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  1. Article ; Online: Photon-Counting Detector CT: Clinical Utility of Virtual Monoenergetic Imaging Combined With Tin Prefiltration to Reduce Metal Artifacts in the Postoperative Ankle.

    Marth, Adrian A / Goller, Sophia S / Kajdi, Georg W / Marcus, Roy P / Sutter, Reto

    Investigative radiology

    2024  

    Abstract: Objectives: The aim of this study was to compare the effectiveness and clinical utility of virtual monoenergetic image (VMI) reconstructions in computed tomography (CT) scans with and without tin prefiltration on a photon-counting detector (PCD) CT ... ...

    Abstract Objectives: The aim of this study was to compare the effectiveness and clinical utility of virtual monoenergetic image (VMI) reconstructions in computed tomography (CT) scans with and without tin prefiltration on a photon-counting detector (PCD) CT system to reduce metal implant artifacts in the postoperative ankle.
    Materials and methods: This retrospective study included patients with internal fixation of the ankle scanned with and without tin prefiltration (Sn) on a PCD CT scanner between March and October 2023. Virtual monoenergetic images between 60 and 190 keV were reconstructed with a 10-keV increment in a bone kernel for both acquisitions (VMISn and VMIStd, respectively). Noise measurements assessed artifact reduction in the most prominent near-metal image distortions and were compared between acquisitions modes as well as between polychromatic images and VMIs. Three readers assessed the visibility of osseous healing along with interpretability and artifact extent for 5 reconstruction levels.
    Results: A total of 48 patients (21 females, 27 males; mean age, 55.1 ± 19.4 years) were included in this study. Tin-prefiltered acquisitions (n = 30) had a lower artifact level for polychromatic images and VMIs compared with non-tin-prefiltered acquisitions (n = 18; P ≤ 0.043). A significant reduction of metal artifacts was observed for VMISn ≥120 keV compared with polychromatic images (hyperdense artifacts: 40.2 HU [interquartile range (IQR) 39.8] vs 14.0 HU [IQR 11.1]; P ≤ 0.01 and hypodense artifacts: 91.2 HU [IQR 82.4] vs 29.7 HU [IQR 39.6]; P ≤ 0.001). For VMIStd, this applied to reconstructions ≥100 keV (hyperdense artifacts: 57.7 HU [IQR 33.4] vs 19.4 HU [IQR 27.6]; P ≤ 0.001 and hypodense artifacts: 106.9 HU [IQR 76.1] vs 57.4 HU [IQR 55.7]; P ≤ 0.021). For visibility of osseous healing, VMISn at 120 keV yielded higher ratings compared with polychromatic images (P ≤ 0.001), whereas image interpretability was rated better (P = 0.023), and artifact extent was rated lower (P ≤ 0.001) compared with polychromatic images.
    Conclusions: Tin-prefiltered VMI at 120 keV showed a significant reduction in metal artifacts compared with polychromatic images, whereas visibility of osseous healing and image interpretability was improved. Therefore, tin-prefiltration PCD CT with VMI reconstructions may be a helpful complement to postsurgical CT imaging of the ankle in patients with metal implants.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80345-5
    ISSN 1536-0210 ; 0020-9996
    ISSN (online) 1536-0210
    ISSN 0020-9996
    DOI 10.1097/RLI.0000000000001058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How accurate is MRI for diagnosing tarsal coalitions? A retrospective diagnostic accuracy study.

    Marth, Adrian A / Feuerriegel, Georg C / Marcus, Roy P / Sutter, Reto

    European radiology

    2023  

    Abstract: Objectives: This study aimed to evaluate the diagnostic accuracy, inter-reader agreement, and associated pathologies on MR images of patients with confirmed TC.: Methods and materials: In this retrospective study, 168 ankle MRI exams were included, ... ...

    Abstract Objectives: This study aimed to evaluate the diagnostic accuracy, inter-reader agreement, and associated pathologies on MR images of patients with confirmed TC.
    Methods and materials: In this retrospective study, 168 ankle MRI exams were included, consisting of 56 patients with clinically or surgically confirmed TC and 112 controls without TC, matched for age and sex. Images were analyzed independently by three radiologists blinded to clinical information. The evaluation criteria included the presence, type, and location of TC, as well as associated pathologies. After calculating diagnostic accuracy and the odds ratio of demographic data and anatomic coalition type for associated pathologies, inter-reader agreement was assessed using kappa statistics.
    Results: The majority of TCs were non-osseous (91.1%) and located at the calcaneonavicular (33.9%) or talocalcaneal joint (66.1%). Associated pathologies included adjacent and distant bone marrow edema (57.1% and 25.0%), osteochondral defect of the talar dome (OCD, 19.6%), and joint effusion (10.7%) and accessory anterolateral talar facet (17.9%). Talar OCD was associated with increased patient age (p = 0.03). MRI exhibited a cumulative sensitivity and specificity of 95.8% and 94.3% with almost perfect inter-reader agreement (κ = 0.895).
    Conclusion: MRI is a reliable method for detecting tarsal coalition and identifying commonly associated pathologies. Therefore, we recommend the routine use of MRI in the diagnostic workup of patients with foot pain and suspected tarsal coalition.
    Clinical relevance statement: MRI is an accurate and reliable modality for diagnosing tarsal coalitions and detecting associated pathologies, while improving patient safety compared to computed tomography by avoiding radiation exposure.
    Key points: • Despite the technological progress in magnetic resonance imaging (MRI), computed tomography (CT) is still regarded as the gold standard for diagnosing tarsal coalition (TC). • MRI had a cumulative sensitivity of 95.8% and specificity of 94.3% for detecting tarsal coalition with an almost perfect inter-reader agreement. • MRI demonstrates high accuracy and reliability in diagnosing tarsal coalitions and is useful for identifying associated pathologies, while also improving patient safety by avoiding radiation exposure.
    Language English
    Publishing date 2023-10-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10304-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: How accurate is MRI for diagnosing tarsal coalitions? A retrospective diagnostic accuracy study.

    Marth, Adrian A / Feuerriegel, Georg C / Marcus, Roy P / Sutter, Reto

    European radiology

    2023  

    Language English
    Publishing date 2023-12-22
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10531-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Photon-Counting Detector CT Versus Energy-Integrating Detector CT of the Lumbar Spine: Comparison of Radiation Dose and Image Quality.

    Marth, Adrian A / Marcus, Roy P / Feuerriegel, Georg C / Nanz, Daniel / Sutter, Reto

    AJR. American journal of roentgenology

    2023  Volume 222, Issue 1, Page(s) e2329950

    Abstract: BACKGROUND. ...

    Abstract BACKGROUND.
    MeSH term(s) Male ; Humans ; Female ; Adult ; Tin ; Prospective Studies ; Retrospective Studies ; Photons ; Phantoms, Imaging ; Tomography, X-Ray Computed/methods ; Radiation Dosage
    Chemical Substances Tin (7440-31-5)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.23.29950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Photon-Counting Detector CT With Denoising for Imaging of the Osseous Pelvis at Low Radiation Doses: A Phantom Study.

    Marcus, Roy P / Nagy, Daniel A / Feuerriegel, Georg C / Anhaus, Julian / Nanz, Daniel / Sutter, Reto

    AJR. American journal of roentgenology

    2023  Volume 222, Issue 1, Page(s) e2329765

    Abstract: BACKGROUND. ...

    Abstract BACKGROUND.
    MeSH term(s) Humans ; Tin ; Photons ; Tomography, X-Ray Computed/methods ; Phantoms, Imaging ; Radiation Dosage ; Pelvis
    Chemical Substances Tin (7440-31-5)
    Language English
    Publishing date 2023-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.23.29765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Fat Fractions of the Rotator Cuff Muscles Acquired With 2-Point Dixon MRI: Predicting Outcome After Arthroscopic Rotator Cuff Repair.

    Feuerriegel, Georg C / Marcus, Roy P / Sommer, Stefan / Wieser, Karl / Bouaicha, Samy / Sutter, Reto

    Investigative radiology

    2023  Volume 59, Issue 4, Page(s) 328–336

    Abstract: Objectives: The aim of this study was to quantify and compare fat fraction (FF) and muscle volume between patients with failed and intact rotator cuff (RC) repair as well as a control group with nonsurgical conservative treatment to define FF cutoff ... ...

    Abstract Objectives: The aim of this study was to quantify and compare fat fraction (FF) and muscle volume between patients with failed and intact rotator cuff (RC) repair as well as a control group with nonsurgical conservative treatment to define FF cutoff values for predicting the outcome of RC repair.
    Materials and methods: Patients with full-thickness RC tears who received magnetic resonance imaging (MRI) before and after RC repair including a 2-point Dixon sequence were retrospectively screened. Patients with retear of 1 or more tendons diagnosed on MRI (Sugaya IV-V) were enrolled and matched to patients with intact RC repair (Sugaya I-II) and to a third group with conservatively treated RC tears. Two radiologists evaluated morphological features (Cofield, Patte, and Goutallier), as well as the integrity of the RC after repair (Sugaya). Fat fractions were calculated from the 2-point Dixon sequence, and the RC muscles were segmented semiautomatically to calculate FFs and volume for each muscle. Receiver operator characteristics curves were used to determine FF cutoff values that best predict RC retears.
    Results: In total, 136 patients were enrolled, consisting of 3 groups: 41 patients had a failed RC repair (58 ± 7 years, 16 women), 50 patients matched into the intact RC repair group, and 45 patients were matched into the conservative treatment group. Receiver operator characteristics curves showed reliable preoperative FF cutoff values for predicting retears at 6.0% for the supraspinatus muscle (0.83 area under the curve [AUC]), 7.4% for the infraspinatus muscle (AUC 0.82), and 8.3% for the subscapularis muscle (0.94 AUC).
    Conclusions: Preoperative quantitative FF calculated from 2-point Dixon MRI can be used to predict the risk of retear after arthroscopic RC repair with cutoff values between 6% and 8.3%.
    MeSH term(s) Humans ; Female ; Rotator Cuff/diagnostic imaging ; Rotator Cuff/surgery ; Rotator Cuff/pathology ; Retrospective Studies ; Rotator Cuff Injuries/diagnostic imaging ; Rotator Cuff Injuries/surgery ; Rotator Cuff Injuries/pathology ; Tendons ; Magnetic Resonance Imaging/methods ; Treatment Outcome
    Language English
    Publishing date 2023-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80345-5
    ISSN 1536-0210 ; 0020-9996
    ISSN (online) 1536-0210
    ISSN 0020-9996
    DOI 10.1097/RLI.0000000000001024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dynamic computed tomographic assessment of the mitral annulus in patients with and without mitral prolapse.

    Rizvi, Asim / Marcus, Roy P / Guo, Yugene / Carter, Rickey / Mark, Ian T / Foley, Thomas A / Weber, Nikkole M / Sheedy, Emily N / Leng, Shuai / Williamson, Eric E

    Journal of cardiovascular computed tomography

    2020  Volume 14, Issue 6, Page(s) 502–509

    Abstract: Objectives: To obtain 3D CT measurements of mitral annulus throughout cardiac cycle using prototype mitral modeling software, assess interobserver agreement, and compare among patients with mitral prolapse (MP) and control group.: Background: Pre- ... ...

    Abstract Objectives: To obtain 3D CT measurements of mitral annulus throughout cardiac cycle using prototype mitral modeling software, assess interobserver agreement, and compare among patients with mitral prolapse (MP) and control group.
    Background: Pre-procedural imaging is critical for planning of transcatheter mitral valve (MV) replacement. However, there is limited data regarding reliable CT-based measurements to accurately characterize the dynamic geometry of the mitral annulus in patients with MV disease.
    Methods: Patients with MP and control subjects without any MV disease who underwent ECG-gated cardiac CT were retrospectively identified. Multiphasic CT data was loaded into a prototype mitral modeling software. Multiple anatomical parameters in 3D space were recorded throughout the cardiac cycle (0-95%): annular circumference, planar-surface-area (PSA), anterior-posterior (A-P) distance, and anterolateral-posteromedial (AL-PM) distance. Comparisons were made among the two groups, with p < 0.05 considered statistically significant. Interobserver agreement was assessed on ten patients using intraclass correlation coefficient (ICC) among 4 experienced readers.
    Results: A total of 100 subjects were included: 50 with MP and 50 control. Annular dimensions were significantly higher in the MP group than control group, with circumference (144 ± 11 vs. 117±8 mm), PSA (1533 ± 247 vs. 1005 ± 142 mm
    Conclusion: A significant variation in the mitral annular measures between different cardiac phases and two groups was observed with excellent interobserver agreement.
    MeSH term(s) Adult ; Aged ; Cardiac-Gated Imaging Techniques ; Computed Tomography Angiography ; Coronary Angiography ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/physiopathology ; Mitral Valve Prolapse/diagnostic imaging ; Mitral Valve Prolapse/physiopathology ; Observer Variation ; Predictive Value of Tests ; Reproducibility of Results ; Retrospective Studies
    Language English
    Publishing date 2020-02-27
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 2394360-9
    ISSN 1876-861X ; 1934-5925
    ISSN (online) 1876-861X
    ISSN 1934-5925
    DOI 10.1016/j.jcct.2020.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The evolution of radiation dose over time: Measurement of a patient cohort undergoing whole-body examinations on three computer tomography generations.

    Marcus, Roy P / Koerner, Elise / Aydin, Roland C / Zinsser, Dominik / Finke, Tobias / Cyron, Christian J / Bamberg, Fabian / Nikolaou, Konstantin / Notohamiprodjo, Mike

    European journal of radiology

    2017  Volume 86, Page(s) 63–69

    Abstract: Objectives: To evaluate and compare the radiation dose and image quality of whole-body-CT (WBCT) performed on the 3rd-generation dual-source-CT (DSCT) with 2nd-generation DSCT and 64-slices-Single-Source-CT (SSCT) in a large patient cohort.: Material ... ...

    Abstract Objectives: To evaluate and compare the radiation dose and image quality of whole-body-CT (WBCT) performed on the 3rd-generation dual-source-CT (DSCT) with 2nd-generation DSCT and 64-slices-Single-Source-CT (SSCT) in a large patient cohort.
    Material and methods: Using a monitoring and tracking software 1451, 747 and 1861 patients scanned with a one-spiral-thorax-abdomen-pelvis-CT-examination on a 3rd-, 2nd-generation DSCT and SSCT, respectively, were extracted from the PACS server. For the intra-individual analysis, 203 patients on the 3rd-generation DSCT were identified. Out of those 203 patients, 155 had the same examination on the 2nd-generation DSCT, 91 patients had the same examination on the SSCT and 43 patients had an examination on all three CT-generations. Automatic tube current modulation was active on all three CT-generations, whereas automatic tube voltage selection was only available on both DSCT-generations. Dose was recorded by the size-specific-dose-estimate-method (SSDE); signal-to-noise-ratio (SNR) and contrast-to-noise-ratio (CNR) were calculated placing a ROI on the ascending aorta/liver and the subcutaneous adipose tissue at comparable level. Image quality of axillary and mediastinal lymph nodes and adrenal glands was assessed by two experienced radiologists.
    Results: Subjective image quality was excellent throughout all three CT-generations (p=0.38-0.98). Quantitative image quality in both DSCT generations was superior to SSCT (p<0.001). SNR and CNR in the liver parenchyma were superior in the 3rd-generation DSCT compared to the 2nd generation DSCT (p<0.001), whereas there was no difference in the aorta. In the inter-individual analysis, CTDI
    Conclusion: State-of-the-art CT-equipment substantially reduce radiation dose without affecting image quality.
    MeSH term(s) Aorta, Thoracic/radiation effects ; Female ; Humans ; Liver/radiation effects ; Male ; Middle Aged ; Physical Examination ; Radiation Dosage ; Radiographic Image Interpretation, Computer-Assisted/methods ; Retrospective Studies ; Signal-To-Noise Ratio ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2017-01
    Publishing country Ireland
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2016.11.002
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  9. Article ; Online: The use of coronary CT angiography for the evaluation of chest pain.

    Schlett, Christopher L / Pursnani, Amit / Marcus, Roy P / Truong, Quynh A / Hoffmann, Udo

    Cardiology in review

    2014  Volume 22, Issue 3, Page(s) 117–127

    Abstract: Coronary computed tomography angiography (CCTA) may improve the diagnosis and management of acute and stable chest pain syndromes. The key for caregivers of patients presenting with acute chest pain is the early identification and management of life- ... ...

    Abstract Coronary computed tomography angiography (CCTA) may improve the diagnosis and management of acute and stable chest pain syndromes. The key for caregivers of patients presenting with acute chest pain is the early identification and management of life-threatening conditions, such as acute coronary syndromes, pulmonary embolism, and acute aortic dissection. The main goal in stable chest pain syndromes is to determine the extent and severity of coronary artery disease. This review article will critically evaluate the current literature supporting the evidence for the clinical use of CCTA in acute and stable chest pain syndromes, considering the latest innovations in CCTA technology and their potential impact on patient care.
    MeSH term(s) Chest Pain/diagnostic imaging ; Coronary Angiography ; Humans ; Radiation Dosage ; Tomography, X-Ray Computed
    Language English
    Publishing date 2014-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1294965-6
    ISSN 1538-4683 ; 1061-5377
    ISSN (online) 1538-4683
    ISSN 1061-5377
    DOI 10.1097/CRD.0000000000000015
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  10. Article ; Online: Detection and Characterization of Renal Stones by Using Photon-Counting-based CT.

    Marcus, Roy P / Fletcher, Joel G / Ferrero, Andrea / Leng, Shuai / Halaweish, Ahmed F / Gutjahr, Ralf / Vrtiska, Terri J / Wells, Mike L / Enders, Felicity T / McCollough, Cynthia H

    Radiology

    2018  Volume 289, Issue 2, Page(s) 436–442

    Abstract: Purpose To compare a research photon-counting-detector (PCD) CT scanner to a dual-source, dual-energy CT scanner for the detection and characterization of renal stones in human participants with known stones. Materials and Methods Thirty study ... ...

    Abstract Purpose To compare a research photon-counting-detector (PCD) CT scanner to a dual-source, dual-energy CT scanner for the detection and characterization of renal stones in human participants with known stones. Materials and Methods Thirty study participants (median age, 61 years; 10 women) underwent a clinical renal stone characterization scan by using dual-energy CT and a subsequent research PCD CT scan by using the same radiation dose (as represented by volumetric CT dose index). Two radiologists were tasked with detection of stones, which were later characterized as uric acid or non-uric acid by using a commercial dual-energy CT analysis package. Stone size and contrast-to-noise ratio were additionally calculated. McNemar odds ratios and Cohen k were calculated separately for all stones and small stones (≤3 mm). Results One-hundred sixty renal stones (91 stones that were ≤ 3 mm in axial length) were visually detected. Compared with 1-mm-thick routine images from dual-energy CT, the odds of detecting a stone at PCD CT were 1.29 (95% confidence interval: 0.48, 3.45) for all stones. Stone segmentation and characterization were successful at PCD CT in 70.0% (112 of 160) of stones versus 54.4% (87 of 160) at dual-energy CT, and was superior for stones 3 mm or smaller at PCD CT (45 vs 25 stones, respectively; P = .002). Stone characterization agreement between scanners for stones of all sizes was substantial (k = 0.65). Conclusion Photon-counting-detector CT is similar to dual-energy CT for helping to detect renal stones and is better able to help characterize small renal stones. © RSNA, 2018.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Kidney/diagnostic imaging ; Kidney Calculi/diagnostic imaging ; Male ; Middle Aged ; Photons ; Prospective Studies ; Radiographic Image Interpretation, Computer-Assisted/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Signal-To-Noise Ratio ; Tomography, X-Ray Computed/instrumentation ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2018-08-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2018180126
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