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  1. Article ; Online: Spatial-Explicit Climate Change Vulnerability Assessments Based on Impact Chains. Findings from a Case Study in Burundi

    Stefan Schneiderbauer / Daniel Baunach / Lydia Pedoth / Kathrin Renner / Kerstin Fritzsche / Christina Bollin / Marco Pregnolato / Marc Zebisch / Stefan Liersch / María del Rocío Rivas López / Salvator Ruzima

    Sustainability, Vol 12, Iss 6354, p

    2020  Volume 6354

    Abstract: Climate change vulnerability assessments are an essential instrument to identify regions most vulnerable to adverse impacts of climate change and to determine appropriate adaptation measures. Vulnerability assessments directly support countries in ... ...

    Abstract Climate change vulnerability assessments are an essential instrument to identify regions most vulnerable to adverse impacts of climate change and to determine appropriate adaptation measures. Vulnerability assessments directly support countries in developing adaptation plans and in identifying possible measures to reduce adverse consequences of changing climate conditions. Against this background, this paper describes a vulnerability assessment using an integrated and participatory approach that builds on standardized working steps of previously developed ‘Vulnerability Sourcebook’ guidelines. The backbone of this approach is impact chains as a conceptual model of cause–effect relationships as well as a structured selection of indicators according to the three main components of vulnerability, namely exposure, sensitivity and adaptive capacity. We illustrate our approach by reporting the results of a vulnerability assessment conducted in Burundi focusing on climate change impacts on water and soil resources. Our work covers two analysis scales: a national assessment with the aim to identify climate change ‘hotspot regions’ through vulnerability mapping; and a local assessment aiming at identifying local-specific drivers of vulnerability and appropriate adaptation measures. Referring to this vulnerability assessment in Burundi, we discuss the potentials and constraints of the approach. We stress the need to involve stakeholders in every step of the assessment and to communicate limitations and uncertainties of the applied methods, indicators and maps in order to increase the comprehension of the approach and the acceptance of the results by different stakeholders. The study proved the practical usability of the approach at the national level by the selection of three particularly vulnerable areas. The results at a local scale supported the identification of adaption measures through intensive engagement of local rural populations.
    Keywords climate change vulnerability assessment ; impact chain ; vulnerability indicators ; stakeholder involvement ; vulnerability mapping ; climate change adaptation ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Subject code 333
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

    Melusine Bleu / Swann Gaulis / Rui Lopes / Kathleen Sprouffske / Verena Apfel / Sjoerd Holwerda / Marco Pregnolato / Umut Yildiz / Valentina Cordoʹ / Antonella F. M. Dost / Judith Knehr / Walter Carbone / Felix Lohmann / Charles Y. Lin / James E. Bradner / Audrey Kauffmann / Luca Tordella / Guglielmo Roma / Giorgio G. Galli

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in ... ...

    Abstract Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
    Keywords Science ; Q
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: PAX8 activates metabolic genes via enhancer elements in Renal Cell Carcinoma

    Melusine Bleu / Swann Gaulis / Rui Lopes / Kathleen Sprouffske / Verena Apfel / Sjoerd Holwerda / Marco Pregnolato / Umut Yildiz / Valentina Cordoʹ / Antonella F. M. Dost / Judith Knehr / Walter Carbone / Felix Lohmann / Charles Y. Lin / James E. Bradner / Audrey Kauffmann / Luca Tordella / Guglielmo Roma / Giorgio G. Galli

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 10

    Abstract: Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in ... ...

    Abstract Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activating genes associated with metabolic pathways.
    Keywords Science ; Q
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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