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Article ; Online: Hip-Spine Relationship: Thoracolumbar Deformation in a Patient with Limited Hip Flexion: A Case Report.

Margalit, Adam / Sponseller, Paul D

JBJS case connector

2021 Volume 11, Issue 2, Page(s) e20.00548

Abstract: Case: We describe thoracolumbar kyphosis with severe vertebral deformation in a 13-year-old boy with cerebral palsy, hip extension contractures, and history of hip flexion-adduction releases.: Conclusion: Patients with cerebral palsy and hip ... ...

Abstract	Case: We describe thoracolumbar kyphosis with severe vertebral deformation in a 13-year-old boy with cerebral palsy, hip extension contractures, and history of hip flexion-adduction releases. Conclusion: Patients with cerebral palsy and hip extension contractures may develop thoracolumbar kyphosis to maintain sitting balance. It is important to recognize hip extension contractures as the underlying cause of the compensatory kyphosis and to be familiar with treatment options that address the hips and the spine.
MeSH term(s)	Adolescent ; Cerebral Palsy/complications ; Contracture ; Hip/diagnostic imaging ; Humans ; Kyphosis/complications ; Kyphosis/diagnostic imaging ; Male ; Spine
Language	English
Publishing date	2021-04-21
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	2160-3251
ISSN (online)	2160-3251
DOI	10.2106/JBJS.CC.20.00548
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Article: Rate of Tibiotalocalcaneal (TTC) Fusion Using the Surgical Implant Generation Network (SIGN) Intramedullary Nail in Developing Countries.

MacKenzie, James S / Suresh, Krishna V / Margalit, Adam / Shafiq, Babar / Zirkle, Lewis / Ficke, James

Journal of surgical orthopaedic advances

2024 Volume 32, Issue 3, Page(s) 187–192

Abstract: Outcomes of the Surgical Implant Generation Network (SIGN) nail have been reported for femur and tibial fractures, but its use in tibiotalocalcaneal arthrodesis (TTCA) is not well studied. Radiographic and clinical outcomes of TTCA using the SIGN ... ...

Abstract	Outcomes of the Surgical Implant Generation Network (SIGN) nail have been reported for femur and tibial fractures, but its use in tibiotalocalcaneal arthrodesis (TTCA) is not well studied. Radiographic and clinical outcomes of TTCA using the SIGN database in patients with > 6 months of radiographic follow up were analyzed. Rates of tibiotalar (TT) fusion and subtalar (ST) fusion at final follow up were assessed by two independent reviewers. Of the 62 patients identified, use of the SIGN nail for TCCA resulted in 53% rate of fusion in the TT joint and 20% in the ST joint. Thirty-seven patients (60%) demonstrated painless weight bearing at final follow up. There were no differences in incidence of painless weight bearing between consensus fused and not fused cohorts for TT and ST joints (p > 0.05). There were five implant failures, no cases of infection, and seven cases of reoperation. (Journal of Surgical Orthopaedic Advances 32(3):187-192, 2023).
MeSH term(s)	Humans ; Developing Countries ; Reoperation ; Orthopedics ; Arthrodesis ; Thiazolidines
Chemical Substances	2-thioxo-4-thiazolidinecarboxylic acid (20933-67-9) ; Thiazolidines
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2189157-6
ISSN	2158-3811 ; 1548-825X ; 1059-1052
ISSN (online)	2158-3811
ISSN	1548-825X ; 1059-1052
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Zs.A 4751: Show issues

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Article ; Online: Flexible nailing: Pushing the indications for diametaphyseal lower-extremity fractures.

Benes, Gregory / Schmerler, Jessica / Harris, Andrew B / Margalit, Adam / Lee, Rushyuan Jay

Medicine

2024 Volume 103, Issue 11, Page(s) e37417

Abstract: Elastic stable intramedullary nailing (ESIN) has been shown to be an effective form of surgical management for lower-extremity diametaphyseal fractures in pediatric patients, but studies are limited because ESIN treatment for these fractures is ... ...

Abstract	Elastic stable intramedullary nailing (ESIN) has been shown to be an effective form of surgical management for lower-extremity diametaphyseal fractures in pediatric patients, but studies are limited because ESIN treatment for these fractures is relatively uncommon. We sought to determine whether ESIN can be used effectively in the most distal or proximal short-segment forms of these fractures. We queried the electronic medical record system at Johns Hopkins Hospital using Current Procedural Terminology codes for femur and tibia fractures treated with ESIN in patients under 18 years old between January 2015 and October 2022. Preoperative and postoperative radiographs were subsequently reviewed to identify patients with a proximal or distal third femoral or tibial shaft fracture treated with ESIN and to define criteria for short-segment diametaphyseal fractures. We used Beaty radiological criteria to evaluate radiographic outcomes and Flynn titanium elastic nails (TENs) outcome scale to assess clinical recovery after radiographic evidence of union. There were 43 children who met the inclusion criteria. Among them, 10 patients had short-segment diametaphyseal fractures. There were 22 (51.2%) who sustained femur fractures and 21 (48.8%) who sustained tibia fractures. Using Beaty radiologic criteria, ESIN was associated with more satisfactory outcomes in patients with distal or proximal third shaft fractures (32/33) than in patients with short-segment diametaphyseal fractures (7/10) (P = .03). Using the TENs outcome scale, 21 (63.4%) patients with distal or proximal third shaft fractures had excellent results, 11 (33.3%) had satisfactory results, and 1 (3%) had a poor result. Among patients with short-segment diametaphyseal fractures, 4 (40%) had excellent results, 5 (50%) had satisfactory results, and 1 (10%) had a poor result. There were no differences in TENs outcomes between the groups (P = .24). Patients with short-segment lower-extremity diametaphyseal fractures treated with ESIN had worse radiographic outcomes but did no worse clinically than patients with distal or proximal third shaft fractures. Consequently, ESIN should be considered a safe and effective surgical management option for pediatric patients with even the most distal or proximal forms of these fractures.
MeSH term(s)	Humans ; Child ; Adolescent ; Fracture Fixation, Intramedullary/methods ; Femoral Fractures/diagnostic imaging ; Femoral Fractures/surgery ; Radiography ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Lower Extremity ; Treatment Outcome ; Bone Nails ; Fracture Healing ; Retrospective Studies
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037417
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Ua VI Zs.171: Show issues

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Article ; Online: Partial Resection of First Dorsal Compartment Extensor Retinaculum in De Quervain's Stenosing Tendovaginitis Release.

Monárrez, Rubén / Bains, Sandeep S / Margalit, Adam / Ingari, John V

Techniques in hand & upper extremity surgery

2023 Volume 27, Issue 1, Page(s) 14–16

Abstract: Various surgical techniques exist to treat de Quervain's stenosing tendovaginitis. Specific surgical techniques for de Quervain's are designed to avoid complications including injury to branches of the superficial branch of the radial nerve, inadequate ... ...

Abstract	Various surgical techniques exist to treat de Quervain's stenosing tendovaginitis. Specific surgical techniques for de Quervain's are designed to avoid complications including injury to branches of the superficial branch of the radial nerve, inadequate decompression, reflex sympathetic dystrophy, and palmar subluxation of the released tendons. A simple dorsal incision through the extensor retinaculum is advocated by many as a means to release the compartment while preventing postoperative subluxation. A single incision through the retinaculum limits exposure of the compartment and could lead to reannealing of the retinaculum and recurrent symptoms. Partial resection of the extensor retinaculum provides a more complete release and has not been found to lead to palmar tendon subluxation.
MeSH term(s)	Humans ; Tenosynovitis/surgery ; Tendons/surgery ; Tendon Entrapment/complications ; Forearm ; Tenotomy ; Joint Dislocations/surgery ; De Quervain Disease/complications ; De Quervain Disease/diagnosis ; De Quervain Disease/surgery
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2075789-X
ISSN	1531-6572 ; 1089-3393
ISSN (online)	1531-6572
ISSN	1089-3393
DOI	10.1097/BTH.0000000000000402
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Zs.A 5635: Show issues

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Article ; Online: Evaluating the sagittal spinal and pelvic parameters in Marfan syndrome patients affected by scoliosis.

Suresh, Sukrit Jushay / Margalit, Adam / Sponseller, Paul D

Spine deformity

2022 Volume 10, Issue 4, Page(s) 873–881

Abstract: Introduction: Spinal deformities present a common finding in patients affected with Marfan syndrome (MFS). More specifically, sagittal spine imbalances reflect the typical finding of such deformities. Observing spino-pelvic radiographs, we focused on ... ...

Abstract	Introduction: Spinal deformities present a common finding in patients affected with Marfan syndrome (MFS). More specifically, sagittal spine imbalances reflect the typical finding of such deformities. Observing spino-pelvic radiographs, we focused on eliciting any correlation between the pelvic incidence (PI), sacral slope (SS) and thoracolumbar kyphosis measurements, and categorising them according to a sagittal spinal classification system. Materials and methods: One hundred seventy patient records were found over a 6 year period, and further refined to incorporate a total of 44 patients. 25 males and 19 females with an average age of 20 years at imaging. Electronic and hard copies of radiographs were used and measurements were made with virtual Cobb meters, rulers and protractors. Results: The mean PI was significantly different between type-I (46°) and type-II spines (35°) (p = 0.04), and the values for each class were as follows: type IA-53°, type IB-44°, type IC-36°, type IIA-42°, and type IIB-34°. Type II spines had a lower PI compared to type IA spines (p = 0.037) and to that of an unaffected population. Statistically significant differences were noted in SS between groups (t test; p < 0.001), and ANOVA demonstrated that the largest differences between spinal classes were found in SS. Conclusion: In our study, PI values were much higher in type I compared to type II spines. Type II spines had PI values as expected, however, had higher than expected SS values. SS followed a down trending pattern across all spinal classes. Type IIA spines had a much greater preponderance for male patients. Overall, we wish to highlight in particular that type II spines were associated with a much lower PI and SS, and report these differences in pelvic morphology and sagittal spine patterns seen in MFS patients. The pelvic tilt and sacral slope parameters observed in our Type II spines may further reflect and characterize the deformity.
MeSH term(s)	Adult ; Female ; Humans ; Kyphosis/diagnostic imaging ; Kyphosis/etiology ; Male ; Marfan Syndrome/complications ; Marfan Syndrome/diagnostic imaging ; Posture ; Sacrum/diagnostic imaging ; Scoliosis/diagnostic imaging ; Scoliosis/etiology ; Young Adult
Language	English
Publishing date	2022-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2717704-X
ISSN	2212-1358 ; 2212-134X ; 2212-1358
ISSN (online)	2212-1358 ; 2212-134X
ISSN	2212-1358
DOI	10.1007/s43390-022-00484-x
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Article ; Online: Exposure to the

Margalit, Anatte / Sheehan, David / Carolan, James C / Kavanagh, Kevin

Microbiology (Reading, England)

2022 Volume 168, Issue 3

Abstract: The fungal ... ...

Abstract	The fungal pathogen
MeSH term(s)	Aspergillus fumigatus ; Humans ; Proteome/metabolism ; Proteomics ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/metabolism ; Secretome
Chemical Substances	Proteome
Language	English
Publishing date	2022-03-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1180712-x
ISSN	1465-2080 ; 1350-0872
ISSN (online)	1465-2080
ISSN	1350-0872
DOI	10.1099/mic.0.001164
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Article ; Online: Global protein responses of multidrug resistance plasmid-containing Escherichia coli to ampicillin, cefotaxime, imipenem and ciprofloxacin.

Margalit, Anatte / Carolan, James C / Walsh, Fiona

Journal of global antimicrobial resistance

2021 Volume 28, Page(s) 90–96

Abstract: Objectives: This study compared the proteomics of Escherichia coli containing the multidrug resistance plasmid pEK499 under antimicrobial stress and with no antimicrobial.: Methods: We utilised mass spectrometry-based proteomics to compare the ... ...

Abstract	Objectives: This study compared the proteomics of Escherichia coli containing the multidrug resistance plasmid pEK499 under antimicrobial stress and with no antimicrobial. Methods: We utilised mass spectrometry-based proteomics to compare the proteomes of the bacteria and plasmid under antimicrobial stress and no antimicrobial. Results: Our analysis identified statistically significant differentially abundant (SSDA) proteins common to groups exposed to the β-lactam antimicrobials but not ciprofloxacin, indicating a β-lactam stress response to exposure from this class of drugs, irrespective of β-lactam resistance or susceptibility. Data arising from comparisons of the proteomes of ciprofloxacin-treated E. coli and controls detected an increase in the relative abundance of proteins associated with ribosomes, translation, the TCA cycle and several proteins associated with detoxification, and a decrease in the relative abundance of proteins associated with the stress response, including oxidative stress. We identified changes in proteins associated with persister formation in the presence of ciprofloxacin but not the β-lactams. The plasmid proteome differed across each treatment and did not follow the pattern of antimicrobial-antimicrobial resistance (AMR) protein associations: a relative increase was observed in the amount of CTX-M-15 in the presence of cefotaxime and ciprofloxacin, but not the other β-lactams, suggesting regulation of CTX-M-15 protein production. Conclusion: The proteomic data from this study provided novel insights into the proteins produced from the chromosome and plasmid under different antimicrobial stresses. These data also identified novel proteins not previously associated with AMR or antimicrobial responses in pathogens, which may well represent potential targets of AMR inhibition.
MeSH term(s)	Ampicillin/pharmacology ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Cefotaxime/pharmacology ; Ciprofloxacin/pharmacology ; Drug Resistance, Multiple ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Imipenem ; Plasmids/genetics ; Proteome ; Proteomics ; beta-Lactamases/metabolism ; beta-Lactams
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents ; Proteome ; beta-Lactams ; Ciprofloxacin (5E8K9I0O4U) ; Imipenem (71OTZ9ZE0A) ; Ampicillin (7C782967RD) ; beta-Lactamases (EC 3.5.2.6) ; Cefotaxime (N2GI8B1GK7)
Language	English
Publishing date	2021-12-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2710046-7
ISSN	2213-7173 ; 2213-7173
ISSN (online)	2213-7173
ISSN	2213-7173
DOI	10.1016/j.jgar.2021.12.006
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Article ; Online: Occurrence of comorbidities in newly diagnosed type 2 diabetes patients and their impact after 11 years' follow-up.

Eilat-Tsanani, Sophia / Margalit, Avital / Golan, Liran Nevet

Scientific reports

2021 Volume 11, Issue 1, Page(s) 11071

Abstract: The burden of type 2 diabetes is growing, not only through increased incidence, but also through its comorbidities. Concordant comorbidities for type 2 diabetes, such as cardiovascular diseases, are considered expected outcomes of the disease or disease ... ...

Abstract	The burden of type 2 diabetes is growing, not only through increased incidence, but also through its comorbidities. Concordant comorbidities for type 2 diabetes, such as cardiovascular diseases, are considered expected outcomes of the disease or disease complications, while discordant comorbidities are not considered to be directly related to type 2 diabetes and are less extensively addressed under diabetes management. Here we show that the combination of concordant and discordant comorbidities appears frequently in persons with diabetes (75%). Persons with combined comorbidities visited family physicians more than persons with discordant, concordant or no comorbidity (17.3 ± 10.2, 11.6 ± 6.5, 8.7 ± 6.8, 6.3 ± 6.6 visits/person/year respectively, p < 0.0001). The risk of death during the study period was highest in persons with combined comorbidities and discordant only comorbidities (HR = 33.4; 95% CI 12.5-89.2 and HR = 33.5; 95% CI 11.7-95.8), emphasizing the contribution of discordant comorbidities to the outcome. Our study is unique as a long-term follow-up of an 11-year cohort of 9725 persons with new-onset type 2 diabetes. The findings highlight the contribution of discordant comorbidity to the burden of the disease. The high prevalence of the combination of both concordant and discordant comorbidities, and their appearance before the onset of type 2 diabetes, indicates a continuum of morbidity.
MeSH term(s)	Adult ; Age of Onset ; Aged ; Comorbidity ; Diabetes Complications/epidemiology ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Middle Aged ; Prevalence ; Retrospective Studies
Language	English
Publishing date	2021-05-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-90379-0
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Article: Bacterial Interactions with

Margalit, Anatte / Carolan, James C / Kavanagh, Kevin

Microorganisms

2021 Volume 9, Issue 2

Abstract: The immunocompromised airways are susceptible to infections caused by a range of pathogens which increases the opportunity for polymicrobial interactions to occur. ...

Abstract	The immunocompromised airways are susceptible to infections caused by a range of pathogens which increases the opportunity for polymicrobial interactions to occur.
Language	English
Publishing date	2021-02-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms9020435
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Article ; Online: Proteomic profiling of bacterial and fungal induced immune priming in Galleria mellonella larvae.

Sheehan, Gerard / Margalit, Anatte / Sheehan, David / Kavanagh, Kevin

Journal of insect physiology

2021 Volume 131, Page(s) 104213

Abstract: Some insects display immunological priming as a result of elevated humoral and cellular responses which give enhanced survival against subsequent infection. The humoral immune response of Galleria mellonella larvae following pre-exposure to heat killed ... ...

Abstract	Some insects display immunological priming as a result of elevated humoral and cellular responses which give enhanced survival against subsequent infection. The humoral immune response of Galleria mellonella larvae following pre-exposure to heat killed Staphylococcus aureus or Candida albicans cells was determined by quantitative mass spectrometry in order to assess the relationship between the humoral immune response and resistance to subsequent bacterial or fungal infection. Larvae pre-exposed to heat killed S. aureus showed increased resistance to subsequent bacterial and fungal infection. Larvae displayed an increased hemocyte density (14.08 ± 2.14 × 10
MeSH term(s)	Animals ; Candida albicans ; Hemocytes ; Host-Pathogen Interactions ; Immunity, Cellular ; Immunity, Humoral ; Larva/immunology ; Larva/metabolism ; Larva/microbiology ; Moths/immunology ; Moths/metabolism ; Moths/microbiology ; Proteome ; Staphylococcus aureus
Chemical Substances	Proteome
Language	English
Publishing date	2021-03-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1879-1611
ISSN (online)	1879-1611
DOI	10.1016/j.jinsphys.2021.104213
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