohuis, Matthijs N / Pie, Jean L / Marchesi, Pietro / Montijn, Jorrit S / de Kock, Christiaan P J / Pennartz, Cyriel M A / Olcese, Umberto

    Nature communications

    2022  Band 13, Heft 1, Seite(n) 2864

    Abstract: Primary sensory areas constitute crucial nodes during perceptual decision making. However, it remains unclear to what extent they mainly constitute a feedforward processing step, or rather are continuously involved in a recurrent network together with ... ...

    Abstract Primary sensory areas constitute crucial nodes during perceptual decision making. However, it remains unclear to what extent they mainly constitute a feedforward processing step, or rather are continuously involved in a recurrent network together with higher-order areas. We found that the temporal window in which primary visual cortex is required for the detection of identical visual stimuli was extended when task demands were increased via an additional sensory modality that had to be monitored. Late-onset optogenetic inactivation preserved bottom-up, early-onset responses which faithfully encoded stimulus features, and was effective in impairing detection only if it preceded a late, report-related phase of the cortical response. Increasing task demands were marked by longer reaction times and the effect of late optogenetic inactivation scaled with reaction time. Thus, independently of visual stimulus complexity, multisensory task demands determine the temporal requirement for ongoing sensory-related activity in V1, which overlaps with report-related activity.
    Mesh-Begriff(e) Auditory Perception/physiology ; Optogenetics ; Photic Stimulation ; Reaction Time/physiology ; Visual Cortex/physiology ; Visual Perception/physiology
    Sprache Englisch
    Erscheinungsdatum 2022-05-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-30600-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Author Correction: Multisensory task demands temporally extend the causal requirement for visual cortex in perception.

    Lohuis, Matthijs N Oude / Pie, Jean L / Marchesi, Pietro / Montijn, Jorrit S / de Kock, Christiaan P J / Pennartz, Cyriel M A / Olcese, Umberto

    Nature communications

    2022  Band 13, Heft 1, Seite(n) 4088

    Sprache Englisch
    Erscheinungsdatum 2022-07-14
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-31518-7
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  8. Artikel ; Online: Spike-based coupling between single neurons and populations across rat sensory cortices, perirhinal cortex, and hippocampus.

    Dorman, Reinder / Bos, Jeroen J / Vinck, Martin A / Marchesi, Pietro / Fiorilli, Julien / Lorteije, Jeanette A M / Reiten, Ingrid / Bjaalie, Jan G / Okun, Michael / Pennartz, Cyriel M A

    Cerebral cortex (New York, N.Y. : 1991)

    2023  Band 33, Heft 13, Seite(n) 8247–8264

    Abstract: Cortical computations require coordination of neuronal activity within and across multiple areas. We characterized spiking relationships within and between areas by quantifying coupling of single neurons to population firing patterns. Single-neuron ... ...

    Abstract Cortical computations require coordination of neuronal activity within and across multiple areas. We characterized spiking relationships within and between areas by quantifying coupling of single neurons to population firing patterns. Single-neuron population coupling (SNPC) was investigated using ensemble recordings from hippocampal CA1 region and somatosensory, visual, and perirhinal cortices. Within-area coupling was heterogeneous across structures, with area CA1 showing higher levels than neocortical regions. In contrast to known anatomical connectivity, between-area coupling showed strong firing coherence of sensory neocortices with CA1, but less with perirhinal cortex. Cells in sensory neocortices and CA1 showed positive correlations between within- and between-area coupling; these were weaker for perirhinal cortex. All four areas harbored broadcasting cells, connecting to multiple external areas, which was uncorrelated to within-area coupling strength. When examining correlations between SNPC and spatial coding, we found that, if such correlations were significant, they were negative. This result was consistent with an overall preservation of SNPC across different brain states, suggesting a strong dependence on intrinsic network connectivity. Overall, SNPC offers an important window on cell-to-population synchronization in multi-area networks. Instead of pointing to specific information-coding functions, our results indicate a primary function of SNPC in dynamically organizing communication in systems composed of multiple, interconnected areas.
    Mesh-Begriff(e) Rats ; Animals ; Perirhinal Cortex ; Hippocampus ; Neurons/physiology ; CA1 Region, Hippocampal/physiology ; Parietal Lobe
    Sprache Englisch
    Erscheinungsdatum 2023-04-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077450-6
    ISSN 1460-2199 ; 1047-3211
    ISSN (online) 1460-2199
    ISSN 1047-3211
    DOI 10.1093/cercor/bhad111
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Neural Correlates of Multisensory Detection Behavior: Comparison of Primary and Higher-Order Visual Cortex.

    Meijer, Guido T / Marchesi, Pietro / Mejias, Jorge F / Montijn, Jorrit S / Lansink, Carien S / Pennartz, Cyriel M A

    Cell reports

    2020  Band 31, Heft 6, Seite(n) 107636

    Abstract: We act upon stimuli in our surrounding environment by gathering the multisensory information they convey and by integrating this information to decide on a behavioral action. We hypothesized that the anterolateral secondary visual cortex (area AL) of the ...

    Abstract We act upon stimuli in our surrounding environment by gathering the multisensory information they convey and by integrating this information to decide on a behavioral action. We hypothesized that the anterolateral secondary visual cortex (area AL) of the mouse brain may serve as a hub for sensorimotor transformation of audiovisual information. We imaged neuronal activity in primary visual cortex (V1) and AL of the mouse during a detection task using visual, auditory, and audiovisual stimuli. We found that AL neurons were more sensitive to weak uni- and multisensory stimuli compared to V1. Depending on contrast, different subsets of AL and V1 neurons showed cross-modal modulation of visual responses. During audiovisual stimulation, AL neurons showed stronger differentiation of behaviorally reported versus unreported stimuli compared to V1, whereas V1 showed this distinction during unisensory visual stimulation. Thus, neural population activity in area AL correlates more closely with multisensory detection behavior than V1.
    Mesh-Begriff(e) Animals ; Auditory Perception/genetics ; Humans ; Mice ; Neurons/metabolism ; Photic Stimulation/methods ; Visual Cortex/physiology ; Visual Perception/genetics
    Sprache Englisch
    Erscheinungsdatum 2020-06-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2020.107636
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Multiplexing of Information about Self and Others in Hippocampal Ensembles.

    Bos, Jeroen J / Vinck, Martin / Marchesi, Pietro / Keestra, Amos / van Mourik-Donga, Laura A / Jackson, Jadin C / Verschure, Paul F M J / Pennartz, Cyriel M A

    Cell reports

    2019  Band 29, Heft 12, Seite(n) 3859–3871.e6

    Abstract: In addition to coding a subject's location in space, the hippocampus has been suggested to code social information, including the spatial position of conspecifics. "Social place cells" have been reported for tasks in which an observer mimics the behavior ...

    Abstract In addition to coding a subject's location in space, the hippocampus has been suggested to code social information, including the spatial position of conspecifics. "Social place cells" have been reported for tasks in which an observer mimics the behavior of a demonstrator. We examine whether rat hippocampal neurons may encode the behavior of a minirobot, but without requiring the animal to mimic it. Rather than finding social place cells, we observe that robot behavioral patterns modulate place fields coding animal position. This modulation may be confounded by correlations between robot movement and changes in the animal's position. Although rat position indeed significantly predicts robot behavior, we find that hippocampal ensembles code additional information about robot movement patterns. Fast-spiking interneurons are particularly informative about robot position and global behavior. In conclusion, when the animal's own behavior is conditional on external agents, the hippocampus multiplexes information about self and others.
    Mesh-Begriff(e) Action Potentials ; Animals ; Behavior, Animal ; CA1 Region, Hippocampal/cytology ; CA1 Region, Hippocampal/physiology ; Conditioning, Psychological ; Interneurons/cytology ; Interneurons/physiology ; Male ; Movement ; Orientation/physiology ; Rats ; Robotics ; Space Perception ; Spatial Behavior/physiology
    Sprache Englisch
    Erscheinungsdatum 2019-12-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2019.11.057
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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