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  1. Article ; Online: Predictive Role of Admission Venous Lactate Level in Patients with Upper Gastrointestinal Bleeding

    Marcin Strzałka / Marek Winiarski / Marcin Dembiński / Michał Pędziwiatr / Andrzej Matyja / Michał Kukla

    Journal of Clinical Medicine, Vol 11, Iss 335, p

    A Prospective Observational Study

    2022  Volume 335

    Abstract: Upper gastrointestinal bleeding (UGIB) is one of the most common emergencies. Risk stratification is essential in patients with this potentially life-threatening condition. The aim of this prospective study was to evaluate the usefulness of the admission ...

    Abstract Upper gastrointestinal bleeding (UGIB) is one of the most common emergencies. Risk stratification is essential in patients with this potentially life-threatening condition. The aim of this prospective study was to evaluate the usefulness of the admission venous lactate level in predicting clinical outcomes in patients with UGIB. All consecutive adult patients hospitalized due to UGIB were included in the study. The clinical data included the demographic characteristics of the observed population, etiology of UGIB, need for surgical intervention and intensive care, bleeding recurrence, and mortality rates. Venous lactate was measured in all patients on admission. Logistic regression analyses were used to calculate the odds ratios (OR) of lactate levels for all outcomes. The receiver operating characteristic (ROC) curve was used to determine the accuracy of lactate levels in measuring clinical outcomes, while Youden index was used to calculate the best cut-off points. A total of 221 patients were included in the study (151M; 70F). There were 24 cases of UGIB recurrence (10.8%), 19 patients (8.6%) required surgery, and 37 individuals (16.7%) required intensive care. Mortality rate was 11.3% (25 cases). The logistic regression analysis showed statistically significant association between admission venous lactate and all clinical outcomes: mortality (OR = 1.39, 95%CI: 1.22–1.58, p < 0.001), recurrence of bleeding (OR = 1.16, 95%CI: 1.06; 1.28, p = 0.002), surgical intervention (OR = 1.17, 95%CI: 1.06–1.3, p = 0.002) and intensive care (OR = 1.33, 95%CI: 1.19–1.5, p < 0.001). The ROC curve analysis showed a high predictive value of lactate levels for all outcomes, especially mortality: cut-off point 4.3 (AUC = 0.82, 95%CI: 0.72–0.92, p < 0.001) and intensive care: cut-off point 4.2 (AUC = 0.76, 95%CI: 0.66–0.85, p < 0.001). Admission venous lactate level may be a useful predictive factor of clinical outcomes in patients with UGIB.
    Keywords upper gastrointestinal bleeding ; venous lactate ; prediction of clinical outcomes ; peptic ulcer ; esophageal varices ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Quest for the optimal technique of laparoscopic splenectomy – vessels first or hilar transection?

    Dorota Radkowiak / Anna Zychowicz / Michał Wysocki / Anna Lasek / Piotr Major / Michał Pędziwiatr / Piotr Budzyński / Marcin Dembiński / Jadwiga Dworak / Andrzej Budzynski

    Videosurgery and Other Miniinvasive Techniques, Vol 13, Iss 4, Pp 460-

    2018  Volume 468

    Keywords laparoscopy ; spleen ; splenectomy ; vessels first ; hilar transection ; morbidity ; mortality ; Medicine ; R
    Language English
    Publishing date 2018-05-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Anti-inflammatory adipokines

    Michał Kukla / Tomasz Menżyk / Marcin Dembiński / Marek Winiarski / Aleksander Garlicki / Monika Bociąga-Jasik / Magdalena Skonieczna / Dorota Hudy / Barbara Maziarz / Beata Kusnierz-Cabala / Lubomir Skladany / Ivica Grgurevic / Małgorzata Wójcik-Bugajska / Tomasz Grodzicki / Dominika Stygar / Tomasz Rogula

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes

    2021  Volume 13

    Abstract: Abstract Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin ... ...

    Abstract Abstract Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on adipokines relationship with COVID-19 severity, concomitant metabolic abnormalities and liver dysfunction. Serum chemerin, omentin and vaspin concentrations were measured in serum collected from 70 COVID-19 patients at the moment of admission to hospital, before any treatment was applied and 20 healthy controls. Serum chemerin and omentin concentrations were significantly decreased in COVID-19 patients compared to healthy volunteers (271.0 vs. 373.0 ng/ml; p < 0.001 and 482.1 vs. 814.3 ng/ml; p = 0.01, respectively). There were no correlations of analyzed adipokines with COVID-19 severity based on the presence of pneumonia, dyspnea, or necessity of Intensive Care Unit hospitalization (ICU). Liver test abnormalities did not influence adipokines levels. Elevated GGT activity was associated with ICU admission, presence of pneumonia and elevated concentrations of CRP, ferritin and interleukin 6. Chemerin and omentin depletion in COVID-19 patients suggests that this adipokines deficiency play influential role in disease pathogenesis. However, there was no relationship between lower adipokines level and frequency of COVID-19 symptoms as well as disease severity. The only predictive factor which could predispose to a more severe COVID-19 course, including the presence of pneumonia and ICU hospitalization, was GGT activity.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Correction

    Zygmunt Warzecha / Paweł Sendur / Piotr Ceranowicz / Marcin Dembiński / Jakub Cieszkowski / Beata Kuśnierz-Cabala / Rafał Olszanecki / Romana Tomaszewska / Tadeusz Ambroży / Artur Dembiński

    International Journal of Molecular Sciences, Vol 20, Iss 12, p

    Warzecha, Z. et al. Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis. Int. J. Mol. Sci. 2016, 17 , 1709

    2019  Volume 2893

    Abstract: We would like to submit the correction to our published paper [.] ...

    Abstract We would like to submit the correction to our published paper [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Correction

    Zygmunt Warzecha / Paweł Sendur / Piotr Ceranowicz / Jakub Cieszkowski / Marcin Dembiński / Ryszard Sendur / Joanna Bonior / Jolanta Jaworek / Tadeusz Ambroży / Rafał Olszanecki / Beata Kuśnierz-Cabala / Kaczmarzyk Tomasz / Romana Tomaszewska / Artur Dembiński

    International Journal of Molecular Sciences, Vol 20, Iss 12, p

    Warzecha, Z., et al. Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats. Int. J. Mol. Sci. 2017 , 18 , 882

    2019  Volume 3086

    Abstract: We would like to submit this correction to our published paper [.] ...

    Abstract We would like to submit this correction to our published paper [.]
    Keywords n/a ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2019-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Therapeutic Effect of Low Doses of Acenocoumarol in the Course of Ischemia/Reperfusion-Induced Acute Pancreatitis in Rats

    Zygmunt Warzecha / Paweł Sendur / Piotr Ceranowicz / Jakub Cieszkowski / Marcin Dembiński / Ryszard Sendur / Joanna Bonior / Jolanta Jaworek / Tadeusz Ambroży / Rafał Olszanecki / Beata Kuśnierz-Cabala / Kaczmarzyk Tomasz / Romana Tomaszewska / Artur Dembiński

    International Journal of Molecular Sciences, Vol 18, Iss 4, p

    2017  Volume 882

    Abstract: Intravascular activation of coagulation is observed in acute pancreatitis and is related to the severity of this inflammation. The aim of our study was to evaluate the impact of acenocoumarol therapy on the course of acute pancreatitis induced in male ... ...

    Abstract Intravascular activation of coagulation is observed in acute pancreatitis and is related to the severity of this inflammation. The aim of our study was to evaluate the impact of acenocoumarol therapy on the course of acute pancreatitis induced in male rats by pancreatic ischemia followed by reperfusion. Acenocoumarol at a dose of 50, 100, or 150 µg/kg/dose was administered intragastrically once a day, starting the first dose 24 h after the initiation of pancreatic reperfusion. Results: Histological examination showed that treatment with acenocoumarol reduces pancreatic edema, necrosis, and hemorrhages in rats with pancreatitis. Moreover, the administration of acenocoumarol decreased pancreatic inflammatory infiltration and vacuolization of pancreatic acinar cells. These findings were accompanied with a reduction in the serum activity of lipase and amylase, concentration of interleukin-1β, and plasma d-Dimer concentration. Moreover, the administration of acenocoumarol improved pancreatic blood flow and pancreatic DNA synthesis. Acenocoumarol given at a dose of 150 µg/kg/dose was the most effective in the treatment of early phase acute pancreatitis. However later, acenocoumarol given at the highest dose failed to exhibit any therapeutic effect; whereas lower doses of acenocoumarol were still effective in the treatment of acute pancreatitis. Conclusion: Treatment with acenocoumarol accelerates the recovery of ischemia/reperfusion-induced acute pancreatitis in rats.
    Keywords acute pancreatitis ; acenocoumarol ; pancreatic blood flow ; interleukin-1β ; ">d-dimer ; lipase ; amylase ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610 ; 630
    Language English
    Publishing date 2017-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Protective Effect of Pretreatment with Acenocoumarol in Cerulein-Induced Acute Pancreatitis

    Zygmunt Warzecha / Paweł Sendur / Piotr Ceranowicz / Marcin Dembiński / Jakub Cieszkowski / Beata Kuśnierz-Cabala / Rafał Olszanecki / Romana Tomaszewska / Tadeusz Ambroży / Artur Dembiński

    International Journal of Molecular Sciences, Vol 17, Iss 10, p

    2016  Volume 1709

    Abstract: Coagulation is recognized as a key player in inflammatory and autoimmune diseases. The aim of the current research was to examine the effect of pretreatment with acenocoumarol on the development of acute pancreatitis (AP) evoked by cerulein. Methods: AP ... ...

    Abstract Coagulation is recognized as a key player in inflammatory and autoimmune diseases. The aim of the current research was to examine the effect of pretreatment with acenocoumarol on the development of acute pancreatitis (AP) evoked by cerulein. Methods: AP was induced in rats by cerulein administered intraperitoneally. Acenocoumarol (50, 100 or 150 µg/kg/dose/day) or saline were given once daily for seven days before AP induction. Results: In rats with AP, pretreatment with acenocoumarol administered at the dose of 50 or 100 µg/kg/dose/day improved pancreatic histology, reducing the degree of edema and inflammatory infiltration, and vacuolization of acinar cells. Moreover, pretreatment with acenocoumarol given at the dose of 50 or 100 µg/kg/dose/day reduced the AP-evoked increase in pancreatic weight, serum activity of amylase and lipase, and serum concentration of pro-inflammatory interleukin-1β, as well as ameliorated pancreatic DNA synthesis and pancreatic blood flow. In contrast, acenocoumarol given at the dose of 150 μg/kg/dose did not exhibit any protective effect against cerulein-induced pancreatitis. Conclusion: Low doses of acenocoumarol, given before induction of AP by cerulein, inhibit the development of that inflammation.
    Keywords acute pancreatitis ; coagulation ; inflammation ; interleukin-1β ; lipase ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2016-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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