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Article ; Online: CD34 and CD105 Microvessels in Resected Bone Specimen May Implicate Wound Healing in MRONJ.

Marcianò, Antonia / Ieni, Antonio / Mauceri, Rodolfo / Oteri, Giacomo

International journal of environmental research and public health

2021 Volume 18, Issue 21

Abstract: Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of ...

Abstract	Clinical treatment outcome of MRONJ (medication-related osteonecrosis of the jaw) surgery despite radical osseous removal and primary closure healing still shows differences in terms of outcome and disease recurrence. The study aims to assess the rate of angiogenesis of MRONJ lesions in order to understand the impact of angiogenesis and neoangiogenesis status on MRONJ surgical treatment outcome. This is the first study correlating microvessel density with prognosis in MRONJ surgically-treated patients. The immunohistochemical expression of CD34 and CD105 in MRONJ specimens obtained from surgically-treated patients was evaluated. The most vascularized areas detected by CD34 and CD105 were selected and the microvessel density value of the samples was registered. Samples were retrospectively divided according to the clinical outcome of MRONJ surgical treatment, dividing patients into two groups, "healed" and "not healed". Statistical analysis was performed to assess if neovessels could influence treatment outcome in patients undergoing radical surgery. In the examined cohort, this value was highly predictive of better treatment outcome after radical surgery of MRONJ. Understanding of angiogenesis-dependent factors deserves further attention as a future target for MRONJ prevention and therapies.
MeSH term(s)	Bisphosphonate-Associated Osteonecrosis of the Jaw ; Humans ; Microvessels ; Retrospective Studies ; Treatment Outcome ; Wound Healing
Language	English
Publishing date	2021-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph182111362
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis: a scoping review.

La Rosa, Giusy Rita Maria / Marcianò, Antonia / Priolo, Carlotta Ylenia / Peditto, Matteo / Pedullà, Eugenio / Bianchi, Alberto

Clinical oral investigations

2023 Volume 27, Issue 7, Page(s) 3321–3330

Abstract: Objectives: The aim of this scoping review was to determine the effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis.: Materials and methods: Reporting was based on Preferred Reporting Items for ... ...

Abstract	Objectives: The aim of this scoping review was to determine the effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis. Materials and methods: Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. A literature search was conducted in the PubMed and Scopus databases to identify all clinical studies on the application of platelet-rich fibrin in the control of pain caused by alveolar osteitis. Data were extracted independently by two reviewers and qualitatively described. Results: The initial search returned 81 articles, with 49 identified after duplicates removal; of these, 8 were selected according to the inclusion criteria. Three of the eight studies were randomized controlled clinical trials, and four were non-randomized clinical studies, two of which were controlled. One study was case series. In all of these studies, pain control was evaluated using the visual analog scale. Overall, the use of platelet-rich fibrin resulted effective in the control of pain determined by alveolar osteitis. Conclusions: Within the limits of this scoping review, the application of platelet-rich fibrin in the post-extra-extraction alveolus reduced the pain associated with alveolar osteitis in almost all the included studies. Nevertheless, high-quality randomized trials with adequate sample size are warranted to draw firm conclusions. Clinical relevance: Pain associated with alveolar osteitis causes discomfort to the patient and is challenging to be treated. Use of platelet-rich fibrin could be a promising clinical strategy for pain control in alveolar osteitis if its effectiveness will be confirmed by further high-quality studies.
MeSH term(s)	Humans ; Dry Socket ; Molar, Third ; Pain ; Platelet-Rich Fibrin ; Tooth Extraction/adverse effects ; Wound Healing
Language	English
Publishing date	2023-04-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1364490-7
ISSN	1436-3771 ; 1432-6981
ISSN (online)	1436-3771
ISSN	1432-6981
DOI	10.1007/s00784-023-05012-3
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Zs.A 4788: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Oral Surgical Management of Bone and Soft Tissues in MRONJ Treatment: A Decisional Tree.

Marcianò, Antonia / Rubino, Erasmo / Peditto, Matteo / Mauceri, Rodolfo / Oteri, Giacomo

Life (Basel, Switzerland)

2020 Volume 10, Issue 7

Abstract: Background: The aim of the present work was to analyze a 10-year retrospective series of surgically treated medication-related osteonecrosis of the jaws (MRONJ) cases, reporting the clinical outcome and success rate for each adopted procedure in order ... ...

Abstract	Background: The aim of the present work was to analyze a 10-year retrospective series of surgically treated medication-related osteonecrosis of the jaws (MRONJ) cases, reporting the clinical outcome and success rate for each adopted procedure in order to draw a treatment algorithm that is able to standardize clinical decision making and maximize the success of oral surgical treatment of MRONJ. Methods: Different surgical approaches were categorized taking into consideration two variables a) hard tissue management (defined as debridement, saucerization or marginal resective surgery of maxillary necrotic bone) and b) soft tissue management (defined as type of flap design and related modality of wound-healing). Results: For the retrospective cohort study, 103 MRONJ patients were enrolled and a total of 128 surgical procedures were performed. The role of radical-intended surgery using local flaps in MRONJ treatment was investigated, as well as palliative treatments. All stage I-II patients completely healed when a combination of radical necrotic bone surgery associated with a first intention healing of soft tissues was obtained. In stage III, when a patient was not eligible for maxillo-facial surgery, the use of palliative surgical strategies was effective in symptom relief in order to maintain a better quality of life for the duration of the patient's life. Conclusions: Oral surgery with radical intent associated with a flap design able to ensure first intention healing might represent a valid option for the majority of MRONJ patients. The designed decision tree allows clinicians to assess individual surgical approaches for MRONJ treatment in accordance with patient-centered outcomes and surgical skills.
Language	English
Publishing date	2020-06-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life10070099
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Article ; Online: Dentistry during the COVID-19 Epidemic: An Italian Workflow for the Management of Dental Practice.

Peditto, Matteo / Scapellato, Simone / Marcianò, Antonia / Costa, Paola / Oteri, Giacomo

International journal of environmental research and public health

2020 Volume 17, Issue 9

Abstract: The COVID-19 outbreak has raised concerns about infection control all over the world. Among health workers, dentists are particularly exposed to the COVID-19 infection risk. The aim of this paper is to present a workflow to manage dental procedures ... ...

Abstract	The COVID-19 outbreak has raised concerns about infection control all over the world. Among health workers, dentists are particularly exposed to the COVID-19 infection risk. The aim of this paper is to present a workflow to manage dental procedures already in use at the Dental Unit of the University Hospital of Messina. The proposed workflow accounts for the many aspects of dental practitioners' risk in the COVID-19 era, and focuses on the assessment of patient risk level, a two-phase dental procedure management (remote and face-to-face), and the use of specific preventive measures. No cases of COVID-19 infection were detected among patients and staff of the dental unit in a two-month period of time while using this protocol. This workflow seems a promising and effective solution to manage dental procedures during the COVID-19 outbreak, and could be implemented in both public and private practices until the emergency is contained.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Dentistry/methods ; Dentists ; Disease Outbreaks/prevention & control ; Humans ; Infection Control ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Practice Management, Dental ; Professional Role ; SARS-CoV-2 ; Workflow
Keywords	covid19
Language	English
Publishing date	2020-05-11
Publishing country	Switzerland
Document type	Journal Article
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph17093325
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Article ; Online: Role of Local Flaps to Achieve Primary Wound Closure in Medication-Related Osteonecrosis of the Jaws Osseous-Resective Surgery.

Marcianò, Antonia / Peditto, Matteo / Cicciù, Marco / Rubino, Erasmo / Oteri, Giacomo

The Journal of craniofacial surgery

2020 Volume 31, Issue 4, Page(s) e347–e352

Abstract: The aim of the present work is to evaluate the most suitable surgical technique in relation to location and extent of medication-related osteonecrosis of the jaws (MRONJ) through comparison of success rate between the routinely used mucoperiostal flaps ... ...

Abstract	The aim of the present work is to evaluate the most suitable surgical technique in relation to location and extent of medication-related osteonecrosis of the jaws (MRONJ) through comparison of success rate between the routinely used mucoperiostal flaps and different local flaps designs and propose a standardization of surgical procedures according to MRONJ stage and localization with 2 objectives: to provide the surgeon with an algorithm of treatment according to MRONJ localization and extension; to maximize the success of surgical treatment.Thirteen consecutive patients affected by focal MRONJ were surgically treated with radical osteotomy at the Center for Treatment of the Osteonecrosis of the Jaws (University of Messina, Italy).Initial defects were classified according to the classification of the Italian Societies of Oral Medicine and Maxillofacial Surgery (the SICMF-SIPMO staging system) which consider not only bone exposure but also radiological bone involvement. Treatment outcome was retrospectively assessed according to the different adopted surgical procedure: mucoperiostal flaps (GROUP A) advanced mucoperiostal flaps or rotation flaps (GROUP B) local flaps (GROUP C).Outcome after surgical treatment of focal MRONJ was positive in every group irrespective of MRONJ localization and extension. This may be due to the appropriate selection of surgical procedure.The results obtained demonstrated that focal MRONJ surgical treatment is a reliable procedure irrespective of the initial clinical situation. Radical osteotomy combined with appropriate selection of soft tissue management is crucial.
MeSH term(s)	Humans ; Italy ; Jaw ; Jaw Diseases/surgery ; Orthognathic Surgical Procedures ; Osteotomy ; Retrospective Studies ; Surgical Flaps/surgery ; Treatment Outcome
Language	English
Publishing date	2020-02-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000006288
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Zs.A 3761: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 175: Show issues

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Article ; Online: Reply to Fusco et al. Is Medication-Related Osteonecrosis of the Jaws (MRONJ) Associated to Cyclin-Dependent Kinase (CDK) 4/6 Inhibitors? A Word of Cautiousness. Comment on "Marcianò et al. Medication-Related Osteonecrosis of the Jaws and CDK4/6 Inhibitors: A Recent Association.

Marcianò, Antonia / Guzzo, Gian Marco / Peditto, Matteo / Picone, Antonio / Oteri, Giacomo

International journal of environmental research and public health

2021 Volume 18, Issue 19

Abstract: We read the letter from Dr. Fusco and colleagues with great interest, and we would like to thank them for the stimulating comments regarding our paper "Medication-Related Osteonecrosis of the Jaws and CDK4/6 Inhibitors: A Recent Association" [ ... ]. ...

Abstract	We read the letter from Dr. Fusco and colleagues with great interest, and we would like to thank them for the stimulating comments regarding our paper "Medication-Related Osteonecrosis of the Jaws and CDK4/6 Inhibitors: A Recent Association" [...].
MeSH term(s)	Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinases ; Humans ; Jaw ; Osteonecrosis/chemically induced ; Public Health
Chemical Substances	CDK4 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22)
Language	English
Publishing date	2021-09-27
Publishing country	Switzerland
Document type	Journal Article ; Comment
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph181910145
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Article: Impact of electro-neuro-feedback on postoperative outcome of impacted lower third molar surgery.

Oteri, Giacomo / Marcianò, Antonia / Cervino, Gabriele / Peditto, Matteo

European journal of dentistry

2018 Volume 12, Issue 1, Page(s) 77–88

Abstract: Objective: The purpose of this study was to evaluate the impact of a treatment with electro-neuro-feedback (ENF), a portable transcutaneous electrical nerve stimulation (TENS) device, on the clinical outcome and inflammatory biochemical parameters ... ...

Abstract	Objective: The purpose of this study was to evaluate the impact of a treatment with electro-neuro-feedback (ENF), a portable transcutaneous electrical nerve stimulation (TENS) device, on the clinical outcome and inflammatory biochemical parameters related to the impacted lower third molar surgery. Materials and methods: A randomized, split-mouth, and single-blind study was conducted on 32 patients requiring lower third molars extractions and referred to the Oral Surgery Unit of the School of Dentistry of the University of Messina. Every patient underwent surgical removal of both lower third molars. The first extraction included a placebo (electrodes placement with turned-off device) treatment following the surgery, while the second had the ENF used next to the avulsion and the following days. Clinical parameters were collected 4 days before, immediately after, 2, 4, and 7 days after the surgical procedure. Biochemical parameters were obtained 1 day before the surgical removal and 7 days after. Data were processed using Wilcoxon-Mann-Whitney test, with significance being set at Results: Clinical outcome parameters showed a significant improvement after the ENF treatment, while considered inflammatory markers expressed different patterns. Conclusions: ENF, a reliable portable TENS device, has demonstrated to be a useful tool in the managing of the postsurgical phases, reducing edema, pain, and consequent pain-killers consumption.
Language	English
Publishing date	2018-04-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2491711-4
ISSN	1305-7464 ; 1305-7456
ISSN (online)	1305-7464
ISSN	1305-7456
DOI	10.4103/ejd.ejd_296_17
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Article: 3D Printing beyond Dentistry during COVID 19 Epidemic: A Technical Note for Producing Connectors to Breathing Devices

Cavallo, Leonardo / Marcianò, Antonia / Cicciù, Marco / Oteri, Giacomo

Prosthesis 2020, Vol. 2, Pages 46-52

Abstract: 1) Background: To mitigate the shortage of respiratory devices during the Covid-19 epidemic, dental professional volunteers can contribute to create printed plastic valves, adapting the dental digital workflow and converting snorkeling masks in ... ...

Abstract	(1) Background: To mitigate the shortage of respiratory devices during the Covid-19 epidemic, dental professional volunteers can contribute to create printed plastic valves, adapting the dental digital workflow and converting snorkeling masks in emergency CPAP (continuous positive airways pressure) devices The objective of this report was to provide the specific settings to optimize printing with the 3D printers of the dental industry (2) Methods: In order to provide comprehensive technical notes to volunteer dental professionals interested in printing Charlotte and Dave connectors to breathing devices, the entire digital workflow is reported (3) Results: The present paper introduces an alternative use of the dental Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) machinery, and reports on the fabrication of a 3D printed connection prototypes suitable for connection to face masks, thereby demonstrating the feasibility of this application (4) Conclusions: This call for action was addressed to dentists and dental laboratories who are willing to making available their experience, facilities and machinery for the benefit of patients, even way beyond dentistry
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #38296
Database	COVID19

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Article ; Online: 3D Printing beyond Dentistry during COVID 19 Epidemic

Cavallo, Leonardo. / Marcianò, Antonia / Cicciù, M / Oteri, Giacomo

A Technical Note for Producing Connectors to Breathing Devices

2020

Keywords	covid19
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: 3D Printing beyond Dentistry during COVID 19 Epidemic

Cavallo, Leonardo / Marcianò, Antonia / Cicciù, Marco / Oteri, Giacomo

Prosthesis, 2(2):46-52

A Technical Note for Producing Connectors to Breathing Devices

2020

Abstract	(1) Background: To mitigate the shortage of respiratory devices during the Covid-19 epidemic, dental professional volunteers can contribute to create printed plastic valves, adapting the dental digital workflow and converting snorkeling masks in emergency CPAP (continuous positive airways pressure) devices. The objective of this report was to provide the specific settings to optimize printing with the 3D printers of the dental industry. (2) Methods: In order to provide comprehensive technical notes to volunteer dental professionals interested in printing Charlotte and Dave connectors to breathing devices, the entire digital workflow is reported. (3) Results: The present paper introduces an alternative use of the dental Computer Aided Design/Computer Aided Manufacturing (CAD/CAM) machinery, and reports on the fabrication of a 3D printed connection prototypes suitable for connection to face masks, thereby demonstrating the feasibility of this application. (4) Conclusions: This call for action was addressed to dentists and dental laboratories who are willing to making available their experience, facilities and machinery for the benefit of patients, even way beyond dentistry.
Keywords	COVID-19 ; 3D printing ; CAD/CAM ; dental prostheses ; resin printed device ; covid19
Language	English
Publishing country	de
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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