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  1. Article ; Online: Can We Rely on Resting Metabolic Rate Equations? Large Variance in Crohn Disease Pediatric Patients.

    Marderfeld, Luba / Guz Mark, Anat / Biran, Neta / Shamir, Raanan

    Journal of pediatric gastroenterology and nutrition

    2023  Volume 77, Issue 3, Page(s) 389–392

    Abstract: Objectives: Inadequate caloric intake is common in Crohn disease (CD) and nutrition support plays an important role in remission induction and in meeting nutritional needs. For nutritional planning, determining resting metabolic rate (RMR) is essential ... ...

    Abstract Objectives: Inadequate caloric intake is common in Crohn disease (CD) and nutrition support plays an important role in remission induction and in meeting nutritional needs. For nutritional planning, determining resting metabolic rate (RMR) is essential in pediatric patients with CD.
    Study aim: To measure RMR in CD pediatric patients using indirect calorimetry, and compare it with estimated RMR (eRMR) calculated by Schofield equation.
    Methods: Children with CD treated in a tertiary pediatric inflammatory bowel disease center in Israel participated in the cross-sectional study. At study visits, weight, height, clinical and laboratory assessments, bioelectrical impedance, and RMR measured by indirect calorimetry were done. Additionally, disease severity was determined by the Pediatric Crohn Disease Activity Index and eRMR was calculated using the Schofield equation. The ratio of the measured RMR to eRMR was performed in addition to the Spearman correlation test.
    Results: The study group included 73 children (49 boys) with mean age of 13.9 ± 2.3 years. Children with moderate or severe disease had lower weight for age z score, lower BMI- z , and lower RMR compared to children with mild disease. However, when RMR was adjusted for fat free mass (n = 50), the association between RMR and disease severity disappeared. Variance in RMR was high between subjects.
    Conclusions: Our data suggest that the Schofield equation is inadequate for determining RMR in pediatric CD and that RMR should be measured to guarantee the most appropriate nutritional intervention.
    MeSH term(s) Male ; Humans ; Child ; Adolescent ; Basal Metabolism ; Crohn Disease ; Cross-Sectional Studies ; Energy Intake ; Calorimetry, Indirect ; Body Composition
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000003878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A randomized trial evaluating the utility of non-targeted biopsies for colorectal neoplasia detection in adults with inflammatory bowel disease: a pilot study protocol.

    Murthy, Sanjay K / Marderfeld, Luba / Fergusson, Dean / Ramsay, Tim / Bernstein, Charles N / Nguyen, Geoffrey C / Jairath, Vipul / Riddell, Robert

    Pilot and feasibility studies

    2024  Volume 10, Issue 1, Page(s) 20

    Abstract: Background: Persons with inflammatory bowel diseases are at increased risk of developing colorectal cancer and require frequent colonoscopy surveillance. Guidelines recommend taking 30 to 40 non-targeted biopsies throughout the colorectum to detect " ... ...

    Abstract Background: Persons with inflammatory bowel diseases are at increased risk of developing colorectal cancer and require frequent colonoscopy surveillance. Guidelines recommend taking 30 to 40 non-targeted biopsies throughout the colorectum to detect "invisible" neoplasia in this setting, despite a lack of evidence supporting this practice. We sought to assess the utility of this practice through a randomized controlled trial. We first propose an internal pilot study to assess recruitment potential, protocol adherence and data capture to guide the full trial.
    Methods: We have designed a multi-centre, parallel-group, non-inferiority randomized controlled trial to test the utility of non-targeted biopsies as an adjunct to colonoscopy surveillance for neoplasia detection in persons with inflammatory bowel disease involving the colorectum in routine clinical practice. Participants are randomized 1:1, stratified by study site, to either standard of care high-definition white-light colonoscopy with 32 to 40 non-targeted biopsies of non-neoplastic-appearing mucosa along with a sampling of abnormal-appearing mucosa (control group) or modified colonoscopy with targeted sampling alone (intervention group). The primary outcome for the full trial will be the proportion of persons with ≥ 1 neoplastic focus detected during colonoscopy. For the pilot phase, we will assess the feasibility of recruiting a minimum of 15% of the estimated sample size within 1 year, under identical conditions as the full trial, while maintaining ≥ 90-95% rate of protocol adherence and data capture. These participants will contribute data to the full trial. The trial is being conducted at 12 centres across Canada, with a total sample size of 1952 persons.
    Discussions: The trial protocol has been approved by the ethics committees of all participating sites, and the pilot study has received funding through the Canadian Institutes of Health Research (PJT 159607). If feasibility metrics are met during the pilot phase, we will complete the full trial. The trial outcomes will contribute to update the practice guidelines in this area.
    Trial registration: ClinicalTrials.gov, NCT04067778.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2809935-7
    ISSN 2055-5784
    ISSN 2055-5784
    DOI 10.1186/s40814-023-01434-8
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  3. Article: Children with Intestinal Failure Maintain Their Renal Function on Long-Term Parenteral Nutrition

    Guz Mark, Anat / Levi, Shelly / Davidovits, Miriam / Marderfeld, Luba / Shamir, Raanan

    Nutrients. 2021 Oct. 18, v. 13, no. 10

    2021  

    Abstract: Background: Long-term parenteral nutrition (PN) has been associated with renal complications, including hypercalciuria, nephrocalcinosis, proteinuria and reduced glomerular filtration rate (GFR). Pediatric data are scarce and mostly short-term. Our study ...

    Abstract Background: Long-term parenteral nutrition (PN) has been associated with renal complications, including hypercalciuria, nephrocalcinosis, proteinuria and reduced glomerular filtration rate (GFR). Pediatric data are scarce and mostly short-term. Our study aimed to evaluate renal complications in children with intestinal failure (IF) receiving long-term PN. Methods: A cross-sectional study was performed in a tertiary pediatric IF clinic of patients receiving home-PN treatment for more than 1 year. Data regarding medical background, anthropometrics, laboratory investigations and abdominal sonography were retrieved. Results: Complete data were available for 15 children (67% males), with a median age of 6 (range 1.5–15) years and a median (IQR) PN duration of 4 (1.5–6) years. Low-grade proteinuria was identified in 61% and microalbuminuria in 30% of the cohort. Hypercalciuria and hyperoxaluria were present in 50% and 46%, respectively. One patient had nephrocalcinosis. The estimated GFR was normal in all but one patient who had pre-existing kidney disease. Conclusions: Pediatric IF patients can present with preserved kidney function after years of PN treatment. Despite the high prevalence of hypercalciuria, nephrocalcinosis was not common. Base line and long-term monitoring of various aspects of renal function would be essential to characterize the effects of prolonged PN on kidney functions in pediatric patients.
    Keywords albuminuria ; anthropometric measurements ; cross-sectional studies ; glomerular filtration rate ; intestines ; kidneys ; nephrocalcinosis ; parenteral feeding ; patients ; ultrasonography
    Language English
    Dates of publication 2021-1018
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13103647
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Children with Intestinal Failure Maintain Their Renal Function on Long-Term Parenteral Nutrition.

    Guz Mark, Anat / Levi, Shelly / Davidovits, Miriam / Marderfeld, Luba / Shamir, Raanan

    Nutrients

    2021  Volume 13, Issue 10

    Abstract: Background: Long-term parenteral nutrition (PN) has been associated with renal complications, including hypercalciuria, nephrocalcinosis, proteinuria and reduced glomerular filtration rate (GFR). Pediatric data are scarce and mostly short-term. Our ... ...

    Abstract Background: Long-term parenteral nutrition (PN) has been associated with renal complications, including hypercalciuria, nephrocalcinosis, proteinuria and reduced glomerular filtration rate (GFR). Pediatric data are scarce and mostly short-term. Our study aimed to evaluate renal complications in children with intestinal failure (IF) receiving long-term PN.
    Methods: A cross-sectional study was performed in a tertiary pediatric IF clinic of patients receiving home-PN treatment for more than 1 year. Data regarding medical background, anthropometrics, laboratory investigations and abdominal sonography were retrieved.
    Results: Complete data were available for 15 children (67% males), with a median age of 6 (range 1.5-15) years and a median (IQR) PN duration of 4 (1.5-6) years. Low-grade proteinuria was identified in 61% and microalbuminuria in 30% of the cohort. Hypercalciuria and hyperoxaluria were present in 50% and 46%, respectively. One patient had nephrocalcinosis. The estimated GFR was normal in all but one patient who had pre-existing kidney disease.
    Conclusions: Pediatric IF patients can present with preserved kidney function after years of PN treatment. Despite the high prevalence of hypercalciuria, nephrocalcinosis was not common. Base line and long-term monitoring of various aspects of renal function would be essential to characterize the effects of prolonged PN on kidney functions in pediatric patients.
    MeSH term(s) Adolescent ; Amino Acids/metabolism ; Child ; Child, Preschool ; Creatinine/urine ; Female ; Humans ; Infant ; Intestines/physiopathology ; Kidney/physiopathology ; Male ; Parenteral Nutrition, Total ; Proteinuria/complications ; Proteinuria/urine
    Chemical Substances Amino Acids ; Creatinine (AYI8EX34EU)
    Language English
    Publishing date 2021-10-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu13103647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Eosinophilic Esophagitis Patients Are Not at Increased Risk of Severe COVID-19: A Report From a Global Registry.

    Zevit, Noam / Chehade, Mirna / Leung, John / Marderfeld, Luba / Dellon, Evan S

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 1, Page(s) 143–149.e9

    Abstract: Background: The impact of coronavirus disease 2019 (COVID-19) on eosinophilic esophagitis (EoE) and eosinophilic gastrointestinal diseases (EGIDs) is unknown.: Objective: We aimed to characterize patients with EoE and EGIDs who had COVID-19, assess ... ...

    Abstract Background: The impact of coronavirus disease 2019 (COVID-19) on eosinophilic esophagitis (EoE) and eosinophilic gastrointestinal diseases (EGIDs) is unknown.
    Objective: We aimed to characterize patients with EoE and EGIDs who had COVID-19, assess severity of COVID-19 in the EoE/EGID population, and evaluate for COVID-19-induced EoE/EGID flares.
    Methods: We established an online global registry collecting physician entered, deidentified data related to patient demographics, EoE/EGID disease features, comorbidities, and treatments, COVID-19 source of exposure, symptoms, illness severity, hospitalizations, and deaths.
    Results: Ninety-four cases were reported between March 2020 and April 2021 (median age, 21 years; range, 1.5-53 years; 73% male). Most had atopy (73%), and 80% had isolated EoE. Before COVID-19, the EoE/EGID activity was reported as clinical remission in 51 (54%) and moderate in 20 (21%). EoE/EGID treatments at the time of COVID-19 included proton pump inhibitors 49 (52%), swallowed/topical steroids 48 (51%), and dietary elimination 34 (36%). COVID-19 symptoms included cough (56%), fever (49%), anosmia (21%), and ageusia (22%). Most patients with COVID-19 had a mild course (70%), with 15% asymptomatic, 12% moderate, and 2% severe. Three patients were hospitalized, and no intensive care unit admissions or deaths were reported. Mean time from first symptoms to resolution in symptomatic patients was 10 days (range, 1-90 days). A single EGID flare was reported during COVID-19.
    Conclusions: In a global EoE/EGID registry, relatively few COVID-19 cases have been reported. COVID-19 severity was comparable to the general population. Based on this registry, it does not appear that patients with EoE are at increased risk for severe COVID-19 infection or that COVID-19 leads to EGID flares.
    MeSH term(s) Adult ; COVID-19 ; Enteritis ; Eosinophilic Esophagitis ; Female ; Humans ; Male ; Registries ; SARS-CoV-2 ; Young Adult
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.10.019
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  6. Article: The Long-Term Effects of Dietary Nutrient Intakes during the First 2 Years of Life in Healthy Infants from Developed Countries: An Umbrella Review

    Agostoni, Carlo / Guz-Mark, Anat / Marderfeld, Luba / Milani, Gregorio P / Silano, Marco / Shamir, Raanan

    Advances in nutrition. 2019 May 01, v. 10, no. 3

    2019  

    Abstract: The role of both qualitative and quantitative early nutrient intakes on later health has been suggested for decades and supported by observational studies on humans, mainly preterm and low-birth-weight infants, and animal models. However, to date, no ... ...

    Abstract The role of both qualitative and quantitative early nutrient intakes on later health has been suggested for decades and supported by observational studies on humans, mainly preterm and low-birth-weight infants, and animal models. However, to date, no comprehensive review has been conducted to evaluate the full impact of nutritional variables on healthy full-term infants. This umbrella review considers meta-analyses and systematic reviews on the health effects of different nutritional exposures or interventions in the first 2 y of life of healthy full-term infants in developed countries. The systematic reviews and meta-analyses published by March 2018 in MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews were included. The following outcomes were considered: growth and obesity, cardiovascular disease, neurodevelopment, allergy and autoimmunity, infections, and malignancy. Breastfeeding and complementary feeding were considered separately and analyzed by means of their differences in delivering heterogeneous food-related variables. The resulting data on the long-term effect of early nutritional differences in healthy full-term infants were found to be inconclusive. Only breastfeeding has a beneficial effect, which is nevertheless slight and limited to just a few outcome measures, whereas the type and duration required to be effective are still unclear. As regards the complementary feeding period, no clear effects of different dietary interventions emerge in terms of health outcomes. Available evidence on the health effects of differences in early nutrition in healthy full-term infants still remains largely inconclusive.
    Keywords animal models ; autoimmunity ; breast feeding ; cardiovascular diseases ; complementary feeding ; complementary foods ; databases ; developed countries ; health effects assessments ; humans ; hypersensitivity ; infants ; long term effects ; low birth weight ; meta-analysis ; neurodevelopment ; nutritional intervention ; obesity ; observational studies ; systematic review
    Language English
    Dates of publication 2019-0501
    Size p. 489-501.
    Publishing place Oxford University Press
    Document type Article
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2161-8313
    ISSN (online) 2156-5376
    ISSN 2161-8313
    DOI 10.1093/advances/nmy106
    Database NAL-Catalogue (AGRICOLA)

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  7. Article: Validation and impact of paediatric malnutrition screening tool in hospitalised children on awareness of medical staff and health‐related outcomes

    Marderfeld, Luba / Rub, Gal / Hodik, Gavriel / Poraz, Irit / Hartman, Corina / Ashkenazi, Shai / Shamir, Raanan

    Nutrition & dietetics. 2019 Nov., v. 76, no. 5

    2019  

    Abstract: AIMS: This study aimed to evaluate the use of the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) among children admitted in a paediatric hospital, and assess its impact on the nutritional status awareness among the medical staff ...

    Abstract AIMS: This study aimed to evaluate the use of the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) among children admitted in a paediatric hospital, and assess its impact on the nutritional status awareness among the medical staff and on health outcomes at discharge. METHODS: STAMP performed by nurses on admission was compared with full nutritional assessment performed by a dietitian. Area under the receiving operating characteristic (AUROC) curve was used to evaluate validity of the tool. To assess how the tool affected awareness among the staff, information on nutritional status was compared prior to and following the intervention period. Therewith, health outcomes at discharge were compared for the children who had been screened by STAMP and the children who had not. RESULTS: The analysis was performed for a total of 60 children (38 boys, 63%). The mean age was 7.8 ± 4.7 years. Malnutrition was found in 16% of patients, segregating equally between acute and chronic malnutrition. Sensitivity, specificity, positive predictive value and negative predictive value were 95.7% (95% confidence interval, CI = 85.75–98.83%), 76.9% (95% CI = 49.74–91.82%), 93.7 and 83.3, respectively. AUROC was 0.863 (95% CI = 0.72–1). There was no difference either in malnutrition awareness among the medical staff before and after the intervention period or in health outcomes at discharge. CONCLUSIONS: STAMP is a valid tool for malnutrition screening in hospitalised children; however, its use does not influence admitted patients’ nutritional status awareness among the medical staff nor their outcomes at discharge.
    Keywords boys ; children ; confidence interval ; dietitians ; hospitals ; malnutrition ; nurses ; nutrition assessment ; nutritional status ; patients ; pediatrics ; screening
    Language English
    Dates of publication 2019-11
    Size p. 574-579.
    Publishing place John Wiley & Sons Australia, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2082047-1
    ISSN 1747-0080 ; 1446-6368
    ISSN (online) 1747-0080
    ISSN 1446-6368
    DOI 10.1111/1747-0080.12529
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  8. Article ; Online: The Long-Term Effects of Dietary Nutrient Intakes during the First 2 Years of Life in Healthy Infants from Developed Countries: An Umbrella Review.

    Agostoni, Carlo / Guz-Mark, Anat / Marderfeld, Luba / Milani, Gregorio P / Silano, Marco / Shamir, Raanan

    Advances in nutrition (Bethesda, Md.)

    2019  Volume 10, Issue 3, Page(s) 489–501

    Abstract: The role of both qualitative and quantitative early nutrient intakes on later health has been suggested for decades and supported by observational studies on humans, mainly preterm and low-birth-weight infants, and animal models. However, to date, no ... ...

    Abstract The role of both qualitative and quantitative early nutrient intakes on later health has been suggested for decades and supported by observational studies on humans, mainly preterm and low-birth-weight infants, and animal models. However, to date, no comprehensive review has been conducted to evaluate the full impact of nutritional variables on healthy full-term infants. This umbrella review considers meta-analyses and systematic reviews on the health effects of different nutritional exposures or interventions in the first 2 y of life of healthy full-term infants in developed countries. The systematic reviews and meta-analyses published by March 2018 in MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews were included. The following outcomes were considered: growth and obesity, cardiovascular disease, neurodevelopment, allergy and autoimmunity, infections, and malignancy. Breastfeeding and complementary feeding were considered separately and analyzed by means of their differences in delivering heterogeneous food-related variables. The resulting data on the long-term effect of early nutritional differences in healthy full-term infants were found to be inconclusive. Only breastfeeding has a beneficial effect, which is nevertheless slight and limited to just a few outcome measures, whereas the type and duration required to be effective are still unclear. As regards the complementary feeding period, no clear effects of different dietary interventions emerge in terms of health outcomes. Available evidence on the health effects of differences in early nutrition in healthy full-term infants still remains largely inconclusive.
    MeSH term(s) Child, Preschool ; Developed Countries ; Eating/physiology ; Female ; Humans ; Infant ; Infant Nutritional Physiological Phenomena/physiology ; Infant, Newborn ; Male ; Meta-Analysis as Topic ; Nutrients/analysis ; Systematic Reviews as Topic ; Term Birth/physiology ; Time Factors
    Language English
    Publishing date 2019-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2583634-1
    ISSN 2156-5376 ; 2156-5376
    ISSN (online) 2156-5376
    ISSN 2156-5376
    DOI 10.1093/advances/nmy106
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  9. Article ; Online: Validation and impact of paediatric malnutrition screening tool in hospitalised children on awareness of medical staff and health-related outcomes.

    Marderfeld, Luba / Rub, Gal / Hodik, Gavriel / Poraz, Irit / Hartman, Corina / Ashkenazi, Shai / Shamir, Raanan

    Nutrition & dietetics: the journal of the Dietitians Association of Australia

    2019  Volume 76, Issue 5, Page(s) 574–579

    Abstract: Aims: This study aimed to evaluate the use of the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) among children admitted in a paediatric hospital, and assess its impact on the nutritional status awareness among the medical ... ...

    Abstract Aims: This study aimed to evaluate the use of the Screening Tool for the Assessment of Malnutrition in Paediatrics (STAMP) among children admitted in a paediatric hospital, and assess its impact on the nutritional status awareness among the medical staff and on health outcomes at discharge.
    Methods: STAMP performed by nurses on admission was compared with full nutritional assessment performed by a dietitian. Area under the receiving operating characteristic (AUROC) curve was used to evaluate validity of the tool. To assess how the tool affected awareness among the staff, information on nutritional status was compared prior to and following the intervention period. Therewith, health outcomes at discharge were compared for the children who had been screened by STAMP and the children who had not.
    Results: The analysis was performed for a total of 60 children (38 boys, 63%). The mean age was 7.8 ± 4.7 years. Malnutrition was found in 16% of patients, segregating equally between acute and chronic malnutrition. Sensitivity, specificity, positive predictive value and negative predictive value were 95.7% (95% confidence interval, CI = 85.75-98.83%), 76.9% (95% CI = 49.74-91.82%), 93.7 and 83.3, respectively. AUROC was 0.863 (95% CI = 0.72-1). There was no difference either in malnutrition awareness among the medical staff before and after the intervention period or in health outcomes at discharge.
    Conclusions: STAMP is a valid tool for malnutrition screening in hospitalised children; however, its use does not influence admitted patients' nutritional status awareness among the medical staff nor their outcomes at discharge.
    MeSH term(s) Attitude of Health Personnel ; Child ; Child, Hospitalized ; Female ; Humans ; Male ; Malnutrition/diagnosis ; Malnutrition/diet therapy ; Mass Screening ; Medical Staff ; Nutrition Assessment ; Sensitivity and Specificity
    Language English
    Publishing date 2019-04-22
    Publishing country Australia
    Document type Evaluation Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2082047-1
    ISSN 1747-0080 ; 1446-6368
    ISSN (online) 1747-0080
    ISSN 1446-6368
    DOI 10.1111/1747-0080.12529
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  10. Article ; Online: Body composition correlates with laboratory parameters and disease severity in infants with biliary atresia.

    Marderfeld, Luba / Waisbourd-Zinman, Orith / Biran, Neta / Rozenfeld Bar-Lev, Michal / Silbermintz, Ari / Poraz, Irit / Reznik, Dana / Jack, Yifat / Mozer Glassberg, Yael / Shamir, Raanan

    Pediatric transplantation

    2021  Volume 26, Issue 3, Page(s) e14208

    Abstract: Aim: Infants with biliary atresia (BA) generally have chronic malnutrition. However, the best anthropometric measure to assess malnutrition and its correlation with disease severity is unknown. We aimed to assess correlations of various anthropometric ... ...

    Abstract Aim: Infants with biliary atresia (BA) generally have chronic malnutrition. However, the best anthropometric measure to assess malnutrition and its correlation with disease severity is unknown. We aimed to assess correlations of various anthropometric measurements, including air displacement plethysmography (ADP), with laboratory parameters and with the pediatric end-stage liver disease (PELD) score in infants with BA.
    Methods: Infants with BA were followed at a pediatric liver transplantation center during 2014-2018. Follow-up comprised laboratory tests and nutritional assessment by a dietitian including dietary intake, weight, height, mid-upper arm circumference (MUAC), and skin-fold thickness. Fat-free mass (FFM) and fat mass (FM) were measured by ADP.
    Results: Forty-three nutritional evaluations were performed in 28 infants with BA (13 boys, 44.4%). The median age was 20.7 weeks (IQR: 13-25.9). Based on the various anthropometry modalities, infants with BA were found to be malnourished on most of the visits; 63% had a MUAC-Z score lower than -2 standard deviations. High serum bilirubin level predicted lower weight for age, length for age, and MUAC-Z. Lower MUAC-Z was associated with a higher PELD score. Neither FM mass nor FFM correlated with PELD or with serum bilirubin level. However, FM correlated with skin-fold thickness-Z and was low in most patients.
    Conclusions: The majority of BA infants suffer from malnutrition as assessed by most anthropometrics modalities; low MUAC correlated best with disease severity and serum bilirubin level. Further studies are warranted to determine the contribution of FM measurement by ADP to the anthropometric assessment of infants with BA.
    MeSH term(s) Adenosine Diphosphate ; Anthropometry ; Arm/anatomy & histology ; Biliary Atresia/complications ; Biliary Atresia/diagnosis ; Biliary Atresia/surgery ; Bilirubin ; Body Composition ; Body Weight ; Child ; End Stage Liver Disease ; Female ; Humans ; Infant ; Male ; Malnutrition ; Nutritional Status ; Severity of Illness Index
    Chemical Substances Adenosine Diphosphate (61D2G4IYVH) ; Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2021-12-19
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/petr.14208
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