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  1. Article ; Online: Oral Administration and Intralesional Injection of Hyaluronic Acid Versus Intralesional Injection Alone in Peyronie’s Disease

    Tommaso Cai / Daniele Tiscione / Vincenzo Favilla / Marco Puglisi / Fabrizio Palumbo / Alessandro Zucchi / Gianni Malossini / Alessandro Palmieri / Truls E. Bjerklund Johansen

    The World Journal of Men's Health, Vol 39, Iss 3, Pp 526-

    Results from a Phase III Study

    2021  Volume 532

    Abstract: Purpose: The aim of this study was to compare the effect of combined oral administration and intralesional injection of hyal-uronic acid (HA) with intralesional injections alone, in patients with early onset of Peyronie’s disease (PD). Materials and ... ...

    Abstract Purpose: The aim of this study was to compare the effect of combined oral administration and intralesional injection of hyal-uronic acid (HA) with intralesional injections alone, in patients with early onset of Peyronie’s disease (PD). Materials and Methods:Materials and Methods: For this prospective, randomized phase III clinical trial we included patients with recent diagnosis of PD. Eighty-one patients were randomized into two groups. Group A consisted of 41 patients receiving oral administration of HA in combination with weekly intralesional injection of HA for 6 weeks. Group B consisted of 40 patients group B who re-ceived weekly intralesional injections of HA for 6 weeks, only. The main outcome measures were the changes from baseline to the end of therapy after three months in penile curvature (°) and changes in the international index of erectile function (IIEF-5) score and patient’s global impressions of improvement (PGI-I) score. Results:Results: Group A had a significantly larger reduction in penile curvature as compared with group B (Group A: -7.8°, Group B: -4.1° [p<0.001]). Group A also showed a higher improvement in IIEF-5 and PGI-I scores in comparison with Group B (Group A:+4 IIEF-5, Group B: +2 IIEF-5 [p<0.001]; Group A: 3 PGI-I, Group B: 1 PGI-I, [p<0.001]). At three months both groups had a significant reduction of penile curvature from baseline (p<0.001). Conclusions:Conclusions: Oral administration combined with intralesional treatment with HA shows greater efficacy to improve penile curvature and overall sexual satisfaction in comparison with intralesional HA treatment alone.
    Keywords hyaluronic acid ; injections intralesional ; international index of erectile function-5 ; penile induration ; quality of life ; therapeutics ; Medicine ; R ; Diseases of the genitourinary system. Urology ; RC870-923
    Subject code 610
    Language English
    Publishing date 2021-07-01T00:00:00Z
    Publisher Korean Society for Sexual Medicine and Andrology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: External Validation of a Novel Comprehensive Trifecta System in Predicting Oncologic and Functional Outcomes of Partial Nephrectomy

    Umberto Anceschi / Rocco Simone Flammia / Daniele Mattevi / Antonio Tufano / Aldo Brassetti / Maria Consiglia Ferriero / Gabriele Tuderti / Leonardo Misuraca / Alfredo Maria Bove / Riccardo Mastroianni / Davide Marsiliani / Marco Puglisi / Tommaso Cai / Costantino Leonardo / Michele Gallucci / Gianni Malossini / Lorenzo Giuseppe Luciani / Giuseppe Simone

    Journal of Clinical Medicine, Vol 11, Iss 796, p

    Results of a Multicentric Series

    2022  Volume 796

    Abstract: Background: To validate a novel trifecta for evaluating outcomes of partial nephrectomy (PN) on a multicentric dataset. Methods: Between 2007 and 2020, three renal cancer databases were queried for patients with solitary renal masses who underwent PN (n = ...

    Abstract Background: To validate a novel trifecta for evaluating outcomes of partial nephrectomy (PN) on a multicentric dataset. Methods: Between 2007 and 2020, three renal cancer databases were queried for patients with solitary renal masses who underwent PN (n = 649). Trifecta was estimated for overall cohort and contributing centers. Overall survival (OS), cancer-specific survival (CSS) and end-stage renal disease (ESRD) probabilities were assessed by Kaplan–Meier. Cox regression was used to identify predictors of OS, CSS, ESRD. For all analyses, a p < 0.05 was considered significant. Results: At a median follow-up of 22.7 months (IQR 12.5–76.5) overall trifecta was 76.7% [Centre A; (n = 230; 68.6%), B (n = 68; 77.3%), C (n = 200; 88.4%); p = 0.001). On Kaplan–Meier, patients achieving trifecta exhibited higher OS ( p = 0.024), higher CSS ( p = 0.015) and lower ESRD rates ( p = 0.024). On multivariable analysis, age (HR 1.04; 95% CI 1.01–1.08) and trifecta (HR 0.34; 95% CI 0.15–0.76) were independent predictors of OS while pT stage (HR 1.95; 95% CI 0.45–8.43) and trifecta (HR 0.33; 95% CI 0.16–0.67) were predictors of CSS (each p < 0.01). Preoperative CKD stage ≥ 3a (HR 13.1; 95% CI 4.07–42.6) and trifecta (HR 0.41; 95% CI 0.19–0.87) were independent predictors of ESRD (each p < 0.05). Conclusions: On external validation, trifecta was an independent predictor of all PN endpoints, regardless of hilar control and ischemia duration.
    Keywords partial nephrectomy ; trifecta ; survival ; end-stage renal disease (ESRD) ; ischemia ; Medicine ; R
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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