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  1. Article ; Online: Vaxxing to elimination: smallpox vaccines as tools to fight mpox.

    Titanji, Boghuma K / Marconi, Vincent C

    The Journal of clinical investigation

    2023  Volume 133, Issue 2

    MeSH term(s) Humans ; Smallpox Vaccine ; Vaccination ; Mpox (monkeypox)/prevention & control
    Chemical Substances Smallpox Vaccine
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI167632
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  2. Article ; Online: Addressing coloniality of power to improve HIV care in South Africa and other LMIC.

    Ordóñez, Claudia E / Marconi, Vincent C / Manderson, Lenore

    Frontiers in reproductive health

    2023  Volume 5, Page(s) 1116813

    Abstract: We describe the appropriateness and potential for effectiveness of three strategic approaches for improving HIV care in South Africa: community-based primary healthcare, local/community-based stakeholder engagement, and community-engaged research. At ... ...

    Abstract We describe the appropriateness and potential for effectiveness of three strategic approaches for improving HIV care in South Africa: community-based primary healthcare, local/community-based stakeholder engagement, and community-engaged research. At their core, these approaches are related to overcoming health inequity and inequality resulting from coloniality of power's heterogenous structural processes impacting health care in many low- and middle-income countries (LMIC). We turn to South Africa, a middle-income country, as an example. There the HIV epidemic began in the 1980s and its ending is as elusive as achieving universal healthcare. Despite impressive achievements such as the antiretroviral treatment program (the largest in the world) and the country's outstanding cadre of HIV experts, healthcare workers and leaders, disadvantaged South Africans continue to experience disproportionate rates of HIV transmission. Innovation in global public health must prioritize overcoming the coloniality of power in LMIC, effected through the imposition of development and healthcare models conceived in high-income countries (HIC) and insufficient investment to address social determinants of health. We advocate for a paradigm shift in global health structures and financing to effectively respond to the HIV pandemic in LMIC. We propose ethically responsive, local/community-based stakeholder engagement as a key conceptual approach and strategy to improve HIV care in South Africa and elsewhere. We join in solidarity with local/community-based stakeholders' longstanding efforts and call upon others to change the current status quo characterized by global public health power concentrated in HIC.
    Language English
    Publishing date 2023-03-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3153
    ISSN (online) 2673-3153
    DOI 10.3389/frph.2023.1116813
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  3. Article ; Online: Healthy aging: Linking causal mechanisms with holistic outcomes.

    Montano, Monty / Oursler, Krisann K / Marconi, Vincent C

    Aging cell

    2023  Volume 23, Issue 1, Page(s) e14065

    Abstract: Identifying and understanding the impact of differing exposures over the lifecourse necessitates contextualizing different levels of influence ranging from genetics, epigenetics, geography, and psychosocial networks. ...

    Abstract Identifying and understanding the impact of differing exposures over the lifecourse necessitates contextualizing different levels of influence ranging from genetics, epigenetics, geography, and psychosocial networks.
    MeSH term(s) Healthy Aging ; Epigenesis, Genetic
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Editorial
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.14065
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  4. Article: VA Big Data Science: A Model for Improved National Pandemic Response Present and Future.

    Young-Xu, Yinong / Davey, Victoria / Marconi, Vincent C / Cunningham, Francesca E

    Federal practitioner : for the health care professionals of the VA, DoD, and PHS

    2023  Volume 40, Issue 11 Suppl 5, Page(s) S39–S42

    Abstract: Background: The US Department of Veterans Affairs (VA) enterprise approach to research (VA Research) has built a data-sharing framework available to all research teams within VA. Combined with robust analytic systems and tools available for ... ...

    Abstract Background: The US Department of Veterans Affairs (VA) enterprise approach to research (VA Research) has built a data-sharing framework available to all research teams within VA. Combined with robust analytic systems and tools available for investigators, VA Research has produced actionable results during the COVID-19 pandemic. Big data science techniques applied to VA's health care data demonstrate that medical research can be performed quickly and judiciously during nationwide health care emergencies.
    Observations: We envision a common framework of data collection, management, and surveillance implemented in partnership with other health care agencies that would capture even broader, actionable, and timely observational data on populations, while providing opportunities for enhanced collaborative research across agencies. This model should be continued and expanded through the current COVID-19 and future pandemics.
    Conclusions: Extending the achievements of VA Research in the COVID-19 pandemic to date, we advocate national goals of open science by working toward a synergistic national framework of anonymized, synchronized, shared health data that would provide researchers with potent tools to combat future public health crises.
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 1078-4497
    ISSN 1078-4497
    DOI 10.12788/fp.0412
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  5. Article ; Online: A complex system of chemokines may hold the key to optimal CD4+ T-cell recovery after antiretroviral therapy.

    Sun, Yan V / Marconi, Vincent C

    EBioMedicine

    2020  Volume 62, Page(s) 103113

    MeSH term(s) Antiretroviral Therapy, Highly Active ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Chemokines/metabolism ; HIV Infections/drug therapy ; HIV Infections/immunology ; HIV Infections/metabolism ; HIV Infections/virology ; Humans ; Immunomodulation ; Treatment Outcome ; Viral Load
    Chemical Substances Chemokines
    Language English
    Publishing date 2020-11-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2020.103113
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  6. Article ; Online: Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression.

    Titanji, Boghuma K / Gwinn, Marta / Marconi, Vincent C / Sun, Yan V

    Clinical epigenetics

    2022  Volume 14, Issue 1, Page(s) 8

    Abstract: Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease ... ...

    Abstract Despite significant advances in the treatment and care of people with HIV (PWH), several challenges remain in our understanding of disease pathogenesis to improve patient care. HIV infection can modify the host epigenome and as such can impact disease progression, as well as the molecular processes driving non-AIDS comorbidities in PWH. Epigenetic epidemiologic studies including epigenome-wide association studies (EWAS) offer a unique set of tools to expand our understanding of HIV disease and to identify novel strategies applicable to treatment and diagnosis in this patient population. In this review, we summarize the current state of knowledge from epigenetic epidemiologic studies of PWH, identify the main challenges of this approach, and highlight future directions for the field. Emerging epigenetic epidemiologic studies of PWH can expand our understanding of HIV infection and health outcomes, improve scientific validity through collaboration and replication, and increase the coverage of diverse populations affected by the global HIV pandemic. Through this review, we hope to highlight the potential of EWAS as a tool for HIV research and to engage more investigators to explore its application to important research questions.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Disease Progression ; Epidemiologic Studies ; Epigenesis, Genetic ; Epigenome ; Female ; Genome-Wide Association Study ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/genetics ; HIV Infections/therapy ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2022-01-11
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-022-01230-w
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  7. Article ; Online: "Call 911 - That's my [Advance Care] Plan": Factors that Inform Advance Care Planning Conversation Readiness Among Aging Persons Living With HIV.

    Pinto Taylor, Emily / Halpin, Sean N / Marconi, Vincent C / Justice, Amy C / Johnson, Theodore M / McInnes, D Keith / Perkins, Molly M

    Journal of applied gerontology : the official journal of the Southern Gerontological Society

    2024  , Page(s) 7334648241233377

    Abstract: Antiretroviral therapy has dramatically increased the lifespan of people living with HIV (PLWH), but advance care planning (ACP) and hospice services are underutilized in this population. The purpose of this study was to understand barriers and ... ...

    Abstract Antiretroviral therapy has dramatically increased the lifespan of people living with HIV (PLWH), but advance care planning (ACP) and hospice services are underutilized in this population. The purpose of this study was to understand barriers and facilitators to ACP among this group. PLWH (
    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 155897-3
    ISSN 1552-4523 ; 0733-4648
    ISSN (online) 1552-4523
    ISSN 0733-4648
    DOI 10.1177/07334648241233377
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    Zs.A 2901: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Noncommunicable Diseases: Yet Another Challenge for Human Immunodeficiency Virus Treatment and Care in Sub-Saharan Africa.

    Agan, Brian K / Marconi, Vincent C

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2019  Volume 71, Issue 8, Page(s) 1874–1876

    MeSH term(s) Diagnostic Tests, Routine ; HIV ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Kenya ; Noncommunicable Diseases/epidemiology ; Noncommunicable Diseases/therapy
    Language English
    Publishing date 2019-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciz1104
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    Zs.A 1505: Show issues Location:
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  9. Article ; Online: Co-occurrence of injection drug use and hepatitis C increases epigenetic age acceleration that contributes to all-cause mortality among people living with HIV.

    Liang, Xiaoyu / Justice, Amy C / Marconi, Vincent C / Aouizerat, Bradley E / Xu, Ke

    Epigenetics

    2023  Volume 18, Issue 1, Page(s) 2212235

    Abstract: Co-occurrence of injection drug use (IDU) and hepatitis C virus infection (HCV) is common in people living with HIV (PLWH) and leads to significantly increased mortality. Epigenetic clocks derived from DNA methylation (DNAm) are associated with disease ... ...

    Abstract Co-occurrence of injection drug use (IDU) and hepatitis C virus infection (HCV) is common in people living with HIV (PLWH) and leads to significantly increased mortality. Epigenetic clocks derived from DNA methylation (DNAm) are associated with disease progression and all-cause mortality. In this study, we hypothesized that epigenetic age mediates the relationships between the co-occurrence of IDU and HCV with mortality risk among PLWH. We tested this hypothesis in the Veterans Aging Cohort Study (
    MeSH term(s) Humans ; Hepacivirus/genetics ; Risk Factors ; Cohort Studies ; HIV Infections/complications ; HIV Infections/genetics ; DNA Methylation ; Substance Abuse, Intravenous/complications ; Hepatitis C/complications ; Hepatitis C/genetics ; Epigenesis, Genetic
    Language English
    Publishing date 2023-05-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1559-2308
    ISSN (online) 1559-2308
    DOI 10.1080/15592294.2023.2212235
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  10. Article ; Online: DNA methylation-based telomere length is associated with HIV infection, physical frailty, cancer, and all-cause mortality.

    Liang, Xiaoyu / Aouizerat, Bradley E / So-Armah, Kaku / Cohen, Mardge H / Marconi, Vincent C / Xu, Ke / Justice, Amy C

    Aging cell

    2024  , Page(s) e14174

    Abstract: Telomere length (TL) is an important indicator of cellular aging. Shorter TL is associated with several age-related diseases including coronary heart disease, heart failure, diabetes, osteoporosis, and cancer. Recently, a DNA methylation-based TL (DNAmTL) ...

    Abstract Telomere length (TL) is an important indicator of cellular aging. Shorter TL is associated with several age-related diseases including coronary heart disease, heart failure, diabetes, osteoporosis, and cancer. Recently, a DNA methylation-based TL (DNAmTL) estimator has been developed as an alternative method for directly measuring TL. In this study, we examined the association of DNAmTL with cancer prevalence and mortality risk among people with and without HIV in the Veterans Aging Cohort Study Biomarker Cohort (VACS, N = 1917) and Women's Interagency HIV Study Cohort (WIHS, N = 481). We profiled DNAm in whole blood (VACS) or in peripheral blood mononuclear cells (WIHS) using an array-based method. Cancer prevalence was estimated from electronic medical records and cancer registry data. The VACS Index was used as a measure of physiologic frailty. Models were adjusted for self-reported race and ethnicity, batch, smoking status, alcohol consumption, and five cell types (CD4, CD8, NK, B cell, and monocyte). We found that people with HIV had shorter average DNAmTL than those without HIV infection [beta = -0.25, 95% confidence interval (-0.32, -0.18), p = 1.48E-12]. Greater value of VACS Index [beta = -0.002 (-0.003, -0.001), p = 2.82E-05] and higher cancer prevalence [beta = -0.07 (-0.10, -0.03), p = 1.37E-04 without adjusting age] were associated with shortened DNAmTL. In addition, one kilobase decrease in DNAmTL was associated with a 40% increase in mortality risk [hazard ratio: 0.60 (0.44, 0.82), p = 1.42E-03]. In summary, HIV infection, physiologic frailty, and cancer are associated with shortening DNAmTL, contributing to an increased risk of all-cause mortality.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.14174
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